The University of Queensland

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

Teasdale, Rohan D. and Collins, Brett M. (2012). Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochemical Journal, 441 (Part 1), 39-59. doi: 10.1042/BJ20111226

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108

A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles

Miller, Sharon E., Collins, Brett M., McCoy, Airlie J., Robinson, Margaret S. and Owen, David J. (2007). A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Nature, 450 (7169), 570-574. doi: 10.1038/nature06353

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience

Brooks, John W., Tillu, Vikas, Eckert, Julia, Verma, Suzie, Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2023). Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience. Molecular Biology of the Cell mbcE23050163. doi: 10.1091/mbc.e23-05-0163

Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation

Morales-Paytuví, Frederic, Fajardo, Alba, Ruiz-Mirapeix, Carles, Rae, James, Tebar, Francesc, Bosch, Marta, Enrich, Carlos, Collins, Brett M., Parton, Robert G. and Pol, Albert (2023). Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation. Journal of Cell Biology, 222 (9). doi: 10.1083/jcb.202204020

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite <scp>PSG‐Syt1</scp> ‐ <scp>SV2</scp> plasma membrane nanocluster for synaptic vesicle entry

Joensuu, Merja, Syed, Parnayan, Saber, Saber H, Lanoue, Vanessa, Wallis, Tristan P, Rae, James, Blum, Ailisa, Gormal, Rachel S, Small, Christopher, Sanders, Shanley, Jiang, Anmin, Mahrhold, Stefan, Krez, Nadja, Cousin, Michael A, Cooper‐White, Ruby, Cooper‐White, Justin J, Collins, Brett M, Parton, Robert G, Balistreri, Giuseppe, Rummel, Andreas and Meunier, Frédéric A (2023). Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry. The EMBO Journal, 42 (13) e112095. doi: 10.15252/embj.2022112095

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Healy, Michael D., McNally, Kerrie E., Butkovič, Rebeka, Chilton, Molly, Kato, Kohji, Sacharz, Joanna, McConville, Calum, Moody, Edmund R. R., Shaw, Shrestha, Planelles-Herrero, Vicente J., Yadav, Sathish K. N., Ross, Jennifer, Borucu, Ufuk, Palmer, Catherine S., Chen, Kai-En, Croll, Tristan I., Hall, Ryan J., Caruana, Nikeisha J., Ghai, Rajesh, Nguyen, Thi H. D., Heesom, Kate J., Saitoh, Shinji, Berger, Imre, Schaffitzel, Christiane, Williams, Tom A., Stroud, David A., Derivery, Emmanuel, Collins, Brett M. and Cullen, Peter J. (2023). Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell, 186 (10), 2219-2237.e29. doi: 10.1016/j.cell.2023.04.003

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767. doi: 10.15252/embj.2022112767

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

Healy, Michael D., Sacharz, Joanna, McNally, Kerrie E., McConville, Calum, Tillu, Vikas A., Hall, Ryan J., Chilton, Molly, Cullen, Peter J., Mobli, Mehdi, Ghai, Rajesh, Stroud, David A. and Collins, Brett M. (2022). Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins. Structure, 30 (12), 1590-1602.e6. doi: 10.1016/j.str.2022.10.001

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Simonetti, Boris, Daly, James L., Simón-Gracia, Lorena, Klein, Katja, Weeratunga, Saroja, Antón-Plágaro, Carlos, Tobi, Allan, Hodgson, Lorna, Lewis, Philip A., Heesom, Kate J., Shoemark, Deborah K., Davidson, Andrew D., Collins, Brett M., Teesalu, Tambet, Yamauchi, Yohei and Cullen, Peter J. (2022). ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1. Proceedings of the National Academy of Sciences, 119 (25) e2201980119, 1-11. doi: 10.1073/pnas.2201980119

The structure of caveolin finally takes shape

Parton, Robert G. and Collins, Brett M. (2022). The structure of caveolin finally takes shape. Science Advances, 8 (19) eabq6985, eabq6985. doi: 10.1126/sciadv.abq6985

SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Simonetti, Boris, Guo, Qian, Giménez-Andrés, Manuel, Chen, Kai-En, Moody, Edmund R. R., Evans, Ashley J., Chandra, Mintu, Danson, Chris M., Williams, Tom A., Collins, Brett M. and Cullen, Peter J. (2022). SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biology, 20 (4) e3001601, e3001601. doi: 10.1371/journal.pbio.3001601

Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins

Paul, Blessy, Weeratunga, Saroja, Tillu, Vikas A., Hariri, Hanaa, Henne, W. Mike and Collins, Brett M. (2022). Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins. Frontiers in Cell and Developmental Biology, 10 826688, 826688. doi: 10.3389/fcell.2022.826688

