Oxidative stress and autoaggregation in Escherichia coli (2004)
The oxidative stress response of Escherichia coli is an important defence mechanism coordinated by the actions of more than 30 genes. The aims of this project are to (i) identify novel genes within the oxidative stress regulon of pathogenic E. coli (ii) examine how the oxidative stress response regulator OxyR effects expression of the self-recognizing Antigen 43 autotransporter protein and (iii) study the structure-function relationship of Antigen 43. The work is important for our understanding of gene regulation in E. coli. Expected outcomes include development of forefront technologies and increased knowledge of bacterial resistance mechanisms.