Professor Linda Richards

Deputy Director (Research)

Queensland Brain Institute
richards@uq.edu.au
+61 7 334 66355

Overview

Linda J. Richards, PhD, FAA, FAHMS is a Professor of Neuroscience and Deputy Director of the Queensland Brain Institute at The University of Queensland, Brisbane, Australia. She is a Fellow of both the Australian Academy of Science and the Australian Academy of Health and Medical Sciences and is a National Health and Medical Research Council Principal Research Fellow. She is President of the Australasian Neuroscience Society and co-chair of the Australian Brain Alliance.

Professor Richards is head of the brain development and disorders laboratory at QBI. Her laboratory team strives to understand how the brain forms during development and how these processes are disrupted causing human developmental brain disorders and brain cancer. Professor Richards is a leading expert on the formation of the corpus callosum and is scientific advisor and patron for AusDoCC.

In 2015 she co-founded an International Consortium for the Corpus Callosum and Cerebral Connectivity with colleagues from Australia, USA, France and Brazil. The consortium brings together clinicians and scientists working to identify the causes of developmental brain disorders and how best to provide support and care for affected individuals and their families.

Professor Richards has received a number of awards and fellowships throughout her career including the Charles Judson Herrick Award from the American Association of Anatomists in 2004 and the Nina Kondelos award from the Australasian Neuroscience Society in 2010.

Professor Richards is passionate about the public awareness of science and in 2006 she founded the Australian Brain Bee Challenge, a competition for high school students to learn about the brain. Over 30,000 high school students have participated in the challenge and students from Australia have won the international brain bee competition three times and placed in every event since 2006.

Research Impacts

The defining goal throughout my career has been to understand how the brain becomes wired up during development. My research is focussed on the cellular and molecular mechanisms regulating the formation of the corpus callosum, the largest fibre tract connecting the two hemispheres in the brain. My current research investigates the mechanisms regulating how callosal axons cross the interhemispheric midline, and find their target in the opposing hemisphere. A serendipitous finding from our work has also led to the discovery of a gene that may be involved in adult brain cancer and we are currently developing a potential therapeutic approach for treatment. My work is informed by, and directed towards understanding human brain development and disease. I am also passionate about promoting our discoveries to the public: I have recently become a scientific advisor to the newly formed patient support group AusDoCC (Australian Disorders of the Corpus Callosum) and I have founded the Australian Brain Bee Challenge, a program designed to inspire and excite high school students about neuroscience.

Qualifications

  • Doctor of Philosophy, University of Melbourne

Publications

View all Publications

Supervision

  • (2017) Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Kozulin, Peter and Richards, Linda (2016). Axonal guidance: making connections. In Donald W. Pfaff and Nora D. Volkow (Ed.), Neuroscience in the 21st century 2nd ed. (pp. 201-224) New York: Springer New York. doi:10.1007/978-1-4939-3474-4_131

  • Morcom, Laura R., Edwards, Timothy J. and Richards, Linda J. (2016). Cortical architecture, midline guidance, and tractography of 3D white matter tracts. In Kathleen S. Rockland (Ed.), Axons and brain architecture (pp. 289-313) Cambridge, United Kingdom: Academic Press. doi:10.1016/B978-0-12-801393-9.00014-1

  • Kozulin, Peter, Almarza, Gonzalo, Gobius, Ilan and Richards, Linda J. (2016). Investigating early formation of the cerebral cortex by in utero electroporation: Methods and protocols. In Walker, David W. (Ed.), Prenatal and Postnatal Determinants of Development (pp. 3-20) New York, United States: Humana Press. doi:10.1007/978-1-4939-3014-2_1

Journal Article

Conference Publication

  • Stringer, Brett, Day, Bryan, Barry, Guy, Piper, Michael, Jamieson, Paul, Ensbey, Kathleen, Bruce, Zara, Richards, Linda and Boyd, Andrew (2013). The Glial Differentiation Factor Nuclear Factor One B (Nfib) Induces Differentiation and Inhibits Growth of Glioblastoma.. In: 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO), San Francisco, United States, (27-27). Nov 21-24, 2013. doi:10.1093/neuonc/not174

  • Subramanian, Lakshmi, Sarkar, Anindita, Shetty, Ashwin S., Muralidharan, Bhavana, Padmanabhan, Hari, Piper, Michael, Monuki, Edwin S., Bach, Ingolf, Gronostajski, Richard M., Richards, Linda J. and Tole, Shubha (2012). Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. In: Abstracts to the 19th Biennial Meeting of the International Society for Developmental Neuroscience. 19th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN), Mumbai India, (690-690). 11-14 January 2012. doi:10.1016/j.ijdevneu.2012.10.058

