Dr Aparna Jayachandran

Research Officer

Greenslopes Clinical Unit
Faculty of Medicine
a.jayachandran@uq.edu.au
+61 7 334 60695

Overview

Dr Aparna Jayachandran is a laboratory-based cancer researcher within The Gallipoli Medical Research Institute (GMRI) and Greenslopes Clinical Unit, The University of Queensland (2015-current). She is currently appointed as a Research Officer within the Liver Research Unit. Dr Jayachandran’s research work has focused on her expertise in the research areas of epithelial-to-mesenchymal transition (EMT), cancer biology, cancer stem cells and animal models of disease. Dr Jayachandran obtained a PhD with Summa cum laude in Molecular Biology from the University of Giessen, Germany. She was the first to identify the role of TGF-β signal transduction in EMT and its relevance to disease models of lung and kidney fibrosis. In 2010, she joined the Ludwig Institute for Cancer Research, Melbourne, Australia, as a postdoctoral fellow. Dr Jayachandran was the first to establish the mechanism of Thrombospondin1 in EMT in melanoma and highlighted the relationship between embryonic development and cancer metastasis in embryonic chicken. After joining GMRI in October 2015, she is extending her knowledge into Hepatocellular Carcinoma (HCC) biology and liver diseases. Her research focuses on EMT based-therpies to specifically target HCC.

Research Impacts

Given the poor patient outcomes and global increasing incidence of HCC, there is a great need to develop new therapies for effective treatment of this cancer. The development of new drugs that effectively treat HCC patients once the tumour has spread is an important goal for HCC researchers. Dr Jayachandran is involved in developing innovative models that will enable the determination of the external environmental factors and internal processes that regulate, trigger and can halt tumorigenesis. If successful, such drugs could transform the medical care and treatment of HCC patients and extend and enhance the quality of their lives.

Qualifications

  • Doctor of Philosophy, JLU

Publications

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Supervision

  • Doctor Philosophy

  • Master Philosophy

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Publications

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision