Professor Elizabeth Coulson

Professor

School of Biomedical Sciences
Faculty of Medicine

Professor

Queensland Brain Institute
e.coulson@uq.edu.au
+61 7 336 59022

Overview

Professor Lizzie Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer’s disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institute before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute.

Research Interests

  • Role of p75NTR in neurodegenerative disease.
    The laboratory recently reported that p75NTR death signalling can be promoted by amyloid-ß peptide that characteristically accumulates in Alzheimer’s disease. We are investigating the regulation and activation of p75NTR death signalling in cholinergic neurons in this condition, and testing whether disrupting p75NTR function can prevent cholinergic degeneration, and cognitive decline, in animal models. As an extension of this work we are developing methods to assess cholinergic degeneration and amyloid plaque deposition in animal models of Alzheimer’s disease by magnetic resonance imaging (MRI).
  • How neurotransmitter- and neurotrophin-mediated signals determine cell survival.
    We are investigating the basic molecular mechanisms by which neurotransmitter receptor activation and receptor trafficking affect p75NTR activation and subsequent death signalling using molecular and biochemical techniques in in vitro and in vivo models. We are also investigating the role of p75NTR cleavage in promoting death signalling, using confocal microscopy techniques to image live cells and cell membranes in real time. This project will lead to a greater understanding of p75NTR biology, and will also provide knowledge of the kinetics of p75NTR-mediated death signals and the time frame within which they can be inhibited.

Qualifications

  • PhD, University of Melbourne
  • BSc (Hons), University of Melbourne

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Master Philosophy

  • (2016) Doctor Philosophy

View all Supervision

Publications

Book Chapter

Journal Article

Conference Publication

  • Qian, L., Marks, N., Sharma, A., Bellingham, M. and Coulson, E. (2015). Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease. In: Journal of Neurochemistry. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (343-343). Aug 23-27, 2015.

  • Coulson, E. (2015). Disruption to long-range anterograde neurotrophin signalling in alzheimer's disease. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (79-79). 23-27 August 2015. doi:10.1111/jnc.13185

  • Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (208-208). 23-27 August 2015. doi:10.1111/jnc.13188

  • Coulson, E. J. and Matusica, D. (2012). Regulation of neuronal survival and death by the cleaved fragments of p75 neurotrophin receptor. In: Journal of Neurochemistry. , , (18-18). .

  • Kerbler, Georg, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2011). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 10th International Conference on Alzheimer's and Parkinson Diseases, Barcelona, Spain, (). 9-13 March 2011.

  • Edwards, Stephen R., Coulson, Elizabeth J. and Smith, Maree T. (2010). A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.. In: Found in translation: Integrated approaches to drug development. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) 44th Annual Scientific Meeting 2010, Melbourne, Australia, (10-10). 28 November-1 December 2010.

  • Georg Kerbler, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2010). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 3rd Brain Plasticity Symposium, Brisbane, Australia, (). 14-16 September 2010.

  • Keller, Marianne D., Kerbler, Georg, Hamlin, Adam S., Brereton, Ian and Coulson, Elizabeth J. (2010). Tractography in a Saporine Alzheimer's Disease mouse model. In: Proceedings of the 2010 World Molecular Imaging Congress. World Molecular Imaging Conference in Kyoto, Japan, Kyoto, Japan, (). 8-11 September 2010.

  • Kurniawan, N., Fox, B., Xu, Z., Li, L., Rogers, F., Lu, G., Galloway, G., Rose, S., Bartlett, P. F. and Coulson, E. J. (2006). Magnetic resonance micro-imaging at the University of Queensland. In: The 2nd Pacific Rim Brain Conference Proceedings. The 2nd Pacific Rim Brain Conference, Sunshine Coast, Australia, (39-39). 14-16 August 2006.

  • Kurniawan, N. D., Fox , B., Rogers, F., Butler, T., Li, L., Wallace, R., Cowin, G., Rose, S., Coulson, E., Galloway, G., Bartlett, P. F. and Brereton, I. M. (2006). Magnetic resonance neuroimaging at 16.4T. In: UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, Australia, (). 21-22 October 2006.

  • Catts, V. S., Catts, S., McGrath, J. J., Mackay-Sim, A., Feron, F., McLean, D., Coulson, E. J. and Lutze-Mann, L. H. (2005). Apoptotic markers in fibroblast cultures from patients with schizophrenia, bipolar disorder and non-affected controls. In: Psychiatry in a changing world. The Royal Aust & NZ College of Psychiatrists 40th Congress, Sydney, (A14-A14). 22-26 May, 2005.

  • Kurniawan, N., Rogers, F., Li, L., Fox, B., Xu. G., Bartlett, P. F., Coulson, E. and Rose, S. (2005). Development of contrast agents for magnetic resonance microimaging. In: The Queensland Brain Institute Brain Plasticity Symposium. The Queensland Brain Institute Brain Plasticity Symposium, Brisbane, Australia, (). 12-15 September, 2005.

  • Catts, V. S., Catts, S., Fernandez, H.R., Taylor, J., Coulson, E. and Lutzemann, L.H. (2004). A microarray study of postmortem mRNA degradation in mouse brain tissue. In: Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, (150-150). 27-30 January 2004.

  • Coulson, E., Sah, P., May, L. M., Morley, S. N. and Bartlett, P. F. (2004). Stimulation of Girk channel activity by P75 neurotrophin receptor (p 75NTR) promotes neuronal death. In: Society for Neuroscience 34th Annual Meeting, San Diego, (). 23-27 October, 2004.

  • Coulson, E., Reid, K. M., Shipham, K. M., Morley, S. N., Kilpatrick, T. J. and Bartlett, P. F. (2004). The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling. In: Luigi Aloe and Laura Calza, Progress in Brain Research: NGF and Related Molecules in Health and Disease. 7th International Conference on NGF and Related Molecules, Modena, Italy, (41-62). 15-19 May, 2002. doi:10.1016/S0079-6123(03)46003-2

  • Morley, S. N., Coulson, E. and Bartlett, P. F. (2004). Zinc neurotoxicity is promoted by nerve growth factor but is prevented by leukaemia inhibitor factor. In: Society for Neuroscience 34th Annual Meeting. Society for Neuroscience 34th Annual Meeting, San Diego, (). 23-27 October.

  • Young, K. M., Coulson, E. and Bartlett, P. F. (2004). p75NTR: The first positive marker for neural stem cell selection and its role in cell fate determination. In: Professor Paul Martin, Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, (44-44). 27-30 January.

  • Coulson, EJ, Reid, K, Murray, SS, Cheema, SS and Bartlett, PF (2000). Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. In: Annual Scientific Meeting of the Australasian-Society-of-Clinical-and-Experimental-Pharmacologists-and-Toxicologists, Hobart Australia, (537-541). Dec 13-16, 1998. doi:10.1046/j.1440-1681.2000.03295.x

  • Whyte, S, Jones, L, Coulson, EJ, Moir, RD, Bush, AI, Beyreuther, K and Masters, CL (1997). The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc. In: Alzheimer'S Disease: Biology, Diagnosis and Therapeutics. 5th International Conference on Alzheimers Disease and Related Disorders, Osaka Japan, (417-422). Jul 24-29, 1996.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Master Philosophy — Principal Advisor

Completed Supervision