Associate Professor Gary Leong

Academic Title-Associate Professor

Mater Research Institute-UQ
Faculty of Medicine

Academic Title-Associate Professor

Children's Health Queensland Clinical Unit
Faculty of Medicine

Overview

Normal growth in children requires different hormones and molecules to act to increase height and regulate fat, bone and muscle tissue in the body. Our studies at the molecular level investigate how these hormones co-ordinate cellular growth to try understand how diseases such as osteoporosis and obesity develop in children.

Dr. Leong's research interests are in the molecular mechanisms of nuclear hormone receptor regulation of growth and body composition; childhood growth disorders; glucocorticoid-induced osteoporosis and obesity in children.

He is a physician-scientist and clinical paediatric endocrinologist. He received his clinical and basic research training in Australia and at NIH in the USA. This included undertaking a NIH paediatric endocrine research fellowship and a PhD within the Bone and Mineral Research Program at the Garvan Institute, Sydney. During his PhD he investigated the role of cofactors in vitamin D receptor action in bone cells. From 2002-2004 he was a Senior Research Officer (SRO) in the Pituitary Research Unit, Garvan Institute. In July 2004 he was appointed as a staff specialist and Senior Lecturer in the Department of Paediatric Endocrinology and Diabetes at the Mater Children’s Hospital and as a NHMRC SRO at the Institute for Molecular Biosciences (IMB), University of Queensland. In 2010 he was promoted to Associate Professor in the UQ School of Medicine. His work has been published in international peer-reviewed journals such as Endocrinology, Journal of Biological Chemistry, Journal of Bone and Mineral Research, Journal of Clinical Endocrinology and Metabolism and Proceedings of National Academy of Sciences, USA. From May 2013 to the end of 2014 he was a QLD Health Senior Acdemic Fellow in Child Obesity Research and Prevention at the IMB and the Mater Children's Hospital. Since the end of 2014 he has taken up a staff specialist in Paediatric Endocrinology and Diabetes at the new Lady Cilento Children's Hospital and is also in private practice. He currently undertakes clinical research studies in child growth and obesity and its effects on metabolism. He has major clinical interest in prevention of chronic disease in childhood especially in prevention of Type 2 Diabetes Mellitus.

Research Interests

  • Glucocorticoid Receptor in Muscle Metabolic Function
    GR action plays a role in lipid and glucose homeostasis and energy expenditure in muscle cells. an improved understanding of the effects of GR activation on metabolic genes in muscle may lead to idenfication of novel taget genes involved in the Metabolic syndrome.
  • Childhood Growth and Obesity

Qualifications

  • Bachelor of Medicine/Surgery, University of Melbourne
  • Doctor of Philosophy, University of New South Wales

Publications

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Publications

Book

Journal Article

Conference Publication

PhD and MPhil Supervision

Completed Supervision