Professor Glenn King

Professorial Research Fellow

Institute for Molecular Bioscience

Affiliated Professor

School of Chemistry and Molecular Biosciences
Faculty of Science
glenn.king@imb.uq.edu.au
+61 7 334 62025

Overview

Research Interests

  • Bugs and drugs
    Our research harnesses the chemistry of venoms from arthropod predators, such as spiders, scorpions and centipedes, to develop novel pharmaceuticals to treat chronic pain, epilepsy and stroke. Stroke is the second-leading cause of death worldwide. In addition, it causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Likewise, chronic pain is a huge medical problem that affects one in five adults. There are few drugs available for treating chronic pain, and many of these have limited efficacy and dose-limiting side effects. Animal venoms are a rich source of stable natural peptides that potently modulate the activity of a wide range of neuronal ion channels and receptors. We have the largest collection of arthropod venoms in the world, a high-throughput pipeline for venoms-based drug discovery, protocols for rapid protein expression and structure determination, and links to key laboratories for testing the efficacy of lead molecules in rodent models of pain, epilepsy and stroke. We are using these world-class resources to move us closer to achieving our aim of developing novel analgesics for pain relief, novel drugs for treating severe paediatric epilepsies, and novel neuroprotective agents for treating stroke victims. An equally important focus of our research is on helping to safeguard Australia’s agricultural crops and reduce the spread of disease from insect pests by discovering new environmentally friendly insecticides. Currently, arthropod pests destroy approximately 15 per cent of the world’s food supply and spread pernicious diseases such as dengue and malaria. Our work is finding better, safer ways to control disease-spreading pests and protect crops.

Qualifications

  • Bachelor of Science, The University of Sydney
  • Doctor of Philosophy, The University of Sydney

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

Book

  • Kuchel, Philip W., Ralston, Gregory B., Bersten, Audrey M., Easterbrook-Smith, Simon B., Jones, Alan R., Montague, M. Dan, Slaytor, Michael B., Thomas, Micahel A. W., Wake, R. Gerard, Chappell, Douglas J., Christopherson, Richard I., Conigrave, Arthur D., Darvey, Ivan G., Guss, J. Mitchell, King, Glenn F., Morris, Michael B., Samman, Samir, Smith, Mark T., Szabados, Eve, Weiss, Anthony S. and Whitelaw, Emma Schaum's outline of theory and problems of biochemistry 2nd ed. New York, United States: McGraw-Hill, 1998.

Book Chapter

  • Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. In Brian Cox and Martin Gosling (Ed.), Ion channel drug discovery (pp. 297-313) Cambridge, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849735087-00297

  • Lavergne, Vincent, Alewood, Paul F., Mobli, Mehdi and King, Glenn F (2015). The Structural Universe of Disulfide-Rich Venom Peptides. In King, Glenn F (Ed.), Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics (pp. 37-79) London, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00037

  • Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. In Glenn F. King (Ed.), Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics (pp. 221-244) Cambridge, United Kingdom: Royal Society of Chemistry.. doi:10.1039/9781849737876-00221

  • Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. In King, Glenn F (Ed.), Venoms to Drugs (pp. 80-96) London, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00080

  • Lavergne, Vincent, King, Glenn F., Lewis, Richard J. and Alewood, Paul F. (2014). Peptide therapeutics from venomous creatures. In Charlotte Allerton (Ed.), Pain therapeutics: current and future treatment paradigms (pp. 217-246) London, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737715-00217

  • Herzig, Volker and King, Glenn F. (2013). The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae. In Wolfgang Nentwig (Ed.), Spider Ecophysiology (pp. 203-215) Heidelberg, Germany: Springer-Verlag. doi:10.1007/978-3-642-33989-9_15

  • Mobli, Mehdi, Hoch, Jeffrey C. and King, Glenn F. (2011). Fast acquisition methods in multidimensional NMR. In Andrew J. Dingley and Steven M. Pascal (Ed.), Biomolecular NMR spectroscopy (pp. 305-337) Amsterdam , Netherlands: IOS Press. doi:10.3233/978-1-60750-695-9-305

  • Herzig, V. and King, G. F. (2010). Addendum: Spider toxins and their potential for insect control. In Lawrence I. Gilbert and Sarjeet S. Gill (Ed.), Insect pharmacology: Channels, receptors, toxins and enzymes (pp. 119-123) London, U.K.: Academic Press.

  • King, Glenn F and Mehdi Mobli (2010). Determination of peptide and protein structures using NMR Spectroscopy. In Lewis Mander and Hung-Wen Liu (Ed.), Comprehensive natural products II: Chemistry and biology (pp. 280-325) Oxford, England: Elsevier Science & Technology Books. doi:10.1016/B978-008045382-8.00653-5

  • Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2010). Spider toxins and their potential for insect control. In Lawrence I. Gilbert and Sarjeet S. Gill (Ed.), Insect pharmacology: Channels, receptors, toxins and enzymes (pp. 101-118) London, U.K.: Academic Press.

  • Maciejewski, M.W., Stern, A. S., King, G. F. and Hoch, J. C. (2006). Nonuniform Sampling in Biomolecular NMR.. In Graham A. Webb (Ed.), Modern Magnetic Resonance (pp. 1287-1293) Dordrecht, The Netherland: Springer.

  • Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2005). Spider toxins and their potential for insect control. In L. I. Gilbert, K. Iatrou and S. S. Gill (Ed.), Comprehensive molecular insect science (pp. 221-238) Amsterdam, Netherlands: Elsevier. doi:10.1016/B0-44-451924-6/00094-6

  • Guss, J. M. and King, G. F. (2003). Macromolecular structure determination: comparison of crystallography and NMR. In David N. Cooper (Ed.), Encyclopedia of the Human Genome (pp. xx-xx) Hoboken, N. J .: Wiley.

