Dr Frank Fontaine

Bioassay Officer

Institute for Molecular Bioscience
f.fontaine@imb.uq.edu.au
+61 7 334 62050

Overview

Dr Frank Fontaine is a postdoctoral researchers and bioassay officer at UQ's Institute for Molecular Bioscience, a position he has held since 2006. He has developed more than fourteen protein- and cell-based bioassays, using spectrophotofluorimetric and high-content imaging methods, in the following indications: CNS, cancer, diabetes, obesity, infection, inflammation, stem cells. He has completed a dozen of screening campaigns on marine extracts and pure compounds and has five years of industry experience in the field of antithrombotics for UQ spin off, Thrombostat Pty Ltd, and as a sub-contractor for European CIRD Galderma, Theramex, Zambon Pharmacia, ADME Bioanalyses and UCB Pharma Sector. More recently, Frank developed a strong interest in the pharmaco-modulation of transcription factors protein-protein interactions. He has 26 publications and is co-inventor on 1 patent.

Qualifications

  • Doctor of Philosophy, Nic.
  • Diploma in Rural Engineering, Ren.

Publications

  • Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017) Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 3: 346-359. doi:10.1016/j.chembiol.2017.01.003

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 . doi:10.7554/eLife.21221

  • Fontaine, Frank, Overman, Jeroen and Francois, Mathias (2015) Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles. Cell Regeneration, 4 2: . doi:10.1186/s13619-015-0015-x

View all Publications

Publications

Journal Article

Conference Publication

  • Lynch, J., Talwar, S., Xiao, X., Balansa, W., Islam, R., Fontaine, F., Piggott, A., Zhang, H., Webb, T., Gilbert, D., Vaughan, C. and Capon, R. (2015). New small molecule analgesics that target the ALPHA3 glycine receptor. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (18-18). 23-27 August 2015. doi:10.1111/jnc.13185

  • Fontaine, F., de Sousa, G., Lesca, P. and Rahmani, R. (1998). Induction of CYP1A1/2 and oxidative stress by primaquine in human and rat hepatocytes. In: Toxicology Letters. -, -, (50-50). 1998. doi:10.1016/S0378-4274(98)80198-7

  • G. de Sousa, F. Fontaine, M. Pralavorio, D. Botta-Fridlund, Y. Letreut and R. Rahmani (1997). Insecticides cytotoxicity and CYP1A1 induction in primary human and rat hepatocytes cultures. In: F. M. Marano, D. J. Benford, J. V. Castell and Ch. A. Reinhardt, Toxicology in vitro. International Workshop on In Vitro Toxicology, Papendal, The Netherlands, (451-453). 24 - 28 June, 1996. doi:10.1016/S0887-2333(97)00061-1