The University of Queensland

CHARLI: A phase Ib/II trial of ipilimumab-nivolumab-denosumab or nivolumab-denosumab in patients with unresectable stage III and IV melanoma

Lau, Peter Kar Han, Harris, Samuel John, Eastgate, Melissa A., Kee, Damien, Mant, Andrew, Nott, Louise M., Gedye, Craig, Inderjeeth, Andrisha Jade, Underhill, Craig, Weppler, Alison Margaret, Wallace, Roslyn, Lee, Belinda, Au-Yeung, George, Williams, Narelle, Ariza Ospino, Daniel, Gonzales, Louise, Shackleton, Mark J., Lo, Serigne N., McArthur, Grant A. and Sandhu, Shahneen (2023). CHARLI: A phase Ib/II trial of ipilimumab-nivolumab-denosumab or nivolumab-denosumab in patients with unresectable stage III and IV melanoma. Journal of Clinical Oncology, 41 (16_suppl), 9525-9525. doi: 10.1200/jco.2023.41.16_suppl.9525

Chemoradiotherapy with concurrent durvalumab for the palliative treatment of oligometastatic esophageal and gastroesophageal carcinoma with dysphagia: A single arm phase 2 clinical trial, PALEO

Day, Fiona, Sridharan, Swetha, Michael, Michael, Christophersen, Louise, Moore, Melissa M., Eastgate, Melissa A., Thompson, Stephen, MWEEMPWA, ANGELA, Oldmeadow, Christopher, Fraser, Allison and Martin, Jarad (2023). Chemoradiotherapy with concurrent durvalumab for the palliative treatment of oligometastatic esophageal and gastroesophageal carcinoma with dysphagia: A single arm phase 2 clinical trial, PALEO. Journal of Clinical Oncology, 41 (16_suppl), TPS4172-TPS4172. doi: 10.1200/jco.2023.41.16_suppl.tps4172

Investigating the dietary knowledge, attitudes, and beliefs of Australian patients with cancer

Lee, Shu Fen, Brown, Teresa, Wyld, David, Edwards, Anna and Eastgate, Melissa (2023). Investigating the dietary knowledge, attitudes, and beliefs of Australian patients with cancer. Journal of Human Nutrition and Dietetics, 36 (3), 612-621. doi: 10.1111/jhn.13091

Toxicity and response to ipilimumab and nivolumab in older patients with metastatic melanoma: A multicentre retrospective analysis

Pathmanathan, Shivanshan, Babu, Hari, Dzienis, Marcin, Azer, Mary and Eastgate, Melissa (2022). Toxicity and response to ipilimumab and nivolumab in older patients with metastatic melanoma: A multicentre retrospective analysis. Pigment Cell and Melanoma Research, 35 (6), 587-594. doi: 10.1111/pcmr.13063

Selective targeting of protein kinase C (PKC)-θ nuclear translocation reduces mesenchymal gene signatures and reinvigorates dysfunctional CD8+ T cells in immunotherapy-resistant and metastatic cancers

Dunn, Jenny, McCuaig, Robert D., Tan, Abel H. Y., Tu, Wen Juan, Wu, Fan, Wagstaff, Kylie M., Zafar, Anjum, Ali, Sayed, Diwakar, Himanshu, Dahlstrom, Jane E., Bean, Elaine G., Forwood, Jade K., Tsimbalyuk, Sofiya, Cross, Emily M., Hardy, Kristine, Bain, Amanda L., Ahern, Elizabeth, Dolcetti, Riccardo, Mazzieri, Roberta, Yip, Desmond, Eastgate, Melissa, Malik, Laeeq, Milburn, Peter, Jans, David A. and Rao, Sudha (2022). Selective targeting of protein kinase C (PKC)-θ nuclear translocation reduces mesenchymal gene signatures and reinvigorates dysfunctional CD8+ T cells in immunotherapy-resistant and metastatic cancers. Cancers, 14 (6) 1596, 1596. doi: 10.3390/cancers14061596

Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions

Jones, M., Okano, S., Looke, D., Kennedy, G., Pavilion, G., Clouston, J., Van Kuilenburg, R., Geary, A., Joubert, W., Eastgate, M. and Mollee, P. (2021). Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions. Journal of Hospital Infection, 118, 70-76. doi: 10.1016/j.jhin.2021.10.008

The effects of a family-centered psychosocial-based nutrition intervention in patients with advanced cancer: the PiCNIC2 pilot randomised controlled trial

Molassiotis, Alex, Brown, Teresa, Cheng, Hui Lin, Byrnes, Angela, Chan, Raymond Javan, Wyld, David, Eastgate, Melissa, Yates, Patsy, Marshall, Andrea P, Fichera, Rebecca, Isenring, Liz, To, Ki Fung, Ko, Po Shan, Lam, Wang, Lam, Yuk Fong, Au, Lai Fan and Lo, Raymond See-kit (2021). The effects of a family-centered psychosocial-based nutrition intervention in patients with advanced cancer: the PiCNIC2 pilot randomised controlled trial. Nutrition Journal, 20 (1) 2, 2. doi: 10.1186/s12937-020-00657-2

Surgical series of metastatic cerebral melanoma: clinical association of resection, BRAF-mutation status, and survival

Colditz, M.J., Lee, S.F., Eastgate, M., Elder, S., Brandis, P., Anderson, D., Withers, T., Jeffree, R.L., Pinkham, M.B. and Olson, S. (2021). Surgical series of metastatic cerebral melanoma: clinical association of resection, BRAF-mutation status, and survival. Interdisciplinary Neurosurgery, 24 101075, 101075. doi: 10.1016/j.inat.2020.101075

Semiqualitative research protocol to explore cancer care workforce perceptions of the health system response to COVID-19 preparations in Southeast Queensland, Australia

Gasper, Harry, Ahern, Elizabeth, Roberts, Natasha, Chan, Bryan, Hughes, Brett, Kennedy, Glen, Wyld, David, Eastgate, Melissa and Lwin, Zarnie (2021). Semiqualitative research protocol to explore cancer care workforce perceptions of the health system response to COVID-19 preparations in Southeast Queensland, Australia. BMJ Open, 11 (5) e044655, e044655. doi: 10.1136/bmjopen-2020-044655

Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma

Atkinson, Victoria, Khattak, Adnan, Haydon, Andrew, Eastgate, Melissa, Roy, Amitesh, Prithviraj, Prashanth, Mueller, Christian, Brignone, Chrystelle and Triebel, Frederic (2020). Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma. Journal for ImmunoTherapy of Cancer, 8 (2) e001681, 1-9. doi: 10.1136/jitc-2020-001681

Catheter-associated bloodstream infections in adults with cancer: a prospective randomized controlled trial

Mollee, P., Okano, S., Abro, E., Looke, D., Kennedy, G., Harper, J., Clouston, J., Van Kuilenburg, R., Geary, A., Joubert, W., Eastgate, M. and Jones, M. (2020). Catheter-associated bloodstream infections in adults with cancer: a prospective randomized controlled trial. Journal of Hospital Infection, 106 (2), 335-342. doi: 10.1016/j.jhin.2020.07.021

Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort study

Kuchel, Anna, Ahern, Elizabeth, Collins, Stephanie, Whitehall, Vicki, Okano, Satomi, Pelecanos, Anita, Wyld, David, Eastgate, Melissa and Burge, Matthew (2020). Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort study. Asia-Pacific Journal of Clinical Oncology, 17 (1) ajco.13420, 84-93. doi: 10.1111/ajco.13420

Supporting patients and carers affected by pancreatic cancer: a feasibility study of a counselling intervention

Beesley, Vanessa L., Turner, Jane M., Chan, Raymond J., Yates, Patsy, Gordon, Louisa G., Burge, Matthew, Eastgate, Melissa A., Staneva, Aleksandra A., Northfield, Sarah, Beebe, Hanna, Wyld, David K. and Neale, Rachel E. (2020). Supporting patients and carers affected by pancreatic cancer: a feasibility study of a counselling intervention. European Journal of Oncology Nursing, 46 101729, 101729. doi: 10.1016/j.ejon.2020.101729

Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma

Lepletier, Ailin, Madore, Jason, O'Donnell, Jake S., Johnston, Rebecca L., Li, Xian-Yang, McDonald, Elizabeth, Ahern, Elizabeth, Kuchel, Anna, Eastgate, Melissa, Pearson, Sally-Ann, Mallardo, Domenico, Ascierto, Paolo A., Massi, Daniela, Merelli, Barbara, Mandala, Mario, Wilmott, James S., Menzies, Alexander M., Leduc, Charles, Stagg, John, Routy, Bertrand, Long, Georgina V., Scolyer, Richard A., Bald, Tobias, Waddell, Nicola, Dougall, William C., Teng, Michele W. L. and Smyth, Mark J. (2020). Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma. Clinical Cancer Research, 26 (14), 3671-3681. doi: 10.1158/1078-0432.ccr-19-3925

Metastatic colorectal cancer during pregnancy: a tertiary center experience and review of the literature

Lee, Shu Fen, Burge, Matthew and Eastgate, Melissa (2019). Metastatic colorectal cancer during pregnancy: a tertiary center experience and review of the literature. Obstetric Medicine, 12 (1), 38-41. doi: 10.1177/1753495X18755958

Prior bevacizumab and efficacy of later anti-epidermal growth factor receptor antibodies in metastatic colorectal cancer: results from a large international registry

Burge, Matthew, Semira, Christine, Lee, Belinda, Lee, Margaret, Kosmider, Suzanne, Wong, Rachel, Shapiro, Jeremy, Ma, Brigette, Dean, Andrew P., Zimet, Allan S., Steel, Simone A., Lok, Sheau Wen, Torres, Javier, Eastgate, Melissa, Wong, Hui-li and Gibbs., Peter (2018). Prior bevacizumab and efficacy of later anti-epidermal growth factor receptor antibodies in metastatic colorectal cancer: results from a large international registry. Clinical Colorectal Cancer, 17 (3), e593-e599. doi: 10.1016/j.clcc.2018.05.009

Disseminated disease including intra-cardiac metastasis from intermediate trophoblastic tumor of unspecified subtype, presenting in pregnancy

Xu, Wen, Singh, Mahendra, Yan, Hui, Lwin, Zarnie and Eastgate, Melissa (2016). Disseminated disease including intra-cardiac metastasis from intermediate trophoblastic tumor of unspecified subtype, presenting in pregnancy. Gynecologic Oncology Reports, 16, 34-38. doi: 10.1016/j.gore.2016.03.007

A prospective study of the impact of fluorodeoxyglucose positron emission tomography with concurrent non-contrast CT scanning on the management of operable pancreatic and peri-ampullary cancers

Burge, Matthew E., O'Rourke, Nick, Cavallucci, David, Bryant, Richard, Francesconi, Alessandra, Houston, Kathleen, Wyld, David, Eastgate, Melissa, Finch, Robert, Hopkins, George, Thomas, Paul and Macfarlane, David (2015). A prospective study of the impact of fluorodeoxyglucose positron emission tomography with concurrent non-contrast CT scanning on the management of operable pancreatic and peri-ampullary cancers. HPB, 17 (7), 624-631. doi: 10.1111/hpb.12418

A multicenter, randomized, double-blind phase III study of HBI-8000 combined with nivolumab versus placebo with nivolumab in patients with unresectable or metastatic melanoma not previously treated with PD-1 or PD-L1 inhibitors

Khushalani, N.I., Shue, H., Gedye, C., Mazumder, A., Sharma, S., Eastgate, M., Majem Tarruella, M., Antonanzas Basa, M., Montaudie, H., Marais-Nieman, R., de la Cruz Merino, L., Clements, A., Mortier, L., Jameson, M., Shojaei, F., Ning, J., Aiyer, L., Gillings, M., Kabbinavar, F. and Ascierto, P. (2022). A multicenter, randomized, double-blind phase III study of HBI-8000 combined with nivolumab versus placebo with nivolumab in patients with unresectable or metastatic melanoma not previously treated with PD-1 or PD-L1 inhibitors. ESMO Asia Congress 2022, Singapore, 2-4 December 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2022.10.052