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus

Chandra, Mintu, Collins, Brett M. and Jackson, Lauren P. (2022). Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus. Advances in Biological Regulation, 83 100842, 1-9. doi: 10.1016/j.jbior.2021.100842

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Yin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Lo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065

Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides

Huang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554. doi: 10.3390/molecules26185554

Key phases in the formation of caveolae

Parton, Robert G., Tillu, Vikas, McMahon, Kerrie-Ann and Collins, Brett M. (2021). Key phases in the formation of caveolae. Current Opinion in Cell Biology, 71, 7-14. doi: 10.1016/j.ceb.2021.01.009

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1

Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

McMillan, Kirsty J., Banks, Paul J., Hellel, Francesca L. N., Carmichael, Ruth E., Clairfeuille, Thomas, Evans, Ashley J., Heesom, Kate J., Lewis, Philip, Collins, Brett M., Bashir, Zafar, Henley, Jeremy M., Wilkinson, Kevin and Cullen, Peter J. (2021). Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2. eLife, 10 e59432. doi: 10.7554/elife.59432

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338

Community-wide experimental evaluation of the PROSS stability-design method

Peleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964

A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release

Li, Lei, Liu, Haowen, Krout, Mia, Richmond, Janet E., Wang, Yu, Bai, Jihong, Weeratunga, Saroja, Collins, Brett M., Ventimiglia, Donovan, Yu, Yi, Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release. Journal of Cell Biology, 220 (4) e202008121, 1-24. doi: 10.1083/jcb.202008121

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Zhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138

Neuropilin-1 is a host factor for SARS-CoV-2 infection

Daly, James L., Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K., Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F., Horvath, Peter, Sessions, Richard B., Helenius, Ari, Hiscox, Julian A., Teesalu, Tambet, Matthews, David A., Davidson, Andrew D., Collins, Brett M., Cullen, Peter J. and Yamauchi, Yohei (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370 (6518), 861-865. doi: 10.1126/science.abd3072

Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29

Crawley-Snowdon, Harriet, Yang, Ji-Chun, Zaccai, Nathan R., Davis, Luther J., Wartosch, Lena, Herman, Emily K., Bright, Nicholas A., Swarbrick, James S., Collins, Brett M., Jackson, Lauren P., Seaman, Matthew N. J., Luzio, J. Paul, Dacks, Joel B., Neuhaus, David and Owen, David J. (2020). Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29. Nature Communications, 11 (1) 5031, 1-15. doi: 10.1038/s41467-020-18773-2

An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking

Mota Vieira, Marta, Nguyen, Thien A., Wu, Kunwei, Badger, John D., Collins, Brett M., Anggono, Victor, Lu, Wei and Roche, Katherine W. (2020). An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking. Cell Reports, 32 (9) 108104, 108104. doi: 10.1016/j.celrep.2020.108104

Recognising the signals for endosomal trafficking

Weeratunga, Saroja, Paul, Blessy and Collins, Brett M. (2020). Recognising the signals for endosomal trafficking. Current Opinion in Cell Biology, 65, 17-27. doi: 10.1016/j.ceb.2020.02.005

EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in Entamoeba histolytica via actin nucleation

Tripathi, Aashutosh, Jain, Megha, Chandra, Mintu, Parveen, Sameena, Yadav, Rupali, Collins, Brett M., Maiti, Sankar and Datta, Sunando (2020). EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in Entamoeba histolytica via actin nucleation. PLOS Pathogens, 16 (5) e1008489, e1008489. doi: 10.1371/journal.ppat.1008489

Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2

Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007

Caveolae control contractile tension for epithelia to eliminate tumor cells

Teo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002

Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins

Simonetti, Boris, Paul, Blessy, Chaudhari, Karina, Weeratunga, Saroja, Steinberg, Florian, Gorla, Madhavi, Heesom, Kate J., Bashaw, Greg J., Collins, Brett M. and Cullen, Peter J. (2019). Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nature Cell Biology, 21 (10), 1219-1233. doi: 10.1038/s41556-019-0393-3

Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

Ugrankar, Rupali, Bowerman, Jade, Hariri, Hanaa, Chandra, Mintu, Chen, Kevin, Bossanyi, Marie-France, Datta, Sanchari, Rogers, Sean, Eckert, Kaitlyn M., Vale, Gonçalo, Victoria, Alexia, Fresquez, Joseph, McDonald, Jeffrey G., Jean, Steve, Collins, Brett M. and Henne, W. Mike (2019). Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Developmental Cell, 50 (5), 557-572.e5. doi: 10.1016/j.devcel.2019.07.021

STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?

Lanoue, Vanessa, Chai, Ye Jin, Brouillet, Julie Z., Weckhuysen, Sarah, Palmer, Elizabeth E., Collins, Brett M. and Meunier, Frederic A. (2019). STXBP1 encephalopathy: connecting neurodevelopmental disorders with α-synucleinopathies?. Neurology, 93 (3), 114-123. doi: 10.1212/WNL.0000000000007786

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F. and Stinear, Timothy P. (2019). Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications, 10 (1) 3067, 3067. doi: 10.1038/s41467-019-10932-4

Towards a molecular understanding of endosomal trafficking by Retromer and Retriever

Chen, Kai‐En, Healy, Michael D. and Collins, Brett M. (2019). Towards a molecular understanding of endosomal trafficking by Retromer and Retriever. Traffic, 20 (7) tra.12649, 465-478. doi: 10.1111/tra.12649

Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model

Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011

Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs

Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y

Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α

Chen, Kai-En, Tillu, Vikas A., Chandra, Mintu and Collins, Brett M. (2018). Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α. Structure, 26 (12), 1612-1625.e4. doi: 10.1016/j.str.2018.08.010

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography

Kovtun, Oleksiy, Leneva, Natalya, Bykov, Yury S., Ariotti, Nicholas, Teasdale, Rohan D., Schaffer, Miroslava, Engel, Benjamin D., Owen, David. J., Briggs, John A. G. and Collins, Brett M. (2018). Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561 (7724), 561-+. doi: 10.1038/s41586-018-0526-z

A variable undecad repeat domain in cavin1 regulates caveola formation and stability

Tillu, Vikas A., Lim, Ye-Wheen, Kovtun, Oleksiy, Mureev, Sergey, Ferguson, Charles, Bastiani, Michele, McMahon, Kerrie-Ann, Lo, Harriet P., Hall, Thomas E., Alexandrov, Kirill, Collins, Brett M. and Parton, Robert G. (2018). A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO Reports, 19 (9) e45775. doi: 10.15252/embr.201845775

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

Healy, Michael D., Hospenthal, Manuela K., Hall, Ryan J., Chandra, Mintu, Chilton, Molly, Tillu, Vikas, Chen, Kai-En, Celligoi, Dion J., McDonald, Fiona J., Cullen, Peter J., Lott, J. Shaun, Collins, Brett M. and Ghai, Rajesh (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLife, 7 e35898. doi: 10.7554/elife.35898

SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans

Li, Lei, Liu, Haowen, Wang, Wei, Chandra, Mintu, Collins, Brett M. and Hu, Zhitao (2018). SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans. The Journal of Neuroscience, 38 (23), 5313-5324. doi: 10.1523/JNEUROSCI.3097-17.2018

SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes

Tello-Lafoz, M., Rodríguez-Rodríguez, C., Kinna, G., Loo, L. S., Hong, W., Collins, B. M., Teasdale, R. D. and Mérida, I. (2017). SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes. Scientific Reports, 7 (1) 16361, 1-14. doi: 10.1038/s41598-017-16370-w

Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins

Christie, Michelle P., Hu, Shu-Hong, Whitten, Andrew E., Rehman, Asma, Jarrott, Russell J., King, Gordon J., Collins, Brett M. and Martin, Jennifer L. (2017). Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins. PloS one, 12 (10) e0187302, 1-16. doi: 10.1371/journal.pone.0187302

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

McNally, Kerrie E., Faulkner, Rebecca, Steinberg, Florian, Gallon, Matthew, Ghai, Rajesh, Pim, David, Langton, Paul, Pearson, Neil, Danson, Chris M., Nägele, Heike, Morris, Lindsey L., Singla, Amika, Overlee, Brittany L., Heesom, Kate J., Sessions, Richard, Banks, Lawrence, Collins, Brett M., Berger, Imre, Billadeau, Daniel D., Burstein, Ezra and Cullen, Peter J. (2017). Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature cell biology, 19 (10), 1214-1225. doi: 10.1038/ncb3610

Origins of PDZ binding specificity. A computational and experimental study using NHERF1 and the parathyroid hormone receptor

Mamonova, Tatyana, Zhang, Qiangmin, Chandra, Mintu, Collins, Brett M., Sarfo, Edward, Bu, Zimei, Xiao, Kunhong, Bisello, Alessandro and Friedman, Peter A. (2017). Origins of PDZ binding specificity. A computational and experimental study using NHERF1 and the parathyroid hormone receptor. Biochemistry, 56 (20), 2584-2593. doi: 10.1021/acs.biochem.7b00078

The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming

Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016

Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation

Follett, Jordan, Bugarcic, Andrea, Yang, Zhe, Ariotti, Nicholas, Norwood, Suzanne J., Collins, Brett M., Parton, Robert G. and Teasdale, Rohan D. (2016). Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation. Journal of Biological Chemistry, 291 (35), 18283-18298. doi: 10.1074/jbc.M115.703157

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins

McMillan, Kirsty J., Gallon, Matthew, Jellett, Adam P., Clairfeuille, Thomas, Tilley, Frances C., McGough, Ian, Danson, Chris M., Heesom, Kate J., Wilkinson, Kevin A., Collins, Brett M. and Cullen, Peter J. (2016). Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. Journal of Cell Biology, 214 (4), 389-399. doi: 10.1083/jcb.201604057

Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation

Yang, Zhe, Hong, Lee Kian, Follett, Jordan, Wabitsch, Martin, Hamilton, Nicholas A., Collins, Brett, Bugarcic, Andrea and Teasdale, Rohan D. (2016). Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation. The FASEB Journal, 39 (3), 1037-1050. doi: 10.1096/fj.15-274704

Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2

Bugarcic, Andrea, Vetter, Irina, Chalmers, Silke, Kinna, Genevieve, Collins, Brett M. and Teasdale, Rohan D. (2015). Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biology International, 39 (11), 1299-1306. doi: 10.1002/cbin.10508

A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation

Tillu, Vikas A., Kovtun, Oleksiy, McMahon, Kerrie-Ann, Collins, Brett M. and Parton, Robert G. (2015). A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation. Molecular Biology of the Cell, 26 (20), 3561-3569. doi: 10.1091/mbc.E15-06-0359

Molecular characterization of caveolin-induced membrane curvature

Ariotti, Nicholas, Rae, James, Leneva, Natalya, Ferguson, Charles, Loo, Dorothy, Okano, Satomi, Hill, Michelle M., Walser, Piers, Collins, Brett M. and Parton, Robert G. (2015). Molecular characterization of caveolin-induced membrane curvature. Journal of Biological Chemistry, 290 (41), 24875-24890. doi: 10.1074/jbc.M115.644336

Cavin family proteins and the assembly of caveolae

Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G. and Collins, Brett M. (2015). Cavin family proteins and the assembly of caveolae. Journal of Cell Science, 128 (7), 1269-1278. doi: 10.1242/jcs.167866

Phosphoinositide binding by the SNX27 FERM domain regulates localisation at the immune synapse of activated T-cells

Ghai, Rajesh, Tello-Lafoz, Maria, Norwood, Suzanne J., Yang, Zhe, Clairefeuille, Thomas, Teasdale, Rohan D., Mérida, Isabel and Collins, Brett M. (2015). Phosphoinositide binding by the SNX27 FERM domain regulates localisation at the immune synapse of activated T-cells. Journal of Cell Science, 128 (3), 553-565. doi: 10.1242/jcs.158204

Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector

King, Nathan P., Newton, Patrice, Schuelein, Ralf, Brown, Darren L., Petru, Marketa, Zarsky, Vojtech, Dolezal, Pavel, Luo, Lin, Bugarcic, Andrea, Stanley, Amanda C., Murray, Rachael Z., Collins, Brett M., Teasdale, Rohan D., Hartland, Elizabeth L. and Stow, Jennifer L. (2015). Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector. Cellular Microbiology, 17 (6), 767-784. doi: 10.1111/cmi.12405

SNARE-ing the structures of Sec1/Munc18 proteins

Archbold, Julia K., Whitten, Andrew E., Hu, Shu-Hong, Collins, Brett M. and Martin, Jennifer L. (2014). SNARE-ing the structures of Sec1/Munc18 proteins. Current Opinion in Structural Biology, 29, 44-51. doi: 10.1016/j.sbi.2014.09.003

Structural insights into the organization of the cavin membrane coat complex

Kovtun, Oleksiy, Tilu, Vikas A., Jung, WooRam, Leneva, Natalya, Ariotti, Nicholas, Chaudhary, Natasha, Mandyam, Ramya A., Ferguson, Charles, Morgan, Garry P., Johnston, Wayne A., Harrop, Stephen J., Alexandrov, Kirill, Parton, Robert G. and Collins, Brett M. (2014). Structural insights into the organization of the cavin membrane coat complex. Developmental Cell, 31 (4), 405-419. doi: 10.1016/j.devcel.2014.10.002

Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling

Mas, Caroline, Norwood, Suzanne J., Bugarcic, Andrea, Kinna, Genevieve, Leneva, Natalya, Kovtun, Oleksiy, Ghai, Rajesh, Yanez, Lorena E. Ona, Davis, Jasmine L., Teasdale, Rohan D. and Collins, Brett M. (2014). Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. Journal of Biological Chemistry, 289 (41), 28554-28568. doi: 10.1074/jbc.M114.595959

Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis

Martin, Sally, Papadopulos, Andreas, Tomatis, Vanesa M., Sierecki, Emma, Malintan, Nancy T., Gormal, Rachel S., Giles, Nichole, Johnston, Wayne A., Alexandrov, Kirill, Gambin, Yann, Collins, Brett M. and Meunier, Frederic A. (2014). Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis. Cell Reports, 9 (1), 206-218. doi: 10.1016/j.celrep.2014.08.059

Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins

Teasdale, Rohan D. and Collins, Brett (2014). Little evidence that FAM65B belongs to the family of phox homology (PX) and bin/amphiphysin/rvs (BAR) domain-containing proteins. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 111 (39), E4064-E4064. doi: 10.1073/pnas.1412755111

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

Gallon, Matthew, Clairfeuille, Thomas, Steinberg, Florian, Mas, Caroline, Ghai, Rajesh, Sessions, Richard B., Teasdale, Rohan D., Collins, Brett M. and Cullen, Peter J. (2014). A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proceedings of the National Academy of Sciences of the United States of America, 111 (35), E3604-E3613. doi: 10.1073/pnas.1410552111

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Luo, Lin, Wall, Adam A., Yeo, Jeremy C., Condon, Nicholas D., Norwood, Suzanne J., Schoenwaelder, Simone, Chen, Kaiwen W., Jackson, Shaun, Jenkins, Brendan J., Hartland, Elizabeth L., Schroder, Kate, Collins, Brett M., Sweet, Matthew J. and Stow, Jennifer L. (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5 (1) 4407, 4407.1-4407.13. doi: 10.1038/ncomms5407

A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse

Tello-Lafoz, María, Ghai, Rajesh, Collins, Brett and Mérida, Isabel (2014). A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse. BioArchitecture, 4 (6), 215-220. doi: 10.1080/19490992.2015.1031950

Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy

Sierecki, Emma, Stevers, Loes M., Giles, Nichole, Polinkovsky, Mark E., Moustaqil, Mehdi, Mureev, Sergey, Johnston, Wayne A., Dahmer-Heath, Mareike, Skalamera, Duka, Gonda, Thomas J., Gabrielli, Brian, Collins, Brett M., Alexandrov, Kirill and Gambin, Yann (2014). Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy. Molecular and Cellular Proteomics, 13 (9), 2233-2245. doi: 10.1074/mcp.M113.037275

The recognition of membrane-bound PtdIns3P by PX domains

Jia, ZhiGuang, Ghai, Rajesh, Collins, Brett M. and Mark, Alan E. (2014). The recognition of membrane-bound PtdIns3P by PX domains. Proteins: structure, function, and bioinformatics, 82 (10), 2332-2342. doi: 10.1002/prot.24593

The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer

Follett, Jordan, Norwood, Suzanne J., Hamilton, Nicholas A., Mohan, Megha, Kovtun, Oleksiy, Tay, Stephanie, Yang, Zhe, Wood, Stephen A., Mellick, George D., Silburn, Peter A., Collins, Brett M., Bugarcic, Andrea and Teasdale, Rohan D. (2014). The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic, 15 (2), 230-244. doi: 10.1111/tra.12136

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E., Magenau, Astrid, Jung, WooRam, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F., Collins, Brett M., Alexandrov, Kirill and Parton, Robert G. (2014). Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. eLIFE, 2014 (3) e01434, e01434.1-e01434.18. doi: 10.7554/eLife.01434

Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules

Ghai, Rajesh, Mobli, Mehdi and Collins, Brett M. (2014). Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules. Methods in Enzymology, 534, 331-349. doi: 10.1016/B978-0-12-397926-1.00019-6

Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures

Rehman, Asma, Jarrott, Russell J., Whitten, Andrew E., King, Gordon J., Hu, Shu-Hong, Christie, Michelle P., Collins, Brett M. and Martin, Jennifer L. (2013). Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures. PloS One, 8 (12) e83499, e83499.1-e83499.12. doi: 10.1371/journal.pone.0083499

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

Martin, Sally, Tomatis, Vanesa M., Papadopulos, Andreas, Christie, Michelle P., Malintan, Nancy T., Gormal, Rachel S., Sugita, Shuzo, Martin, Jennifer L., Collins, Brett M. and Meunier, Frederic A. (2013). The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. Journal of Cell Science, 126 (11), 2353-2360. doi: 10.1242/jcs.126813

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Ghai, Rajesh, Bugarcic, Andrea, Liu, Huadong, Norwood, Suzanne J., Skeldal, Sune, Coulson, Elizabeth J., Li, Shawn Shun-Cheng, Teasdale, Rohan D. and Collins, Brett M. (2013). Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proceedings of the National Academy of Sciences of the United States of America, 110 (8), E643-E652. doi: 10.1073/pnas.1216229110

The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI

Mangold, Sabine, Norwood, Suzanne J., Yap, Alpha S and Collins, Brett M. (2012). The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI. BioArchitecture, 2 (5), 185-188. doi: 10.4161/bioa.22082

Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI

Tnimov, Zakir, Guo, Zhong, Gambin, Yann, Nguyen, Uyen T. T., Wu, Yao-Wen, Abankwa, Daniel, Stigter, Anouk, Collins, Brett, Waldmann, Herbert, Goody, Roger, S. and Alexandrov, Kirill (2012). Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. Journal of Biological Chemistry, 287 (32), 26549-26562. doi: 10.1074/jbc.M112.371294

Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions

Collins, Brett, Davis, Melissa, Hancock, John F. and Parton, Robert G. (2012). Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions. Developmental Cell, 23 (1), 11-20. doi: 10.1016/j.devcel.2012.06.012

Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

Christie, Michelle P., Whitten, Andrew E., King, Gordon J., Hu, Shu-Hong, Jarrott, Russell J., Chen, Kai-En, Duff, Anthony P., Callow, Philip, Collins, Brett M., James, David E. and Martin, Jennifer L. (2012). Low-resolution solution structures of Munc18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proceedings of the National Academy of Sciences of the United States of America, 109 (25), 9816-9821. doi: 10.1073/pnas.1116975109

Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010

Ghai, Rajesh, Falconer, Robert J. and Collins, Brett M. (2012). Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010. Journal of Molecular Recognition, 25 (1), 32-52. doi: 10.1002/jmr.1167

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

Teasdale, Rohan D. and Collins, Brett M. (2012). Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochemical Journal, 441 (Part 1), 39-59. doi: 10.1042/BJ20111226

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor

Chhabra, Sandeep, Dolezal, Olan, Collins, Brett M., Newman, Janet, Simpson, Jamie S., Macreadie, Ian G., Fernley, Ross, Peat, Thomas S and Swarbrick, James D. (2012). Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor. Plos One, 7 (1) e29444, e29444-1-e29444-16. doi: 10.1371/journal.pone.0029444

VPS26A and VPS26B subunits define distinct Retromer complexes

Bugarcic, Andrea, Yang, Zhe, Kerr, Markus C., Griffith, John Griffin, Collins, Brett M. and Teasdale, Rohan D. (2011). VPS26A and VPS26B subunits define distinct Retromer complexes. Traffic, 12 (12), 1759-1773. doi: 10.1111/j.1600-0854.2011.01284.x

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

Han, Gayoung A., Malintan, Nancy T., Saw, Ner Mu Nar, Li, Lijun, Han, Liping, Meunier, Frederic A., Collins, Brett M. and Sugita, Shuzo (2011). Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Molecular Biology of The Cell, 22 (21), 4134-4149. doi: 10.1091/mbc.E11-02-0135

PX-FERM proteins: A link between endosomal trafficking and signaling?

Ghai, Rajesh and Collins, Brett M. (2011). PX-FERM proteins: A link between endosomal trafficking and signaling?. Small GTPases, 2 (5), 259-263. doi: 10.4161/sgtp.2.5.17276

Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages

Offenhäuser, Carolin, Lei, Nazi, Roy, Sandrine, Collins, Brett M., Stow, Jennifer L. and Murray, Rachael Z. (2011). Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic, 12 (6), 762-773. doi: 10.1111/j.1600-0854.2011.01189.x

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins

Swarbrick, James D., Shaw, Daniel J., Chhabra, Sandeep, Ghai, Rajesh, Valkov, Eugene, Norwood, Suzanne, Seaman, Matthew N. J. and Collins, Brett M. (2011). VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One, 6 (5) e20420, e20420-1-e20420-15. doi: 10.1371/journal.pone.0020420

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108

Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens

Mangold, Sabine, Wu, Selwin K., Norwood, Suzanne J., Collins, Brett M., Hamilton, Nicholas A., Thorn, Peter and Yap, Alpha S. (2011). Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens. Current Biology, 21 (6), 503-507. doi: 10.1016/j.cub.2011.02.018

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

Hu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108

Assembly and solution structure of the core retromer protein complex

Norwood, SJ, Shaw, DJ, Cowieson, NP, Owen, DJ, Teasdale, RD and Collins, BM (2011). Assembly and solution structure of the core retromer protein complex. Traffic, 12 (1), 56-71. doi: 10.1111/j.1600-0854.2010.01124.x

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer, Robert J. and Collins, Brett M. (2011). Survey of the year 2009: applications of isothermal titration calorimetry. Journal of Molecular Recognition, 24 (1), 1-16. doi: 10.1002/jmr.1073

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

Kubala, MH, Kovtun, O, Alexandrov, K and Collins, BM (2010). Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Science, 19 (12), 2389-2401. doi: 10.1002/pro.519

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

Drinkwater, Nyssa, Vu, Hoan, Lovell, Kimberly M., Criscione, Kevin R., Collins, Brett M., Prisinzano, Thomas E., Pulsen, Sally‑Ann, McLeish, Michael J., Grunewald, Gary L. and Martin, Jennifer L. (2010). Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochemical Journal, 431 (1), 51-61. doi: 10.1042/BJ20100651

Munc18-1 as a key regulator of neurosecretion

Han, GA, Malintan, NT, Collins, BM, Meunier, FA and Sugita, S (2010). Munc18-1 as a key regulator of neurosecretion. Journal of Neurochemistry, 115 (1), 1-10. doi: 10.1111/j.1471-4159.2010.06900.x

Survey of the year 2008: Applications of isothermal titration calorimetry

Falconer, RJ, Penkova, A, Jelesarov, I and Collins, BM (2010). Survey of the year 2008: Applications of isothermal titration calorimetry. Journal of Molecular Recognition, 23 (5), 395-413. doi: 10.1002/jmr.1025

A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex

Jackson, Lauren P., Kelly, Bernard T., McCoy, Airlie J., Gaffry, Thomas, James, Leo C., Collins, Brett M., Honing, Stefan, Evans, Philip R. and Owen, David J. (2010). A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell, 141 (7), 1220-1229. doi: 10.1016/j.cell.2010.05.006

Vesicle transport: A new player in APP trafficking

Owen, DJ and Collins, BM (2010). Vesicle transport: A new player in APP trafficking. Current Biology, 20 (9), R413-R415. doi: 10.1016/j.cub.2010.03.017

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells

Han, Liping, Jiang, Tiandan, Han, Gayoung A., Malintan, Nancy T., Xie, Li., Wang, Li., Tse, Frederick W., Gaisano, Herbert Y., Collins, Brett M., Meunier, Frederic A. and Sugita, Shuzo (2009). Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Molecular Biology of the Cell, 20 (23), 4962-4975. doi: 10.1091/mbc.E09-08-0712

Abrogating Munc18-1 SNARE complex interaction has limited impact on exocytosis in PC12 cells

Malintan, Nancy, Nguyen, Tam H, Han, Liping, Latham, Catherine F., Osborne, Shona L., Wen, Peter, Lim, Siew, Joo, Tiffany, Sugita, Shuzo, Collins, Brett M. and Meunier, Frederic A. (2009). Abrogating Munc18-1 SNARE complex interaction has limited impact on exocytosis in PC12 cells. The Journal of Biological Chemistry, 284 (32), 21637-21646. doi: 10.1074/jbc.M109.013508

The structure and function of the retrometer protein complex.

Collins, B. M. (2008). The structure and function of the retrometer protein complex.. Traffic, 9 (11), 1811-1822. doi: 10.1111/j.1600-0854.2008.00777.x

Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex

Collins, Brett M., Norwood, Suzanne J., Kerr, Markus C., Mahony, Donna, Seaman, Matthew N. J. and Teasdale, Rohan D. (2008). Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex. Traffic, 9 (3), 366-379. doi: 10.1111/j.1600-0854.2007.00688.x

A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles

Miller, Sharon E., Collins, Brett M., McCoy, Airlie J., Robinson, Margaret S. and Owen, David J. (2007). A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Nature, 450 (7169), 570-574. doi: 10.1038/nature06353

Molecular Switches Involving the AP-2 Beta 2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly

Edeling, Melissa A., Mishra, Sanjay K., Keyel, Peter A., Steinhauser, Amie L., Collins, Brett M., Roth, Robyn, Heuser, John E., Owen, David J. and Traub, Linton M. (2006). Molecular Switches Involving the AP-2 Beta 2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly. Developmental Cell, 10 (3), 329-342. doi: 10.1016/j.devcel.2006.01.016

Prospect Eleven: Princeton University's entry in the 2005 DARPA Grand Challenge

Atreya, Anand R., Cattle, Bryan C., Collins, Brendan M., Essenburg, Benjamin, Franken, Gordon H., Saxe, Andrew M., Schiffres, Scott N. and Kornhauser, Alain L. (2006). Prospect Eleven: Princeton University's entry in the 2005 DARPA Grand Challenge. Journal of Field Robotics, 23 (9), 745-753. doi: 10.1002/rob.20141

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

Collins, Brett M., Skinner, Claire F., Watson, Peter J., Seaman, Matthew N. J. and Owen, David J. (2005). Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nature Structural & Molecular Biology, 12 (7), 594-602. doi: 10.1038/nsmb954

gamma-COP appendage domain - Structure and function

Watson, Peter J., Frigerio, Gabriella, Collins, Brett M., Duden, Rainer and Owen, David J. (2004). gamma-COP appendage domain - Structure and function. Traffic, 5 (2), 79-88. doi: 10.1111/j.1600-0854.2004.00158.x

Adaptors for Clathrin Coats: Structure and Function

Owen, David J., Collins, Brett M. and Evans, Philip R. (2004). Adaptors for Clathrin Coats: Structure and Function. Annual Review of Cell And Developmental Biology, 20 (1), 153-191. doi: 10.1146/annurev.cellbio.20.010403.104543

Structural basis for binding of accessory proteins by the appendage domain of GGAs

Collins, Brett M., Praefcke, Gerrit J. K., Robinson, Margaret S. and Owen, David J. (2003). Structural basis for binding of accessory proteins by the appendage domain of GGAs. Nature Structural Biology, 10 (8), 607-613. doi: 10.1038/nsb955

Binding partners for the COOH-Terminal appendage domains of the GGAs and gamma-adaptin

Lui, Winnie W. Y., Collins, Brett M., Hirst, Jennifer, Motley, Alison, Millar, Caroline, Schu, Peter, Owen, David J. and Robinson, Margaret S. (2003). Binding partners for the COOH-Terminal appendage domains of the GGAs and gamma-adaptin. Molecular Biology of The Cell, 14 (6), 2385-2398. doi: 10.1091/mbc.E02-11-0735

Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA - Crystal structure of an oligomeric complex of yeast SmF

Collins, Brett M., Cubeddu, Liza, Naidoo, Nishen, Harrop, Stephen J., Kornfeld, Geoff D., Dawes, Ian W., Curmi, Paul M. G. and Mabbutt, Bridget C. (2003). Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA - Crystal structure of an oligomeric complex of yeast SmF. Journal of Biological Chemistry, 278 (19), 17291-17298. doi: 10.1074/jbc.M211826200

The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs

Collins, Brett M., Watson, Peter J. and Owen, David J. (2003). The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Developmental Cell, 4 (3), 321-332. doi: 10.1016/S1534-5807(03)00037-6

Molecular architecture and functional model of the endocytic AP2 complex

Collins, Brett M., McCoy, Airlie J., Kent, Helen M., Evans, Philip R. and Owen, David J. (2002). Molecular architecture and functional model of the endocytic AP2 complex. Cell, 109 (4), 523-535. doi: 10.1016/S0092-8674(02)00735-3

Crystal structure of a heptameric Sm-like protein complex from archaea: Implications for the structure and evolution of snRNPs

Collins, B. M., Harrop, S. J., Kornfeld, G. D., Dawes, I. W., Curmi, P. M. G. and Mabbutt, B. C. (2001). Crystal structure of a heptameric Sm-like protein complex from archaea: Implications for the structure and evolution of snRNPs. Journal of Molecular Biology, 309 (4), 915-923. doi: 10.1006/jmbi.2001.4693

Purification by reflux electrophoresis of whey proteins and of a recombinant protein expressed in Dictyostelium discoideum

Corthals, GL, Collins, BM, Mabbutt, BC, Williams, KL and Gooley, AA (1997). Purification by reflux electrophoresis of whey proteins and of a recombinant protein expressed in Dictyostelium discoideum. Journal of Chromatography A, 773 (1-2), 299-309. doi: 10.1016/S0021-9673(97)00237-9

Characterisation of protein complexes essential to cellular trafficking

Livingstone, Emma, Whitten, Andrew, Weeratunga, Saroja, Martin, Jennifer and Collins, Brett (2018). Characterisation of protein complexes essential to cellular trafficking. 32nd Annual Symposium of the Protein Society, Boston, MA, 9-12 July 2018 . Hoboken, NJ, United States: Wiley-Blackwell.

Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

Paul, B., Kim, H. S., Kerr, M. C., Huston, W. M., Teasdale, R. D. and Collins, B. M. (2017). Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis. Annual Joint Meeting of the American Society for Cell Biology and the European Molecular Biology Organization (ASCB/EMBO), Philadelphia, PA United States, 2-6 December 2017. Bethesda, MD United States: American Society for Cell Biology.

Parkinson-associated VPS35 mutations alter retromer cellular functions

Teasdale, R., Follett, J., Bugarcic, A., Yang, Z. and Collins, B. (2015). Parkinson-associated VPS35 mutations alter retromer cellular functions. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia Conference, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

Gallon, M., Clairfeuille, T., Collins, B. M. and Cullen, P. J. (2014). A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. ASCB/IFCB Meeting, Philadelphia Pa, Dec 06-10, 2014. BETHESDA: AMER SOC CELL BIOLOGY.

PX family proteins at the interface between intracellular trafficking and signalling

Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). PX family proteins at the interface between intracellular trafficking and signalling. 22nd IUBMB Congress/37th FEBS Congress, Seville, Spain, 4-9 September 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1742-4658.2010.08705.x

Structural studies of clathrin adaptors

Collins, BM and Owen, DJ (2004). Structural studies of clathrin adaptors. Annual Meeting of the American-Society-for-Cell-Biology, Washington Dc, Dec 04-08, 2004. BETHESDA: AMER SOC CELL BIOLOGY.

X-ray diffraction images related to PDB file 6E8R

Collins, Brett (2018). X-ray diffraction images related to PDB file 6E8R. The University of Queensland. (Dataset) doi: 10.14264/uql.2018.497