The University of Queensland

Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1

Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2018) Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, . doi:10.1021/acschembio.8b00989

Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption

Lawrence, Nicole, Dennis, Adelaide S. M., Lehane, Adele M., Ehmann, Anna, Harvey, Peta J., Benfield, Aurélie H., Cheneval, Olivier, Henriques, Sónia Troeira, Craik, David J. and McMorran, Brendan J. (2018) Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chemical Biology, . doi:10.1016/j.chembiol.2018.06.009

Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes

Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sonia Troeira and Schroeder, Christina I. (2018) Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. Journal of Biological Chemistry, 293 23: 9041-9052. doi:10.1074/jbc.RA118.002553

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017)

Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sonia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017). Biochimica Et Biophysica Acta-Biomembranes, 1859 11: 2277-2277. doi:10.1016/j.bbamem.2017.08.008

Redesigned spider peptide with improved antimicrobial and anticancer properties

Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017) Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 9: 2324-2334. doi:10.1021/acschembio.7b00459

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sónia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica et Biophysica Acta. Biomembranes, 1859 5: 835-844. doi:10.1016/j.bbamem.2017.01.020

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016) Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 33: 17049-17065. doi:10.1074/jbc.M116.729095

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

Philippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016) Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 6: 853-863. doi:10.1002/bip.22893

Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB

Knapp, O., Nevin, S. T., Yasuda, T., Lawrence, N., Lewis, R. J. and Adams, D. J. (2012) Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology, 166 7: 2148-2160. doi:10.1111/j.1476-5381.2012.01955.x

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

Loughnan, Marion L., Nicke, Annette, Lawrence, Nicole and Lewis, Richard J. (2009) Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry, 48 17: 3717-3729. doi:10.1021/bi9000326

Population dynamics and gene flow of Helicoverpa armigera (Lepidoptera : Noctuidae) on cotton and grain crops in the Murrumbidgee Valley, Australia

Scott, Leon J., Lawrence, Nicole, Lange, Corinna L., Graham, Glenn C., Hardwick, Scott, Rossiter, Louise, Dillon, Martin L. and Scott, Kirsten D. (2006) Population dynamics and gene flow of Helicoverpa armigera (Lepidoptera : Noctuidae) on cotton and grain crops in the Murrumbidgee Valley, Australia. Journal of Economic Entomology, 99 1: 155-163. doi:10.1603/0022-0493(2006)099[0155:PDAGFO]2.0.CO;2

Assessing moth migration and population structuring in Helicoverpa annigera (Lepidoptera : Noctuidae) at the regional scale: Example from the Darling Downs, Australia

Scott, Kirsten D., Lawrence, Nicole, Lange, Corinna L., Scott, Leon J., Wilkinson, Kendle S., Merritt, Melissa A., Miles, Melina, Murray, David and Graham, Glenn C. (2005) Assessing moth migration and population structuring in Helicoverpa annigera (Lepidoptera : Noctuidae) at the regional scale: Example from the Darling Downs, Australia. Journal of Economic Entomology, 98 6: 2210-2219.

Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years

Scott, K. D., Wilkinson, K. S., Lawrence, N., Lange, C. L., Scott, L. J., Merritt, M. A., Lowe, A. J. and Graham, G. C. (2005) Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years. Bulletin of Entomological Research, 95 4: 381-392. doi:10.1079/BER2005369

Recombinant chimeric proteins generated from conserved regions of Plasmodium falciparum merozoite surface protein 2 generate antiparasite humoral responses in mice

Lawrence, N, Stowers, A, Mann, V, Taylor, D and Saul, A (2000) Recombinant chimeric proteins generated from conserved regions of Plasmodium falciparum merozoite surface protein 2 generate antiparasite humoral responses in mice. Parasite Immunology, 22 5: 211-221. doi:10.1046/j.1365-3024.2000.00293.x

Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2

Stowers, Anthony, Taylor, Darrin, Prescott, Nicole, Cheng, Qin, Cooper, Juan and Saul, Allan (1997) Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2. Infection and Immunity, 65 6: 2329-2338.

Evidence of cross-contamination among laboratory lines of Plasmodium berghei

Saul, A, Prescott, N, Smith, F, Cheng, Q and Walliker, D (1997) Evidence of cross-contamination among laboratory lines of Plasmodium berghei. Molecular and Biochemical Parasitology, 84 1: 143-147. doi:10.1016/S0166-6851(96)02779-X

Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2

Stowers, A, Prescott, N, Cooper, J, Takacs, B, Stueber, D, Kennedy, P and Saul, A (1995) Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2. Parasite Immunology, 17 12: 631-642. doi:10.1111/j.1365-3024.1995.tb01009.x

Plasmodium falciparum genetic diversity can be characterised using the polymorphic merozoite surface antigen 2 (MSA-2) gene as a single locus marker

Prescott, N, Stowers, AW, Cheng, Q, Bobogare, A, Rzepczyk, CM and Saul, A (1994) Plasmodium falciparum genetic diversity can be characterised using the polymorphic merozoite surface antigen 2 (MSA-2) gene as a single locus marker. Molecular and Biochemical Parasitology, 63 2: 203-212. doi:10.1016/0166-6851(94)90056-6

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

Schroeder, Christina, Agwa, Akello, Mueller, Alexander, Chow, Chun Yuen, Peigneur, Steve, Lawrence, Nicole, Deplazes, Evelyne, Mark, Alan, Craik, David, Tytgat, Jan, King, Glenn, Vetter, Irina and Henriques, Sonia Troeira (2018). The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S70-S70). 26-31 August 2018.

The importance of peptide-membrane interactions in toxin inhibitions of sodium channels

Schroeder, Christina I., Deplazes, Evelyn, Lawrence, Nicole, Agwa, Akello and Henriques, Sonia T. (2017). The importance of peptide-membrane interactions in toxin inhibitions of sodium channels. In: 58th Annual Meeting of the Biophysical Society, San Francisco, United States, (226A-226A). 15-19 February 2014. doi:10.1016/j.bpj.2016.11.1247

Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562

Huang, Y. -H., Henriques, S. Troeira, Lawrence, N., Kaas, Q. and Craik, D. J. (2016). Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562. In: 34th European Peptide Symposium, Leipzig, Germany, (S174-S174). 4‐9 September 2016. doi:10.1002/psc.2950