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How bacteria form resistant aggregates and biofilms (ARC Discovery Project administered by La Trobe University). (2021–2024)

Abstract:
This research aims to use interdisciplinary approaches to advance fundamental knowledge on bacterial aggregates and biofilms. These bacterial clusters are a significant problem as they have extraordinary resistance to disinfectants and antibiotics, and currently no effective methods are available to disrupt them. The expected outcomes of this project are to dissect how autotransporters, the most common group of bacterial cell-surface proteins, promote aggregation and biofilm formation, and to develop inhibitors that prevent the formation of these damaging bacterial clusters. Ultimately, this new knowledge will help address the increasing economic and social burden of industrial, environmental and biomedical biofilms.
Grant type:
La Trobe University
Researchers:

  • Professor Mark Schembri

    Professorial Research Fellow & Grou
    Institute for Molecular Bioscience
    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
La Trobe University