The University of Queensland

Spider-venom peptides: structure, pharmacology, and potential for control of insect pests

King, Glenn F. and Hardy, Margaret C. (2013). Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annual Review of Entomology, 58, 475-496. doi: 10.1146/annurev-ento-120811-153650

Venoms as a platform for human drugs: Translating toxins into therapeutics

King, Glenn F. (2011). Venoms as a platform for human drugs: Translating toxins into therapeutics. Expert Opinion on Biological Therapy, 11 (11), 1469-1484. doi: 10.1517/14712598.2011.621940

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

Smith, Jennifer J., Hill, Justine M., Little, Michelle J., Nicholson, Graham M., King, Glenn F. and Alewood, Paul F. (2011). Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif. Proceedings of the National Academy of Sciences of the United States of America, 108 (26), 10478-10483. doi: 10.1073/pnas.1103501108

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Pang, Siew Siew, Berry, Richard, Chen, Zhenjun, Kjer-Nielsen, Lars, Perugini, Matthew A., King, Glenn F., Wang, Christina, Chew, Sock Hui, La Gruta, Nicole L., Williams, Neil K., Beddoe, Travis, Tiganis, Tony, Cowieson, Nathan P., Godfrey, Dale I., Purcell, Anthony W., Wilce, Matthew C. J., McCluskey, James and Rossjohn, Jamie (2010). The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature, 467 (7317), 844-848. doi: 10.1038/nature09448

Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy

Mobli, M., Dantas de Araujo, A., Lambert, L. K., Pierens, G. K., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. E. (2009). Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy. Angewandte Chemie International Edition, 48 (49), 9312-9314. doi: 10.1002/anie.200905206

Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics

King, Glenn F. ed. (2015). Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. RSC Drug Discovery Series, Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876

Schaum's outline of theory and problems of biochemistry

Kuchel, Philip W., Ralston, Gregory B., Bersten, Audrey M., Easterbrook-Smith, Simon B., Jones, Alan R., Montague, M. Dan, Slaytor, Michael B., Thomas, Micahel A. W., Wake, R. Gerard, Chappell, Douglas J., Christopherson, Richard I., Conigrave, Arthur D., Darvey, Ivan G., Guss, J. Mitchell, King, Glenn F., Morris, Michael B., Samman, Samir, Smith, Mark T., Szabados, Eve, Weiss, Anthony S. and Whitelaw, Emma (1998). Schaum's outline of theory and problems of biochemistry. 2nd ed. New York, United States: McGraw-Hill.

Plant and animal toxins

Welch, Kevin D., King, Glenn F., White, Julian, Pearson, Leanne A., Neilan, Brett A. and Cook, Daniel (2024). Plant and animal toxins. Hayes’ principles and methods of toxicology: volume I. (pp. 755-830) edited by A. Wallace Hayes and Tetyana Kobets. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9781003390008-17

A Strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli

Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra and King, Glenn F. (2017). A Strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli. In Heterologous Gene Expression in E. coli Methods and Protocols (pp. 155-180) New York, NY United States: Humana Press. doi:10.1007/978-1-4939-6887-9_10

Does nature do ion channel drug discovery better than us?

Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297

Preface

King, Glenn (2015). Preface. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. VII-IX) edited by Glenn F. King. Cambridge, United States: RSC. doi: 10.1039/9781849737876-FP007

The Structural Universe of Disulfide-Rich Venom Peptides

Lavergne, Vincent, Alewood, Paul F., Mobli, Mehdi and King, Glenn F. (2015). The Structural Universe of Disulfide-Rich Venom Peptides. Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. (pp. 37-79) edited by King, Glenn F.. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00037

Therapeutic applications of spider-venom peptides

Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 221-244) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry.. doi: 10.1039/9781849737876-00221

Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches

Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. Venoms to Drugs. (pp. 80-96) edited by King, Glenn F. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00080

Peptide therapeutics from venomous creatures

Lavergne, Vincent, King, Glenn F., Lewis, Richard J. and Alewood, Paul F. (2014). Peptide therapeutics from venomous creatures. Pain therapeutics: current and future treatment paradigms. (pp. 217-246) edited by Charlotte Allerton. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737715-00217

The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae

Herzig, Volker and King, Glenn F. (2013). The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae. Spider Ecophysiology. (pp. 203-215) edited by Wolfgang Nentwig. Heidelberg, Germany: Springer-Verlag. doi: 10.1007/978-3-642-33989-9_15

Fast acquisition methods in multidimensional NMR

Mobli, Mehdi, Hoch, Jeffrey C. and King, Glenn F. (2011). Fast acquisition methods in multidimensional NMR. Biomolecular NMR spectroscopy. (pp. 305-337) edited by Andrew J. Dingley and Steven M. Pascal. Amsterdam , Netherlands: IOS Press. doi: 10.3233/978-1-60750-695-9-305

Addendum: Spider toxins and their potential for insect control

Herzig, V. and King, G. F. (2010). Addendum: Spider toxins and their potential for insect control. Insect pharmacology: Channels, receptors, toxins and enzymes. (pp. 119-123) edited by Lawrence I. Gilbert and Sarjeet S. Gill. London, U.K.: Academic Press.

Determination of peptide and protein structures using NMR Spectroscopy

King, Glenn F and Mehdi Mobli (2010). Determination of peptide and protein structures using NMR Spectroscopy. Comprehensive natural products II: Chemistry and biology. (pp. 280-325) edited by Lewis Mander and Hung-Wen Liu. Oxford, England: Elsevier Science & Technology Books. doi: 10.1016/B978-008045382-8.00653-5

Spider toxins and their potential for insect control

Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2010). Spider toxins and their potential for insect control. Insect pharmacology: Channels, receptors, toxins and enzymes. (pp. 101-118) edited by Lawrence I. Gilbert and Sarjeet S. Gill. London, U.K.: Academic Press.

Nonuniform sampling in biomolecular NMR

Maciejewski, M.W., Stern, A. S., King, G. F. and Hoch, J. C. (2006). Nonuniform sampling in biomolecular NMR. Modern Magnetic Resonance. (pp. 1287-1293) edited by Graham A. Webb. Dordrecht, Netherlands: Springer.

Spider toxins and their potential for insect control

Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2005). Spider toxins and their potential for insect control. Comprehensive molecular insect science. (pp. 221-238) edited by L. I. Gilbert, K. Iatrou and S. S. Gill. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B0-44-451924-6/00094-6

Macromolecular structure determination: comparison of crystallography and NMR

Guss, J. M. and King, G. F. (2003). Macromolecular structure determination: comparison of crystallography and NMR. Encyclopedia of the Human Genome. (pp. xx-xx) edited by David N. Cooper. Hoboken, N. J .: Wiley.

Termination of replication in bacteria

Wilce, Jackie A., Wake, R. Gerry and King, Glenn F. (2001). Termination of replication in bacteria. Encyclopedia of life sciences. (pp. 1-7) Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1038/npg.els.0001056

Macromolecular structure determination: Comparison of crystallography and NMR

Guss, J. Mitchell and King, Glenn F. (2000). Macromolecular structure determination: Comparison of crystallography and NMR. Encyclopedia of life sciences. (pp. 1-5) Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1038/npg.els.0002716

NMR methods for measuring membrane transport

Kuchel, Philip W., Kirk, Kiaran and King, Glenn F. (1994). NMR methods for measuring membrane transport. Physicochemical Methods in the Study of Biomembranes. (pp. 247-327) Boston, MA United States: Springer. doi: 10.1007/978-1-4615-1863-1_7

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Kramer, Simon, Kotapati, Charan, Cao, Yuanzhao, Fry, Bryan G., Palpant, Nathan J., King, Glenn F. and Cardoso, Fernanda C. (2024). High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms. Toxicon: X, 21 100184, 100184. doi: 10.1016/j.toxcx.2024.100184

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants

Robinson, Samuel D., Deuis, Jennifer R., Niu, Pancong, Touchard, Axel, Mueller, Alexander, Schendel, Vanessa, Brinkwirth, Nina, King, Glenn F., Vetter, Irina and Schmidt, Justin O. (2024). Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. Journal of Biological Chemistry, 300 (1) 105577, 1-15. doi: 10.1016/j.jbc.2023.105577

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2023). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal. doi: 10.1093/eurheartj/ehad793

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

Ashwood, Lauren M., Elnahriry, Khaled A., Stewart, Zachary K., Shafee, Thomas, Naseem, Muhammad Umair, Szanto, Tibor G., van der Burg, Chloé A., Smith, Hayden L., Surm, Joachim M., Undheim, Eivind A. B., Madio, Bruno, Hamilton, Brett R., Guo, Shaodong, Wai, Dorothy C. C., Coyne, Victoria L., Phillips, Matthew J., Dudley, Kevin J., Hurwood, David A., Panyi, Gyorgy, King, Glenn F., Pavasovic, Ana, Norton, Raymond S. and Prentis, Peter J. (2023). Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family. BMC Biology, 21 (1) 121, 121. doi: 10.1186/s12915-023-01617-y

Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons

Foster, Victoria S., Saez, Natalie, King, Glenn F. and Rank, Michelle M. (2023). Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons. PLoS One, 18 (11 November) e0289053, 1-23. doi: 10.1371/journal.pone.0289053

Proteome of urticating setae of Ochrogaster lunifer, a processionary caterpillar of medical and veterinary importance, including primary structures of putative toxins

Walker, Andrew A., Perkins, Lynda E., Battisti, Andrea, Zalucki, Myron P. and King, Glenn F. (2023). Proteome of urticating setae of Ochrogaster lunifer, a processionary caterpillar of medical and veterinary importance, including primary structures of putative toxins. Proteomics, 23 (20) 2300204, e2300204. doi: 10.1002/pmic.202300204

From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research

Ahmadi, Shirin, Benard-Valle, Melisa, Boddum, Kim, Cardoso, Fernanda C., King, Glenn F., Laustsen, Andreas Hougaard and Ljungars, Anne (2023). From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research. Frontiers in Pharmacology, 14 1249336, 1-10. doi: 10.3389/fphar.2023.1249336

Immunosuppressive, antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae)

Pinto, Ciro P. G., Walker, Andrew A., King, Glenn F. and Rossi, Guilherme D. (2023). Immunosuppressive, antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae). Insect Science, 30 (4), 1105-1117. doi: 10.1111/1744-7917.13154

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae)

Walker, Andrew A., Robinson, Samuel D., Merritt, David J., Cardoso, Fernanda C., Goudarzi, Mohaddeseh Hedayati, Mercedes, Raine S., Eagles, David A., Cooper, Paul, Zdenek, Christina N., Fry, Bryan G., Hall, Donald W., Vetter, Irina and King, Glenn F. (2023). Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae). Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120. doi: 10.1073/pnas.2305871120

Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)

Goudarzi, Mohaddeseh H., Eagles, David A., Lim, Junxian, Biggs, Kimberley A., Kotze, Andrew C., Ruffell, Angela P., Fairlie, David P., King, Glenn F. and Walker, Andrew A. (2023). Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae). Biochemical Pharmacology, 213 115598, 1-11. doi: 10.1016/j.bcp.2023.115598

Two novel mosquitocidal peptides isolated from the venom of the Bahia scarlet tarantula (Lasiodora klugi)

Ahmed, Jamila, Walker, Andrew A., Perdomo, Hugo D., Guo, Shaodong, Nixon, Samantha A., Vetter, Irina, Okoh, Hilary I., Shehu, Dalhatu M., Shuaibu, Mohammed N., Ndams, Iliya S., King, Glenn F. and Herzig, Volker (2023). Two novel mosquitocidal peptides isolated from the venom of the Bahia scarlet tarantula (Lasiodora klugi). Toxins, 15 (7) 418, 1-14. doi: 10.3390/toxins15070418

Development and validation of nerve-targeted bacteriochlorin sensors

Hernández-Gil, Javier, Chow, Chun Yuen, Chatras, Hugo, de Souza França, Paula Demétrio, Samuels, Zachary V., Cornejo, Mike, King, Glenn F., Lewis, Jason S., Reiner, Thomas and Gonzales, Junior (2023). Development and validation of nerve-targeted bacteriochlorin sensors. Journal of the American Chemical Society, 145 (26), 14276-14287. doi: 10.1021/jacs.3c02520

Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a

Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346

The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on NaV 1.7 gating

Salvage, Samantha C., Rahman, Taufiq, Eagles, David A., Rees, Johanna S., King, Glenn F., Huang, Christopher L‐H. and Jackson, Antony P. (2023). The β3‐subunit modulates the effect of venom peptides ProTx‐II and OD1 on NaV 1.7 gating. Journal of Cellular Physiology, 238 (6), 1354-1367. doi: 10.1002/jcp.31018

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1

New drug targets and preclinical modelling recommendations for treating acute myocardial infarction

Cao, Yuanzhao, Redd, Meredith A., Fang, Chen, Mizikovsky, Dalia, Li, Xichun, Macdonald, Peter S., King, Glenn F. and Palpant, Nathan J. (2023). New drug targets and preclinical modelling recommendations for treating acute myocardial infarction. Heart, Lung and Circulation, 32 (7), 852-869. doi: 10.1016/j.hlc.2022.12.015

Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury

Foster, Victoria, Saez, Natalie, Gillespie, Ellen, Jogia, Trisha, Reid, Chantelle, Maljevic, Snezana, Jung, Woncheol, Lao, Hong W., Ruitenberg, Marc Jan and King, Glen (2023). Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury. Journal of Neurotrauma. doi: 10.1089/neu.2022.0295

The voltage‐gated sodium channel NaV 1 .7 underlies endometriosis‐associated chronic pelvic pain

Castro, Joel, Maddern, Jessica, Chow, Chun Yuen, Tran, Poanna, Vetter, Irina, King, Glenn F. and Brierley, Stuart M. (2023). The voltage‐gated sodium channel NaV 1 .7 underlies endometriosis‐associated chronic pelvic pain. Journal of Neurochemistry. doi: 10.1111/jnc.15795

Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics

Cardoso, F. C., Walker, A. A., King, G. F. and Gomez, M. V. (2023). Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics. Frontiers in Molecular Biosciences, 10 1069764, 1069764. doi: 10.3389/fmolb.2023.1069764

Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant

Robinson, Samuel D., Schendel, Vanessa, Schroeder, Christina I., Moen, Sarah, Mueller, Alexander, Walker, Andrew A., McKinnon, Naomi, Neely, G. Gregory, Vetter, Irina, King, Glenn F. and Undheim, Eivind A. B. (2023). Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant. BMC Biology, 21 (1) 5, 5. doi: 10.1186/s12915-022-01507-9

Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)

Michálek, Ondřej, Walker, Andrew A., Šedo, Ondrej, Zdráhal, Zbyněk, King, Glenn F. and Pekár, Stano (2022). Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.). Scientific Reports, 12 (1) 21597, 1-13. doi: 10.1038/s41598-022-24694-5

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

Shi, Naiqi, Szanto, Tibor G., He, Jia, Schroeder, Christina I., Walker, Andrew A., Deuis, Jennifer R., Vetter, Irina, Panyi, György, King, Glenn F. and Robinson, Samuel D. (2022). Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana. Scientific Reports, 12 (1) 22168, 1-13. doi: 10.1038/s41598-022-26867-8

Holistic profiling of the venom from the lethal spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics

Cardoso, Fernanda C., Walker, Andrew A., King, Glenn F. and Gomez, Marcus V. (2022). Holistic profiling of the venom from the lethal spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics.

The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders

Cardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077

The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF ^V600E

Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923

The tarantula toxin ω-Avsp1a specifically inhibits human CaV3.1 and CaV3.3 via the extracellular S3-S4 loop of the domain 1 voltage-sensor

Herzig, Volker, Chen, Yong-Cyuan, Chin, Yanni K.-Y., Dekan, Zoltan, Chang, Yu-Wang, Yu, Hui-Ming, Alewood, Paul F., Chen, Chien-Chang and King, Glenn F. (2022). The tarantula toxin ω-Avsp1a specifically inhibits human CaV3.1 and CaV3.3 via the extracellular S3-S4 loop of the domain 1 voltage-sensor. Biomedicines, 10 (5) 1066. doi: 10.3390/biomedicines10051066

Proteotranscriptomics reveals the secretory dynamics of teratocytes, regulators of parasitization by an endoparasitoid wasp

Pinto, Ciro P.G., Walker, Andrew A., Robinson, Samuel D., King, Glenn F. and Rossi, Guilherme D. (2022). Proteotranscriptomics reveals the secretory dynamics of teratocytes, regulators of parasitization by an endoparasitoid wasp. Journal of Insect Physiology, 139 104395, 104395. doi: 10.1016/j.jinsphys.2022.104395

Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor

Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals

Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119

The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation

Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Venoms for all occasions: the functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function

Ashwood, Lauren M., Undheim, Eivind A. B., Madio, Bruno, Hamilton, Brett R., Daly, Marymegan, Hurwood, David A., King, Glenn F. and Prentis, Peter J. (2021). Venoms for all occasions: the functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function. Molecular Ecology, 31 (3), 866-883. doi: 10.1111/mec.16286

Total synthesis of the spider-venom peptide Hi1a

Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112

A pain-causing and paralytic ant venom glycopeptide

Robinson, Samuel D., Kambanis, Lucas, Clayton, Daniel, Hinneburg, Hannes, Corcilius, Leo, Mueller, Alexander, Walker, Andrew A., Keramidas, Angelo, Kulkarni, Sameer S., Jones, Alun, Vetter, Irina, Thaysen-Andersen, Morten, Payne, Richard J., King, Glenn F. and Undheim, Eivind A.B. (2021). A pain-causing and paralytic ant venom glycopeptide. iScience, 24 (10) 103175, 1-21. doi: 10.1016/j.isci.2021.103175

Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities

Nixon, Samantha A., Robinson, Samuel D., Agwa, Akello J., Walker, Andrew A., Choudhary, Shivani, Touchard, Axel, Undheim, Eivind A.B., Robertson, Alan, Vetter, Irina, Schroeder, Christina I., Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2021). Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities. Biochemical Pharmacology, 192 114693, 114693. doi: 10.1016/j.bcp.2021.114693

Venom composition of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae) and functional characterization of a major venom peptide

Pinto, Ciro P.G., Walker, Andrew A., Robinson, Samuel D., Chin, Yanni K.-Y, King, Glenn F. and Rossi, Guilherme D. (2021). Venom composition of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae) and functional characterization of a major venom peptide. Toxicon, 202, 1-12. doi: 10.1016/j.toxicon.2021.09.002

Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury

Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Foster, Victoria S., Rash, Lachlan D., King, Glenn F. and Rank, Michelle M. (2021). Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System. Frontiers in cellular neuroscience, 15 738043, 1-16. doi: 10.3389/fncel.2021.738043

Tentacle morphological variation coincides with differential expression of toxins in sea anemones

Ashwood, Lauren M., Mitchell, Michela L., Madio, Bruno, Hurwood, David A., King, Glenn F., Undheim, Eivind A. B., Norton, Raymond S. and Prentis, Peter J. (2021). Tentacle morphological variation coincides with differential expression of toxins in sea anemones. Toxins, 13 (7) 452, 1-18. doi: 10.3390/toxins13070452

Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome

Jiang, Yan, Castro, Joel, Blomster, Linda V., Agwa, Akello J., Maddern, Jessica, Schober, Gudrun, Herzig, Volker, Chow, Chun Yuen, Cardoso, Fernanda C., Demétrio De Souza França, Paula, Gonzales, Junior, Schroeder, Christina I., Esche, Steffen, Reiner, Thomas, Brierley, Stuart M. and King, Glenn F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology & Translational Science, 4 (4) acsptsci.1c00072, 1362-1378. doi: 10.1021/acsptsci.1c00072

Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae)

Jensen, Timo, Walker, Andrew A., Nguyen, Son H., Jin, Ai-Hua, Deuis, Jennifer R., Vetter, Irina, King, Glenn F., Schmidt, Justin O. and Robinson, Samuel D. (2021). Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae). Cellular and Molecular Life Sciences, 78 (12), 5163-5177. doi: 10.1007/s00018-021-03847-1

Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans

Walker, Andrew A., Robinson, Samuel D., Paluzzi, Jean-Paul V., Merritt, David J., Nixon, Samantha A., Schroeder, Christina I., Jin, Jiayi, Goudarzi, Mohaddeseh Hedayati, Kotze, Andrew C., Dekan, Zoltan, Sombke, Andy, Alewood, Paul F., Fry, Bryan G., Epstein, Marc E., Vetter, Irina and King, Glenn F. (2021). Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans. Proceedings of the National Academy of Sciences of the United States of America, 118 (18) 2023815118, e2023815118. doi: 10.1073/pnas.2023815118

Trends in peptide drug discovery

Muttenthaler, Markus, King, Glenn F., Adams, David J. and Alewood, Paul F. (2021). Trends in peptide drug discovery. Nature Reviews Drug Discovery, 20 (4), 309-325. doi: 10.1038/s41573-020-00135-8

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041

Bimodal imaging of mouse peripheral nerves with chlorin tracers

Gonzales, Junior, Hernández-Gil, Javier, Wilson, Thomas C., Adilbay, Dauren, Cornejo, Mike, Demétrio de Souza Franca, Paula, Guru, Navjot, Schroeder, Christina I., King, Glenn F., Lewis, Jason S. and Reiner, Thomas (2021). Bimodal imaging of mouse peripheral nerves with chlorin tracers. Molecular Pharmaceutics, 18 (3) acs.molpharmaceut.0c00946, 940-951. doi: 10.1021/acs.molpharmaceut.0c00946

Crouching tiger, hidden protein: searching for insecticidal toxins in venom of the red tiger assassin bug (Havinthus rufovarius)

Wait, Laura C., Walker, Andrew A. and King, Glenn F. (2020). Crouching tiger, hidden protein: searching for insecticidal toxins in venom of the red tiger assassin bug (Havinthus rufovarius). Toxins, 13 (1) 3, 3. doi: 10.3390/toxins13010003

Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?

Eagles, David A., Chow, Chun Yuen and King, Glenn F. (2020). Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?. British Journal of Pharmacology, 179 (14) bph.15327, 3592-3611. doi: 10.1111/bph.15327

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

Peschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107

Venom of the red-bellied black snake Pseudechis porphyriacus shows immunosuppressive potential

Ryan, Rachael Y. M., Lutzky, Viviana P., Herzig, Volker, Smallwood, Taylor B., Potriquet, Jeremy, Wong, Yide, Masci, Paul, Lavin, Martin F., King, Glenn F., Lopez, J. Alejandro, Ikonomopoulou, Maria P. and Miles, John J. (2020). Venom of the red-bellied black snake Pseudechis porphyriacus shows immunosuppressive potential. Toxins, 12 (11) 674, 674. doi: 10.3390/toxins12110674

Olfactory bulb‐targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice

Schwartz, Austin B., Kapur, Anshika, Huang, Zhenbo, Anangi, Raveendra, Spear, John M., Stagg, Scott, Fardone, Erminia, Dekan, Zolan, Rosenberg, Jens T., Grant, Samuel C., King, Glenn F., Mattoussi, Hedi and Fadool, Debra Ann (2020). Olfactory bulb‐targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. Journal of Neurochemistry, 157 (6) jnc.15200, 1876-1896. doi: 10.1111/jnc.15200

Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms

Touchard, Axel, Mendel, Helen C., Boulogne, Isabelle, Herzig, Volker, Braga Emidio, Nayara, King, Glenn F., Triquigneaux, Mathilde, Jaquillard, Lucie, Beroud, Rémy, De Waard, Michel, Delalande, Olivier, Dejean, Alain, Muttenthaler, Markus and Duplais, Christophe (2020). Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms. ACS Pharmacology and Translational Science, 3 (6) acsptsci.0c00119, 1211-1224. doi: 10.1021/acsptsci.0c00119

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

Herzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117

Deadly proteomes: a practical guide to proteotranscriptomics of animal venoms

Walker, Andrew A., Robinson, Samuel D., Hamilton, Brett F., Undheim, Eivind A. B. and King, Glenn F. (2020). Deadly proteomes: a practical guide to proteotranscriptomics of animal venoms. Proteomics, 20 (17-18) 1900324, e1900324. doi: 10.1002/pmic.201900324

It takes two: Dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula

Nixon, Samantha A., Dekan, Zoltan, Robinson, Samuel D., Guo, Shaodong, Vetter, Irina, Kotze, Andrew C., Alewood, Paul F., King, Glenn F. and Herzig, Volker (2020). It takes two: Dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula. Biomedicines, 8 (7) 185, 1-13. doi: 10.3390/biomedicines8070185

Venom-derived modulators of epilepsy-related ion channels

Chow, Chun Yuen, Absalom, Nathan, Biggs, Kimberley, King, Glenn F. and Ma, Linlin (2020). Venom-derived modulators of epilepsy-related ion channels. Biochemical Pharmacology, 181 114043, 114043. doi: 10.1016/j.bcp.2020.114043

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117

A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy

Chow, Chun Yuen, Chin, Yanni K.Y., Ma, Linlin, Undheim, Eivind A.B., Herzig, Volker and King, Glenn F. (2020). A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy. Biochemical Pharmacology, 181 113991, 113991. doi: 10.1016/j.bcp.2020.113991

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Luna-Ramirez, Karen, Csoti, Agota, McArthur, Jeffrey R., Chin, Yanni K.Y., Anangi, Raveendra, Najera, Rosby del Carmen, Possani, Lourival D., King, Glenn F., Panyi, Gyorgy, Yu, Haibo, Adams, David J. and Finol-Urdaneta, Rocio K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochemical Pharmacology, 174 113782, 113782. doi: 10.1016/j.bcp.2019.113782

Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

Jin, Jiayi, Agwa, Akello J., Szanto, Tibor G., Csóti, Agota, Panyi, Gyorgy, Schroeder, Christina I., Walker, Andrew A. and King, Glenn F. (2020). Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochemistry and Molecular Biology, 118 103310, 1-12. doi: 10.1016/j.ibmb.2019.103310

Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7

Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037

Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery

Herzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina and King, Glenn F. (2020). Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery. Biochemical Pharmacology, 181 114096, 114096. doi: 10.1016/j.bcp.2020.114096

Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization

Gonzales, Junior, Pirovano, Giacomo, Chow, Chun Yuen, de Souza Franca, Paula Demetrio, Carter, Lukas M., Klint, Julie K., Guru, Navjot, Lewis, Jason S., King, Glenn F. and Reiner, Thomas (2020). Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Research, 10 (1) 49, 49. doi: 10.1186/s13550-020-00630-4

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7

Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080

Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs

Chow, Chun Yuen, Chin, Yanni K.-Y., Walker, Andrew A., Guo, Shaodong, Blomster, Linda V., Ward, Micaiah J., Herzig, Volker, Rokyta, Darin R. and King, Glenn F. (2019). Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs. ACS Pharmacology & Translational Science, 3 (1) acsptsci.9b00079, 119-134. doi: 10.1021/acsptsci.9b00079

A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa

Chen, Xingchen, Leahy, Darren, Van Haeften, Jessica, Hartfield, Perry, Prentis, Peter J., van der Burg, Chloé A., Surm, Joachim M., Pavasovic, Ana, Madio, Bruno, Hamilton, Brett R., King, Glenn F., Undheim, Eivind A. B., Brattsand, Maria and Harris, Jonathan M. (2019). A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa. Marine Drugs, 17 (12) 701, 701. doi: 10.3390/md17120701

Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus

Walker, Andrew A., Robinson, Samuel D., Undheim, Eivind A. B., Jin, Jiayi, Han, Xiao, Fry, Bryan G., Vetter, Irina and King, Glenn F. (2019). Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus. Toxins, 11 (11) 673, 673. doi: 10.3390/toxins11110673

Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide

Gonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J., Schroeder, Christina I, Patel, Snehal, Ganly, Ian, King, Glenn F. and Reiner, Thomas (2019). Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide. Bioconjugate Chemistry, 30 (11) acs.bioconjchem.9b00612, 2879-2888. doi: 10.1021/acs.bioconjchem.9b00612

The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides

Deplazes, Evelyne, Chin, Yanni K.‐Y., King, Glenn F. and Mancera, Ricardo L. (2019). The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides. Proteins, 88 (3) prot.25828, 485-502. doi: 10.1002/prot.25828

Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms

Bibic, Lucka, Herzig, Volker, King, Glenn F. and Stokes, Leanne (2019). Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms. Journal of Natural Products, 82 (9) acs.jnatprod.9b00410, 2559-2567. doi: 10.1021/acs.jnatprod.9b00410

A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain

Lin King, John V., Emrick, Joshua J., Kelly, Mark J. S., Herzig, Volker, King, Glenn F., Medzihradszky, Katalin F. and Julius, David (2019). A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain. Cell, 178 (6), 1362-1374.e16. doi: 10.1016/j.cell.2019.07.014

Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides

King, Glenn F. (2019). Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides. Pest Management Science, 75 (9) ps.5452, 2437-2445. doi: 10.1002/ps.5452

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F. and Stinear, Timothy P. (2019). Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications, 10 (1) 3067, 3067. doi: 10.1038/s41467-019-10932-4

Sea anemone toxins: a structural overview

Madio, Bruno, King, Glenn F. and Undheim, Eivind A. B. (2019). Sea anemone toxins: a structural overview. Marine Drugs, 17 (6) 325, 325. doi: 10.3390/md17060325

The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro

Nixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019). The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270, 40-46. doi: 10.1016/j.vetpar.2019.05.008

Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR

El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues

Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors

Gartia, Janeka, Anangi, Raveendra, Joshi, Rakesh S., Giri, Ashok P., King, Glenn F., Barnwal, Ravi P. and Chary, Kandala V. R. (2019). NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. Journal of Biomolecular Structure and Dynamics, 38 (5), 1-10. doi: 10.1080/07391102.2019.1607559

A process of convergent amplification and tissue‐specific expression dominate the evolution of toxin and toxin‐like genes in sea anemones

Surm, Joachim M., Smith, Hayden L., Madio, Bruno, Undheim, Eivind A. B., King, Glenn F., Hamilton, Brett R., van der Burg, Chloé A., Pavasovic, Ana and Prentis, Peter J. (2019). A process of convergent amplification and tissue‐specific expression dominate the evolution of toxin and toxin‐like genes in sea anemones. Molecular Ecology, 28 (9) mec.15084, 2272-2289. doi: 10.1111/mec.15084

Can we resolve the taxonomic bias in spider venom research?

Herzig, Volker, King, Glenn F. and Undheim, Eivind A.B. (2019). Can we resolve the taxonomic bias in spider venom research?. Toxicon: X, 1 100005, 100005. doi: 10.1016/j.toxcx.2018.100005

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

Ma, Linlin, Chin, Yanni K.Y., Dekan, Zoltan, Herzig, Volker, Chow, Chun Yuen, Heighway, Jacqueline, Lam, Sau Wing, Guillemin, Gilles J., Alewood, Paul F. and King, Glenn F. (2018). Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochemical Pharmacology, 158, 60-72. doi: 10.1016/j.bcp.2018.08.038

Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae)

Walker, Andrew, Dobson, James, Jin, Jiayi, Robinson, Samuel, Herzig, Volker, Vetter, Irina, King, Glenn and Fry, Bryan (2018). Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins, 10 (11) 456, 456. doi: 10.3390/toxins10110456

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi: 10.1021/acs.bioconjchem.8b00505

Entomo-venomics: the evolution, biology and biochemistry of insect venoms

Walker, Andrew A., Robinson, Samuel D., Yeates, David K., Jin, Jiayi, Baumann, Kate, Dobson, James, Fry, Bryan G. and King, Glenn F. (2018). Entomo-venomics: the evolution, biology and biochemistry of insect venoms. Toxicon: official journal of the International Society on Toxinology, 154, 15-27. doi: 10.1016/j.toxicon.2018.09.004

1H, 13C and 15N NMR assignments of two plant protease inhibitors (IRD7 and IRD12) from the plant Capsicum annuum

Gartia, Janeka, Barnwal, Ravi Pratap, Anangi, Raveendra, Giri, Ashok R., King, Glenn and Chary, Kandala V. R. (2018). 1H, 13C and 15N NMR assignments of two plant protease inhibitors (IRD7 and IRD12) from the plant Capsicum annuum. Biomolecular NMR Assignments, 13 (1), 31-35. doi: 10.1007/s12104-018-9846-z

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family

Robinson, Samuel D., Mueller, Alexander, Clayton, Daniel, Starobova, Hana, Hamilton, Brett R., Payne, Richard J., Vetter, Irina, King, Glenn F. and Undheim, Eivind A. B. (2018). A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family. Science Advances, 4 (9) eaau4640, eaau4640. doi: 10.1126/sciadv.aau4640

Venoms to the rescue

Holford, Mande, Daly, Marymegan, King, Glenn F. and Norton, Raymond S. (2018). Venoms to the rescue. Science, 361 (6405), 842-844. doi: 10.1126/science.aau7761

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Herzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold

Madio, Bruno, Peigneur, Steve, Chin, Yanni K. Y., Hamilton, Brett R., Henriques, Sónia Troeira, Smith, Jennifer J., Cristofori-Armstrong, Ben, Dekan, Zoltan, Boughton, Berin A., Alewood, Paul F., Tytgat, Jan, King, Glenn F. and Undheim, Eivind A. B. (2018). PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular and Molecular Life Sciences, 75 (24), 4511-4524. doi: 10.1007/s00018-018-2897-6

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F. and Petrou, Steven (2018). Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proceedings of the National Academy of Sciences, 115 (34), 201804764-E8085. doi: 10.1073/pnas.1804764115

Dipteran toxicity assays for determining the oral insecticidal activity of venoms and toxins

Guo, Shaodong, Herzig, Volker and King, Glenn F. (2018). Dipteran toxicity assays for determining the oral insecticidal activity of venoms and toxins. Toxicon, 150, 297-303. doi: 10.1016/j.toxicon.2018.06.077

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

Ikonomopoulou, Maria P., Fernandez-Rojo, Manuel A., Pineda, Sandy S., Cabezas-Sainz, Pablo, Winnen, Brit, Morales, Rodrigo A. V., Brust, Andreas, Sanchez, Laura, Alewood, Paul F., Ramm, Grant A., Miles, John J. and King, Glenn F. (2018). Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. Scientific Reports, 8 (1) 11519, 11519. doi: 10.1038/s41598-018-29826-4

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J., Chin, Yanni K. Y., Lei, Jianlin, Zhou, Qiang, King, Glenn F. and Yan, Nieng (2018). Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362 (6412) eaau2596, eaau2596-+. doi: 10.1126/science.aau2596

NaV1.1 inhibition can reduce visceral hypersensitivity

Salvatierra, Juan, Castro, Joel, Erickson, Andelain, Li, Qian, Braz, Joao, Gilchrist, John, Grundy, Luke, Rychkov, Grigori Y., Deiteren, Annemie, Rais, Rana, King, Glenn F., Slusher, Barbara S., Basbaum, Allan, Pasricha, Pankaj J., Brierley, Stuart M. and Bosmans, Frank (2018). NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight, 3 (11). doi: 10.1172/jci.insight.121000

Identification and functional characterization of sugarcane invertase inhibitor (ShINH1): a potential candidate for reducing pre- and post-harvest loss of sucrose in sugarcane

Shivalingamurthy, Suresha G., Anangi, Raveendra, Kalaipandian, Sundaravelpandian, Glassop, Donna, King, Glenn F. and Rae, Anne L. (2018). Identification and functional characterization of sugarcane invertase inhibitor (ShINH1): a potential candidate for reducing pre- and post-harvest loss of sucrose in sugarcane. Frontiers in Plant Science, 9 598, 598. doi: 10.3389/fpls.2018.00598

Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes

Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sonia Troeira and Schroeder, Christina I. (2018). Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. Journal of Biological Chemistry, 293 (23), 9041-9052. doi: 10.1074/jbc.RA118.002553

Harvesting venom toxins from assassin bugs and other heteropteran insects

Walker, Andrew Allan, Rosenthal, Max, Undheim, Eivind E. A. and King, Glenn F (2018). Harvesting venom toxins from assassin bugs and other heteropteran insects. Journal of Visualized Experiments, 2018 (134) e57729. doi: 10.3791/57729

The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens

Walker, Andrew A., Mayhew, Mark L., Jin, Jiayi, Herzig, Volker, Undheim, Eivind A. B., Sombke, Andy, Fry, Bryan G., Meritt, David J. and King, Glenn F. (2018). The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens. Nature Communications, 9 (1) 755, 755. doi: 10.1038/s41467-018-03091-5

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells

Fernandez-Rojo, Manuel A., Deplazes, Evelyne, Pineda, Sandy S., Brust, Andreas, Marth, Tano, Wilhelm, Patrick, Martel, Nick, Ramm, Grant A., Mancera, Ricardo L., Alewood, Paul F., Woods, Gregory M., Belov, Katherine, Miles, John J., King, Glenn F. and Ikonomopoulou, Maria P. (2018). Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell Death Discovery, 4 (1) 19, 19. doi: 10.1038/s41420-018-0030-0

Giant fish-killing water bug reveals ancient and dynamic venom evolution in Heteroptera

Walker, Andrew A., Hernández-Vargas, Maria José, Corzo, Gerardo, Fry, Bryan G. and King, Glenn F. (2018). Giant fish-killing water bug reveals ancient and dynamic venom evolution in Heteroptera. Cellular and Molecular Life Sciences, 75 (17), 1-15. doi: 10.1007/s00018-018-2768-1

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089

The North American Society of Toxinology establishes formal affiliation with Toxicon

Keyler, Daniel E. and King, Glenn F. (2017). The North American Society of Toxinology establishes formal affiliation with Toxicon. Toxicon, 142, A1-A1. doi: 10.1016/j.toxicon.2017.11.009

ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins

Pineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017). ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 (6), 1074-1076. doi: 10.1093/bioinformatics/btx661

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Revisiting venom of the sea anemone Stichodactyla haddoni: omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus

Madio, Bruno, Undheim, Eivind A. B. and King, Glenn F. (2017). Revisiting venom of the sea anemone Stichodactyla haddoni: omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus. Journal of Proteomics, 166, 83-92. doi: 10.1016/j.jprot.2017.07.007

Improved efficacy of an arthropod toxin expressing fungus against insecticide-resistant malaria-vector mosquitoes

Bilgo, Etienne, Lovett, Brian, Fang, Weiguo, Bende, Niraj, King, Glenn F., Diabate, Abdoulaye and St Leger, Raymond J. (2017). Improved efficacy of an arthropod toxin expressing fungus against insecticide-resistant malaria-vector mosquitoes. Scientific Reports, 7 (1) 3433, 3433. doi: 10.1038/s41598-017-03399-0

Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883)

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus

Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865

Insect-active toxins with promiscuous pharmacology from the African theraphosid spider Monocentropus balfouri

Smith, Jennifer J., Herzig, Volker, Ikonomopoulou, Maria P., Dziemborowicz, Slawomir, Bosmans, Frank, Nicholson, Graham M. and King, Glenn F. (2017). Insect-active toxins with promiscuous pharmacology from the African theraphosid spider Monocentropus balfouri. Toxins, 9 (5) 155, 155. doi: 10.3390/toxins9050155

Melt with this kiss: paralyzing and liquefying venom of the assassin bug Pristhesancus plagipennis (Hemiptera: Reduviidae)

Walker, Andrew A. , Madio, Bruno, Jin, Jiayi, Undheim, Eivind A. B. , Fry, Bryan G. and King, Glenn F. (2017). Melt with this kiss: paralyzing and liquefying venom of the assassin bug Pristhesancus plagipennis (Hemiptera: Reduviidae). Molecular and Cellular Proteomics, 16 (4), 552-566. doi: 10.1074/mcp.M116.063321

Venom profiling of a population of the theraphosid spider Phlogius crassipes reveals continuous ontogenetic changes from juveniles through adulthood

Santana, Renan C., Perez, David, Dobson, James, Panagides, Nadya, Raven, Robert J., Nouwens, Amanda, Jones, Alun, King, Glenn F. and Fry, Bryan G. (2017). Venom profiling of a population of the theraphosid spider Phlogius crassipes reveals continuous ontogenetic changes from juveniles through adulthood. Toxins, 9 (4) 116, 116. doi: 10.3390/toxins9040116

The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant

Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114

Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus

Matsubara, F. H., Meissner, G. O., Herzig, V., Justa, H. C., Dias, B. C. L., Trevisan-Silva, D., Gremski, L. H., Gremski, W., Senff-Ribeiro, A., Chaim, O. M., King, G. F. and Veiga, S. S. (2017). Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus. Insect Molecular Biology, 26 (1), 25-34. doi: 10.1111/imb.12268

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, Michela L., Hamilton, Brett R., Madio, Bruno, Morales, Rodrigo A. V., Tonkin-Hill, Gerry Q., Papenfuss, Anthony T., Purcell, Anthony W., King, Glenn F., Undheim, Eivind A. B. and Norton, Raymond S. (2017). The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones. Australian Journal of Chemistry, 70 (11), 1235-1237. doi: 10.1071/CH17228

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery

Robinson, Samuel D., Undheim, Eivind A. B., Ueberheide, Beatrix and King, Glenn F. (2017). Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery. Expert Review of Proteomics, 14 (10), 931-939. doi: 10.1080/14789450.2017.1377613

Centipede venoms as a source of drug leads

Undheim, Eivind A. B., Jenner, Ronald A. and King, Glenn F. (2016). Centipede venoms as a source of drug leads. Expert Opinion on Drug Discovery, 11 (12), 1139-1149. doi: 10.1080/17460441.2016.1235155

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

Ikonomopoulou, Maria P., Smith, Jennifer J., Herzig, Volker, Pineda, Sandy S., Dziemborowicz, Sławomir, Er, Sing-Yan, Durek, Thomas, Gilchrist, John, Alewood, Paul F., Nicholson, Graham M., Bosmans, Frank and King, Glenn F. (2016). Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix. Toxicon, 123, 62-70. doi: 10.1016/j.toxicon.2016.10.013

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Vazirani, Mansha, Ilyichova, Olga, Wang, Geqing, Bermel, Wolfgang, Simpson, Jamie S., Chalmers, David K., King, Glenn F., Mobli, Mehdi and Scanlon, Martin J. (2016). Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data. Journal of Biomolecular NMR, 66 (3), 195-208. doi: 10.1007/s10858-016-0067-4

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels

Lau, Carus H.Y., King, Glenn F and Mobli, Mehdi (2016). Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels. Scientific Reports, 6 (1) 34333, 34333. doi: 10.1038/srep34333

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016). Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 (33), 17049-17065. doi: 10.1074/jbc.M116.729095

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus

Touchard, Axel, Brust, Andreas, Cardoso, Fernanda C., Chin, K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme and Escoubas, Pierre (2016). Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica et Biophysica Acta, 1860 (11 Part A), 2553-2562. doi: 10.1016/j.bbagen.2016.07.027

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

Koehn, Liam M, Noor, Natassya M, Dong, Qing, Er, Sing-Yan, Rash, Lachlan D, King, Glenn F, Dziegielewska, Katarzyna M, Saunders, Norman R and Habgood, Mark D (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury. F1000Research, 5 1822, 1822. doi: 10.12688/f1000research.9094.2

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]

Koehn, Liam M., Dong, Qing, Er, Sing-Yan, Rash, Lachlan D., King, Glenn F., Dziegielewska, Katarzyna M., Saunders, Norman R. and Habgood, Mark D. (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]. F1000Research, 5 1822, 1822. doi: 10.12688/F1000RESEARCH.9094.1

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

Herzig, Volker, Ikonomopoulou, Maria, Smith, Jennifer J., Dziemborowicz, Slawomir, Gilchrist, John, Kuhn-Nentwig, Lucia, Rezende, Fernanda Oliveira, Moreira, Luciano Andrade, Nicholson, Graham M., Bosmans, Frank and King, Glenn F. (2016). Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami. Scientific Reports, 6 (1) 29538, 29538. doi: 10.1038/srep29538

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Osteen, Jeremiah D., Herzig, Volker, Gilchrist, John, Emrick, Joshua J., Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y., Weyer, Andy D., Dekan, Zoltan, Undheim, Eivind A. B., Alewood, Paul, Stucky, Cheryl L., Brierley, Stuart M., Basbaum, Allan I., Bosmans, Frank, King, Glenn F. and Julius, David (2016). Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature, 543 (7608), 494-499. doi: 10.1038/nature17976

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

Undheim, Eivind A., Mobli, Mehdi and King, Glenn F. (2016). Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides. Bioessays, 38 (6), 539-548. doi: 10.1002/bies.201500165

Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica

Ariki, Nathanial K., Muñoz, Lisa E., Armitage, Elizabeth L., Goodstein, Francesca R., George, Kathryn G, Smith, Vanessa L., Vetter, Irina, Herzig, Volker, King, Glenn F. and Loening, Nikolaus M. (2016). Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS One, 11 (5) e0156291, e0156291. doi: 10.1371/journal.pone.0156291

Combining Mass Spectrometry Cross‐Linking, Molecular Docking and NMR Titration to Dissect ZapA‐FtsZ Protein Interaction

Nogueira, Maria Luiza Caldas, Sforça, Mauricio Luis, Leme, Adriana Franco Paes, Pauletti, Bianca Alves, de Oliveira, Paulo Sergio Lopes, Honorato, Rodrigo Vargas, King, Glenn F, Filho, Frederico José Gueiros and de Mattos Zeri, Ana Carolina (2016). Combining Mass Spectrometry Cross‐Linking, Molecular Docking and NMR Titration to Dissect ZapA‐FtsZ Protein Interaction. The FASEB Journal, 30 (S1). doi: 10.1096/fasebj.30.1_supplement.lb60

Venoms of heteropteran insects: a treasure trove of diverse pharmacological toolkits

Walker, Andrew A., Weirauch, Christiane, Fry, Bryan G. and King, Glenn F. (2016). Venoms of heteropteran insects: a treasure trove of diverse pharmacological toolkits. Toxins, 8 (2) 43, 43. doi: 10.3390/toxins8020043

Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating

Deplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 (4), 872-882. doi: 10.1016/j.bbamem.2016.02.002

Combination of Ambiguous and Unambiguous Data in the Restraint-driven Docking of Flexible Peptides with HADDOCK: The Binding of the Spider Toxin PcTx1 to the Acid Sensing Ion Channel (ASIC) 1a

Deplazes, Evelyne, Davies, Josephine, Bonvin, Alexandre M. J. J., King, Glenn F. and Mark, Alan E. (2016). Combination of Ambiguous and Unambiguous Data in the Restraint-driven Docking of Flexible Peptides with HADDOCK: The Binding of the Spider Toxin PcTx1 to the Acid Sensing Ion Channel (ASIC) 1a. Journal of Chemical Information and Modeling, 56 (1), 127-138. doi: 10.1021/acs.jcim.5b00529

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F. and Widdop, Robert E. (2015). PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology, 99 5986, 650-657. doi: 10.1016/j.neuropharm.2015.08.040

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267

Widespread convergence in toxin resistance by predictable molecular evolution

Ujvari, Beata, Casewell, Nicholas R., Sunagar, Kartik, Arbuckle, Kevin, Wuester, Wolfgang, Lo, Nathan, O'Meally, Denis, Beckmann, Christa, King, Glenn F., Deplazes, Evelyne and Madsen, Thomas (2015). Widespread convergence in toxin resistance by predictable molecular evolution. Proceedings of the National Academy of Sciences of the United States of America, 112 (38), 11911-11916. doi: 10.1073/pnas.1511706112

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators

Undheim, Eivind A. B., Grimm, Lena L., Low, Chek -Fong, Morgenstern, David, Herzig, Volker, Zobel-Thropp, Pamela, Pineda, Sandy Steffany, Habib, Rosaline, Dziemborowicz, Slawomir, Fry, Bryan G., Nicholson, Graham M., Binford, Greta J., Mobli, Mehdi and King, Glenn F. (2015). Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators. Structure, 23 (7) 3184, 1283-1292. doi: 10.1016/j.str.2015.05.003

Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula

Chow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F. and Rash, Lachlan D. (2015). Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula. Toxins, 7 (7), 2494-2513. doi: 10.3390/toxins7072494

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ

Nogueira, Maria Luiza C., Sforca, Mauricio Luis, Chin, Yanni K. -Y., Mobli, Mehdi, Handler, Aaron, Gorbatyuk, Vitaliy Y., Robson, Scott A., King, Glenn F., Gueiros-Filho, Frederico J. and de Mattos Zeri, Ana Carolina (2015). Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ. Biomolecular NMR Assignments, 9 (2), 387-391. doi: 10.1007/s12104-015-9615-1

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081

Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint

Undheim, Eivind A.B., Hamilton, Brett R., Kurniawan, Nyoman D., Bowlay, Greg, Cribb, Bronwen W., Merritt, David J., Fry,Bryan G., King, Glenn F and Venter, Deon J. (2015). Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 (13), 4026-4031. doi: 10.1073/pnas.1424068112

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex

Ma, Cong, Mobli, Mehdi, Yang, Xiao, Keller, Andrew N., King, Glenn F. and Lewis, Peter J. (2015). RNA polymerase-induced remodelling of NusA produces a pause enhancement complex. Nucleic Acids Research, 43 (5), 2829-2840. doi: 10.1093/nar/gkv108

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

Bende, Niraj S., Dziemborowicz, Slawomir, Herzig, Volker, Ramanujam, Venkatraman, Brown, Geoffrey W., Bosmans, Frank, Nicholson, Graham M., King, Glenn F. and Mobli, Mehdi (2015). The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS Journal, 282 (5), 904-920. doi: 10.1111/febs.13189

Centipede venom: Recent discoveries and current state of knowledge

Undheim, Eivind, Fry, Bryan and King, Glenn F (2015). Centipede venom: Recent discoveries and current state of knowledge. Toxins, 7 (3), 679-704. doi: 10.3390/toxins7030679

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015)

Simons, Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, Franois-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Goezde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015). Nature Genetics, 47 (3), 304-304. doi: 10.1038/ng0315-304b

From foe to friend: using animal toxins to investigate ion channel function

Kalia, Jeet, Milescu, Mirela, Salvatierra, Juan, Wagner, Jordan, Klint, Julie K., King, Glenn F., Olivera, Baldomero M. and Bosmans, Frank (2015). From foe to friend: using animal toxins to investigate ion channel function. Journal of Molecular Biology, 427 (1), 158-175. doi: 10.1016/j.jmb.2014.07.027

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Simons Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, François-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Gözde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nature Genetics, 47 (1), 73-77. doi: 10.1038/ng.3153

The cystine knot is responsible for the exceptional stability of the insecticidal spider toxin ω-Hexatoxin-Hv1a

Herzig, Volker and King, Glenn F. (2015). The cystine knot is responsible for the exceptional stability of the insecticidal spider toxin ω-Hexatoxin-Hv1a. Toxins, 7 (10), 4366-4380. doi: 10.3390/toxins7104366

Construction of a hypervirulent and specific mycoinsecticide for locust control

Fang, Weiguo, Lu, Hsiao-Ling, King, Glenn F and St. Leger, Raymond J. (2014). Construction of a hypervirulent and specific mycoinsecticide for locust control. Scientific Reports, 4 (1) 7345, 7345.1-7345.6. doi: 10.1038/srep07345

No gain, no pain: NaV1.7 as an analgesic target

King, Glenn F and Vetter, Irina (2014). No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience, Articles ASAP (9), 749-751. doi: 10.1021/cn500171p

Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes)

Undheim, Eivind, Jones, Alun, Clauser, Karl R., Holland, John W., Pineda Gonzalez, Sandy, King, Glenn F and Bryan Fry (2014). Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes). Molecular Biology and Evolution, 31 (8), 2124-2148. doi: 10.1093/molbev/msu162

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Bende, Niraj S., Dziemborowicz, Sławomir, Mobli, Mehdi, Herzig, Volker, Gilchrist, John, Wagner, Jordan, Nicholson, Graham M., King, Glenn F and Bosmans, Frank (2014). A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nature Communications, 5 (1) 4350, 4350. doi: 10.1038/ncomms5350

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008

Multifunctional warheads: diversification of the toxin arsenal of centipedes via novel multidomain transcripts

Undheim, Eivind A. B., Sunagar, Kartik, Hamilton, Brett R., Jones, Alun, Venter, Deon J., Fry, Bryan G. and King, Glenn F. (2014). Multifunctional warheads: diversification of the toxin arsenal of centipedes via novel multidomain transcripts. Journal of Proteomics, 102, 1-10. doi: 10.1016/j.jprot.2014.02.024

Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6

Bobby, Romel, Robustelli, Paul, Kralicek, Andrew V., Mobli, Mehdi, King, Glenn F., Grotzinger, Joachim and Dingley, Andrew J. (2014). Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6. FEBS Journal, 281 (10), 2471-2483. doi: 10.1111/febs.12800

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications

Sunagar, Kartik, Undheim, Eivind A. B., Scheib, Holger, Gren, Eric C. K., Cochran, Chip, Person, Carl E., Koludarov, Ivan, Kelln, Wayne, Hayes, William K., King, Glenn F., Antunes, Agosthino and Fry, Bryan Grieg (2014). Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications. Journal of Proteomics, 99, 68-83. doi: 10.1016/j.jprot.2014.01.013

Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders

Pineda, Sandy S., Sollod, Brianna L., Wilson, David, Darling, Aaron, Sunagar, Kartik, Undheim, Eivind A. B., Kely, Laurence, Antunes, Agostinho, Fry, Bryan G. and King, Glenn F (2014). Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders. BMC Genomics, 15 (1) 177, 177.1-177.16. doi: 10.1186/1471-2164-15-177

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain

Gui, Junhong, Liu, Boyi, Cao, Guan, Lipchik, Andrew M., Perez, Minervo, Dekan, Zoltan, Mobli, Mehdi, Daly, Norelle L., Alewood, Paul F., Parker, Laurie L., King, Glenn F., Zhou, Yufeng, Jordt, Sven-Eric and Nitabach, Michael N. (2014). A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain. Current Biology, 24 (5), 473-483. doi: 10.1016/j.cub.2014.01.013

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898

Methods for deployment of spider venom peptides as bioinsecticides

Herzig, Volker, Bende, Niraj S., Alam, Md. Shohidul, Tedford, H. William, Kennedy, Robert M. and King, Glenn F. (2014). Methods for deployment of spider venom peptides as bioinsecticides. Advances in Insect Physiology, 47, 389-411. doi: 10.1016/B978-0-12-800197-4.00008-7

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165

Spider venomics: implications for drug discovery

Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P. and King, Glenn F. (2014). Spider venomics: implications for drug discovery. Future Medicinal Chemistry, 6 (15), 1699-1714. doi: 10.4155/FMC.14.103

The future of venoms-based drug discovery: an interview with Glenn King

King, Glenn F. (2014). The future of venoms-based drug discovery: an interview with Glenn King. Future Medicinal Chemistry, 6 (15), 1613-1615. doi: 10.4155/FMC.14.102

Toxin delivery by the coat protein of an aphid-vectored plant virus provides plant resistance to aphids

Bonning, Bryony C., Pal, Narinder, Liu, Sijun, Wang, Zhaohui, Sivakumar, S., Dixon, Philip M., King, Glenn F. and Miller, W. Allen (2014). Toxin delivery by the coat protein of an aphid-vectored plant virus provides plant resistance to aphids. Nature Biotechnology, 32 (1), 102-105. doi: 10.1038/nbt.2753

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p

Venoms to drugs: translating venom peptides into therapeutics

King, Glenn (2013). Venoms to drugs: translating venom peptides into therapeutics. Australian Biochemist, 44 (3).

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Dantas De Araujo, Aline, Herzig, Volker, Windley, Monique J., Dziemborowicz, Slawomir, Mobli, Mehdi, Nicholson, Graham M., Alewood, Paul F. and King, Glenn F. (2013). Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?. Antioxidants and Redox Signaling, 19 (16), 1976-1980. doi: 10.1089/ars.2013.5365

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf

Sunagar, Kartik, Fry, Bryan Grieg, Jackson, Timothy N. W., Casewell, Nicholas R., Undheim, Eivind A. B., Vidal, Nicolas, Ali, Syed A., King, Glenn F., Vasudevan, Karthikeyan, Vasconcelos, Vitor and Antunes, Agostinho (2013). Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf. PLoS One, 8 (11) e81827, e81827.1-e81827.19. doi: 10.1371/journal.pone.0081827

Discovery of a selective Na(V)1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

Yang, Shilong, Xiao, Yao, Kang, Di, Liu, Jie, Li, Yuan, Undheim, Eivind A. B., Klint, Julie K., Rong, Mingqiang, Lai, Ren and King, Glenn F. (2013). Discovery of a selective Na(V)1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proceedings of the National Academy of Sciences of the United States of America, 110 (43), 17534-17539. doi: 10.1073/pnas.1306285110

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula

Hardy, Margaret C., Daly, Norelle L., Mobli, Mehdi, Morales, Rodrigo A. V. and King, Glenn F. (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula. PLoS ONE, 8 (9), e73136.1-e73136.12. doi: 10.1371/journal.pone.0073136

Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms

Ruder, Tim, Ali, Syed Abid, Ormerod, Kiel, Brust, Andreas, Roymanchadi, Mary-Louise, Ventura, Sabatino, Undheim, Eivind A. B., Jackson, Timothy N. W., Mercier, A. Joffre, King, Glenn F., Alewood, Paul F. and Fry, Bryan G. (2013). Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms. Peptides, 47, 71-76. doi: 10.1016/j.peptides.2013.07.002

Aphicidal efficacy of scorpion- and spider-derived neurotoxins

Pal, Narinder, Yamamoto, Takashi, King, Glenn F., Waine, Clement and Bonning, Bryony (2013). Aphicidal efficacy of scorpion- and spider-derived neurotoxins. Toxicon, 70, 114-122. doi: 10.1016/j.toxicon.2013.04.015

Dracula's children: molecular evolution of vampire bat venom

Low, Dolyce H. W., Sunagar, Kartik, Undheim, Eivind A. B., Ali, Syed A., Alagon, Alejandro C., Ruder, Tim, Jackson, Timothy N. W., Gonzalez, Sandy Pineda, King, Glenn F., Jones, Alun, Antunes, Agostinho and Fry, Bryan G. (2013). Dracula's children: molecular evolution of vampire bat venom. Journal of Proteomics, 89, 95-111. doi: 10.1016/j.jprot.2013.05.034

SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula

Wong, Emily S. W., Hardy, Margaret C., Wood, David, Bailey, Timothy and King, Glenn F. (2013). SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula. PLoS ONE, 8 (7) e66279, e66279.1-e66279.11. doi: 10.1371/journal.pone.0066279

Squeezers and leaf-cutters: differential diversification and degeneration of the venom system in toxicoferan reptiles

Fry, Bryan G., Undheim, Eivind A. B., Ali, Syed A., Jackson, Timothy N. W., Debono, Jordan, Scheib, Holger, Ruder, Tim, Morgenstern, David, Cadwallader, Luke, Whitehead, Darryl, Nabuurs, Rob, van der Weerd, Louise, Vidal, Nicolas, Roelants, Kim, Hendrikx, Iwan, Gonzalez, Sandy Pineda, Koludarov, Ivan, Jones, Alun, King, Glenn F., Antunes, Agostinho and Sunagar, Kartik (2013). Squeezers and leaf-cutters: differential diversification and degeneration of the venom system in toxicoferan reptiles. Molecular and Cellular Proteomics, 12 (7), 1881-1899. doi: 10.1074/mcp.M112.023143

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013). Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 (5) e63865, e63865.1-e63865.12. doi: 10.1371/journal.pone.0063865

Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA

Winnen, Brit, Anderson, Eric, Cole, James L., King, Glenn F. and Rowland, S. L. (2013). Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA. Journal of Bacteriology, 195 (10), 2349-2358. doi: 10.1128/JB.00096-13

Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands

Ruder, Tim, Sunagar, Kartik, Undheim, Eivind A. B., Ali, Syed A., Wai, Tak-Cheung, Low, Dolyce H. W., Jackson, Timothy N. W., King, Glenn F., Antunes, Agostinho and Fry, Bryan G. (2013). Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands. Journal of Molecular Evolution, 76 (4), 192-204. doi: 10.1007/s00239-013-9552-5

The insecticidal potential of venom peptides

Smith, Jennifer J., Herzig, Volker, King, Glenn F. and Alewood, Paul F. (2013). The insecticidal potential of venom peptides. Cellular and Molecular Life Sciences, 70 (19), 3665-3693. doi: 10.1007/s00018-013-1315-3

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Brust, Andreas, Sunagar, Kartik, Eivind Undheim, Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Ruder, Tim, Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2013). Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular and Cellular Proteomics, 12 (3), 651-663. doi: 10.1074/mcp.M112.023135

The venom optimization hypothesis revisited

Morgenstern, David and King, Glenn F. (2013). The venom optimization hypothesis revisited. Toxicon, 63 (1), 120-128. doi: 10.1016/j.toxicon.2012.11.022

Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry

Palagi, Alexandre, Koh, Jennifer M. S., Leblanc, Mathieu, Wilson, David, Dutertre, Sebastien, King, Glenn F., Nicholson, Graham M. and Escoubas, Pierre (2013). Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry. Journal of Proteomics, 80, 292-310. doi: 10.1016/j.jprot.2013.01.002

A proteomics and transcriptomics investigation of the venom from the Barychelid spider Trittame loki (brush-foot trapdoor)

Undheim, Eivind A. B., Sunagar, Kartik, Herzig, Volker, Kely, Laurence, Low, Dolyce H. W., Jackson, Timothy N. W., Jones, Alun, Kurniawan, Nyoman, King, Glenn F., Ali, Syed A., Antunes, Agostino, Ruder, Tim and Fry, Bryan G. (2013). A proteomics and transcriptomics investigation of the venom from the Barychelid spider Trittame loki (brush-foot trapdoor). Toxins, 5 (12), 2488-2503. doi: 10.3390/toxins5122488

From kinetics to imaging: An NMR odyssey-a festschrift symposium in honour of Philip William Kuchel

Vandenberg, Jamie L., Conigrave, Arthur, King, Glenn F. and Kirk, Kiaran (2013). From kinetics to imaging: An NMR odyssey-a festschrift symposium in honour of Philip William Kuchel. European Biophysical Journal, 42 (1), 1-2. doi: 10.1007/s00249-012-0883-8

Natural born insect killers: Spider-venom peptides and their potential for managing arthropod pests

Ikonomopoulou, Maria and King, Glenn (2013). Natural born insect killers: Spider-venom peptides and their potential for managing arthropod pests. Outlooks on Pest Management, 24 (1), 16-19. doi: 10.1564/v24_feb_05

Spider-venom peptides: structure, pharmacology, and potential for control of insect pests

King, Glenn F. and Hardy, Margaret C. (2013). Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annual Review of Entomology, 58, 475-496. doi: 10.1146/annurev-ento-120811-153650

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

Bende, Niraj S., Kang, Eunji, Herzig, Volker, Bosmans, Frank, Nicholson, Graham M., Mobli, Mehdi and King, Glenn F. (2013). The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels. Biochemical Pharmacology, 85 (10), 1542-1554. doi: 10.1016/j.bcp.2013.02.030

Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers

Anangi, Raveendra, Koshy, Shyny, Huq, Redwan, Beeton, Christine, Chuang, Woei-Jer and King, Glenn F. (2012). Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. PLoS One, 7 (12) e52965, e52965.1-e52965.9. doi: 10.1371/journal.pone.0052965

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013)

Brust, Andreas, Sunagar, Kartik, Undheim, Eivind A. B., Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2012). Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013). Molecular & Cellular Proteomics, 12 (5), 1488-1488. doi: 10.1074/mcp.M112.023135

Structural and molecular diversification of the Anguimorpha lizard mandibular venom gland system in the arboreal species Abronia graminea

Koludarov, Ivan, Sunagar, Kartik, Undheim, Eivind A. B., Jackson, Timothy N. W., Ruder, Tim, Whitehead, Darryl, Saucedo, Alejandro C., Roberto Mora, G., Alagon, Alejandro C., King, Glenn, Antunes, Agostinho and Fry, Bryan G. (2012). Structural and molecular diversification of the Anguimorpha lizard mandibular venom gland system in the arboreal species Abronia graminea. Journal of Molecular Evolution, 75 (5-6), 168-183. doi: 10.1007/s00239-012-9529-9

Cyclization of peptides by using selenolanthionine bridges

Dantas de Araujo, Aline, Mobli, Mehdi, King, Glenn F. and Alewood, Paul F. (2012). Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie International Edition, 51 (41), 10298-10302. doi: 10.1002/anie.201204229

Development of a rational nomenclature for naming peptide and protein toxins from sea anemones

Oliveira, Joacir Stolarz, Fuentes-Silva, Deyanira and King, Glenn F. (2012). Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon, 60 (4), 539-550. doi: 10.1016/j.toxicon.2012.05.020

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads

Klint, Julie K., Senff, Sebastian, Rupasinghe, Darshani B., Er, Sing Yan, Herzig, Volker, Nicholson, Graham M. and King, Glenn F. (2012). Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads. Toxicon, 60 (4), 478-491. doi: 10.1016/j.toxicon.2012.04.337

