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Mimicking the perivascular niche with boronolectin-based biomaterials (2019–2022)

Abstract:
This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary, high throughput approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from these project outcomes and the application of this scalable biomaterial platform.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Justin Cooper-White

    Head of School
    School of Chemical Engineering
    Faculty of Engineering, Architecture and Information Technology
    Professor
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology

  • Professor Ernst Wolvetang

    Senior Group Leader
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council