Neural mechanisms of water flow perception and spatial integration

Abstract:: The lateral line in fish detects water flow, and its input is essential for normal behaviour. How the brain interprets lateral line inputs, and how this information meshes with information from other senses, remains poorly understood. This project proposes a novel preparation in the zebrafish model for applying controlled water flow using microfluidics, thereby stimulating the lateral line. Because the animal remains stationary, it is possible to perform whole-brain calcium imaging of cells and circuits that respond to water flow, and to use optogenetics to stimulate or silence these neurons. This will reveal the circuitry mediating flow perception, and its relationship with other senses, in a way that has been previously impossible.
Grant type:: ARC Discovery Projects
Funded by:: Australian Research Council

The University of Queensland