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Dr Aparna Jayachandran

Research Officer

Greenslopes Clinical Unit
Faculty of Medicine
a.jayachandran@uq.edu.au
+61 7 334 60695

Overview

Dr Aparna Jayachandran is a laboratory-based cancer researcher within The Gallipoli Medical Research Institute (GMRI) and Greenslopes Clinical Unit, The University of Queensland (2015-current). She is currently appointed as a Research Officer within the Liver Research Unit. Dr Jayachandran’s research work has focused on her expertise in the research areas of epithelial-to-mesenchymal transition (EMT), cancer biology, cancer stem cells and animal models of disease. Dr Jayachandran obtained a PhD with Summa cum laude in Molecular Biology from the University of Giessen, Germany. She was the first to identify the role of TGF-β signal transduction in EMT and its relevance to disease models of lung and kidney fibrosis. In 2010, she joined the Ludwig Institute for Cancer Research, Melbourne, Australia, as a postdoctoral fellow. Dr Jayachandran was the first to establish the mechanism of Thrombospondin1 in EMT in melanoma and highlighted the relationship between embryonic development and cancer metastasis in embryonic chicken. After joining GMRI in October 2015, she is extending her knowledge into Hepatocellular Carcinoma (HCC) biology and liver diseases. Her research focuses on EMT based-therpies to specifically target HCC.

Research Impacts

Given the poor patient outcomes and global increasing incidence of HCC, there is a great need to develop new therapies for effective treatment of this cancer. The development of new drugs that effectively treat HCC patients once the tumour has spread is an important goal for HCC researchers. Dr Jayachandran is involved in developing innovative models that will enable the determination of the external environmental factors and internal processes that regulate, trigger and can halt tumorigenesis. If successful, such drugs could transform the medical care and treatment of HCC patients and extend and enhance the quality of their lives.

Qualifications

  • Doctor of Philosophy, JLU

Publications

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Grants

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Supervision

  • Epithelial-to-mesenchymal transition, cancer stem cells and drug resistance: the mechanistic link and clinical relevance in hepatocellular carcinoma

    Doctor Philosophy

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Publications

Journal Article

Conference Publication

  • Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium

    Layton, C. J., Dhungel, B. , Andrzejewski, S. , Jayachandran, A. , Murali, A. and Steel, J. S. (2017). Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium. In: Special Issue: Abstracts from the 2017 European Association for Vision and Eye Research Conference. European Association for Vision and Eye Research Conference, Nice, France, (). 27-30 September 2017. doi:10.1111/j.1755-3768.2017.02683

  • Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma

    Goh, A. , Ramlogan‐Steel, C. , Jayachandran, A., Steel, J. and Layton, C. J. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. In: Special Issue: Abstracts from the 2017 European Association for Vision and Eye Research Conference. European Association for Vision and Eye Research Conference, Nice, France, (). 27-30 September 2017. doi:10.1111/j.1755-3768.2017.02787

  • In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe

    Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. In: Hutchinson, MR and Goldys, EM, Spie Biophotonics Australasia. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, (). 17 - 19 October 2016. doi:10.1117/12.2242978

PhD and MPhil Supervision

Current Supervision

  • Epithelial-to-mesenchymal transition, cancer stem cells and drug resistance: the mechanistic link and clinical relevance in hepatocellular carcinoma

    Doctor Philosophy — Principal Advisor

    Other advisors:

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