Professor Rod Minchin

Chair of Molecular Pharmacology

School of Biomedical Sciences
Faculty of Medicine
r.minchin@uq.edu.au
+61 7 334 61620

Overview

Professor Minchin received his PhD from the Department of Pharmacology at the University of Western Australia before undertaking post-doctoral studies at the National Cancer Institute in Washington DC. His major work was on pulmonary toxicology of anti-cancer drugs and chemical carcinogenesis. He returned as a QEII Fellow to the University of New South Wales to investigate polyamine transport in the lung. Eventually, he returned to the University of Western Australia as a teaching and research academic where his interest in arylamine N-acetyltransferases and gene therapy developed. Currently, Professor Minchin is the Chair of Molecular Pharmacology at the University of Queensland and is Head, Laboratory for Moleculkar and Cellular Pharmacology in the School of Biomedical Sciences

Research Interests

  • •Cellular activity to arylamine N-acetyltransferase, its subcellular localisation and modulation of growth and resistance
  • •Role of sulfotransferases in neurodegenerative diseases
  • •Interaction of nanomaterials with macromolecules and cells

Research Impacts

The Laboratory for Molecular and Cellular Pharmacology investigates the effects that drugs and other chemicals exert in human health and disease. Our research aims to identify biochemical pathways and cellular processes that may be targets for novel drug development and use. The Laboratory focuses on several cellular proteins (arylamine N-acetyltransferases and cytosolic sulfotransferases) that have a central role in cancer initiation and progression as well as neurological diseases such as Parkinsons. We also investigate the interaction of nanoparticles and nanomaterials with proteins and cells in order to better understand their potential future pharmacological applications.

Qualifications

  • Doctor of Philosophy, W.Aust
  • Bachelor of Science (Hons), W.Aust

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

View all Available Projects

Publications

Book Chapter

  • Mortimer, G. M. and Minchin, R. F. (2016). Nanotoxicology and nanovaccines. In Mariusz Skwarczynski and Istvan Toth (Ed.), Micro and nanotechnology in vaccine development (pp. 373-392) Oxford, United Kingdom: Elsevier . doi:10.1016/B978-0-323-39981-4.00020-8

  • Martin, D., Minchin, R. F., Belkina, M., Milev, A. and Kannangara, G. S. Kamali (2011). Toxicity and regulatory perspectives of carbon nanotubes. In Tony McNally and Petra Pötschke (Ed.), Polymer-carbon nanotube composites : Preparation, properties and applications (pp. 621-653) Cambridge, U.K.: Woodhead Publishing.

  • Butcher, Neville J. and Minchin, Rodney F. (2008). Arylamine N-Acetyltransferases. In Manfred Schwab (Ed.), Encyclopedia of cancer 2nd ed. (pp. 255-257) Berlin, Germany: Springer Verlag.

  • Butcher, N. J. and Minchin, R. F. (2005). Arylamine N-Acetyltransferase Gene Polymorphism. In Jurgen Fuchs and Maurizio Podda (Ed.), Encyclopedia of Medical Genomics and Proteomics (pp. 79-83) New York: Marcel Dekker.

Journal Article

Conference Publication

  • Wiliem, Arnold, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2011). An automatic image based single dilution method for end point titre quantitation of antinuclear antibodies tests using HEp-2 cells. In: Proceedings of the 2011 International Conference on Digital Image Computing: Techniques and Applications. 2011 International Conference on Digital Image Computing: Techniques and Applications (DICTA 2011), Noosa, QLD, Australia, (1-6). 6 - 8 December 2011. doi:10.1109/DICTA.2011.9

  • Musumeci, Anthony, Broadhurst, Gysell, Smith, Suzanne, Xu, Zhi P., Minchin, Rodney F. and Martin, Darren J. (2009). Radiolabeled clay nanoparticles for toxicological investigations. In: Proceedings of the 8th World Biomaterials Congress. 8th World Biomaterials Conference, Amsterdam, The Netherlands, (). 28 May 2008 - 1 June, 2008.

  • Coles, D., Yang, S., Esposito, A., Mitchell, D., Minchin, R. and Toth, I. (2007). The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry. In: Wilce, J., Proceedings of the 4th International Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th International Peptide Symposium, Cairns, (1-2). 21-25 October 2007.

  • Khoshnejad, M., Toth, I., Young, P. R. and Minchin, R. F. (2006). Modified influenza virosomes for gene delivery. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, Qld, (Abstract). 24 Nov 2006.

  • Coles, D. J., Yang, S., Esposito, A., Mitchell, D. J., Minchin, R. F. and Toth, I. (2006). The synthesis of a novel dendritic system for gene delivery. In: Proceedings of: Annual Conference of the Australasian Pharmaceutical Science Association. Annual Conference of the Australasian Pharmaceutical Science Association, Adelaide, Australia, (). 3-5 December, 2006.

  • Coles, D. J., Yang, S, Esposito, A., Mitchell, D J, Minchin, R F and Toth, I (2006). The synthesis of a novel dendritic system for gene delivery. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 24 November 2006.

  • Yang, S, Coles, D. J., Esposito, A., Mitchell, D J, Toth, I and Minchin, R F (2006). Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells. In: Annual Conference of the Australasian Pharmaceutical Science Assn. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, (Poster). 3-5 December, 2006.

  • Minchin, Ron (2004). Arylamine N-acetyltransferase - from xenobiotic metabolising enzyme to regulation of transcription. In: C. J. Waterfield, Proceedings of the British Toxicology Society Annual Congress. The British Toxicology Society Annual Congress 2003, Nottingham, UK, (33-33). 1st - 4th September, 2003. doi:10.1016/j.tox.2004.06.030

  • Kendrick, T., Mus, A. M., Minchin, R., Leedman, P. and Klinken, P. (2004). The chromatin remodeller ATRX is a thyroid hormone responsive gene with a potential role as a repressor of erythropoiesis. In: Faseb: Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Congress of the International Union for Biochemistry and Molecular Biology. Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Congress of the International Union for Biochemistry and Molecular Biology, Boston, MA, (C195-C196). 12-16 Jun 2004.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.