Functional role of a novel DNA modification in the adult brain (2019–2021)

Abstract:
Emerging evidence indicates that DNA methylation is essential process involved in learning and memory process; however, recent discoveries indicate that the epigenome, and DNA modifications, in particular, are far more complex than currently appreciated. The primary aim of this proposal is to understand how neuronal DNA is modified upon learning and how this impacts memory formation. The proposed research will combine different genome-wide sequencing approaches and molecular and cell biological assays to provide new insight into the functional role of a novel DNA modification, N6-methyl-2'-deoxyadenosine, in the adult brain, and help to shape a new way of thinking about gene-environment interactions.
Grant type:
ARC Discovery Early Career Researcher Award
Researchers:
  • ARC DECRA Research Fellow
    Queensland Brain Institute
Funded by:
Australian Research Council