Dr Juan Polanco

Research Fellow

Clem Jones Centre for Ageing Dementia Research
Queensland Brain Institute
+61 7 334 66326


Research Interests

  • The role of extracellular vesicles in the spreading of Alzheimer disease
    I am investigating the role of extracellular vesicles, such as exosomes, in the spreading and induction of Alzheimer's pathology. In 2016, we reported that tau-protein seeds are found within exosomes, having the ability to induce tau misfolding and aggregation in naïve cells. Exosomes are internalised by recipient cells via endocytosis and escaping the endosome is essential for tau aggregation and the impairment of cellular physiology that derives from it. Consequently, I am currently focusing my research on endosome escape of tau seeds in exosomes, exosome biogenesis, and trafficking. Furthermore, I am also interested in mechanisms of tau aggregation.


  • Doctor of Philosophy, The University of Queensland


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