Research Officer
Overview
Dr Aparna Jayachandran is a laboratory-based cancer researcher within The Gallipoli Medical Research Institute (GMRI) and Greenslopes Clinical Unit, The University of Queensland (2015-current). She is currently appointed as a Research Officer within the Liver Research Unit. Dr Jayachandran’s research work has focused on her expertise in the research areas of epithelial-to-mesenchymal transition (EMT), cancer biology, cancer stem cells and animal models of disease. Dr Jayachandran obtained a PhD with Summa cum laude in Molecular Biology from the University of Giessen, Germany. She was the first to identify the role of TGF-β signal transduction in EMT and its relevance to disease models of lung and kidney fibrosis. In 2010, she joined the Ludwig Institute for Cancer Research, Melbourne, Australia, as a postdoctoral fellow. Dr Jayachandran was the first to establish the mechanism of Thrombospondin1 in EMT in melanoma and highlighted the relationship between embryonic development and cancer metastasis in embryonic chicken. After joining GMRI in October 2015, she is extending her knowledge into Hepatocellular Carcinoma (HCC) biology and liver diseases. Her research focuses on EMT based-therpies to specifically target HCC.
Research Impacts
Given the poor patient outcomes and global increasing incidence of HCC, there is a great need to develop new therapies for effective treatment of this cancer. The development of new drugs that effectively treat HCC patients once the tumour has spread is an important goal for HCC researchers. Dr Jayachandran is involved in developing innovative models that will enable the determination of the external environmental factors and internal processes that regulate, trigger and can halt tumorigenesis. If successful, such drugs could transform the medical care and treatment of HCC patients and extend and enhance the quality of their lives.
Qualifications
- Doctor of Philosophy, JLU
Publications
-
Journal Article: Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma
Dhungel, Bijay, Andrzejewski, Slawomir, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018) Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma. Molecular Therapy, . doi:10.1038/s41434-018-0002-2
-
Journal Article: Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity
Jayachandran, Aparna, Shrestha, Ritu, Dhungel, Bijay, Huang, I-Tao, Vasconcelos, Marianna Yumi Kawashima, Morrison, Brian J., Ramlogan-Steel, Charmaine A. and Steel, Jason C. (2017) Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity. World Journal of Stem Cells, 9 9: 159-168. doi:10.4252/wjsc.v9.i9.159
-
Journal Article: Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017) Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 . doi:10.1038/srep45374
Supervision
-
Immunotherapy in HCC
Doctor Philosophy
-
An investigation into the aetiological factors of uveal melanoma
Master Philosophy
Publications
Journal Article
-
Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma
Dhungel, Bijay, Andrzejewski, Slawomir, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018) Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma. Molecular Therapy, . doi:10.1038/s41434-018-0002-2
-
Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity
Jayachandran, Aparna, Shrestha, Ritu, Dhungel, Bijay, Huang, I-Tao, Vasconcelos, Marianna Yumi Kawashima, Morrison, Brian J., Ramlogan-Steel, Charmaine A. and Steel, Jason C. (2017) Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity. World Journal of Stem Cells, 9 9: 159-168. doi:10.4252/wjsc.v9.i9.159
-
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017) Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 . doi:10.1038/srep45374
-
Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma
Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J. and Steel, Jason C. (2017) Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma. Drug Delivery, 24 1: 289-299. doi:10.1080/10717544.2016.1247926
-
Mir, Nabiel, Jayachandran, Aparna, Dhungel, Bijay, Shrestha, Ritu and Steel, Jason C. (2017) Epithelial-to-mesenchymal transition: a mediator of sorafenib resistance in advanced hepatocellular carcinoma. Current Cancer Drug Targets, 17 8: 698-706. doi:10.2174/1568009617666170427104356
-
Jayachandran, Aparna, Dhungel, Bijay and Steel, Jason C. (2016) Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma. Journal of Hematology and Oncology, 9 74: . doi:10.1186/s13045-016-0307-9
-
Identifying and targeting determinants of melanoma cellular invasion
Jayachandran, Aparna, Prithviraj, Prashanth, Lo, Pu-Han, Walkiewicz, Marzena, Anaka, Matthew, Woods, Briannyn L., Tan, BeeShin, Behren, Andreas, Cebon, Jonathan and McKeown, Sonja J. (2016) Identifying and targeting determinants of melanoma cellular invasion. Oncotarget, 7 27: 41186-41202. doi:10.18632/oncotarget.9227
-
Jayachandran, Aparna, Lo, Pu-Han, Chueh, Anderly C., Prithviraj, Prashanth, Molania, Ramyar, Davalos-Salas, Mercedes, Anaka, Matthew, Walkiewicz, Marzena, Cebon, Jonathan and Behren, Andreas (2016) Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. Bmc Cancer, 16 1: . doi:10.1186/s12885-016-2185-5
Conference Publication
-
Layton, C. J., Dhungel, B. , Andrzejewski, S. , Jayachandran, A. , Murali, A. and Steel, J. S. (2017). Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium. In: Special Issue: Abstracts from the 2017 European Association for Vision and Eye Research Conference. European Association for Vision and Eye Research Conference, Nice, France, (). 27-30 September 2017. doi:10.1111/j.1755-3768.2017.02683
-
Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma
Goh, A. , Ramlogan‐Steel, C. , Jayachandran, A., Steel, J. and Layton, C. J. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. In: Special Issue: Abstracts from the 2017 European Association for Vision and Eye Research Conference. European Association for Vision and Eye Research Conference, Nice, France, (). 27-30 September 2017. doi:10.1111/j.1755-3768.2017.02787
-
Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. In: Spie Biophotonics Australasia. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, (). 17 - 19 October 2016. doi:10.1117/12.2242978
PhD and MPhil Supervision
Current Supervision
-
Immunotherapy in HCC
Doctor Philosophy — Principal Advisor
Other advisors:
-
An investigation into the aetiological factors of uveal melanoma
Master Philosophy — Associate Advisor
Other advisors:
