Dr. Chun Xu received his Ph.D. in Biomedical Engineering and Nanotechnology at The University of Queensland, Australia in 2016. Before that, he got a M.D.S. in Oral and Maxillofacial Surgery and a B.D.S. in Dentistry from Wuhan University, China. He is currently a NHMRC Senior Research Officer and C.J. Martin fellow at The University of Queensland. He has published over 80 peer-reviewed scientific papers in top journals and hold several patents. He also serves as review editor on the editorial board of Nanoscience, Frontiers in Chemistry. He is a member of ISO experts committee for Nanoscience and Nanotechnologies. His reseach interests include the synethesis and application of nanomaterials for biomedical applications.
Journal Article: Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy
Ding, Feixiang, Liu, Junyan, Ai, Kelong, Xu, Chun, Mao, Xiaoyuan, Liu, Zhaoqian and Xiao, Haihua (2023). Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy. Advanced Materials. doi: 10.1002/adma.202306419
Journal Article: The application of lasers in vital pulp therapy: a review of histological effects
Afkhami, Farzaneh, Rostami, Golriz, Xu, Chun, Walsh, Laurence J. and Peters, Ove A. (2023). The application of lasers in vital pulp therapy: a review of histological effects. Lasers in Medical Science, 38 (1) 215, 215. doi: 10.1007/s10103-023-03854-7
Journal Article: Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses
Ren, Fuqiang, Wang, Feifei, Baghdasaryan, Ani, Li, Ying, Liu, Haoran, Hsu, RuSiou, Wang, Chuchu, Li, Jiachen, Zhong, Yeteng, Salazar, Felix, Xu, Chun, Jiang, Yingying, Ma, Zhuoran, Zhu, Guanzhou, Zhao, Xiang, Wong, Kerry Kaili, Willis, Richard, Christopher Garcia, K., Wu, Anna, Mellins, Elizabeth and Dai, Hongjie (2023). Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses. Nature Biomedical Engineering, 1-14. doi: 10.1038/s41551-023-01083-5
Testing of a cannabinoid, botanical-based formulation for oral pain relief applications
(2023–2024) Innovation Connections
Nano-engineered bacteriobot for the treatment of biofilms infection on dental implants
(2023) Australian Dental Research Fund Inc
3D bioprinting based tunable microRNAs delivery for bone tissue engineering
(2022–2023) Australian Dental Research Fund Inc
Mesoporous silica nanoparticle-based non-viral gene delivery systems for bone regeneration
(2023) Doctor Philosophy
Dual functional layered double hydroxide nanoparticles for osteosarcoma treatment
Doctor Philosophy
Promoting periodontal regeneration through 3D printed nano-engineered membrane delivering lithium and VEGF
Doctor Philosophy
Functional nano-cement scaffolds for bone repair
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Smart Nanomachine for drug delivery
Nanoparticles possess unique physical, chemical and biological properties due to the nanosize effects and offer various advantages for biomedical applications such as drug delivery and tissue engineering. Mesoporous silica nanoparticles (MSNs) are of special interest due to their good biocompatibility, high stability, rigid framework, well-defined pore structure, easily controllable morphology and tuneable surface chemistry. MSNs based delivery systems offer a promising strategy to improve the drawbacks of traditional therapeutic drugs such as low stability and difficulty of crossing the cell membranes. In this project we will develop novel smart MSNs which enable the loading and delivery of large therapeutic molecules including proteins and genes.
Bioceramics for Craniofacial and dental tissue Regeneration
Bioceramics scaffold is one of the promising candidates for bone repair and regeneration. This project aims to develop a multifunctional mesoporous bioceramics scaffold with antibiotic/growth factor to repair craniofacial bone defects. The advanced 3D printing technique will be employed to precisely fabricate tissues with designed structures and functions while providing biomimetic microenvironments. The unique design and functionality will improve the life quality of patients with bone defects.
Nanobiomaterials in craniofacial bone regeneration
Hosseinpour, Sepanta, Nanda, Ashwin, Lei, Chang, Lowe, Baboucarr, Ye, Qingsong and Xu, Chun (2021). Nanobiomaterials in craniofacial bone regeneration. Advances in Dental Implantology using Nanomaterials and Allied Technology Applications. (pp. 25-52) edited by Ramesh S. Chaughule and Rajesh Dashaputra. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-52207-0_2
Regenerative approaches in orthodontic and orthopedic treatment
He, Yan, Guastaldi, Fernando, Xu, Chun and Ye, Qingsong (2021). Regenerative approaches in orthodontic and orthopedic treatment. Regenerative approaches in dentistry: an evidence-based perspective. (pp. 151-170) edited by Sepanta Hosseinpour, Laurence J. Walsh and Keyvan Moharamzadeh. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-59809-9_8
Tooth bioengineering and whole tooth regeneration
Cheng, Ning, Wen, Juan, Hitching, Rita, Lei, Chang and Xu, Chun (2021). Tooth bioengineering and whole tooth regeneration. Regenerative approaches in dentistry: an evidence-based perspective. (pp. 89-102) edited by Sepanta Hosseinpour, Laurence J. Walsh and Keyvan Moharamzadeh. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-59809-9_5
Ding, Feixiang, Liu, Junyan, Ai, Kelong, Xu, Chun, Mao, Xiaoyuan, Liu, Zhaoqian and Xiao, Haihua (2023). Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy. Advanced Materials. doi: 10.1002/adma.202306419
The application of lasers in vital pulp therapy: a review of histological effects
Afkhami, Farzaneh, Rostami, Golriz, Xu, Chun, Walsh, Laurence J. and Peters, Ove A. (2023). The application of lasers in vital pulp therapy: a review of histological effects. Lasers in Medical Science, 38 (1) 215, 215. doi: 10.1007/s10103-023-03854-7
Ren, Fuqiang, Wang, Feifei, Baghdasaryan, Ani, Li, Ying, Liu, Haoran, Hsu, RuSiou, Wang, Chuchu, Li, Jiachen, Zhong, Yeteng, Salazar, Felix, Xu, Chun, Jiang, Yingying, Ma, Zhuoran, Zhu, Guanzhou, Zhao, Xiang, Wong, Kerry Kaili, Willis, Richard, Christopher Garcia, K., Wu, Anna, Mellins, Elizabeth and Dai, Hongjie (2023). Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses. Nature Biomedical Engineering, 1-14. doi: 10.1038/s41551-023-01083-5
Hosseinpour, Sepanta, Dai, Huan, Walsh, Laurence J. and Xu, Chun (2023). Mesoporous Core–Cone Silica Nanoparticles Can Deliver miRNA-26a to Macrophages to Exert Immunomodulatory Effects on Osteogenesis In Vitro. Nanomaterials, 13 (11) 1755, 1755. doi: 10.3390/nano13111755
Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management
Wen, Juan, Li, Huimin, Dai, Huan, Hua, Shu, Long, Xing, Li, Huang, Ivanovski, Sašo and Xu, Chun (2023). Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management. Materials Today Bio, 19 100597, 1-31. doi: 10.1016/j.mtbio.2023.100597
The delivery and activation of growth factors using nanomaterials for bone repair
Li, Yiwei, Xu, Chun and Lei, Chang (2023). The delivery and activation of growth factors using nanomaterials for bone repair. Pharmaceutics, 15 (3) 1017, 1-24. doi: 10.3390/pharmaceutics15031017
Ali, Masood, He, Yan, Chang, Anna Sze Ni, Wu, Alice, Liu, Jingyu, Cao, Yuxue, Mohammad, Yousuf, Popat, Amirali, Walsh, Laurie, Ye, Qingsong, Xu, Chun and Kumeria, Tushar (2023). Osteoimmune-modulating and BMP-2-eluting anodised 3D printed titanium for accelerated bone regeneration. Journal of Materials Chemistry B. doi: 10.1039/d3tb01029e
Hosseinpour, Sepanta, Gomez-Cerezo, Maria Natividad, Cao, Yuxue, Lei, Chang, Dai, Huan, Walsh, Laurence J., Ivanovski, Saso and Xu, Chun (2022). A comparative study of mesoporous silica and mesoporous bioactive glass nanoparticles as non-viral microRNA vectors for osteogenesis. Pharmaceutics, 14 (11) 2302, 1-19. doi: 10.3390/pharmaceutics14112302
Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era
Xu, Chun, Lei, Chang, Hosseinpour, Sepanta, Ivanovski, Saso, Walsh, Laurence J. and Khademhosseini, Ali (2022). Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era. National Science Review, 9 (10) nwac124, 1-13. doi: 10.1093/nsr/nwac124
Baghdasaryan, Ani, Wang, Feifei, Ren, Fuqiang, Ma, Zhuoran, Li, Jiachen, Zhou, Xueting, Grigoryan, Lilit, Xu, Chun and Dai, Hongjie (2022). Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models. Nature Communications, 13 (1) 5613, 1-11. doi: 10.1038/s41467-022-33341-6
Nanomaterials integrated 3D printing for biomedical application
Zhang, Liwen, Forgham, Helen, Shen, Ao, Wang, Jiafan, Zhu, Jiayuan, Huang, Xumin, Tang, Shiyang, Xu, Chun, Davis, Thomas P. and Qiao, Ruirui (2022). Nanomaterials integrated 3D printing for biomedical application. Journal of Materials Chemistry B, 10 (37), 7473-7490. doi: 10.1039/d2tb00931e
A shear-thinning biomaterial-mediated immune checkpoint blockade
Wu, Qingzhi, Qu, Moyuan, Kim, Han-Jun, Zhou, Xingwu, Jiang, Xing, Chen, Yi, Zhu, Jixiang, Ren, Li, Wolter, Tyler, Kang, Heemin, Xu, Chun, Gu, Zhen, Sun, Wujin and Khademhosseini, Ali (2022). A shear-thinning biomaterial-mediated immune checkpoint blockade. ACS Applied Materials & Interfaces, 14 (31), 35309-35318. doi: 10.1021/acsami.2c06137
Recent advances in silica-nanomaterial-assisted lateral flow assay
Zhuang, Han, Xu, Chun, Gao, Fang, Li, Yiwei, Lei, Chang and Yu, Chengzhong (2022). Recent advances in silica-nanomaterial-assisted lateral flow assay. Bioengineering, 9 (7) 266, 266. doi: 10.3390/bioengineering9070266
Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy
Li, Su-Ran, Huo, Fang-Yi, Wang, Han-Qi, Wang, Jing, Xu, Chun, Liu, Bing and Bu, Lin-Lin (2022). Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy. Journal of Nanobiotechnology, 20 (1) 277, 1-19. doi: 10.1186/s12951-022-01489-4
Wang, Feifei, Ren, Fuqiang, Ma, Zhuoran, Qu, Liangqiong, Gourgues, Ronan, Xu, Chun, Baghdasaryan, Ani, Li, Jiachen, Zadeh, Iman Esmaeil, Los, Johannes W. N., Fognini, Andreas, Qin-Dregely, Jessie and Dai, Hongjie (2022). In vivo non-invasive confocal fluorescence imaging beyond 1,700 nm using superconducting nanowire single-photon detectors. Nature Nanotechnology, 17 (6), 653-660. doi: 10.1038/s41565-022-01130-3
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie International Edition, 61 (12) e202112752, 1-22. doi: 10.1002/anie.202112752
Advances in porous inorganic nanomaterials for bone regeneration
Dai, Huan, Hosseinpour, Sepanta, Hua, Shu and Xu, Chun (2022). Advances in porous inorganic nanomaterials for bone regeneration. Nano TransMed, 1 (1) 9130005, 1-12. doi: 10.26599/ntm.2022.9130005
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie, 134 (12) e202112752, 1-22. doi: 10.1002/ange.202112752
Targeting innate immunity in breast cancer therapy: a narrative review
Ye, Yanqi, Xu, Chun, Chen, Fengqian, Liu, Qi and Cheng, Ning (2021). Targeting innate immunity in breast cancer therapy: a narrative review. Frontiers in Immunology, 12 771201, 771201. doi: 10.3389/fimmu.2021.771201
Modulating osteoimmune responses by mesoporous silica nanoparticles
Hosseinpour, Sepanta, Walsh, Laurence J. and Xu, Chun (2021). Modulating osteoimmune responses by mesoporous silica nanoparticles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00899, 4110-4122. doi: 10.1021/acsbiomaterials.1c00899
Hosseinpour, Sepanta, Nanda, Ashwin, Walsh, Laurence J. and Xu, Chun (2021). Microbial decontamination and antibacterial activity of nanostructured titanium dental implants: a narrative review. Nanomaterials, 11 (9) 2336. doi: 10.3390/nano11092336
Cao, Yuxue, Xu, Chun, Wright, Patricia P., Liu, Jingyu, Kong, Yueqi, Wang, Yue, Huang, Xiaodan, Song, Hao, Fu, Jianye, Gao, Fang, Liu, Yang, Walsh, Laurence J. and Lei, Chang (2021). Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules. ACS Applied Nano Materials, 4 (9) acsanm.1c01365, 8761-8769. doi: 10.1021/acsanm.1c01365
Multimaterial bioprinting towards the fabrication of biomimetic tissues and organs
Tavafoghi, Maryam, Darabi, Mohammad Ali, Mahmoodi, Mahboobeh, Tutar, Rumeysa, Xu, Chun, Mirjafari, Arshia, Billi, Fabrizio, Swieszkowski, Wojciech, Nasrollahi, Fatemeh, Ahadian, Samad, Hosseini, Vahid, Khademhosseini, Ali and Ashammakhi, Nureddin (2021). Multimaterial bioprinting towards the fabrication of biomimetic tissues and organs. Biofabrication, 13 (4) 042002, 042002. doi: 10.1088/1758-5090/ac0b9a
Hosseinpour, Sepanta, Cao, Yuxue, Liu, Jingyu, Xu, Chun and Walsh, Laurence J. (2021). Efficient transfection and long-term stability of rno-miRNA-26a-5p for osteogenic differentiation by large pore sized mesoporous silica nanoparticles. Journal of Materials Chemistry B, 9 (9), 2275-2284. doi: 10.1039/d0tb02756a
Lei, Chang, Cao, Yuxue, Hosseinpour, Sepanta, Gao, Fang, Liu, Jingyu, Fu, Jianye, Staples, Reuben, Ivanovski, Saso and Xu, Chun (2021). Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo. Nano Research, 14 (3), 770-777. doi: 10.1007/s12274-020-3112-2
In vivo NIR-II structured-illumination light-sheet microscopy
Wang, Feifei, Ma, Zhuoran, Zhong, Yeteng, Salazar, Felix, Xu, Chun, Ren, Fuqiang, Qu, Liangqiong, Wu, Anna M and Dai, Hongjie (2021). In vivo NIR-II structured-illumination light-sheet microscopy. Proceedings of the National Academy of Sciences of the United States of America, 118 (6) e2023888118, 1-10. doi: 10.1073/pnas.2023888118
Hosseinpour, Sepanta, Xu, Chun and Walsh, Laurence J. (2021). Impact of photobiomodulation using four diode laser wavelengths of on cationic liposome gene transfection into pre-osteoblast cells. Journal of Photochemistry and Photobiology B: Biology, 215 112108, 112108. doi: 10.1016/j.jphotobiol.2020.112108
Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery
Hines, Elizabeth, Cheng, Dan, Wu, Weixi, Yu, Meihua, Xu, Chun, Song, Hao and Yu, Chengzhong (2021). Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery. Journal of Materials Science, 56 (9), 5830-5844. doi: 10.1007/s10853-020-05660-w
Li, Hui Min, Guo, Hui Lin, Xu, Chun, Liu, Li, Hu, Shi Yu, Hu, Zhi Hui, Jiang, Heng Hua, He, Yan Ming, Li, Ying Jie, Ke, Jin and Long, Xing (2020). Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis. Bone, 141 115584, 1-10. doi: 10.1016/j.bone.2020.115584
Albashari, Abdullkhaleg, He, Yan, Zhang, Yanni, Ali, Jihea, Lin, Feiou, Zheng, Zengming, Zhang, Keke, Cao, Yanfan, Xu, Chun, Luo, Lihua, Wang, Jianming and Ye, Qingsong (2020). Thermosensitive bFGF-modified hydrogel with dental pulp stem cells on neuroinflammation of spinal cord injury. ACS Omega, 5 (26) acsomega.0c01379, 16064-16075. doi: 10.1021/acsomega.0c01379
Zhou, Xingwu, Luo, Zhimin, Baidya, Avijit, Kim, Han-jun, Wang, Canran, Jiang, Xing, Qu, Moyuan, Zhu, Jixiang, Ren, Li, Vajhadin, Fereshteh, Tebon, Peyton, Zhang, Niyuan, Xue, Yumeng, Feng, Yudi, Xue, Chengbin, Chen, Yi, Lee, KangJu, Lee, Junmin, Zhang, Shiming, Xu, Chun, Ashammakhi, Nureddin, Ahadian, Samad, Dokmeci, Mehmet Remzi, Gu, Zhen, Sun, Wujin and Khademhosseini, Ali (2020). Biodegradable beta-cyclodextrin conjugated gelatin methacryloyl microneedle for delivery of water-insoluble drug. Advanced Healthcare Materials, 9 (11) 2000527, 2000527. doi: 10.1002/adhm.202000527
Hoffman, Tyler, Antovski, Petar, Tebon, Peyton, Xu, Chun, Ashammakhi, Nureddin, Ahadian, Samad, Morsut, Leonardo and Khademhosseini, Ali (2020). Synthetic biology and tissue engineering: toward fabrication of complex and smart cellular constructs. Advanced Functional Materials, 30 (26) 1909882, 1909882. doi: 10.1002/adfm.201909882
Xu, Chun, Cao, Yuxue, Lei, Chang, Li, Zhihao, Kumeria, Tushar, Meka, Anand Kumar, Xu, Jia, Liu, Jingyu, Yan, Cheng, Luo, Lihua, Khademhosseini, Ali, Popat, Amirali, He, Yan and Ye, Qingsong (2020). Polymer-mesoporous silica nanoparticle core-shell nanofibers as a dual-drug-delivery system for guided tissue regeneration. ACS Applied Nano Materials, 3 (2), 1457-1467. doi: 10.1021/acsanm.9b02298
Carluccio, Danilo, Xu, Chun, Venezuela, Jeffrey, Cao, Yuxue, Kent, Damon, Bermingham, Michael, Demir, Ali Gökhan, Previtali, Barbara, Ye, Qingsong and Dargusch, Matthew (2020). Additively manufactured iron-manganese for biodegradable porous load-bearing bone scaffold applications. Acta Biomaterialia, 103, 346-360. doi: 10.1016/j.actbio.2019.12.018
Liu, Jingyu, Xu, Chun, Xu, Yanan, Ye, Qingsong, Fu, Shaoyun, Hu, Ning and Yan, Cheng (2020). Bioinspired scaffolds with hierarchical structures for tailored mechanical behaviour and cell migration. Ceramics International, 46 (15), 24102-24109. doi: 10.1016/j.ceramint.2020.06.189
Hosseinpour, Sepanta, Walsh, Laurence J. and Xu, Chun (2020). Biomedical application of mesoporous silica nanoparticles as delivery system: a biological-safety perspective. Journal of Materials Chemistry B, 8 (43), 9863-9876. doi: 10.1039/d0tb01868f
Tasia, Winda, Lei, Chang, Cao, Yuxue, Ye, Qingsong, He, Yan and Xu, Chun (2020). Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles. Nanoscale, 12 (4), 2328-2332. doi: 10.1039/c9nr08467c
Xu, Chun, Xiao, Lan, Cao, Yuxue, He, Yan, Lei, Chang, Xiao, Yin, Sun, Wujin, Ahadian, Samad, Zhou, Xueting, Khademhosseini, Ali and Ye, Qingsong (2020). Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration. Nano Research, 13 (9), 2323-2331. doi: 10.1007/s12274-020-2783-z
Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
Chen, Yihang, Zhang, Shiming, Cui, Qingyu, Ni, Jiahua, Wang, Xiaochen, Cheng, Xuanbing, Alem, Halima, Tebon, Peyton, Xu, Chun, Guo, Changliang, Nasiri, Rohollah, Moreddu, Rosalia, Yetisen, Ali K., Ahadian, Samad, Ashammakhi, Nureddin, Emaminejad, Sam, Jucaud, Vadim, Dokmeci, Mehmet R. and Khademhosseini, Ali (2020). Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing. Lab on a Chip, 20 (22), 4205-4214. doi: 10.1039/d0lc00446d
Non-antibiotic antimicrobial agents to combat biofilm-forming bacteria
Cao, Yuxue, Naseri, Mahdi, He, Yan, Xu, Chun, Walsh, Laurence J. and Ziora, Zyta M. (2019). Non-antibiotic antimicrobial agents to combat biofilm-forming bacteria. Journal of Global Antimicrobial Resistance, 21, 445-451. doi: 10.1016/j.jgar.2019.11.012
Liu, Jingyu, Bai, Ruixiang, Lei, Zhenkun, Xu, Chun, Ye, Qingsong, Martens, Wayde, Yarlagadda, Prasad KDV and Yan, Cheng (2019). Experimental and numerical investigation of the toughening mechanisms in bioinspired composites prepared by freeze casting. Composites Science and Technology, 182 107768, 107768. doi: 10.1016/j.compscitech.2019.107768
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019). Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 31 (46) 1904535, 1904535. doi: 10.1002/adma.201904535
Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release
Chen, Xiaobo, Xu, Chun and He, Hong (2019). Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release. Biochemical and Biophysical Research Communications, 516 (4), 1085-1089. doi: 10.1016/j.bbrc.2019.06.163
Cao, Yuxue, Xiao, Lan, Cao, Yanfan, Ashwin, Nanda, Xu, Chun and Ye, Qingsong (2019). 3D printed b-TCP scaffold with sphingosine 1-phosphate coating promotes osteogenesis and inhibits inflammation. Biochemical and Biophysical Research Communications, 512 (4), 889-895. doi: 10.1016/j.bbrc.2019.03.132
Lowe, Baboucarr, Ottensmeyer, Mark.P., Xu, Chun, He, Yan, Ye, Qingsong and Troulis, Maria (2019). The regenerative applicability of bioactive glass and beta-tricalcium phosphate in bone tissue engineering: a transformation perspective. Journal of Functional Biomaterials, 10 (1) 16, 16. doi: 10.3390/jfb10010016
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N. and Khademhosseini, A. (2019). Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs. Materials Today Bio, 1 100008, 100008. doi: 10.1016/j.mtbio.2019.100008
Dargusch, Matthew, Dehghan-Manshadi, Ali, Shahbazi, Mahboobeth, Venezuela, Jeffrey, Tran, Xuan, Song, Jing, Liu, Na, Xu, Chun, Ye, Qingsong and Wen, Cuie (2019). Exploring the role of manganese on the microstructure, mechanical properties, biodegradability and biocompatibility of porous iron-based scaffolds. ACS Biomaterials Science and Engineering, 5 (4) acsbiomaterials.8b01497, 1686-1702. doi: 10.1021/acsbiomaterials.8b01497
Mesoporous silica nanoparticles for protein protection and delivery
Xu, Chun, Lei, Chang and Yu, Chengzhong (2019). Mesoporous silica nanoparticles for protein protection and delivery. Frontiers in Chemistry, 7 (APR) 290, 290. doi: 10.3389/fchem.2019.00290
Xie, Huixu, Gu, Zhipeng, He, Yan, Xu, Jia, Xu, Chun, Li, Longjiang and Ye, Qingsong (2018). Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium. Journal of Materials Chemistry B, 6 (15), 2332-2339. doi: 10.1039/c8tb00306h
Xu, Chun, He, Yan, Li, Zhihao, Ahmad Nor, Yusilawati and Ye, Qingsong (2018). Nanoengineered hollow mesoporous silica nanoparticles for the delivery of antimicrobial proteins into biofilms. Journal of Materials Chemistry B, 6 (13), 1899-1902. doi: 10.1039/c7tb03201c
Double-layered microsphere based dual growth factor delivery system for guided bone regeneration
Xu, Chun, Xu, Jia, Xiao, Lan, Li, Zhihao, Xiao, Yin, Dargusch, Matthew, Lei, Chang, He, Yan and Ye, Qingsong (2018). Double-layered microsphere based dual growth factor delivery system for guided bone regeneration. RSC Advances, 8 (30), 16503-16512. doi: 10.1039/c8ra02072h
Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017). Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 (18), 7725-7732. doi: 10.1021/acs.chemmater.7b01804
Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities
Lin, Chun Xiang Cynthia, Xu, Chun, Yang, Yannan, Lei, Chang, Zhang, Haijiao and Yu, Chengzhong (2017). Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities. New Journal of Chemistry, 41 (17), 8754-8760. doi: 10.1039/c7nj00713b
Abbaraju, Prasanna Lakshmi, Yang, Yannan, Yu, Meihua, Fu, Jianye, Xu, Chun and Yu, Chengzhong (2017). Core-shell-structured dendritic mesoporous silica nanoparticles for combined photodynamic therapy and antibody delivery. Chemistry - An Asian Journal, 12 (13), 1465-1469. doi: 10.1002/asia.201700392
Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration
Sun, Xiaoyu, Xu, Chun, Wu, Gang, Ye, Qingsong and Wang, Changning (2017). Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration. Polymers, 9 (6) 189, 189. doi: 10.3390/polym9060189
Abbaraju, Prasanna Lakshmi, Meka, Anand Kumar, Song, Hao, Yang, Yannan, Jambhrunkar, Manasi, Zhang, Jun, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2017). Asymmetric silica nanoparticles with tunable head-tail structures enhance hemocompatibility and maturation of immune cells. Journal of the American Chemical Society, 139 (18), 6321-6328. doi: 10.1021/jacs.6b12622
Kalantari, Mohammad, Yu, Meihua, Noonan, Owen, Song, Hao, Xu, Chun, Huang, Xiaodan, Xiang, Feixiang, Wang, Xiaolin and Yu, Chengzhong (2017). Rattle-type magnetic mesoporous hollow carbon as a high-performance and reusable adsorbent for water treatment. Chemosphere, 166, 109-117. doi: 10.1016/j.chemosphere.2016.09.083
The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs
Wu, Tao, Cheng, Ning, Xu, Chun, Sun, Wei, Yu, Chengzhong and Shi, Bin (2016). The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs. Journal of Biomedical Materials Research Part A, 104 (12), 3004-3014. doi: 10.1002/jbm.a.35841
Liu, Yang, Zhang, Hongwei, Noonan, Owen, Xu, Chun, Niu, Yuting, Yang, Yannan, Zhou, Liang, Huang, Xiaodan and Yu, Chengzhong (2016). Kinetically controlled assembly of nitrogen-doped invaginated carbon nanospheres with tunable mesopores. Chemistry - A European Journal, 22 (42), 14962-14967. doi: 10.1002/chem.201602672
Meka, Anand Kumar, Abbaraju, Prasanna Lakshmi, Song, Hao, Xu, Chun, Zhang, Jun, Zhang, Hongwei, Yu, Meihua and Yu, Chengzhong (2016). A vesicle supra-assembly approach to synthesize amine-functionalized hollow dendritic mesoporous silica nanospheres for protein delivery. Small, 12 (37), 5169-5177. doi: 10.1002/smll.201602052
Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides
Lei, Chang, Zhou, Liang, Xu, Chun, Sun, Xiaoran, Nouwens, Amanda and Yu, Chengzhong (2016). Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides. Australian Journal of Chemistry, 69 (12), 1396-1401. doi: 10.1071/CH16443
Nor, Yusilawati Ahmad, Zhou, Liang, Meka, Anand Kumar, Xu, Chun, Niu, Yuting, Zhang, Hongwei, Mitter, Neena, Mahony, Donna and Yu, Chengzhong (2016). Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment. Advanced Functional Materials, 26 (30), 5408-5418. doi: 10.1002/adfm.201601459
Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles
Lei, Chang, Xu, Chun, Nouwens, Amanda and Yu, Chengzhong (2016). Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles. Journal of Materials Chemistry B, 4 (29), 4975-4979. doi: 10.1039/c6tb01023g
Noonan, Owen, Zhang, Hongwei, Song, Hao, Xu, Chun, Huang, Xiaodan and Yu, Chengzhong (2016). In situ Stöber templating: facile synthesis of hollow mesoporous carbon spheres from silica-polymer composites for ultra-high level in-cavity adsorption. Journal of Materials Chemistry A, 4 (23), 9063-9071. doi: 10.1039/c6ta02265k
Silica nanopollens enhance adhesion for long-term bacterial inhibition
Song, Hao, Ahmad Nor, Yusilawati, Yu, Meihua, Yang, Yannan, Zhang, Jun, Zhang, Hongwei, Xu, Chun, Mitter, Neena and Yu, Chengzhong (2016). Silica nanopollens enhance adhesion for long-term bacterial inhibition. Journal of the Americal Chemical Society, 138 (20), 6455-6462. doi: 10.1021/jacs.6b00243
Surfactant-free assembly of mesoporous carbon hollow spheres with large tunable pore sizes
Zhang, Hongwei, Noonan, Owen, Huang, Xiaodan, Yang, Yannan, Xu, Chun, Zhou, Liang and Yu, Chengzhong (2016). Surfactant-free assembly of mesoporous carbon hollow spheres with large tunable pore sizes. ACS Nano, 10 (4), 4579-4586. doi: 10.1021/acsnano.6b00723
Wang, Yue, Nor, Yusilawati Ahmad, Song, Hao, Yang, Yannan, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2016). Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. Journal of Materials Chemistry B, 4 (15), 2646-2653. doi: 10.1039/c6tb00053c
Chang, Ting, Xu, Chun, Wang, Cong-Yi, Fang, Wei, Li, Ying-Jie, Dai, Lin and Long, Xing (2016). The effect of TNF-alpha on the development of degenerative changes in anterior disc displacement of the temporomandibular joint. International Journal of Clinical and Experimental Medicine, 9 (3), 5813-5820.
Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015). Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 (44), 5949-5955. doi: 10.1002/smll.201501449
Niu, Yuting, Yu, Meihua, Zhang, Jun, Yang, Yannan, Xu, Chun, Yeh, Michael, Taran, Elena, Hou, Jeff Jia Cheng, Gray, Peter P. and Yu, Chengzhong (2015). Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery. Journal of Materials Chemistry B, 3 (43), 8477-8485. doi: 10.1039/c5tb01405k
Ahmad Nor, Yusilawati, Niu, Yuting, Karmakar, Surajit, Zhou, Liang, Xu, Chun, Zhang, Jun, Zhang, Hongwei, Yu, Meihua, Mahony, Donna, Mitter, Neena, Cooper, Matthew and Yu, Cheng Zhong (2015). Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery. ACS Central Science, 1 (6), 328-334. doi: 10.1021/acscentsci.5b00199
Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015). Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum. Chemical Communications, 51 (71), 13642-13645. doi: 10.1039/c5cc04458h
Yang, Yannan, Niu, Yuting, Zhang, Jun, Meka, Anand Kumar, Zhang, Hongwei, Xu, Chun, Lin, Chun Xiang Cynthia, Yu, Meihua and Yu, Chengzhong (2015). Biphasic synthesis of large-pore and well-dispersed benzene bridged mesoporous organosilica nanoparticles for intracellular protein delivery. Small, 11 (23), 2743-2749. doi: 10.1002/smll.201402779
Li, Chunyan, Meng, Gang, Su, Lei, Chen, Aiping, Xia, Mao, Xu, Chun, Yu, Decai, Jiang, Aiqin and Wei, Jiwu (2015). Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma. Oncotarget, 6 (3), 1544-1555. doi: 10.18632/oncotarget.2838
Floating tablets from mesoporous silica nanoparticles
Abbaraju, Prasanna Lakshmi, Meka, Anand kumar, Jambhrunkar, Siddharth, Zhang, Jun, Xu, Chun, Popat, Amirali and Yu, Chengzhong (2014). Floating tablets from mesoporous silica nanoparticles. Journal of Materials Chemistry B, 2 (47), 8298-8302. doi: 10.1039/c4tb01337a
Jambhrunkar, Siddharth, Qu, Zhi, Popat, Amirali, Karmakar, Surajit, Xu, Chun and Yu, Chengzhong (2014). Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. Journal of Colloid and Interface Science, 434, 218-225. doi: 10.1016/j.jcis.2014.08.019
Sensitive detection of human insulin using a designed combined pore approach
Lei, Chang, Noonan, Owen, Jambhrunkar, Siddharth, Qian, Kun, Xu, Chun, Zhang, Jun, Nouwens, Amanda and Yu, Chengzhong (2014). Sensitive detection of human insulin using a designed combined pore approach. Small, 10 (12), 2413-2418. doi: 10.1002/smll.201303748
Popat, Amirali, Karmakar, Surajit, Jambhrunkar, Siddharth, Xu, Chun and Yu, Chengzhong (2014). Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and Surfaces B: Biointerfaces, 117, 520-527. doi: 10.1016/j.colsurfb.2014.03.005
Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery
Xu, Chun, Niu, Yuting, Popat, Amirali, Jambhrunkar, Siddharth, Karmakar, Surajit and Yu, Chengzhong (2014). Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery. Journal of Materials Chemistry B, 2 (3), 253-256. doi: 10.1039/c3tb21431a
Chitosan as a barrier membrane material in periodontal tissue regeneration
Xu, Chun, Lei, Chang, Meng, Liuyan, Wang, Changning and Song, Yaling (2012). Chitosan as a barrier membrane material in periodontal tissue regeneration. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100 B (5), 1435-1443. doi: 10.1002/jbm.b.32662
Design of Mesoporous Silica Nanoparticles as Drug Carriers
Xu, Chun (2016). Design of Mesoporous Silica Nanoparticles as Drug Carriers. PhD Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.818
Developing sensitive detection nanotechnology to better identify insulin in serum
Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015). Developing sensitive detection nanotechnology to better identify insulin in serum. The Royal Society of Chemistry. (Dataset) doi: 10.14264/uql.2016.842
Testing of a cannabinoid, botanical-based formulation for oral pain relief applications
(2023–2024) Innovation Connections
Nano-engineered bacteriobot for the treatment of biofilms infection on dental implants
(2023) Australian Dental Research Fund Inc
3D bioprinting based tunable microRNAs delivery for bone tissue engineering
(2022–2023) Australian Dental Research Fund Inc
Nanotechnology for Bone Tissue Engineering
(2022–2023) U21 Health Sciences Group Early Career Research Fund
Nano delivery system for guided dental stem cell differentiation
(2022) Australian Dental Research Fund Inc
Development of nano-formulation for topical application
(2021–2022) UQ Knowledge Exchange & Translation Fund
(2021) Australian Dental Research Fund Inc
(2020) Australian Dental Research Fund Inc
(2019) Australian Dental Research Fund Inc
Functional nano-cement scaffolds for the treatment of osteoporotic bone defects
(2018–2021) NHMRC Early Career Fellowships
(2018) Australian Dental Research Fund Inc
Three-Dimensional Printing of Functional Mesoporous Bioceramics for Craniofacial Regeneration
(2017) UQ Early Career Researcher
Dual functional layered double hydroxide nanoparticles for osteosarcoma treatment
Doctor Philosophy — Principal Advisor
Other advisors:
Promoting periodontal regeneration through 3D printed nano-engineered membrane delivering lithium and VEGF
Doctor Philosophy — Principal Advisor
Other advisors:
Multifunctional nanoparticles with targeting and controlled release ability for the management of osteoarthritis
Doctor Philosophy — Principal Advisor
Other advisors:
The efficacy of nanoencapsulation as a delivery system of Terminalia ferdinandiana extract for periodontal disease therapy
Doctor Philosophy — Associate Advisor
Other advisors:
Point-of-Service Pulp Testing: Molecular and Optical Approaches
Doctor Philosophy — Associate Advisor
Other advisors:
Additive Manufacturing of High Entropy Alloys
Doctor Philosophy — Associate Advisor
Other advisors:
Laser additive manufacturing of iron and its alloys
Doctor Philosophy — Associate Advisor
Other advisors:
Assessment of the effects of professionally applied Silver Diamine Fluoride on early childhood caries
Doctor Philosophy — Associate Advisor
Mesoporous silica nanoparticle-based non-viral gene delivery systems for bone regeneration
(2023) Doctor Philosophy — Principal Advisor
Other advisors:
Development of Silica Based Nanoparticles for Plasmid DNA Delivery
(2021) Master Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Functional nano-cement scaffolds for bone repair
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Smart Nanomachine for drug delivery
Nanoparticles possess unique physical, chemical and biological properties due to the nanosize effects and offer various advantages for biomedical applications such as drug delivery and tissue engineering. Mesoporous silica nanoparticles (MSNs) are of special interest due to their good biocompatibility, high stability, rigid framework, well-defined pore structure, easily controllable morphology and tuneable surface chemistry. MSNs based delivery systems offer a promising strategy to improve the drawbacks of traditional therapeutic drugs such as low stability and difficulty of crossing the cell membranes. In this project we will develop novel smart MSNs which enable the loading and delivery of large therapeutic molecules including proteins and genes.
Bioceramics for Craniofacial and dental tissue Regeneration
Bioceramics scaffold is one of the promising candidates for bone repair and regeneration. This project aims to develop a multifunctional mesoporous bioceramics scaffold with antibiotic/growth factor to repair craniofacial bone defects. The advanced 3D printing technique will be employed to precisely fabricate tissues with designed structures and functions while providing biomimetic microenvironments. The unique design and functionality will improve the life quality of patients with bone defects.