Dr Wenyi Gu

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology
w.gu@uq.edu.au
+61 7 334 64168

Overview

Dr. Wenyi Gu’s early education was conducted in China which include his undergraduate and master’s degrees in veterinary medicine. In 1996, he migrated to Australia and pursued his PhD study in biochemistry & molecular biology at the Australian National University (ANU). After a short period of work at John Curtin Medical School ANU as a junior scientist, he moved to Brisbane in 2001 for his post-doc at the University of Queensland and currently a post-doctoral research fellow at AIBN. He held a Peter Doherty Fellowship (2006-2009) and was further supported by NHMRC to spend 7 months at Harvard University as a visiting fellow in 2008. Since his post-doctoral research he has been working in the area of using RNAi to treat viral diseases and cancers. He also has a strong background in immunology and vaccine development.

Research Interests

  • Rational design and delivery of small RNAs for effective cancer gene therapies
    Major research focus is on RNA interference (RNAi) based gene therapy and cancer therapy. Closely associated with this focus, research areas such as oncogenes, cancer stem cells, targeted delivery systems, cancer cell biomarkers, and cancer immunotherapy are also covered. My recent research is more concentrated on RNAi delivery with nano-particles and on identifying therapeutic targets for cancer stem cells and exploring novel therapeutic approaches including using small RNAs or chemotherapeutic drugs or nature compounds to inhibit cancer stem cell growth.

Research Impacts

Dr. Gu's research focus is on RNA interference (RNAi) based gene therapy and cancer therapy. Closely associated with this focus, he also interests in subjects such as oncogenes, cancer stem cells, targeted delivery, cancer cell biomarkers, and cancer immunotherapy. His recent research more focuses on RNAi delivery with nano-particles and on identifying therapeutic targets for cancer stem cells and exploring novel therapeutic approaches to inhibit cancer stem cell growth. His discovery that RNAi induces immunity to tumour antigens has led to a whole new field of biomedical research – that is the relationship between RNAi and acquired immune responses, and the role of RNAi techniques as specific and effective vaccine development tools for cancers and other diseases. This discovery has not only underpinned a high quality publication in PNAS USA but also an international patent that has been licensed by the world’s largest RNAi company, Alnylam Pharmaceuticals USA. Building on this, his recent research confirms that RNAi therapy has a profound effect on cancer stem cells (Gu et al 2011). More recently, he worked with his colleagues on RNAi therapy on osteoarthritis, which led to a high quality paper published by Nature Communication.

Qualifications

  • Doctor of Philosophy, Australian National University
  • Bachelor of Science, Tarim University
  • Master of Science, Northeast Ag. Coll.

Publications

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

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Publications

Featured Publications

Book Chapter

  • Gu, Wenyi, McMillan, Nigel and Yu, Chengzhong (2015). Silencing of E6/E7 expression in cervical cancer stem-like cells. In Daniel Keppler and Athena W. Lin (Ed.), Cervical cancer: methods and protocols (pp. 173-182) New York, NY United States: Springer. doi:10.1007/978-1-4939-2013-6_12

  • Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi (2013). Mesenchymal stem cells and nano-structured surfaces. In Turksen, K (Ed.), Stem Cell Nanotechnology: Methods and Protocols (pp. 133-148) New York, NY, United States: Humana Press. doi:10.1007/7651_2013_30

  • Gu, W., Putral, L. and McMillan, N. A. J. (2008). siRNA and shRNA as anti-cancer agents in a cervical cancer model. In J. M. Walker (Ed.), RNAi : design and application (pp. 159-172) Totowa, N.J., U.S.A.: Humana Press, Inc..

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.