Chemical punch packed in venoms makes centipedes excellent predators

Yang, Shilong, Liu, Zhonghua, Xiao, Yao, Li, Yuan, Rong, Mingqiang, Liang, Songping, Yu, Haining, King, Glenn F., Lai, Ren and Zhang, Zhiye (2012). Chemical punch packed in venoms makes centipedes excellent predators. Molecular and Cellular Proteomics, 11 (9), 640-650. doi: 10.1074/mcp.M112.018853

The lethal toxin from Australian funnel-web spiders is encoded by an intronless gene

Pineda, Sandy Steffany, Wilson, David, Mattick, John S. and King, Glenn F. (2012). The lethal toxin from Australian funnel-web spiders is encoded by an intronless gene. PLoS One, 7 (8) e43699, E43699.1-E43699.8. doi: 10.1371/journal.pone.0043699

Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profiles

Wong, Emily S. W., Morgenstern, David, Mofiz, Ehtesham, Gombert, Sara, Morris, Katrina M., Temple-Smith, Peter, Renfree, M.B., Whittington, Camilla M., King, Glenn F., Warren, Wesley C., Papenfuss, Anthony T. and Belov, Katherine (2012). Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profiles. Molecular and Cellular Proteomics, 11 (11), 1354-1364. doi: 10.1074/mcp.M112.017491

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

Anangi, Raveendra, Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2012). Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 (7), 1605-1618. doi: 10.3390/md10071605

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2012). Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10 (7), 1511-1527. doi: 10.3390/md10071511

Fusion to snowdrop lectin magnifies the oral activity of insecticidal omega-hexatoxin-Hv1a peptide by enabling its delivery to the central nervous system

Fitches, Elaine C., Pyati, Prashant, King, Glenn F. and Gatehouse, John A. (2012). Fusion to snowdrop lectin magnifies the oral activity of insecticidal omega-hexatoxin-Hv1a peptide by enabling its delivery to the central nervous system. PLoS One, 7 (6) e39389, e39389.1-e39389.10. doi: 10.1371/journal.pone.0039389

Spider-venom peptides as bioinsecticides

Windley, Monique J., Herzig, Volker, Dziemborowicz, Sławomir A., Hardy, Margaret C., King, Glenn F. and Nicholson, Graham M. (2012). Spider-venom peptides as bioinsecticides. Toxins, 4 (3), 191-227. doi: 10.3390/toxins4030191

Insulin-like growth factor binding protein 2: NMR analysis and structural characterization of the N-terminal domain

Galea, Charles A., Mobli, Mehdi, McNeil, Kerrie A., Mulhern, Terrence D., Wallace, John C., King, Glenn F., Forbes, Briony E. and Norton, Raymond S. (2012). Insulin-like growth factor binding protein 2: NMR analysis and structural characterization of the N-terminal domain. Biochimie, 94 (3), 608-616. doi: 10.1016/j.biochi.2011.09.012

Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function

Rupasinghe, Darshani B., Knapp, Oliver, Blomster, Linda V., Schmid, Annina B., Adams, David J., King, Glenn F. and Ruitenberg, Marc J. (2012). Localization of Na(v)1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function. Channels, 6 (2), 103-110. doi: 10.4161/chan.19484

Cloning and activity of a novel alpha-latrotoxin from red-back spider venom

Graudins, Andis, Little, Michelle J., Pineda, Sandy S., Hains, Peter G., King, Glenn F., Broady, Kevin W. and Nicholson, Graham M. (2012). Cloning and activity of a novel alpha-latrotoxin from red-back spider venom. Biochemical Pharmacology, 83 (1), 170-183. doi: 10.1016/j.bcp.2011.09.024

Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR

Mobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011). Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 (50), 11952-11955. doi: 10.1002/anie.201104169

Venoms as a platform for human drugs: Translating toxins into therapeutics

King, Glenn F. (2011). Venoms as a platform for human drugs: Translating toxins into therapeutics. Expert Opinion on Biological Therapy, 11 (11), 1469-1484. doi: 10.1517/14712598.2011.621940

A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011). A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 (5), 796-808. doi: 10.1124/mol.111.072207

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

Smith, Jennifer J., Hill, Justine M., Little, Michelle J., Nicholson, Graham M., King, Glenn F. and Alewood, Paul F. (2011). Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif. Proceedings of the National Academy of Sciences of the United States of America, 108 (26), 10478-10483. doi: 10.1073/pnas.1103501108

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108

The tale of a resting gland: Transcriptome of a replete venom gland from the scorpion Hottentotta judaicus

Morgenstern, David, Rohde, Bettina H., King, Glenn F., Tal, Tzachy, Sher, Daniel and Zlotkin, Eliahu (2011). The tale of a resting gland: Transcriptome of a replete venom gland from the scorpion Hottentotta judaicus. Toxicon, 57 (5), 695-703. doi: 10.1016/j.toxicon.2011.02.001

On the venom system of centipedes (Chilopoda), a neglected group of venomous animals

Undheim, Eivind A. B. and King, Glenn F. (2011). On the venom system of centipedes (Chilopoda), a neglected group of venomous animals. Toxicon, 57 (4), 512-524. doi: 10.1016/j.toxicon.2011.01.004

Macromolecular NMR spectroscopy for the non-spectroscopist

Kwan, Ann H., Mobli, Mehdi, Gooley, Paul R., King, Glenn F. and Mackay, Joel P. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist. Febs Journal, 278 (5), 687-703. doi: 10.1111/j.1742-4658.2011.08004.x

Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular structure determination

Bieri, Michael, Kwan, Ann H., Mobli, Mehdi, King, Glenn F., Mackay, Joel P. and Gooley, Paul R. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular structure determination. Febs Journal, 278 (5), 704-715. doi: 10.1111/j.1742-4658.2011.08005.x

The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation

Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela and Vandenberg, Jamie I. (2011). The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation. PLoS One, 6 (1) e16191, e16191.1-e16191.9. doi: 10.1371/journal.pone.0016191

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

Volker, Herzig, Wood, David, Newell, Felicity, Chaumeil, Pierre-Alain, Kaas, Quentin, Binford, Greta J., Nicholson, Graham M., Gorse, Dominique and King, Glenn F. (2011). ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures. Nucleic Acids Research, 39 (Supp. 1), D653-D657. doi: 10.1093/nar/gkq1058

Venomics: A new paradigm for natural products-based drug discovery

Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4

Spider-venom peptides as therapeutics

Seaz, Natalie J., Senff, Sebastian, Jensen, Jonas E., Er, Sing Yan, Herzig, Volker, Rash, Lachlan D. and King, Glenn F. (2010). Spider-venom peptides as therapeutics. Toxins, 2 (12), 2851-2871. doi: 10.3390/toxins2122851

Evidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic beta domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2B

Rowland, Susan L., Wadsworth, Kimberly D., Robson, Scott A., Robichon, Carine, Beckwith, Jon and King, Glenn F. (2010). Evidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic beta domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2B. Journal of Bacteriology, 192 (23), 6116-6125. doi: 10.1128/JB.00783-10

NMR methods for determining disulfide-bond connectivities

Mobli, Mehdi and King, Glenn F. (2010). NMR methods for determining disulfide-bond connectivities. Toxicon, 56 (6), 849-854. doi: 10.1016/j.toxicon.2010.06.018

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Pang, Siew Siew, Berry, Richard, Chen, Zhenjun, Kjer-Nielsen, Lars, Perugini, Matthew A., King, Glenn F., Wang, Christina, Chew, Sock Hui, La Gruta, Nicole L., Williams, Neil K., Beddoe, Travis, Tiganis, Tony, Cowieson, Nathan P., Godfrey, Dale I., Purcell, Anthony W., Wilce, Matthew C. J., McCluskey, James and Rossjohn, Jamie (2010). The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature, 467 (7317), 844-848. doi: 10.1038/nature09448

Chemical synthesis and structure of the prokineticin Bv8

Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330

A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment

Mobli, Mehdi, Stern, Alan S., Bermel, Wolfgang, King, Glenn F. and Hoch, Jeffrey C. (2010). A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment. Journal of Magnetic Resonance, 204 (1), 160-164. doi: 10.1016/j.jmr.2010.02.012

Tandem use of selective insecticides and natural enemies for effective, reduced-risk pest management

Gentz, Margaret C., Murdoch, Gregory and King, Glenn F. (2010). Tandem use of selective insecticides and natural enemies for effective, reduced-risk pest management. Biological Control, 52 (3), 208-215. doi: 10.1016/j.biocontrol.2009.07.012

Derivation of Peptide and Protein Structure using NMR Spectroscopy

King, Glenn F. and Mobli, Mehdi (2010). Derivation of Peptide and Protein Structure using NMR Spectroscopy. Comprehensive Natural Products Ii: Chemistry and Biology, Vol 9: Modern Methods in Natural Products Chemistry, 9, 279-325.

Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy

Mobli, M., Dantas de Araujo, A., Lambert, L. K., Pierens, G. K., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. E. (2009). Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy. Angewandte Chemie International Edition, 48 (49), 9312-9314. doi: 10.1002/anie.200905206

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

Fry, Bryan G., Roelants, Kim, Champagne, Donald E., Scheib, Holger, Tyndall, Joel D. A., King, Glenn F., Nevalainen, Timo J., Norman, Janette A., Lewis, Richard J., Norton, Raymond S., Renjifo, Camila and Rodriguez de la Vega, Ricardo C. (2009). The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms. Annual Review of Genomics and Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356

ArachnoServer: a database of protein toxins from spiders

Wood, D. L. A., Miljenovic, T, Cai, S, Raven, R. J., Kaas, Q, Escoubas, P, Herzig, V, Wilson, D and King, G (2009). ArachnoServer: a database of protein toxins from spiders. BMC Genomics, 10 (Article #375) 375, 1-8. doi: 10.1186/1471-2164-10-375

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

Jensen, J. E., Durek, T, Alewood, P. F., Adams, D. J., King, G. F. and Rash, L. D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. TOXICON, 54 (1), 56-61. doi: 10.1016/j.toxicon.2009.03.014

Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state

Jacques, D. A., Streamer, M, Rowland, S. L., King, G. F., Guss, J. M., Trewhella, J and Langley, D. B. (2009). Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state. Acta Crystallographica Section D: Biological Crystallography, 65 (Part 6), 574-581. doi: 10.1107/S090744490901169X

Venomics as a drug discovery platform

Escoubas, Pierre and King, Glenn F. (2009). Venomics as a drug discovery platform. Expert Review of Proteomics, 6 (3), 221-224. doi: 10.1586/EPR.09.45

Comparison of the peptidome and insecticidal activity of venom from a taxonomically diverse group of theraphosid spiders

Gentz, M. C., Jones, A, Clement, H and King, G. F. (2009). Comparison of the peptidome and insecticidal activity of venom from a taxonomically diverse group of theraphosid spiders. Toxicon, 53 (5), 496-502. doi: 10.1016/j.toxicon.2009.01.025

Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: An interspecies approach to the study of protein-protein interactions in multiprotein complexes

Robichon, C., King, G. F., Goehring, N. W. and Beckwith, J. (2008). Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: An interspecies approach to the study of protein-protein interactions in multiprotein complexes. Journal of Bacteriology, 190 (18), 6048-6059. doi: 10.1128/JB.00462-08

Peptide toxins that selectively target insect NaV and CaV channels

King, Glenn F., Escoubas, Pierre and Nicholson, Graham M. (2008). Peptide toxins that selectively target insect NaV and CaV channels. Channels, 2 (2), 100-116. doi: 10.4161/chan.2.2.6022

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

King, G. F., Gentz, M. C., Escoubas, P. and Nicholson, G. M. (2008). A rational nomenclature for naming peptide toxins from spiders and other venomous animals. Toxicon, 52 (2), 264-276. doi: 10.1016/j.toxicon.2008.05.020

The Janus-faced atracotoxins are specific blockers of invertebrate KCa channels

Gunning, Simon J., Maggio, Francesco, Windley, Monique J., Valenzuela, Stella M., King, Glenn F. and Nicholson, Graham M. (2008). The Janus-faced atracotoxins are specific blockers of invertebrate KCa channels. The FEBS Journal, 275 (16), 4045-4059. doi: 10.1111/j.1742-4658.2008.06545.x

The divisomal protein DivIB contains multiple epitopes that mediate its recruitment to incipient division sites

Wadswoth, Kimberly D., Rowland, Susan L., Harry, Elizabeth J. and King, Glenn F. (2008). The divisomal protein DivIB contains multiple epitopes that mediate its recruitment to incipient division sites. Molecular Microbiology, 67 (5), 1143-1155. doi: 10.1111/j.1365-2958.2008.06114.x

The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases.

Vajjhala, P. R., Nguyen , C. H., Landsberg, M. J., Kistler, C., Gan, A. L., King, G. F., Hankamer, B. and Munn, A. L. (2008). The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases.. Febs Journal, 275 (7), 1427-1449. doi: 10.1111/j.1742-4658.2008.06300.x

Histidine kinases as antimicrobial targets: prospects and pitfalls

Rowland, S. L. and King, G. F. (2007). Histidine kinases as antimicrobial targets: prospects and pitfalls. Mini-Reviews in Medicinal Chemistry, 7 (11), 1144-1154. doi: 10.2174/138955707782331759

The ω-atracotoxins: Selective blockers of insect M-LVA and HVA calcium channels

Chong, Youmie, Hayes, Jessica L., Sollod, Brianna, Wen, Suping, Wilson, David T., Hains, Peter G., Hodgson, Wayne C., Broady, Kevin W., King, Glenn F. and Nicholson, Graham M. (2007). The ω-atracotoxins: Selective blockers of insect M-LVA and HVA calcium channels. Biochemical Pharmacology, 74 (4), 623-638. doi: 10.1016/j.bcp.2007.05.017

The structure of the KinA-Sda complex suggest an allosteric mechanism of histidine kinase inhibition

Whitten, Andrew E., Jacques, David A., Hammouda, Boualem, Hanley, Tracey, King, Glenn F., Guss, J. Mitchell, Trewhella, Jill and Langley, David B. (2007). The structure of the KinA-Sda complex suggest an allosteric mechanism of histidine kinase inhibition. Journal of Molecular Biology, 368 (2), 407-420. doi: 10.1016/j.jmb.2007.01.064

Modulation of insect Cav channels by peptidic spider toxins

King, G. F. (2007). Modulation of insect Cav channels by peptidic spider toxins. Toxicon, 49 (4), 513-530. doi: 10.1016/j.toxicon.2006.11.012

Domain architecture and structure of the bacterial cell division protein DivIB

Robson, S. A. and King, G. F. (2006). Domain architecture and structure of the bacterial cell division protein DivIB. Proceedings of The National Academy of Sciences of The United States of America, 103 (17), 6700-6705. doi: 10.1073/pnas.0601397103

Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction

Gorbatyuk, V. Y., Nosworthy, N. J., Robson, S. A., Bains, N. P. S., Maciejewski, M. W., dos Remedios, C. G. and King, G. F. (2006). Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Molecular Cell, 24 (4), 511-522. doi: 10.1016/j.molcel.2006.10.007

Orally active acaricidal peptide toxins from spider venom

Mukherjee, A. K., Sollod, B. L., Wikel, S. K. and King, G. F. (2006). Orally active acaricidal peptide toxins from spider venom. Toxicon, 47 (2), 182-187. doi: 10.1016/j.toxicon.2005.10.011

Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions

Schiller, M. R., Chakrabarti, K., King, G. F., Schiller, N. I., Eipper, B. A. and Maciejewski, M. W. (2006). Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. Journal of Biological Chemistry, 281 (27), 18774-18786. doi: 10.1074/jbc.M512482200

Venom landscapes: Mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach

Escoubas, P., Sollod, B. and King, G. F. (2006). Venom landscapes: Mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach. Toxicon, 47 (6), 650-663. doi: 10.1016/j.toxicon.2006.01.018

Backbone and Side-Chain 1H, 15N and 13C Assignments for the cis Conformer of the β Domain of the Bacterial Cell Division Protein DivIB (Letters to the Editor)

Robson, Scott A. and King, Glenn F. (2005). Backbone and Side-Chain 1H, 15N and 13C Assignments for the cis Conformer of the β Domain of the Bacterial Cell Division Protein DivIB (Letters to the Editor). Journal of Biomolecular NMR, 33 (2), 135-135. doi: 10.1007/s10858-005-2590-6

Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for the β domain of the bacterial cell division protein DivIB

Robson, Scott A., Gorbatyuk, Vitaliy Y., Maciejewski, Mark W. and King, Glenn F. (2005). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for the β domain of the bacterial cell division protein DivIB. Journal of Biomolecular NMR, 31 (3), 261-262. doi: 10.1007/s10858-005-0178-9

Were arachnids the first to use combinatorial peptide libraries

Sollod, Brianna L., Wilson, David, Zhaxybayeva, Olga, Gogarten, J. Peter, Drinkwater, Roger and King, Glenn F. (2005). Were arachnids the first to use combinatorial peptide libraries. Peptides, 26 (1), 131-139. doi: 10.1016/j.peptides.2004.07.016

Australian funnel-web spiders: master insecticide chemists

Tedford, H. W., Sollod, B. L., Maggio, F. and King, G. F. (2004). Australian funnel-web spiders: master insecticide chemists. Toxicon, 43 (5), 601-618. doi: 10.1016/j.toxicon.2004.02.010

Differential hydrolysis of erythrocyte and mitochondrial membrane phospholipids by two phospholipase A(2) isoenzymes (NK-PLA(2)-I and NK-PLA(2)-II) from the venom of the Indian monocled cobra Naja kaouthia

Doley, R., King, G. F. and Mukherjee, A. K. (2004). Differential hydrolysis of erythrocyte and mitochondrial membrane phospholipids by two phospholipase A(2) isoenzymes (NK-PLA(2)-I and NK-PLA(2)-II) from the venom of the Indian monocled cobra Naja kaouthia. Archives of Biochemistry And Biophysics, 425 (1), 1-13. doi: 10.1016/j.abb.2004.02.007

Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection

Ma, L. Y., King, G. F. and Rothfield, L. (2004). Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection. Molecular Microbiology, 54 (1), 99-108. doi: 10.1111/j.1365-2958.2004.04265.x

Scanning mutagenesis of omega-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels

Tedford, H. W., Gilles, N., Menez, A., Doering, C. J., Zamponi, G. W. and King, G. F. (2004). Scanning mutagenesis of omega-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels. Journal of Biological Chemistry, 279 (42), 44133-44140. doi: 10.1074/jbc.M404006200

Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis

Rowland, S. L., Burkholder, W. F., Cunningham, K. A., Maciejewski, M. W., Grossman, A. D. and King, G. F. (2004). Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis. Molecular Cell, 13 (5), 689-701. doi: 10.1016/S1097-2765(04)00084-X

The wonderful world of spiders: preface to the special Toxicon issue on spider venoms

King, Glenn F. (2004). The wonderful world of spiders: preface to the special Toxicon issue on spider venoms. Toxicon, 43 (5), 471-475. doi: 10.1016/j.toxicon.2004.02.001

Mapping the MinE site involved in interaction with the MinD division site selection protein of Escherichia coli

Ma, L. Y., King, G. and Rothfield, L. (2003). Mapping the MinE site involved in interaction with the MinD division site selection protein of Escherichia coli. Journal of Bacteriology, 185 (16), 4948-4955. doi: 10.1128/JB.185.16.4948-4955.2003

The MinD membrane targeting sequence is a transplantable lipid-binding helix

Szeto, T. H., Rowland, S. L., Habrukowich, C. L. and King, G. F. (2003). The MinD membrane targeting sequence is a transplantable lipid-binding helix. Journal of Biological Chemistry, 278 (41), 40050-40056. doi: 10.1074/jbc.M306876200

Polar explorers: Membrane proteins that determine division site placement (vol 106, pg 13, 2001)

Rothfield, LI, Shih, YL and King, G (2002). Polar explorers: Membrane proteins that determine division site placement (vol 106, pg 13, 2001). Cell, 110 (4), 533-533. doi: 10.1016/S0092-8674(02)00903-0

Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains

Shih, Y. L., Fu, X. L., King, G. F., Le, T. and Rothfield, L. (2002). Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. Embo Journal, 21 (13), 3347-3357. doi: 10.1093/emboj/cdf323

Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin

Bains, N. P. S., Gorbatyuk, V. Y., Nosworthy, N. J., Robson, S. A., Maciejewski, M. W., dos Remedios, C. G. and King, G. F. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular Nmr, 22 (2), 193-194. doi: 10.1023/A:1014227808686

Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts

Szeto, T. H., Rowland, S. L., Rothfield, L. I. and King, G. F. (2002). Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proceedings of The National Academy of Sciences of The United States of America, 99 (24), 15693-15698. doi: 10.1073/pnas.232590599

Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun

Boysen, R. I., Jong, A. J. O., Wilce, J. A., King, G. F. and Hearn, M. T. W. (2002). Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun. Journal of Biological Chemistry, 277 (1), 23-31. doi: 10.1074/jbc.M104556200

Role of the structurally disordered N- and C-terminal residues in the Janus-faced atracotoxins

Maggio, F. and King, G. F. (2002). Role of the structurally disordered N- and C-terminal residues in the Janus-faced atracotoxins. Toxicon, 40 (9), 1355-1361. doi: 10.1016/S0041-0101(02)00154-X

Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function

Maggio, F. and King, G. F. (2002). Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function. Journal of Biological Chemistry, 277 (25), 22806-22813. doi: 10.1074/jbc.M202297200

Structure and function of insecticidal neurotoxins from Australian funnel-web spiders

King, G. F., Tedford, H. W. and Maggio, F. (2002). Structure and function of insecticidal neurotoxins from Australian funnel-web spiders. Journal of Toxicology-toxin Reviews, 21 (4), 359-389. doi: 10.1081/TXR-120014409

The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components

Robson, S. A., Michie, K. A., Mackay, J. P., Harry, E. and King, G. F. (2002). The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. Molecular Microbiology, 44 (3), 663-674. doi: 10.1046/j.1365-2958.2002.02920.x

Discovery and structure of a potent and highly specific blockerof insect calcium channels

Wang, X., Connors, M., Wilson, D. T. R., Wilson, H. I., Nicholson, G. M., Smith, R., Shaw, D. C., Mackay, J. P., Alewood, P. F., Christie, M. J. and King, G. F. (2001). Discovery and structure of a potent and highly specific blockerof insect calcium channels. The Journal of Biological Chemistry, 276 (43), 40306-40312. doi: 10.1074/jbc.M105206200

Functional significance of the beta-hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a

Tedford, H. W., Fletcher, J. I. and King, G. F. (2001). Functional significance of the beta-hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a. Journal of Biological Chemistry, 276 (28), 26568-26576. doi: 10.1074/jbc.M102199200

Polar explorers: Membrane proteins that determine division site placement

Rothfield, L. I., Shih, Y. L. and King, G. (2001). Polar explorers: Membrane proteins that determine division site placement. Cell, 106 (1), 13-16. doi: 10.1016/S0092-8674(01)00432-9

The dimerization function of MinC resides in a structurally autonomous C-terminal domain

Szeto, T. H., Rowland, S. L. and King, G. F. (2001). The dimerization function of MinC resides in a structurally autonomous C-terminal domain. Journal of Bacteriology, 183 (22), 6684-6687. doi: 10.1128/JB.183.22.6684-6687.2001

Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons

Blair, D. H., Robson, S., King, G. and Bennett, M. R. (2001). Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons. Neuroreport, 12 (3), 607-610. doi: 10.1097/00001756-200103050-00035

Structural basis for the topological specificity function of MinE

King, Glenn F., Shih, Yu-Ling, Maciejewski, Mark W., Bains, Naresh P. S., Pan, Borlan, Rowland, Susan L., Mullen, Gregory P. and Rothfield, Lawrence I. (2000). Structural basis for the topological specificity function of MinE. Nature Structural Biology, 7 (11), 1013-1017. doi: 10.1038/80917

Isolation and pharmacological characterisation of ō-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin

Szeto, Tim H., Birinyi-Strachan, Liesl C., Smith, Ross, Connor, Mark, Christie, Macdonald J., King, Glenn F. and Nicholson, Graham M. (2000). Isolation and pharmacological characterisation of ō-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin. FEBS Letters, 470 (3), 293-299. doi: 10.1016/S0014-5793(00)01339-9

Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge

Wang, X. H., Connor, M., Smith, R. W., Maciejewski, M. W., Howden, M. E. H., Nicholson, G. M., Christie, M. J. and King, G. F. (2000). Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge. Nature Structural Biology, 7 (6), 505-513. doi: 10.1038/75921

Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1

Szeto, T. H., Wang, X. H., Smith, R., Connor, M., Christie, M. J., Nicholson, G. M. and King, G. F. (2000). Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1. Toxicon, 38 (3), 429-442. doi: 10.1016/S0041-0101(99)00174-9

Solution structure of a defensin-like peptide from platypus venom

Torres, A. M., Wang, X., Fletcher, J. I., Alewood, D., Alewood, P. F., Smith, R. W., Simpson, R. J., Nicholson, G. M., Sutherland, S. K., Gallagher, C. H., King, G. and Kuchel, P. W. (1999). Solution structure of a defensin-like peptide from platypus venom. Biochemical Journal, 341 (3), 785-794. doi: 10.1042/0264-6021:3410785

Letter to the Editor: Backbone and side-chain H-1, N-15, and C-13 assignments for the topological specificity domain of the MinE cell division protein

King, Glenn F., Pan, Borlan, Maciejewski, Mark W., Rowland, Susan L., Rothfield, Lawrence I. and Mullen, Gregory P. (1999). Letter to the Editor: Backbone and side-chain H-1, N-15, and C-13 assignments for the topological specificity domain of the MinE cell division protein. Journal of Biomolecular NMR, 13 (4), 395-396. doi: 10.1023/A:1008386622578

The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG

Kowalski, K., Czolij, R., King, G. F., Crossley, M. and Mackay, J. P. (1999). The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG. Journal of Biomolecular NMR, 13 (3), 249-262. doi: 10.1023/A:1008309602929

Controlling leucine zipper specificity with interfacial hydrophobic residues

Bains, Naresh P. S., Wilce, Jackie A., Mackay, Lindsey G. and King, Glenn F. (1999). Controlling leucine zipper specificity with interfacial hydrophobic residues. Letters In Peptide Science, 6 (5-6), 381-390. doi: 10.1007/BF02443435

High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide

Fletcher, Jamie I., Dingley, Andrew J., Smith, Ross, Connor, Mark, Christie, MacDonald J. and King, Glenn F. (1999). High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide. European Journal of Biochemistry, 264 (2), 525-533. doi: 10.1046/j.1432-1327.1999.00659.x

Site-directed mutants of RTP of Bacillus subtilis and the mechanism of replication fork arrest

Duggin, I. G., Andersen, P. A., Smith, M. T., Wilce, J. A., King, G. F. and Wake, R. G. (1999). Site-directed mutants of RTP of Bacillus subtilis and the mechanism of replication fork arrest. Journal of Molecular Biology, 286 (5), 1325-1335. doi: 10.1006/jmbi.1999.2553

Spider toxins: A new group of potassium channel modulators

Fletcher, Jamie I., Wang, Xiuhong, Connor, Mark, Christie, Macdonald J., King, Glenn F. and Nicholson, Graham M. (1999). Spider toxins: A new group of potassium channel modulators. Perspectives In Drug Discovery And Design, 15-16, 61-69. doi: 10.1023/A:1017039418046

Structure-function studies of w-atracotoxin, a potent antagonist of insect voltage-gated calcium channels

Wang, X., Smith, R. W., Fletcher, J. I., Wilson, H., Wood, C. J., Howden, M. E. and King, G. F. (1999). Structure-function studies of w-atracotoxin, a potent antagonist of insect voltage-gated calcium channels. European Journal of Biochemistry, 264 (2), 488-494. doi: 10.1046/j.1432-1327.1999.00646.x

The dimerization and topological specificity functions of MinE reside in a structurally autonomous C-terminal domain

King, Glenn F., Rowland, Susan L., Pan, Borlan, Mackay, Joel P., Mullen, Gregory P. and Rothfield, Lawrence I. (1999). The dimerization and topological specificity functions of MinE reside in a structurally autonomous C-terminal domain. Molecular Microbiology, 31 (4), 1161-1169. doi: 10.1046/j.1365-2958.1999.01256.x

Spectroscopic identification of a dinuclear metal centre in manganese(II)-activated aminopeptidase P from Escherichia coli: implications for human prolidase

Zhang, L., Crossley, M. J., Dixon, N. E., Ellis, P. J., Fisher, M. L., King, G. F., Lilley, P. E., MacLachlan, D., Pace, R. J. and Freeman, H. C. (1998). Spectroscopic identification of a dinuclear metal centre in manganese(II)-activated aminopeptidase P from Escherichia coli: implications for human prolidase. Journal of Biological Inorganic Chemistry, 3 (5), 470-483. doi: 10.1007/s007750050257

The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein

Zhang, Y., Rowland, S., King, G. F., Braswell, E. and Rothfield, L. (1998). The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein. Molecular Microbiology, 30 (2), 265-273. doi: 10.1046/j.1365-2958.1998.01059.x

Involvement of the N-finger in the self-association of GATA-1

Mackay, J. P., Kowalski, K., Fox, A. H., Czolij, R., King, G. F. and Crossley, M. (1998). Involvement of the N-finger in the self-association of GATA-1. Journal of Biological Chemistry, 273 (46), 30560-30567. doi: 10.1074/jbc.273.46.30560

Key residues characteristic of GATA N-fingers are recognized by FOG

Fox, Archa H., Kowalski, Kasper, King, Glenn F., Mackay, Joel P. and Crossley, Merlin (1998). Key residues characteristic of GATA N-fingers are recognized by FOG. Journal of Biological Chemistry, 273 (50), 33595-33603. doi: 10.1074/jbc.273.50.33595

The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel

Fletcher, Jamie I, Chapman, Bogdan E., Mackay, Joel P., Howden, Merlin E. H. and King, Glenn F. (1997). The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel. Structure, 5 (11), 1525-1535. doi: 10.1016/S0969-2126(97)00301-8

The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider

Fletcher, Jamie I., Smith, Ross, O'Donoghue, Séan I., Nilges, Michael, Connor, Mark, Howden, Merlin E. H., Christie, Macdonald J. and King, Glenn F. (1997). The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider. Nature Structural Biology, 4 (7), 559-566. doi: 10.1038/nsb0797-559

Zipping up transcription factors: Rational design of anti-Jun and anti-Fos peptides

Bains, N. P. S., Wilce, J. A., Heuer, K. H., Tunstall, M., Mackay, J. P., Bennett, M. R., Weiss, A. S. and King, G. F. (1997). Zipping up transcription factors: Rational design of anti-Jun and anti-Fos peptides. Letters In Peptide Science, 4 (2), 67-77. doi: 10.1023/A:1008883300477

A tale of two terminators: Crystal structures sharpen the debate on DNA replication fork arrest mechanisms

Wake, R. G. and King, G. F. (1997). A tale of two terminators: Crystal structures sharpen the debate on DNA replication fork arrest mechanisms. Structure, 5 (1), 1-5. doi: 10.1016/S0969-2126(97)00160-3

Measuring macromolecular diffusion using heteronuclear multiple-quantum pulsed-field-gradient NMR

Dingley, Andrew J., Mackay, Joel P., Shaw, Graeme L., Hambly, Brett D. and King, Glenn F. (1997). Measuring macromolecular diffusion using heteronuclear multiple-quantum pulsed-field-gradient NMR. Journal of Biomolecular NMR, 10 (1), 1-8. doi: 10.1023/A:1018339526108

Reorganization of terminator DNA upon binding replication terminator protein: Implications for the functional replication fork arrest complex

Kralicek, A. V., Wilson, P. K., Ralston, G. B., Wake, R. G. and King, G. F. (1997). Reorganization of terminator DNA upon binding replication terminator protein: Implications for the functional replication fork arrest complex. Nucleic Acids Research, 25 (3), 590-596. doi: 10.1093/nar/25.3.590

The generation of H-1-NMR-detectable mobile lipid in stimulated lymphocytes: Relationship ts cellular activation, the cell cycle, and phosphatidylcholine-specific phospholipase C

Veale, M. F., Roberts, N. J., King, G. F. and King, N. J. C. (1997). The generation of H-1-NMR-detectable mobile lipid in stimulated lymphocytes: Relationship ts cellular activation, the cell cycle, and phosphatidylcholine-specific phospholipase C. Biochemical And Biophysical Research Communications, 239 (3), 868-874. doi: 10.1006/bbrc.1997.7566

H-1-NMR visible neutral lipids in activated T lymphocytes: Relationship to phosphatidylcholine cycling

Veale, MF, Dingley, AJ, King, GF and King, NJC (1996). H-1-NMR visible neutral lipids in activated T lymphocytes: Relationship to phosphatidylcholine cycling. Biochimica Et Biophysica Acta-Lipids and Lipid Metabolism, 1303 (3), 215-221. doi: 10.1016/0005-2760(96)00104-X

Calculation of symmetric multimer structures from NMR data using a priori knowledge of the monomer structure, co-monomer restraints, and interface mapping: The case of leucine zippers

ODonoghue, SI, King, GF and Nilges, M (1996). Calculation of symmetric multimer structures from NMR data using a priori knowledge of the monomer structure, co-monomer restraints, and interface mapping: The case of leucine zippers. Journal of Biomolecular Nmr, 8 (2), 193-206. doi: 10.1007/BF00211165

NMR spectroscopy and X-ray crystallography provide complementary information on the structure and dynamics of leucine zippers

King, GF (1996). NMR spectroscopy and X-ray crystallography provide complementary information on the structure and dynamics of leucine zippers. Biophysical Journal, 71 (2), 1152-1153. doi: 10.1016/S0006-3495(96)79317-7

Development of a sensitive peptide-based immunoassay: Application to detection of the Jun and Fos oncoproteins

Heuer, KH, Mackay, JP, Podzebenko, P, Bains, NPS, Weiss, AS, King, GF and EasterbrookSmith, SB (1996). Development of a sensitive peptide-based immunoassay: Application to detection of the Jun and Fos oncoproteins. Biochemistry, 35 (28), 9069-9075. doi: 10.1021/bi952817o

The Bacillus subtilis DNA replication terminator

Smith, MT, deVries, CJ, Langley, DB, King, GF and Wake, RG (1996). The Bacillus subtilis DNA replication terminator. Journal of Molecular Biology, 260 (1), 54-69. doi: 10.1006/jmbi.1996.0381

High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer

Junius, FK, ODonoghue, SI, Nilges, M, Weiss, AS and King, GF (1996). High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. Journal of Biological Chemistry, 271 (23), 13663-13667. doi: 10.1074/jbc.271.23.13663

Backbone dynamics of the c-Jun leucine zipper: N-15 NMR relaxation studies

Mackay, JP, Shaw, GL and King, GF (1996). Backbone dynamics of the c-Jun leucine zipper: N-15 NMR relaxation studies. Biochemistry, 35 (15), 4867-4877. doi: 10.1021/bi952761y

Measuring Protein Self-Association Using Pulsed-Field-Gradient Nmr-Spectroscopy - Application to Myosin Light-Chain-2

Dingley, AJ, Mackay, JP, Chapman, BE, Morris, MB, Kuchel, PW, Hambly, BD and King, GF (1995). Measuring Protein Self-Association Using Pulsed-Field-Gradient Nmr-Spectroscopy - Application to Myosin Light-Chain-2. Journal of Biomolecular Nmr, 6 (3), 321-328. doi: 10.1007/BF00197813

Nuclear-Magnetic-Resonance Characterization of the Jun Leucine-Zipper Domain - Unusual Properties of Coiled-Coil Interfacial Polar Residues

Junius, FK, Mackay, JP, Bubb, WA, Jensen, SA, Weiss, AS and King, GF (1995). Nuclear-Magnetic-Resonance Characterization of the Jun Leucine-Zipper Domain - Unusual Properties of Coiled-Coil Interfacial Polar Residues. Biochemistry, 34 (18), 6164-6174. doi: 10.1021/bi00018a020

Structural and Biochemical-Studies of Human Galanin - Nmr Evidence for Nascent Helical Structures in Aqueous-Solution

Morris, MB, Ralston, GB, Biden, TJ, Browne, CL, King, GF and Iismaa, TP (1995). Structural and Biochemical-Studies of Human Galanin - Nmr Evidence for Nascent Helical Structures in Aqueous-Solution. Biochemistry, 34 (14), 4538-4545. doi: 10.1021/bi00014a006

The solution structure of sarafotoxin-c: implications for ligand recognition by endothelin

Mills, Robyn G., Ralston, Greg B. and King, Glenn F. (1994). The solution structure of sarafotoxin-c: implications for ligand recognition by endothelin. Journal of Biological Chemistry, 269 (38), 23413-23419.

Cloning, Expression, and Spectroscopic Studies of the Jun Leucine-Zipper Domain

Riley, LG, Junius, FK, Swanton, MK, Vesper, NA, Williams, NK, King, GF and Weiss, AS (1994). Cloning, Expression, and Spectroscopic Studies of the Jun Leucine-Zipper Domain. European Journal of Biochemistry, 219 (3), 877-886. doi: 10.1111/j.1432-1033.1994.tb18569.x

Symmetry and Secondary Structure of the Replication Terminator Protein of Bacillus-Subtilis - Sedimentation Equilibrium and Circular Dichroic, Infrared, and Nmr Spectroscopic Studies

Kralicek, AV, Vesper, NA, Ralston, GB, Wake, RG and King, GF (1993). Symmetry and Secondary Structure of the Replication Terminator Protein of Bacillus-Subtilis - Sedimentation Equilibrium and Circular Dichroic, Infrared, and Nmr Spectroscopic Studies. Biochemistry, 32 (38), 10216-10223. doi: 10.1021/bi00089a043

Determination of the Structure of Symmetrical Coiled-Coil Proteins From Nmr Data - Application of the Leucine-Zipper Proteins Jun and Gcn4

Odonoghue, SI, Junius, FK and King, GF (1993). Determination of the Structure of Symmetrical Coiled-Coil Proteins From Nmr Data - Application of the Leucine-Zipper Proteins Jun and Gcn4. Protein Engineering, 6 (6), 557-564. doi: 10.1093/protein/6.6.557

The Solution Structure of the Leucine-Zipper Motif of the Jun Oncoprotein Homodimer

Junius, FK, Weiss, AS and King, GF (1993). The Solution Structure of the Leucine-Zipper Motif of the Jun Oncoprotein Homodimer. European Journal of Biochemistry, 214 (2), 415-424. doi: 10.1111/j.1432-1033.1993.tb17937.x

Determination of the solution structure of a platelet-adhesion peptide of von Willebrand factor

Knott, H M, Berndt, M C, Kralicek, A V, O'Donoghue, S I and King, G F (1992). Determination of the solution structure of a platelet-adhesion peptide of von Willebrand factor. Biochemistry, 31 (45), 11152-8.

Determination of the Solution Structure of a Platelet-Adhesion Peptide of Vonwillebrand-Factor

Knott, HM, Berndt, MC, Kralicek, AV, Odonoghue, SI and King, GF (1992). Determination of the Solution Structure of a Platelet-Adhesion Peptide of Vonwillebrand-Factor. Biochemistry, 31 (45), 11152-11158. doi: 10.1021/bi00160a028

An Nmr Investigation of the Changes in Plasma-Membrane Triglyceride and Phospholipid Precursors During the Activation of Lymphocytes-T

Dingley, AJ, King, Njc and King, GF (1992). An Nmr Investigation of the Changes in Plasma-Membrane Triglyceride and Phospholipid Precursors During the Activation of Lymphocytes-T. Biochemistry, 31 (37), 9098-9106. doi: 10.1021/bi00152a054

Solution Structure of Endothelin-3 Determined Using Nmr-Spectroscopy

Mills, RG, Odonoghue, SI, Smith, R and King, GF (1992). Solution Structure of Endothelin-3 Determined Using Nmr-Spectroscopy. Biochemistry, 31 (24), 5640-5645. doi: 10.1021/bi00139a030

Effects of Ethanol and its Fluorinated Analogs On the Calcium Atpase of Sarcoplasmic-Reticulum

Bennett, FC, Gates, SD, King, GF, Shanley, BC and Smith, R (1992). Effects of Ethanol and its Fluorinated Analogs On the Calcium Atpase of Sarcoplasmic-Reticulum. Biochemistry International, 26 (6), 979-985.

A Sequence Similarity Between Proteins Involved in Initiation and Termination of Bacterial Chromosome-Replication

Kralicek, AV, Day, AJ, Wake, RG and King, GF (1991). A Sequence Similarity Between Proteins Involved in Initiation and Termination of Bacterial Chromosome-Replication. Biochemical Journal, 275 (3), 823-823. doi: 10.1042/bj2750823

A sequence similarity between proteins involved in initiation and termination of bacterial chromosome replication

Kralicek, A V, Day, A J, Wake, R G and King, G F (1991). A sequence similarity between proteins involved in initiation and termination of bacterial chromosome replication. The Biochemical journal, 275 ( Pt 3), 823.

Conformation of Sarafotoxin-6B in Aqueous-Solution Determined by Nmr-Spectroscopy and Distance Geometry

Mills, RG, Atkins, AR, Harvey, T, Junius, FK, Smith, R and King, GF (1991). Conformation of Sarafotoxin-6B in Aqueous-Solution Determined by Nmr-Spectroscopy and Distance Geometry. Febs Letters, 282 (2), 247-252. doi: 10.1016/0014-5793(91)80488-O

Characterization of Peptide Fluxes Into Human Erythrocytes - a Proton-Nmr Study

Odoom, JE, Campbell, ID, Ellory, JC and King, GF (1990). Characterization of Peptide Fluxes Into Human Erythrocytes - a Proton-Nmr Study. Biochemical Journal, 267 (1), 141-147. doi: 10.1042/bj2670141

High-Resolution H-1-Nmr Study of the Solution Structure of the S4 Segment of the Sodium-Channel Protein

Mulvey, D, King, GF, Cooke, RM, Doak, DG, Harvey, TS and Campbell, ID (1989). High-Resolution H-1-Nmr Study of the Solution Structure of the S4 Segment of the Sodium-Channel Protein. Febs Letters, 257 (1), 113-117. doi: 10.1016/0014-5793(89)81799-5

Ciguatera and mannitol: experience with a new treatment regimen

Pearn, J.H., Lewis, R.J., Ruff, T., Tait, M., Quinn, J., Murtha, W., King, G., Mallett, A. and Gillespie, N.C. (1989). Ciguatera and mannitol: experience with a new treatment regimen. Medical Journal of Australia, 151 (2), 77-80.

Inhibition and Active-Site Modeling of Prolidase

King, GF, Crossley, MJ and Kuchel, PW (1989). Inhibition and Active-Site Modeling of Prolidase. European Journal of Biochemistry, 180 (2), 377-384. doi: 10.1111/j.1432-1033.1989.tb14659.x

Quantitation of Metabolites of Isolated Chicken Enterocytes Using Nmr-Spectroscopy

Quirk, PG, King, GF, Campbell, ID and Boyd, Car (1989). Quantitation of Metabolites of Isolated Chicken Enterocytes Using Nmr-Spectroscopy. American Journal of Physiology, 256 (2), G423-G429.

Quantitation of metabolites of isolated chicken enterocytes using NMR spectroscopy

Quirk, P. G., King, G. F., Campbell, I. D. and Boyd, C. A. (1989). Quantitation of metabolites of isolated chicken enterocytes using NMR spectroscopy. The American Journal of Physiology, 256 (2 Pt 1), G423-G429. doi: 10.1152/ajpgi.1989.256.2.G423

The Role of Auxiliary Oxidants in Maintaining Redox Balance During Phototrophic Growth of Rhodobacter-Capsulatus On Propionate or Butyrate

Richardson, DJ, King, GF, Kelly, DJ, McEwan, AG, Ferguson, SJ and Jackson, JB (1988). The Role of Auxiliary Oxidants in Maintaining Redox Balance During Phototrophic Growth of Rhodobacter-Capsulatus On Propionate or Butyrate. Archives of Microbiology, 150 (2), 131-137. doi: 10.1007/BF00425152

Dimethylsulfoxide and Trimethylamine-N-Oxide as Bacterial Electron-Transport Acceptors - Use of Nuclear-Magnetic-Resonance to Assay and Characterize the Reductase System in Rhodobacter-Capsulatus

King, GF, Richardson, DJ, Jackson, JB and Ferguson, SJ (1987). Dimethylsulfoxide and Trimethylamine-N-Oxide as Bacterial Electron-Transport Acceptors - Use of Nuclear-Magnetic-Resonance to Assay and Characterize the Reductase System in Rhodobacter-Capsulatus. Archives of Microbiology, 149 (1), 47-51. doi: 10.1007/BF00423135

No Evidence for Bradykinin Hydrolysis in Human-Erythrocyte Suspensions - H-1-Nmr Studies

Hyslop, SJ, King, GF and Kuchel, PW (1987). No Evidence for Bradykinin Hydrolysis in Human-Erythrocyte Suspensions - H-1-Nmr Studies. American Journal of Hematology, 25 (2), 183-189. doi: 10.1002/ajh.2830250208

No evidence of high capacity alpha-glutamyl-dipeptide transport into human erythrocytes

Kuchel, P W, King, G F and Chapman, B E (1987). No evidence of high capacity alpha-glutamyl-dipeptide transport into human erythrocytes. The Biochemical journal, 242 (1), 311-2.

No Evidence of High-Capacity Alpha-Glutamyl-Dipeptide Transport Into Human-Erythrocytes

Kuchel, PW, King, GF and Chapman, BE (1987). No Evidence of High-Capacity Alpha-Glutamyl-Dipeptide Transport Into Human-Erythrocytes. Biochemical Journal, 242 (1), 311-312. doi: 10.1042/bj2420311

Proton Nmr-Studies of Human-Erythrocyte Prolidase

King, GF, Crossley, MJ and Kuchel, PW (1987). Proton Nmr-Studies of Human-Erythrocyte Prolidase. Biomedica Biochimica Acta, 46 (2-3), S302-S303.

Application of Progress Curve Analysis to Insitu Enzyme-Kinetics Using H-1-Nmr Spectroscopy

Vandenberg, JI, Kuchel, PW and King, GF (1986). Application of Progress Curve Analysis to Insitu Enzyme-Kinetics Using H-1-Nmr Spectroscopy. Analytical Biochemistry, 155 (1), 38-44. doi: 10.1016/0003-2697(86)90221-6

Direct Nmr Evidence That Prolidase Is Specific for the Trans Isomer of Imidodipeptide Substrates

King, GF, Middlehurst, CR and Kuchel, PW (1986). Direct Nmr Evidence That Prolidase Is Specific for the Trans Isomer of Imidodipeptide Substrates. Biochemistry, 25 (5), 1054-1062. doi: 10.1021/bi00353a016

Assimilation of Alpha-Glutamyl-Peptides by Human-Erythrocytes - a Possible Means of Glutamate Supply for Glutathione Synthesis

King, GF and Kuchel, PW (1985). Assimilation of Alpha-Glutamyl-Peptides by Human-Erythrocytes - a Possible Means of Glutamate Supply for Glutathione Synthesis. Biochemical Journal, 227 (3), 833-842. doi: 10.1042/bj2270833

Enkephalin Degradation by Human-Erythrocytes and Hemolysates Studied Using H-1-Nmr Spectroscopy

Vandenberg, JI, King, GF and Kuchel, PW (1985). Enkephalin Degradation by Human-Erythrocytes and Hemolysates Studied Using H-1-Nmr Spectroscopy. Archives of Biochemistry and Biophysics, 242 (2), 515-522. doi: 10.1016/0003-9861(85)90238-3

The Assimilation of Tripeptides and Tetrapeptides by Human-Erythrocytes

Vandenberg, JI, King, GF and Kuchel, PW (1985). The Assimilation of Tripeptides and Tetrapeptides by Human-Erythrocytes. Biochimica Et Biophysica Acta, 846 (1), 127-134. doi: 10.1016/0167-4889(85)90118-1

A Proton Nmr-Study of Iminodipeptide Transport and Hydrolysis in the Human-Erythrocyte - Possible Physiological Roles for the Coupled System

King, GF and Kuchel, PW (1984). A Proton Nmr-Study of Iminodipeptide Transport and Hydrolysis in the Human-Erythrocyte - Possible Physiological Roles for the Coupled System. Biochemical Journal, 220 (2), 553-560. doi: 10.1042/bj2200553

Monitoring Metabolic Reactions in Erythrocytes Using Nmr-Spectroscopy

Kuchel, PW, Chapman, BE, Endre, ZH, King, GF, Thorburn, DR and York, MJ (1984). Monitoring Metabolic Reactions in Erythrocytes Using Nmr-Spectroscopy. Biomedica Biochimica Acta, 43 (6), 719-726.

Monitoring metabolic reactions in erythrocytes using NMR spectroscopy

Kuchel, P W, Chapman, B E, Endre, Z H, King, G F, Thorburn, D R and York, M J (1984). Monitoring metabolic reactions in erythrocytes using NMR spectroscopy. Biomedica biochimica acta, 43 (6), 719-26.

NMR-STUDIES OF MYELIN BASIC-PROTEIN .11. CONFORMATION OF A NONAPEPTIDE FROM A SEGMENT ENCEPHALITOGENIC IN RHESUS-MONKEY

MENDZ, GL, MOORE, WJ, KING, G and WRIGHT, PE (1984). NMR-STUDIES OF MYELIN BASIC-PROTEIN .11. CONFORMATION OF A NONAPEPTIDE FROM A SEGMENT ENCEPHALITOGENIC IN RHESUS-MONKEY. International Journal of Peptide and Protein Research, 24 (3), 208-217.

Studies of Rat-Brain Metabolism Using Proton Nuclear Magnetic-Resonance - Spectral Assignments and Monitoring of Prolidase, Acetylcholinesterase, and Glutaminase

Middlehurst, CR, King, GF, Beilharz, GR, Hunt, GE, Johnson, Gfs and Kuchel, PW (1984). Studies of Rat-Brain Metabolism Using Proton Nuclear Magnetic-Resonance - Spectral Assignments and Monitoring of Prolidase, Acetylcholinesterase, and Glutaminase. Journal of Neurochemistry, 43 (6), 1561-1567. doi: 10.1111/j.1471-4159.1984.tb06079.x

Proton Nmr Spectroscopic Studies of Dipeptidase in Human-Erythrocytes

King, GF, York, MJ, Chapman, BE and Kuchel, PW (1983). Proton Nmr Spectroscopic Studies of Dipeptidase in Human-Erythrocytes. Biochemical and Biophysical Research Communications, 110 (1), 305-312. doi: 10.1016/0006-291X(83)91296-2

A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction

Redd, M. A., Scheuer, S. E., Saez, N. J., Macdonald, P. S., Palpant, N. J. and King, G. F. (2020). A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction. Venom Week, Gainesville, FL, United States, 4-7 March, 2020. Oxford, United Kingdom : Elsevier.

Discovery of a small-molecule toxin with inhibitory activity at human P2X4 ion channels

Bibic, Lucka, Herzig, Volker, King, Glenn F., Searcey, Mark and Stokes, Leanne (2020). Discovery of a small-molecule toxin with inhibitory activity at human P2X4 ion channels. Meeting of the British-Pharmacological-Society, Edinburgh, Scotland, 15-17 December, 2019. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1111/bph.15035

Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity

Nixon, Samantha, Agwa, Akello, Robinson, Sam, Walker, Andrew, Touchard, Axel, Schroeder, Christina, Vetter, Irina, Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2020). Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity. 20th World Congress of the International-Society-on-Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier.

The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation

Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014

Hi1a, an ASIC1a Inhibitor, Significantly Improves the Tolerance of Donor Allografts to Ischaemia in a Rodent Model of DCD Heart Transplantation

Scheuer, S. E., Gao, L., Hicks, M., Chew, H., Doyle, A., Villanueva, J., Jabbour, A., King, G., Macdonald, P. and Dhital, K. (2019). Hi1a, an ASIC1a Inhibitor, Significantly Improves the Tolerance of Donor Allografts to Ischaemia in a Rodent Model of DCD Heart Transplantation. 39th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Orlando Fl, Apr 03-06, 2019. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2019.01.440

Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain

Cardoso, Fernanda C., King, Glenn F. and Lewis, R. J. (2019). Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017. Oxford, United Kingdom: Elsevier.

From pain to pain-killers: using spider-venom peptides to help us understand and treat chronic pain

King, Glenn (2018). From pain to pain-killers: using spider-venom peptides to help us understand and treat chronic pain. HOBOKEN: WILEY.

Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice

Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., Lewis, R., King, G. and Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. HOBOKEN: WILEY.

Bug off pain: probing P2X channels with venoms

Bibic, L., Herzig, V., King, G. F., Ma, L., Chow, C. Y. and Stokes, L. (2018). Bug off pain: probing P2X channels with venoms. Purines 2018 Basic and Translational Science on Purinergic Signaling and its Components for a Healthy and Better World, Foz do Iguaçu, Brazil, 19-22 June 2018. Dordrecht, Netherlands: Springer.

Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.

Cardoso, F. C., Herzig, V., King, G. F. and Lewis, R. J. (2018). Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.. Gordon Research Conference on Venom Evolution, Function and Biomedical Applications 2018, Mount Snow, VT, United States, 5-10 August 2018.

Development and application of a peptide inhibitor-bound quantum dot targeting the voltage-gated potassium channel Kv1.3 in the olfactory bulb

Schwartz, Austin B., Kapur, Anshika, Huang, Zhenbo, Anangi, Raveendra, Dekan, Zoltan, Fardone, Erminia, Palui, Goutam, King, Glenn F., Mattoussi, Hedi and Fadool, Debra A. (2018). Development and application of a peptide inhibitor-bound quantum dot targeting the voltage-gated potassium channel Kv1.3 in the olfactory bulb. 62nd Annual Meeting of the Biophysical Society, San Francisco, CA, United States, 17-21 February 2018. St. Louis, MO, United States : Cell Press. doi: 10.1016/j.bpj.2017.11.1753

Margatoxin-conjugated quantum dots as a tool for targeted inhibition of the voltage-gated potassium channel Kv1.3 in the olfactory bulb

Schwartz, Austin B., Kapur, Anshika, Huang, Zhenbo, Anangi, Raveendra, Deklan, Zoltan, Fardone, Erminia, Palui, Goutam, King, Glenn F., Mattoussi, Hedi and Fadool, Debra A. (2018). Margatoxin-conjugated quantum dots as a tool for targeted inhibition of the voltage-gated potassium channel Kv1.3 in the olfactory bulb. 39th Annual Meeting of the Association for Chemoreception Sciences (AChemS), Bonita Springs, FL, United States, 26-29 April 2017. Oxford, United Kingdom: Oxford University Press .

The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors

Schroeder, Christina, Agwa, Akello, Mueller, Alexander, Chow, Chun Yuen, Peigneur, Steve, Lawrence, Nicole, Deplazes, Evelyne, Mark, Alan, Craik, David, Tytgat, Jan, King, Glenn, Vetter, Irina and Henriques, Sonia Troeira (2018). The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.

Cardoso, Fernanda C., King, Glenn F. and Lewis, Richard J. (2017). Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017.

Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders

Cardoso, Fernanda C., Bellingham, Mark C., King, Glenn F. and Lewis, Richard J. (2017). Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Novel Human Eag Channel Antagonists from Spider Venoms

Ma, Linlin, Chin, Yanni K., Dekan, Zoltan, Ikonomopoulou, Maria, Herzig, Volker, Chow, Chun Yuen, Alewood, Paul and King, Glenn F. (2017). Novel Human Eag Channel Antagonists from Spider Venoms. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, 15-19 February 2014. St. Louis, MO 63146 United States: Cell Press. doi: 10.1016/j.bpj.2016.11.1800

Combining Mass Spectrometry Cross-Linking, Molecular Docking and NMR Titration to Dissect ZapA-FtsZ Protein Interaction

Caldas Nogueira, Maria Luiza, Sforca, Mauricio Luis, Paes Leme, Adriana Franco, Pauletti, Bianca Alves, Lopes de Oliveira, Paulo Sergio, Honorato, Rodrigo Vargas, King, Glenn F., Gueiros Filho, Frederico Jose and de Mattos Zeri, Ana Carolina (2016). Combining Mass Spectrometry Cross-Linking, Molecular Docking and NMR Titration to Dissect ZapA-FtsZ Protein Interaction. Experimental Biology Meeting, San Diego Ca, Apr 02-06, 2016. BETHESDA: FEDERATION AMER SOC EXP BIOL.

Exploring the immunosuppressive potential of venom-derived molecules

Ryan, R., Ikonomopoulou, M., Haigh, O., Lutzky, V, Martinez, Jimenez R., Ratnatunga, C., Wong, Y., Rojas, Leal, I, Lopez, A., Fry, B., Herzig, V, King, G. and Miles, J. (2016). Exploring the immunosuppressive potential of venom-derived molecules. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Investigating venom-derived molecules that augment human immune function

Jimenez-Martinez, R., Ikonomopoulou, M., Haigh, O., Lutzky, V, Leal-Rojas, I, Ryan, R., Ratnatunga, C., Wong, Y., Lopez, A., Fry, B., Herzig, V, King, G. and Miles, J. J. (2016). Investigating venom-derived molecules that augment human immune function. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating

Deplazes, Evelyne, Henriques, Sonia Troeira, King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. 60th Annual Meeting of the Biophysical-Society, Los Angeles, United States, February 27- March 2 2016. St Louis, United States: Cell Press. doi: 10.1016/j.bpj.2015.11.220

Using Spider Venom Peptides as Molecular Tools for Understanding Voltage-Gated Sodium Channel Function

Herzig, V., Osteen, J. D., Bosmans, F., Julius, D. and King, G. F. (2016). Using Spider Venom Peptides as Molecular Tools for Understanding Voltage-Gated Sodium Channel Function. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. HOBOKEN: Wiley.

Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays

Cardoso, Fernanda Caldas , Herzig, Volker , King, Glenn F. and Lewis, Richard J. (2015). Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays. 18th World Congress of the International Society on Toxinology, Oxford UK, 25-30 September 2015.

Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker

Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.

Discovery of voltage-gated sodium channel inhibitors from tarantula venoms

Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.

Erickson, A., Cardoso, F. C., Lewis, R. J. and King, G. F. (2014). Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

Discovery of novel spider peptides blocking hNav1.7

Cardoso, F. C., Herzig, V., Hauke, T., Lewis, R. J. and King, G. F. (2013). Discovery of novel spider peptides blocking hNav1.7. 3rd Annual Conference of the Toxinological Society of India and 1st International Conference on “Biology of Natural Toxins”, Goa, India, 19-21 December, 2013.

Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain

Cardoso, F. C., Herzig, V., Hauke, T., King, G. F. and Lewis, R. J. (2013). Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain. CASB Division Symposium 2013, Brisbane Australia, 7 November, 2013.

An insecticidal spider toxin that acts as a positive allosteric modulator of insect nicotinic acetylcholine receptors

Windley, Monique J., King, Glenn F. and Nicholson, Graham M. (2012). An insecticidal spider toxin that acts as a positive allosteric modulator of insect nicotinic acetylcholine receptors. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.147

Centipede venoms: Old and unusual

Undheim, Eivind A. B., Jones, Alun, Holland, John W., Morales, Rodrigo A. V., Winnen, Brit, Fry, Bryan G. and King, Glenn F. (2012). Centipede venoms: Old and unusual. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.065

Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels

Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.033

Functional redundancy in venoms is an evolutionary by-product

Morgenstern, David, de la Vega, Ricardo C. Rodriguez, Ott, Michael, King, Glenn F. and Fry, Bryan G. (2012). Functional redundancy in venoms is an evolutionary by-product. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.059

PX family proteins at the interface between intracellular trafficking and signalling

Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). PX family proteins at the interface between intracellular trafficking and signalling. 22nd IUBMB Congress/37th FEBS Congress, Seville, Spain, 4-9 September 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1742-4658.2010.08705.x

Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain

Klint, Julie, Anangi, Raveendra, Mobli, Mehdi, Knapp, Oliver, Adams, David J. and King, Glenn F. (2012). Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.032

Tentacles of venom: Molecular evolution of coleoid venoms

Fry, Bryan G., Ruder, Tim, Georgieva, Dessi N., Morgenstern, David, King, Glenn and Undheim, Eivind A. B. (2012). Tentacles of venom: Molecular evolution of coleoid venoms. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.063

The bio-logic of venom complexity

Morgenstern, David, Hamilton, Brett, Sher, Daniel, Jones, Alun, Mattius, Gideon, Zlotkin, Eli, Venter, Deon and King, Glenn F. (2012). The bio-logic of venom complexity. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.285

Understanding the chemical diversity and evolution of spider venoms using comparative transcriptomics

Pineda, Sandy S., Wong, Emily S., Fry, Bryan G., Binford, Greta J. and King, Glenn F. (2012). Understanding the chemical diversity and evolution of spider venoms using comparative transcriptomics. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.270

Understanding the chemical diversity of spider venoms using a combined genomic, transcriptomic and proteomic approach

Pineda, Sandy S., Jones, Alun, Nicholson, Graham M., Escoubas, Pierre, Mattick, John S. and King, Glenn F. (2012). Understanding the chemical diversity of spider venoms using a combined genomic, transcriptomic and proteomic approach. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.060

Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models

Mozar, C. A., Sun, T., Rash, L. D., King, G. F. and Christie, M. J. (2011). Actions of ASIC1a and ASIC3 inhibitors in rat chronic pain models. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, United States, 12-16 November 2011.

Profiling of membrane structure changes during the adsorption, destabilisation and lysis of antimicrobial peptides

Aguilar, M., Lee, T. H., Swann, M., Heng, C., Gehman, J., Park, Y., King, G., Hahm, K. S. and Separovic, F. (2010). Profiling of membrane structure changes during the adsorption, destabilisation and lysis of antimicrobial peptides. The 33rd Annual Meeting of the Australian Society for Biophysics, Sovereign Hill, Ballarat, Australia, 29 November - 2 December 2009. United Kingdom: John Wiley & Sons.

Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins

Dantas de Araujo, A. D., Herzig, V., Mobli, M., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. F. (2010). Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.1303

The Janus-faced atracotoxins are specific blockers of invertebrate K-Ca channels

Gunning, S. J., Maggio, F., Windley, M. J., Valenzuela, S. M., King, G. F. and Nicholson, G. M. (2009). The Janus-faced atracotoxins are specific blockers of invertebrate K-Ca channels. 34th Congress of the Federation-of-European-Biochemical-Societies, Prague Czech Republic, Jul 04-09, 2009. MALDEN: WILEY-BLACKWELL.

Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR

Mobli, M., Lambert, L. K., Pierens, G. K., Dantas de Araujo, A., Alewood, P. F. and King, G. F. (2008). Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR. 7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008), Couran Cove, Australia, 7-11 December 2008.

A model genetic system for testing the in vivo function of peptide toxins

Tedford, Hugo W., Maggio, Francesco, Reenan, Robert A. and King, Glenn F. (2007). A model genetic system for testing the in vivo function of peptide toxins. 7th Invertebrate Neuropeptide Conference (INC2006), Guanajuato, Mexico, 2006. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.peptides.2006.08.026

Were arachnids the first to use combinatorial peptide libraries?

Sollod, Brianna L., Wilson, David, Zhaxybayeva, Olga, Gogarten, J. Peter, Drinkwater, Roger and King, Glenn F. (2005). Were arachnids the first to use combinatorial peptide libraries?. doi: 10.1016/j.peptides.2004.07.016

Proton Nmr-Studies of Transmembrane Solute Transport

King, GF and Boyd, Car (1991). Proton Nmr-Studies of Transmembrane Solute Transport. International Course On New Methods in the Study of Transport Across the Cell Membrane, Lanjaron Spain, Sep 16-24, 1988. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.

A Nuclear Magnetic-Resonance Study of Alamethicin-Induced, Delta-Hemolysin-Induced, and Melittin-Induced Sodium Leakage From Large Unilamellar Vesicles

King, GF, Deegan, J, Smith, R, Matouschek, A and Campbell, ID (1988). A Nuclear Magnetic-Resonance Study of Alamethicin-Induced, Delta-Hemolysin-Induced, and Melittin-Induced Sodium Leakage From Large Unilamellar Vesicles. LONDON: PORTLAND PRESS. doi: 10.1042/bst0160594

Measurement of Peptide-Transport Using Proton Nuclear Magnetic-Resonance Spectroscopy

Odoom, JE, Campbell, ID, Ellory, JC and King, GF (1988). Measurement of Peptide-Transport Using Proton Nuclear Magnetic-Resonance Spectroscopy. LONDON: PORTLAND PRESS. doi: 10.1042/bst0160635

Pest-controlling agents isolated from spider venom and uses thereof

King, Glenn Frederick and Hardy, Margaret Carter (2013). Pest-controlling agents isolated from spider venom and uses thereof. WO 2013026105 A1.

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula (Table S1)

Hardy, Margaret, Daly, Norelle L., Mobli, Mehdi , Morales, Rodrigo and King, Glenn F (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula (Table S1). Figshare. (Dataset) doi: 10.1371/journal.pone.0073136.s001