Dr Linda Harkness

Research Fellow - Stem Cell Bioengi

Australian Institute for Bioengineering and Nanotechnology
l.harkness@uq.edu.au
+61 7 334 63831

Overview

Dr Harkness completed her MPhil at the University of Edinburgh in 1996 and her PhD at the University of Southern Denmark in 2013 before moving to work at AIBN in 2015 as a research fellow. She has co-authored 39 peer-reviewed research papers and 4 book chapters. Her research experience within the stem cell and regenerative medicine field is extensive. She joined the research group of Professor, Sir Ian Wilmut at the Roslin Institute in Edinburgh, Scotland in 1998 where she was part of a successful team utilizing somatic cell nuclear transfer (SCNT) in large and small animals. Additionally, her group established one of the first pluripotent stem cell research laboratories in the UK and successfully derived 6 new stem cell lines. Following her relocation to Denmark in 2005 she continued to derive more hESC lines using these to investigate their prospective applications in bone biology. She was also the Danish representative for the International Stem Cell Initiative (ISCI) between 2007 and 2012.

Her current research at AIBN focuses on developing robust techniques for the maintenance and differentiation of human embryonic stem cells (hESC) cultured as 3D aggregates utilising a thermoresponsive polymer which has been conjugated to an extracellular matrix protein. The goals are to (1) investigate and overcome cellular heterogeneity in pluripotent and differentiated hESC cultures prior to scale up needed for pharmaceutical applications and regenerative medicine protocols; (2) develop new analytical techniques enabling assessment of protein expression in intact 3D aggregates; (3) enable cultures of hESC to be differentiated and maintained as neuronal progenitors for scale up procedures.

Qualifications

  • Doctor of Philosophy, University of Southern Denmark

Publications

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Publications

Book Chapter

Journal Article

Conference Publication

Other Outputs