Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons (2008–2012)

Abstract:
This project aims to develop a novel class of hybrid inorganic nanoparticles for effective delivery of therapeutic siRNAs, either locally or systemically, into the mouse central nervous system to slow the progression of Huntington's disease, one typical neurodegenerative disease. To this end, a more efficient and reliable delivery system will be devised by combining advantages of both layered double hydroxide and silica materials, with suitable surface functionalisation. Such a system will promote passage across the blood brain barrier and improve efficient neuronal uptake of novel drugs (e.g. siRNAs) leading to the effective treatment of genetic and other neuronal diseases.
Grant type:
ARC Discovery Projects
Researchers:
  • Professorial Research Fellow
    Queensland Brain Institute
    Emeritus Professor
    Queensland Brain Institute
  • Snr Group Leader/VC Snr Res Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Principal Research Fellow
    Centre for Horticultural Science
    Queensland Alliance for Agriculture and Food Innovation
  • Professorial Research Fellow
    Queensland Brain Institute
Funded by:
Australian Research Council