Dr Priyakshi Kalita de Croft

Postdoctoral Research Officer

UQ Centre for Clinical Research
Faculty of Medicine
p.kalita@uq.edu.au
+61 7 334 66048

Overview

I am a molecular biologist with an honours degree in Medical Biotechnology (The University of Abertay Dundee, Scotland) and a PhD in Physiology and Medicine from the University of Otago (Dunedin, New Zealand) specialising in the development and use of preclinical disease models. I moved to Australia to pursue my passion for cancer research and employ my expertise of preclinical disease modelling in breast cancer brain metastases in Professor Lakhani’s laboratory.

Research Interests

  • Breast Cancer Metastases
    My research objectives are aimed towards understanding and developing therapeutic interventions for breast cancer metastases. I am interested in understanding the influence of the tumour/tissue microenvironment(TME) in metastases, which is known to play a role in this process. Currently, I am investigating the role of brain TME in establishing brain metastatic tumours from the breast. For this I am looking at the function of different deregulated proteins in brain metastases. I use intra-cranial, intra-cardiac preclinical models along with molecular biology, genomic and proteomic tools for my studies. I would like to expand my future studies to other most commonly metastasised organs for breast cancer such as bone and lungs. Furthermore, I would like to develop patient derived xenograft models to better understand the clinical behaviour of tumours and develop targeted therapies consequently. My long-term goal is to develop a streamlined preclinical programme which can be used for translational breast cancer and metastases research.

Qualifications

  • Doctor of Philosophy, University of Otago

Publications

  • Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017) Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, . doi:10.1007/s10549-017-4496-x

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016) 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 6: 356-367. doi:10.1097/PAP.0000000000000128

  • Kalita-de Croft, Priyakshi, Bedford, Jennifer, Leader, John P. and Walker, Robert J. (2016) Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, . doi:10.1111/nep.12929

View all Publications

Available Projects

  • I am interested in investigating the role of ERBB4 or HER4 protein in breast cancer metastases. The project would involve elucidating the pathways important downstream of HER4 which are critical in metastases. It will employ molecular biology techniques including genetic manipulation and animal modeling. Honours, Masters and PhD seeking students are encouraged to get in contact with me to discuss possibilities.

  • This project will be investigating the unique microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, protein expression and pathway analysis.

View all Available Projects

Publications

Featured Publications

Journal Article

  • Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017) Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, . doi:10.1007/s10549-017-4496-x

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016) 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 6: 356-367. doi:10.1097/PAP.0000000000000128

  • Kalita-de Croft, Priyakshi, Bedford, Jennifer, Leader, John P. and Walker, Robert J. (2016) Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, . doi:10.1111/nep.12929

  • Dias, George Jayantha, Mahoney, Patricia, Hung, Noelyn Anne, Sharma, Lavanya Ajay, Kalita, Priyakshi, Smith, Robert Allen, Kelly, Robert James and Ali, Azam (2016) Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, . doi:10.1002/jbm.b.33735

  • Weiner, I. David, Leader, John P., Bedford, Jennifer J., Verlander, Jill W., Ellis, Gaye, Kalita, Priyakshi, Vos, Frederiek, de Jong, Sylvia and Walker, Robert J. (2014) Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reserach, 2 12: e12242.1-e12242.15. doi:10.14814/phy2.12242

Conference Publication

  • Saunus, Jodi M., Kalita-de Croft, Priyakshi, Lee, F. T., Al-Ejeh, Fares, Lim, Malcolm, Ensbey, Kathleen, Niland, Colleen, Jeffree, Rosalind L., Thomas, Paul, Day, Bryan W., Rose, Stephen, Scott, Andrew M. and Lakhani, Sunil R. (2016). Investigating the Her2-3 dimer as a theranostic target in brain metastases. In: COSA's 43 and ANZBCTG's 38 Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, (114-114). 15-17 November 2016. doi:10.1111/ajco.12646

  • Pearen, M. A., Pozniak, K. N., Pereira, T. N., Kramer, C. S. M., Kalita-De Croft, P., Tirnitz-Parker, J. E. E., Olynyk, J. K., Shepherd, R. W., Lewindon, P. J. and Ramm, G. A. (2016). Taurocholate induces proliferation and biliary differentiation of progenitor cells and stellate cell chemotaxis: insights into the pathophysiology of CF liver disease. In: Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, (3-3). 10–12 October 2016. doi:10.1111/jgh.13514

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • I am interested in investigating the role of ERBB4 or HER4 protein in breast cancer metastases. The project would involve elucidating the pathways important downstream of HER4 which are critical in metastases. It will employ molecular biology techniques including genetic manipulation and animal modeling. Honours, Masters and PhD seeking students are encouraged to get in contact with me to discuss possibilities.

  • This project will be investigating the unique microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, protein expression and pathway analysis.