  • Richards, Linda J. (2012). Wiring the developing brain. In: Abstracts to the 19th Biennial Meeting of the International Society for Developmental Neuroscience. 19th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN), Mumbai India, (637-637). 11-14 January 2012. doi:10.1016/j.ijdevneu.2012.10.097

  • Piper, Michael, Barry, Guy, Hawkins, John, Mason, Sharon, Lindwall, Charlotta, Little, Erica, Moldrich, Randal X., Boyle, Glen M., Gronostajski, Richard M., Bailey, Timothy L. and Richards, Linda (2010). NFIA controls progenitor cell differentiation through repression of the Notch effector Hes1. In: Faseb Journal. , , (). .

  • Piper, Michael, Dawson, Amber-Lee S., Lindwall, Charlotta, Barry, Guy, Plachez, Celine and Richards, Linda J. (2007). Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon. In: Gregory Bock and Jamie Goode, Cortical development: genes and genetic abnormalities: Novartis Foundation Symposium 288. Novartis Foundation Symposium 288, London, (230-245). 6–8 February 2007. doi:10.1002/9780470994030.ch16

  • Zhang, Jiangyang, Richards, Linda J., Miller, Michael. I., Yarowsky, Paul, van Zijl, Peter and Mori, Susumu (2006). Characterization of mouse brain and its development using diffusion tensor imaging and computational techniques. In: 2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-15. 28th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, New York Ny, (6154-6157). Aug 30-Sep 03, 2006.

  • Ren, T., Anderson, A., Shen, W-B., Huang, H., Plachez, C., Mori, S., Kinsman, S. L. and Richards, L. J. (2005). Imaging, anatomical, and molecular analysis of callosal formation in the developing human brain. In: 15th International Society of Developmental Biologists Congress, Sydney, NSW, Australia, (S95-S95). 3-7 September 2005. doi:10.1016/j.mod.2005.06.010

  • Richards, L. J., Plachez, C. and Shen, W-B. (2005). Migration and differentiation of subcallosal sling cells during development. In: 15th International Society of Developmental Biologists Congress, Sydney, NSW, Australia, (S110-S110). 3-7 September 2005. doi:10.1016/j.mod.2005.06.010

  • Plachez, C., Gronostajski, R. M. and Richards, L. J. (2005). Role of the nuclear factor one genes in cortical development. In: 15th International Society of Developmental Biologists Congress, Sydney, NSW, Australia, (S109-S109). 3-7 September 2005. doi:10.1016/j.mod.2005.06.010

  • Shu, T and Richards, LJ (2000). Slit-2 expression by the glial wedge, a new midline glial population, guides cortical axons across the corpus callosum.. In: Proceedings of the Society for Experimental Biology and Medicine. , , (235-235). .

  • Richards, LJ and Shu, T (2000). Slit-2 is a midline axon guidance cue in the developing cortex. In: European Journal of Neuroscience. , , (178-178). .

  • Bartlett, PF, Richards, LR, Kilpatrick, TJ, Talman, PS, Bailey, KA, Brooker, Gjf, Dutton, R, Koblar, S, Nurcombe, V, Ford, M, Cheema, SS, Likiardopoulos, V and Murphy, M (1995). Regulation of Neural Precursor Differentiation in the Embryonic and Adult Forebrain. In: Clinical and Experimental Pharmacology and Physiology. 1994 Australian-Physiological-and-Pharmacological-Society Symposium on Respiratory Systems, Hobart Australia, (559-562). Sep, 1994. doi:10.1111/j.1440-1681.1995.tb02066.x

  • Bartlett, PF, Richards, LR, Kilpatrick, TJ, Talman, PT, Bailey, KA, Brooker, GJ, Dutton, R, Koblar, SA, Nurcombe, V, Ford, MO, Cheema, SS, Likiardopoulos, V, Barrett, G and Murphy, M (1995). Factors regulating the differentiation of neural precursors in the forebrain. In: Development of the Cerebral Cortex. Symposium on Development of the Cerebral Cortex, London England, (85-94). Nov 29-Dec 01, 1994.

  • Richards, LJ, Kilpatrick, TJ, Bartlett, PF and Murphy, M (1993). Leukemia Inhibitory Factor (lif) Promotes the Development of Mammalian Spinal-Cord Precursor Cells-Invitro. In: Journal of Cellular Biochemistry. , , (266-266). .

Other Outputs

  • Richards, Linda Jane (2014): QBI Imaging Data Store. The University of Queensland. Collection. doi:10.14264/uql.2017.90

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision