Regulation of lung immune-epithelial networks sensing environmental change (2023–2026)
Abstract:
This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and
molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance
of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to
induce immune responses to protect against microbial challenges or inhaled potentially toxic substances.
Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to
understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.