Resistance to immunotherapy is associated with high parenchymal PD1+CD8+/CD8+T cells (PD1tR) driven by tumour CD155

de Oliveira, A. Lepletier, Madore, J., O'donnell, S., Johnston, R. L., Eastgate, M., Mallardo, D., Ascierto, P. A., Massi, D., Merelli, B., Mandala, M., Wilmott, J. S., Bald, T., Stagg, J., Routy, B., Long, G. V., Scolyer, R. A., Waddell, N., Dougall, W. C., Teng, M. W. L. and Smyth, M. (2019). Resistance to immunotherapy is associated with high parenchymal PD1+CD8+/CD8+T cells (PD1tR) driven by tumour CD155. Immuno-Oncology Congress of the European-Society-for-Medical-Oncology (ESMO), Geneva, Switzerland, 11-14 December 2019. Oxford, United Kingdom: Oxford University Press.

Royal Brisbane MedicalOncology Clinic Activity Review

Kuchel, Anna, Kermond, Anna, Lonton, Jennifer, Wyld, David and Eastgate, Melissa (2019). Royal Brisbane MedicalOncology Clinic Activity Review. COSA's 46th Annual Scientific Meeting, Urological cancer; Age and gender in cancer practice; Digital health in cancer, Adelaide, SA Australia, 12–14 November 2019. Chichester, West Sussex United Kingdom: Wiley-Blackwell.

Colorectal cancer patient reported outcomes: putting theory into practice

Bryant, Geoffrey, Eastgate, Melissa, Wyld, David, Burge, Matthew, Thaker, Darshit and Busato, Matthew (2018). Colorectal cancer patient reported outcomes: putting theory into practice. COSA's 45th Annual Scientific Meeting, Mesothelioma and Gastro‐Intestinal Cancers: Technology and Genomics, Perth Convention and Exhibition Centre, 13–15 November 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Dietary patterns and attitudes in cancer survivors

Lee, Shu Fen , Wyld, David , Eastgate, Melissa and Brown, Teresa (2018). Dietary patterns and attitudes in cancer survivors. Victorian Cancer Survivorship Conference, Melbourne, Australia, 8-9 February 2018.

Catheter-Associated Bloodstream Infections (CA-BSI) in Adults with Cancer: A Prospective Randomized Controlled Trial

Mollee, Peter, Okano, Satomi, Looke, David, Kennedy, Glen, Harper, John, Clouston, John, Van Kuilenburg, Rosita, Geary, Alanna, Joubert, Warren, Eastgate, Melissa and Jones, Mark (2017). Catheter-Associated Bloodstream Infections (CA-BSI) in Adults with Cancer: A Prospective Randomized Controlled Trial. In: 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, (). 9-12 December 2017.

Characterising Acute Ward Admissions of Advanced Cancer Patients to the Royal Brisbane Hospital

Mittal, Dolly, Eustace, Matthew, Eastgate, Melissa, Burge, Matthew and Wyld, David (2017). Characterising Acute Ward Admissions of Advanced Cancer Patients to the Royal Brisbane Hospital. WILEY.

Exploring attitudes and barriers to research in medical oncology training

Ladwa, R. and Eastgate, M. (2017). Exploring attitudes and barriers to research in medical oncology training. Medical Oncology Group of Australia Incorporated Annual Scientific Meeting, Real World Oncology: Translating Discovery in to Practice, Pullman Hotel, Albert Park, Melbourne, VIC, 2-4 August 2017. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12729

Outcomes comparing right and left-sided metastatic colorectal cancer: A multi-centre retrospective analysis in Queensland, Australia

Allen, Michael , Conroy, Sophie , Eastgate, Melissa , Wyld, David, Whitehall, Vicki and Burge, Matthew (2017). Outcomes comparing right and left-sided metastatic colorectal cancer: A multi-centre retrospective analysis in Queensland, Australia. Australasian Gastro-Intestinal Trials Group (AGITG) 2017 Annual Scientific Meeting, Cairns Convention Centre, Cairns, Australia, 4-6 October 2017. AGITG.

Single institution review of the correlation between the clinical and histopathological staging in newly diagnosed rectal cancer patients in 2015

Thanayankeezhil, Padmini, Wyld, David, Burge, Matthew and Eastgate, Melissa (2017). Single institution review of the correlation between the clinical and histopathological staging in newly diagnosed rectal cancer patients in 2015. Australasian Gastro-Intestinal Trials Group (AGITG) 2017 Annual Scientific Meeting, Cairns Convention Centre, Cairns, Australia, 4-6 October 2017. AGITG.

Assessment of long course chemoradiotherapy (Lccrt) in regards to completion of chemotherapy. The experience of a tertiary referral hospital

Christie, Hayden, Burge, Matthew, Eastgate, Melissa and Wyld, David (2014). Assessment of long course chemoradiotherapy (Lccrt) in regards to completion of chemotherapy. The experience of a tertiary referral hospital. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, Australia, 2-4 December, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Assessment of time to commencement of neoadjuvant long course chemoradiotherapy (Lccrt) for locally advanced rectal adenocarcinoma patients in a tertiary referral hospital

Christie, Hayden, Burge, Matthew, Eastgate, Melissa and Wyld, David (2014). Assessment of time to commencement of neoadjuvant long course chemoradiotherapy (Lccrt) for locally advanced rectal adenocarcinoma patients in a tertiary referral hospital. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, Australia, 2-4 December, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Locally advanced and metastatic pancreatic cancer: an assessment of the provision of chemotherapy at a tertiary referral hospital

Christie, Hayden, Burge, Matthew, Eastgate, Melissa and Wyld, David (2014). Locally advanced and metastatic pancreatic cancer: an assessment of the provision of chemotherapy at a tertiary referral hospital. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, Australia, 2-4 December, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Pathologic response of rectal adenocarcinoma to preoperative long course chemoradiotherapy (Lccrt). An assessment at a tertiary referral hospital

Christie, Hayden, Burge, Matthew, Eastgate, Melissa and Wyld, David (2014). Pathologic response of rectal adenocarcinoma to preoperative long course chemoradiotherapy (Lccrt). An assessment at a tertiary referral hospital. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, Australia, 2-4 December, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Rural Oncology Care Via Teleoncology and Outreach Clinics: Patient and Staff Perspectives and Comparisons

Wyeth, Holly, Chan, Bryan, Burge, Matthew, Wyld, David and Eastgate, Melissa (2014). Rural Oncology Care Via Teleoncology and Outreach Clinics: Patient and Staff Perspectives and Comparisons. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, VIC Australia, 2-4 December 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Time from diagnosis of rectal adenocarcinoma to commencement of long course chemoradiotherapy (Lccrt) for metropolitan versus rural patients referred to a Queensland tertiary referral hospital

Christie, Hayden, Burge, Matthew, Eastgate, Melissa and Wyld, David (2014). Time from diagnosis of rectal adenocarcinoma to commencement of long course chemoradiotherapy (Lccrt) for metropolitan versus rural patients referred to a Queensland tertiary referral hospital. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, Australia, 2-4 December, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12305

Safety of bevacizumab used in routine practice in patients with metastatic colorectal cancer

Dzienis, M., Malczewski, A., Goh, J., Hughes, B., Eastgate, M., Wyld, D. and Burge, M. (2012). Safety of bevacizumab used in routine practice in patients with metastatic colorectal cancer. Medical Oncology Group of Australia Incorporated Annual Scientific Meeting, Program and Abstracts: Targeting Cancer from Diagnosis to Cure & 5th Annual COGNO Annual Scientific Meeting, Brisbane, QLD Australia, 8-10 August 2012. Wiley-Blackwell Publishing.