Dr Priyakshi Kalita de Croft

Postdoctoral Research Officer

UQ Centre for Clinical Research
Faculty of Medicine
p.kalita@uq.edu.au
+61 7 334 66048

Overview

I am a molecular biologist with an honours degree in Medical Biotechnology (The University of Abertay Dundee, Scotland) and a PhD in Physiology and Medicine from the University of Otago (Dunedin, New Zealand) specialising in the development and use of preclinical disease models. I moved to Australia to pursue my passion for cancer research and employ my expertise of preclinical disease modelling in breast cancer brain metastases in Professor Lakhani’s laboratory.

Research Interests

  • Breast Cancer Metastases
    My research objectives are aimed towards understanding and developing therapeutic interventions for breast cancer and metastases. My program of work comprises of two main interests; brain metastasis and role of neo-antigens in triple-negative breast cancer. I am interested in understanding the influence of the unique tumour/tissue microenvironment (TME) in metastases, which is known to play a role in this process. To achieve this I have established brain metastatic tumours from the breast using intra-cranial, intra-cardiac preclinical models along with molecular biology, genomic and proteomic tools. In triple-negative breast cancer I am determining biomarkers in the neoadjuvant setting especially neo-antigens. I am exploring the expression of neo-antigens using immuno histochemical techniques in patients with neoadjuvant chemotherapy. I use a variety of statistical algorithms and clinical data analysis tools to achieve this.

Qualifications

  • Doctor of Philosophy, University of Otago

Publications

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Available Projects

  • I am interested in investigating the role of ERBB4 or HER4 protein in breast cancer metastases. The project would involve elucidating the pathways important downstream of HER4 which are critical in metastases. It will employ molecular biology techniques including genetic manipulation and animal modeling. Honours, Masters and PhD seeking students are encouraged to get in contact with me to discuss possibilities.

  • This project will be investigating the unique microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, protein expression and pathway analysis.

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Publications

Featured Publications

Journal Article

Conference Publication

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • I am interested in investigating the role of ERBB4 or HER4 protein in breast cancer metastases. The project would involve elucidating the pathways important downstream of HER4 which are critical in metastases. It will employ molecular biology techniques including genetic manipulation and animal modeling. Honours, Masters and PhD seeking students are encouraged to get in contact with me to discuss possibilities.

  • This project will be investigating the unique microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, protein expression and pathway analysis.