Dr Stuart Kellie

Reader

School of Chemistry and Molecular Biosciences
Faculty of Science

Affiliate Principal Research Fellow

Institute for Molecular Bioscience
s.kellie@uq.edu.au
+61 7 336 54613

Overview

I was an MRC Postdoctoral Research Fellow at University of Leicester, UK 1980-3, and a Postdoctoral Fellow at the Imperial Cancer Research Fund laboratories, London 1983-6. After a 6 month EMBO Fellowship to the Ludwig Institute for Cancer Research in Berne, Switzerland, in 1986 I was appointed Lecturer in Biochemistry at the Royal College Surgeons (Univ. London). In 1990 I was appointed Group Leader at Yamanouchi Research Institute, Oxford. In 2002 I joined The University of Queensland as Senior Lecturer, and promoted to Associate Professor in 2006. From 2005-8 I was Deputy CEO of the CRC for Chronic Inflammatory Diseases (CRC-CID).

I have international collaborations with Profs Chris Buckley and Steve Watson (University of Birmingham, UK); Prof Simon Lovestone and Dr. Richard Killick (Kings College London).

Research Interests

  • Macrophage intracellular signalling
    My interests lie in the cell and molecular biology of phagocyte function. Phagocytes such as macrophages play a central role in both the innate and acquired immune response. Furthermore aberrant activation of these cells can lead to chronic inflammatory diseases. My interests are in identifying and functionally characterising novel macrophage genes that are associated with inflammation, and in intracellular signalling pathways in macrophages. I am particularly interested in the family of molecules known as tyrosine phosphatases and their role in regulating macrophage function. Current research projects include the molecular mechanisms underlying the regulation of monocyte function by the phosphatase CD148 and the functional characterisation of macrophage genes upregulated by acute and chronic inflammatory stimuli (with Dr. Matt Sweet); cell and structural biology of macrophage signaling proteins (with Profs Bostjan Kobe and Jenny Martin and Dr. Matt Sweet);
  • The role of furin-like molecules in RSV infection
    I am particularly interested in the role of host cell furin-like molecules in Respiratory Syncytial Virus (with Prof Paul Young) with a view to understanding how this virus enters host cells and infection spreads.
  • The role of PTPRJ in breast cancer
    PTPRJ (aka DEP-1 and CD148) is a tyrosine phosphatase that has been reported to be a tumour suppressor for colorectal cancer. With Prof. M. Brown and A/Prof G. Schenk we are interested in elucidating the role of this molecule in breast cancer and in normal mammary cell development

Qualifications

  • PhD (University of St Andrews), University of St Andrews
  • BSc (Hons) (University of Glascow), University of Glasgow

Publications

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Supervision

View all Supervision

Publications

Book Chapter

  • Kellie, S. and Al-Mansour, Z. (2016). Overview of the immune system. In Micro and nanotechnology in vaccine development (pp. 63-81) Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-323-39981-4.00004-X

  • Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. In B. Kobe, M. Guss and T. L. Huber (Ed.), Structural proteomics: High-throughput methods (pp. 577-587) Totowa, N.J.: Humana Press.

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

  • Master Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision