Dr Lauren Aoude

NHMRC Early Career Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine
l.aoude@uq.edu.au
+61 7 344 38027

Overview

Qualifications

  • Bachelor of Arts, The University of Queensland
  • Bachelor of Engineering, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Publications

  • Johansson, Peter, Aoude, Lauren G., Wadt, Karin, Glasson, William J., Warrier, Sunil K., Hewitt, Alex W., Kiilgaard, Jens Folke, Heegaard, Steffen, Isaacs, Tim, Franchina, Maria, Ingvar, Christian, Vermeulen, Tersia, Whitehead, Kevin J., Schmidt, Christopher W., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2016) Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget, 7 4: 4624-4631. doi:10.18632/oncotarget.6614

  • Harland, Mark, Petljak, Mia, Robles-Espinoza, Carla Daniela, Ding, Zhihao, Gruis, Nelleke A., van Doorn, Remco, Pooley, Karen A., Dunning, Alison M., Aoude, Lauren G., Wadt, Karin A. W., Gerdes, Anne-Marie, Brown, Kevin M., Hayward, Nicholas K., Newton-Bishop, Julia A., Adams, David J. and Bishop, D. Timothy (2016) Germline TERT promoter mutations are rare in familial melanoma. Familial Cancer, 15 1: 139-144. doi:10.1007/s10689-015-9841-9

  • Wadt, K. A. W., Aoude, L. G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M. T., Kiilgaard, J. F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J. F., Mccarthy, S. W., Goodwin, A., Tsao, H., Jonsson, G., Busam, K., Gupta, R., Trent, J. M., Gerdes, A. -M., Brown, K. M., Scolyer, R. A. and Hayward, N. K. (2015) A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clinical Genetics, 88 3: 267-272. doi:10.1111/cge.12501

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Grants

View all Grants

Publications

Journal Article

  • Johansson, Peter, Aoude, Lauren G., Wadt, Karin, Glasson, William J., Warrier, Sunil K., Hewitt, Alex W., Kiilgaard, Jens Folke, Heegaard, Steffen, Isaacs, Tim, Franchina, Maria, Ingvar, Christian, Vermeulen, Tersia, Whitehead, Kevin J., Schmidt, Christopher W., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2016) Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget, 7 4: 4624-4631. doi:10.18632/oncotarget.6614

  • Harland, Mark, Petljak, Mia, Robles-Espinoza, Carla Daniela, Ding, Zhihao, Gruis, Nelleke A., van Doorn, Remco, Pooley, Karen A., Dunning, Alison M., Aoude, Lauren G., Wadt, Karin A. W., Gerdes, Anne-Marie, Brown, Kevin M., Hayward, Nicholas K., Newton-Bishop, Julia A., Adams, David J. and Bishop, D. Timothy (2016) Germline TERT promoter mutations are rare in familial melanoma. Familial Cancer, 15 1: 139-144. doi:10.1007/s10689-015-9841-9

  • Wadt, K. A. W., Aoude, L. G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M. T., Kiilgaard, J. F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J. F., Mccarthy, S. W., Goodwin, A., Tsao, H., Jonsson, G., Busam, K., Gupta, R., Trent, J. M., Gerdes, A. -M., Brown, K. M., Scolyer, R. A. and Hayward, N. K. (2015) A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clinical Genetics, 88 3: 267-272. doi:10.1111/cge.12501

  • Aoude, Lauren G., Heitzer, Ellen, Johansson, Peter, Gartside, Michael, Wadt, Karin, Pritchard, Antonia L., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Montgomery, Grant W., Martin, Nicholas G., Tomlinson, Ian, Kearsey, Stephen and Hayward, Nicholas K. (2015) POLE mutations in families predisposed to cutaneous melanoma. Familial Cancer, 14 4: 621-628. doi:10.1007/s10689-015-9826-8

  • Aoude, Lauren G., Gartside, Michael, Johansson, Peter, Palmer, Jane M., Symmons, Judith, Martin, Nicholas G., Montgomery, Grant W. and Hayward, Nicholas K. (2015) Prevalence of germline BAP1, CDKN2A, and CDK4 mutations in an australian population-based sample of cutaneous melanoma cases. Twin Research and Human Genetics, 18 2: 126-133. doi:10.1017/thg.2015.12

  • Aoude, Lauren G, Wadt, A.W, Pritchard, Antonia L and Hayward, Nicholas K (2015) Genetics of familial melanoma: 20 years after CDKN2A. Pigment Cell and Melanoma Research, 28 2: 148-160. doi:10.1111/pcmr.12333

  • Wadt, Karin A. W., Aoude, Lauren G., Krogh, Lotte, Sunde, Lone, Bojesen, Anders, Gronskov, Karen, Wartacz, Nine, Ek, Jakob, Tolstrup-Andersen, Morten, Klarskov-Andersen, Mette, Borg, Ake, Heegaard, Steffen, Kiilgaard, Jens F., Hansen, Thomas V. O., Klein, Kerenaftali, Jonsson, Goran, Drzewiecki, Krzysztof T., Duno, Morten, Hayward, Nicholas K. and Gerdes, Anne-Marie (2015) Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition. PLoS One, 10 3: e0122662.1-e0122662.16. doi:10.1371/journal.pone.0122662

  • Aoude, Lauren G., Pritchard, Antonia L., Robles-Espinoza, Carla Daniela, Wadt, Karin, Harland, Mark, Choi, Jiyeon, Gartside, Michael, Quesada, Victor, Johansson, Peter, Palmer, Jane M., Ramsay, Andrew J., Zhang, Xijun, Jones, Kristine, Symmons, Judith, Holland, Elizabeth A., Schmid, Helen, Bonazzi, Vanessa, Woods, Susan, Dutton-Regester, Ken, Stark, Mitchell S., Snowden, Helen, van Doom, Remco, Montgomery, Grant W., Martin, Nicholas G., Keane, Thomas M., Lopez-Otin, Carlos, Gerdes, Anne-Marie, Olsson, Hakan, Ingvar, Christian, Borg, Ake, Gruis, Nelleke A., Trent, Jeffrey M., Jonsson, Goran, Bishop, D. Timothy, Mann, Graham J., Newton-Bishop, Julia A., Brown, Kevin M., Adams, David J. and Hayward, Nicholas K. (2015) Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute, 107 2: 1-7. doi:10.1093/jnci/dju408

  • Aoude, Lauren G., Xu, Mai, Zhao, Zhen Zhen, Kovacs, Michael, Palmer, Jane M., Johansson, Peter, Symmons, Judith, Trent, Jeffrey M., Martin, Nicholas G., Montgomery, Grant W., Brown, Kevin M. and Hayward, Nicholas K. (2014) Assessment of PALB2 as a candidate melanoma susceptibility gene. PLoS One, 9 6: e100683.1-e100683.7. doi:10.1371/journal.pone.0100683

  • Robles-Espinoza, Carla Daniela, Harland, Mark, Ramsay, Andrew J, Aoude, Lauren G, Quesada, Víctor, Ding, Zhihao, Pooley, Karen A, Pritchard, Antonia L, Tiffen, Jessamy C, Petljak, Mia, Palmer, Jane M, Symmons, Judith, Johansson, Peter, Stark, Mitchell S., Gartside, Michael G, Snowden, Helen, Montgomery, Grant W, Martin, Nicholas G, Liu, Jimmy Z, Choi, Jiyeon, Makowski, Matthew, Brown, Kevin M, Dunning, Alison M, Keane, Thomas M, Lopez-Otin, Carlos, Gruis, Nelleke A, Hayward, Nicholas K, Bishop, D Timothy, Newton-Bishop, Julia A and Adams, David J (2014) POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46 5: 478-481. doi:10.1038/ng.2947

  • Dutton-Regester, K., Kakavand, H., Aoude, L.G., Stark, M.S., Gartside, M.G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G.M., Haydu, L.E., Schmidt, C.W., Mann, G.J., Thompson, J.F., Scolyer, R.A. and Hayward, N.K. (2013) Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell and Melanoma Research, 26 6: 852-860. doi:10.1111/pcmr.12153

  • Cronin, J.C., Watkins-Chow, D.E., Incao, A., Hasskamp, J.H., Schonewolf, N., Aoude, L.G., Hayward, N.K., Bastian, B.C., Dummer, R., Loftus, S.K. and Pavan, W.J. (2013) SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Research, 73 18: 5709-5718. doi:10.1158/0008-5472.CAN-12-4620

  • Aoude, Lauren G., Wadt, Karin, Bojesen, Anders, Cruger, Dorthe, Borg, Ake, Trent, Jeffrey M., Brown, Kevin M., Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2013) A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers. PloS One, 8 8: . doi:10.1371/journal.pone.0072144

  • Aoude, Lauren G., Vajdic, Claire M., Kricker, Anne, Armstrong, Bruce and Hayward, Nicholas K. (2013) Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases. Pigment Cell and Melanoma Research, 26 2: 1-3. doi:10.1111/pcmr.12046

  • Dutton-Regester, Ken, Aoude, Lauren G., Nancarrow, Derek J., Stark, Mitchell S., O'Connor, Linda, Lanagan, Cathy, Pupo, Gulietta M., Tembe, Varsha, Carter, Candace D., O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012) Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes and Cancer, 51 5: 452-461. doi:10.1002/gcc.21932

  • Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 2: 165-169. doi:10.1038/ng.1041

  • Dutton-Regester, Ken, Irwin, Darryl, Hunt, Priscilla, Aoude, Lauren G., Tembe, Varsha, Pupo, Gulietta M., Lanagan, Cathy, Carter, Candace D., O'Connor, Linda, O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012) A high-throughput panel for identifying clinically relevant mutation profiles in melanoma. Molecular Cancer Therapeutics, 11 4: 888-897. doi:10.1158/1535-7163.MCT-11-0676

  • Yokoyama, Satoru, Woods, Susan L., Boyle, Glen M., Aoude, Lauren G., MacGregor, Stuart, Zismann, Victoria, Gartside, Michael, Cust, Anne E., Haq, Rizwan, Harland, Mark, Taylor, John C., Duffy, David L., Holohan, Kelly, Dutton-Regester, Ken, Palmer, Jane M., Bonazzi, Vanessa, Stark, Mitchell S., Symmons, Judith, Law, Matthew H., Schmidt, Christopher, Lanagan, Cathy, O'Connor, Linda, Holland, Elizabeth A., Schmid, Helen, Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Jenkins, Mark A., Kefford, Richard F., Giles, Graham G., Armstrong, Bruce K., Aitken, Joanne F., Hopper, John L., Whiteman, David C., Pharoah, Paul D., Easton, Douglas F., Dunning, Alison M., Newton-Bishop, Julia A., Montgomery, Grant W., Martin, Nicholas G., Mann, Graham J., Bishop, D. Timothy, Tsao, Hensin, Trent, Jeffrey M., Fisher, David E., Hayward, Nicholas K. and Brown, Kevin M. (2011) A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature, 480 7375: 99-103. doi:10.1038/nature10630

  • Bonazzi, Vanessa F., Nancarrow, Derek J., Stark, Mitchell S., Moser, Ralf J., Boyle, Glen M., Aoude, Lauren G., Schmidt, Christopher and Hayward, Nicholas K. (2011) Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS One, 6 10: 1-9. doi:10.1371/journal.pone.0026121

  • Boyle, Glen M., Woods, Susan L., Bonazzi, Vanessa F., Stark, Mitchell S., Hacker, Elke, Aoude, Lauren G., Dutton-Regester, Ken, Cook, Anthony L., Sturm, Richard A. and Hayward, Nicholas K. (2011) Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell and Melanoma Research, 24 3: 525-537. doi:10.1111/j.1755-148X.2011.00849.x

Conference Publication

  • Aoude, L., Ferguson, B., Gordon, V., Johns, J., Maslovskaya, L., Parsons, P., Pierce, C., Reddell, P., Savchenko, A. and Williams, C. (2008). Cell culture-based assays identify edible rainforest fruits with potential for chemoprevention of cancer. In: Proceedings of the Australian Health and Medical Research Congress. 4th Australian Health and Medical Research Congress, Brisbane, Australia, (433-433). 16-21 November 2008.

Grants (Administered at UQ)