  • Wilce, Jackie A., Wake, R. Gerry and King, Glenn F. (2001). Termination of replication in bacteria. In Encyclopedia of life sciences (pp. 1-7) Hoboken, NJ, United States: John Wiley and Sons. doi:10.1038/npg.els.0001056

  • Guss, J. Mitchell and King, Glenn F. (2000). Macromolecular structure determination: Comparison of crystallography and NMR. In Encyclopedia of life sciences (pp. 1-5) Hoboken, NJ, United States: John Wiley and Sons. doi:10.1038/npg.els.0002716

Journal Article

Conference Publication

  • Fernanda Caldas Cardoso, Volker Herzig, King, Glenn F and Lewis, Richard J. (2015). Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays. In: 18th World Congress of the International Society on Toxinology. 18th World Congress of the International Society on Toxinology, Oxford UK, (). 25-30 September 2015.

  • Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. In: The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, (). 8-12 February 2015.

  • Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. In: Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, (). 19-23 October 2014.

  • Erickson, A., Cardoso, F. C., Lewis, R. J. and King, G. F. (2014). Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.. In: Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, (). 19-23 October 2014.

  • Cardoso, F. C., Herzig, V., Hauke, T., Lewis, R. J. and King, G. F. (2013). Discovery of novel spider peptides blocking hNav1.7. In: 3rd Annual Conference of the Toxinological Society of India and 1st International Conference on “Biology of Natural Toxins”, Goa, India, (). 19-21 December, 2013.

  • Cardoso, F. C., Herzig, V., Hauke, T., King, G. F. and Lewis, R. J. (2013). Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain. In: CASB Division Symposium 2013. CASB Division Symposium 2013, Brisbane Australia, (). 7 November, 2013.

  • Windley, Monique J., King, Glenn F. and Nicholson, Graham M. (2012). An insecticidal spider toxin that acts as a positive allosteric modulator of insect nicotinic acetylcholine receptors. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (169-170). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.147

  • Undheim, Eivind A. B., Jones, Alun, Holland, John W., Morales, Rodrigo A. V., Winnen, Brit, Fry, Bryan G. and King, Glenn F. (2012). Centipede venoms: Old and unusual. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (126-126). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.065

  • Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. In: Abstracts: Toxins 2012. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, (111-111). 8 - 13 July 2012. doi:10.1016/j.toxicon.2012.04.033

  • Morgenstern, David, de la Vega, Ricardo C. Rodriguez, Ott, Michael, King, Glenn F. and Fry, Bryan G. (2012). Functional redundancy in venoms is an evolutionary by-product. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (123-124). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.059

  • Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). PX family proteins at the interface between intracellular trafficking and signalling. In: 22nd IUBMB Congress/37th FEBS Congress, Seville, Spain, (420-421). 4-9 September 2012. doi:10.1111/j.1742-4658.2010.08705.x

  • Klint, Julie, Anangi, Raveendra, Mobli, Mehdi, Knapp, Oliver, Adams, David J. and King, Glenn F. (2012). Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain. In: Abstracts: Toxins 2012. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, (110-111). 8 - 13 July 2012. doi:10.1016/j.toxicon.2012.04.032

  • Fry, Bryan G., Ruder, Tim, Georgieva, Dessi N., Morgenstern, David, King, Glenn and Undheim, Eivind A. B. (2012). Tentacles of venom: Molecular evolution of coleoid venoms. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (125-125). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.063

  • Morgenstern, David, Hamilton, Brett, Sher, Daniel, Jones, Alun, Mattius, Gideon, Zlotkin, Eli, Venter, Deon and King, Glenn F. (2012). The bio-logic of venom complexity. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (241-242). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.285

  • Pineda, Sandy S., Wong, Emily S., Fry, Bryan G., Binford, Greta J. and King, Glenn F. (2012). Understanding the chemical diversity and evolution of spider venoms using comparative transcriptomics. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (234-234). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.270

  • Pineda, Sandy S., Jones, Alun, Nicholson, Graham M., Escoubas, Pierre, Mattick, John S. and King, Glenn F. (2012). Understanding the chemical diversity of spider venoms using a combined genomic, transcriptomic and proteomic approach. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (124-124). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.060

  • Mozar, C. A., Sun, T., Rash, L. D., King, G. F. and Christie, M. J. (2011). Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models. In: 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, (). 12-16 November 2011.

  • Dantas de Araujo, A. D., Herzig, V., Mobli, M., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. F. (2010). Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins. In: 31st European Peptide Symposium, Copenhagen, Denmark, (60-61). 5-9 September 2010. doi:10.1002/psc.1303

  • Mobli, M., Lambert, L. K., Pierens, G. K., Dantas de Araujo, A., Alewood, P. F. and King, G. F. (2008). Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR. In: 7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008), Couran Cove, Australia, (). 7-11 December 2008.

  • Tedford, Hugo W., Maggio, Francesco, Reenan, Robert A. and King, Glenn F. (2007). A model genetic system for testing the in vivo function of peptide toxins. In: Ronald J. Nachman, Invertebrate Neuropeptides VII: Invertebrate Neuropeptide Conference 2006. 7th Invertebrate Neuropeptide Conference (INC2006), Guanajuato, Mexico, (51-56). 2006. doi:10.1016/j.peptides.2006.08.026

  • King, GF and Boyd, Car (1991). Proton Nmr-Studies of Transmembrane Solute Transport. In: Cell Membrane Transport. International Course On New Methods in the Study of Transport Across the Cell Membrane, Lanjaron Spain, (297-323). Sep 16-24, 1988.

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision