Dr Pavla Simerska

Postdoctoral Research Fellow

School of Chemistry and Molecular Biosciences
Faculty of Science
p.simerska@uq.edu.au
+61 7 336 54636

Overview

Dr Pavla Simerska has experience in the field of vaccine and drug design, development and delivery, peptide and carbohydrate chemistry and enzymatic glycosylation. She received her Master degree in Biochemistry and Biomedicine from the Institute of Chemical Technology in Prague, Czech Republic in 2002. She was awarded 3 Votoček Fellowships while working on enzymatic glycosylations at the Czech Academy of Science. Pavla defended her PhD in 2006 and since then, she has been working as a Postdoctoral Research Fellow with Prof Istvan Toth at the School of Chemistry and Microbial Biosciences, the University of Queensland. Pavla has been teaching the Medicinal Chemistry course CHEM3008 since 2008 and coordinating it since 2011 when she received the Research & Teaching Award. She has been successful in receiving funding from UQ, Australian Research Council, National Health and Medical Research Council and she was awarded the ARC Australian Postdoctoral Fellowship in 2010 and Deputy Vice Chancellor Fellowship in 2013. Dr Simerska was elected to be a Vice-President of the Australian Chapter of the Controlled Release Society and serves on the Early Career Researcher subcommittee, SCMB, UQ. Pavla has published over 40 peer-reviewed publications/proceedings.

Qualifications

  • Doctor of Philosopy, Institute of Chemical Technology
  • Master of Science, Institute of Chemical Technology

Publications

View all Publications

Publications

Book Chapter

  • Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. In Bernkop-Schnurch, Andreas (Ed.), Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends 1st ed. (pp. 195-222) New York, United States: Springer. doi:10.1007/978-1-4419-0200-9_11

Journal Article

Conference Publication

  • Toth, Istvan, Simerska, Pavla and Skwarczynsky, Mariusz (2011). Dendritic delivery systems for peptide vaccines. In: 1st European Conference of Microbiology and Immunology - Abstracts of oral presentations and posters. 1st European Conference of Microbiology and Immunology, Budapest, Hungary, (117-118). 12-14 May 2011. doi:10.1556/EuJMI.1.2011.2.1

  • Coles, Daniel J., Simerska, Pavla, Fujita, Yoshio and Toth, Istvan (2011). The influence of incorporating lipids or liposaccharides on the particle size of peptide therapeutics. In: Heather Benson and Istvan Toth, The Eighth Australian Peptide Conference. Peptides: Tools, Targets and Therapeutics. 8th Australian Peptide Conference. Peptides: Tools, Targets and Therapeutics, Coran Cove, South Stradbroke Island, QLD, Australia, (172-176). 11-16 October 2009. doi:10.1002/bip.21459

  • Simerska, Pavla, McGeary, Ross P., Abdel-Aal, Abu-Baker M., Moyle, Peter M., Olive, Colleen, Good, Michael F. and Toth, Istvan (2009). Vaccine delivery utilizing liposaccharides. In: Advances in Experimental Medicine and Biology - Peptides for Youth. The Proceedings of the 20th American Peptide Symposium. The 20th American Peptide Symposium, Montreal, Canada, (345-346). 26-30 June, 2007. doi:10.1007/978-0-387-73657-0_153

  • Toth, Istvan, Moyle, Peter M., Simerska, Pavla, Fujita, Yoshio, Olive, Colleen and Good, Michael F. (2009). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. In: Susan Del Valle, Emanuel Escher and William D. Lubell, Peptides for youth: The proceedings of the 20th American Peptide Symposium. 20th American Peptide Symposium, Montréal, Quebec, Canada, (347-349). 26-30 June 2007. doi:10.1007/978-0-387-73657-0_154

  • Simerska, P., Moyle, P. M., Abdel-Aal, A. M., Fujita, Y., Olive, C., Batzloff, M. R., Good, M. F. and Toth, I. (2007). Liposaccharides in Peptide Vaccine Delivery. In: Jackie Wilce, Proceedings of the 4th International Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th International Peptide Symposium, Cairns, (1-2). 21-25 October 2007.

  • Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Novel lipoamino acid based vaccine adjuvant carrier system. In: International Proceedings of the 13th International Congress of Immunology. International Congress of Immunology, Rio de Janeiro, Brazil, (). 21-25 August 2007.

  • Simerska, P., Abdel-Aal, A. B., McGeary, R., Moyle, P.M., Fujita, Y., Good, M.F. and Toth, I. (2007). Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.. In: International Proceedings of the 13th International Congress of Immunology. 13th International Congress of Immunology, Rio de Janeiro, Brazil, (). August 21-25.

  • Abdel-Aal, A. M., Batzloff, M. R., Faria, A., Fujita, Y., Good, M. F., Phillipps, K. S. M., Simerska, P., Toth, I. and Zaman, M. (2007). The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine. In: Proceedings of the 4th international Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th international Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007, Cairns, Queensland, Australia, (). 21 - 25 October 2007.

  • Simerska, P., Moyle, P. M., Zhong, W., McGeary, R., Abdel-Aal, A. B., Good, M. F. and Toth, I. (2007). Vaccine Delivery Utilizing Liposaccharides. In: Biopolymers: 20th American Peptide Symposium. 20th American Peptide Symposium, Montréal, Quebec, Canada, (534-534). 26-30 June 2007. doi:10.1002/bip.20783

  • Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. In: Biopolymers. 20th American Peptide Symposium, Montréal, Quebec, Canada, (535-535). 26-30 June 2007. doi:10.1002/bip.20783

  • Abdel-Aal, A. M., Fujita, Y., Faria, A., Simerska, P., Batzloff, M. R., Good, M. F. and Toth, I. (2006). Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus. In: Andrew Davey, Annual Conference of the Australasian Pharmaceutical Science Assn. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, Australia, (). 3-5 December 2006.

  • Simerska, P., Moyle, P. M., Olive, C., Sun, H. K., Ho, M. F., Pandy, M. G., Dyer, J. R., Burgess, M. L. and Toth, I. (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. In: Proceedings of GPEN 2006. GPEN 2006, Lawrence, USA, (Abstract). 25-27 October, 2006.

  • Simerska, P, Moyle, P. M., Olive, C., Sun, H., Ho, M.-F., Pandy, M.G., Dyer, J. R., Burgess, M L and Toth, I (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. In: Abstracts of the Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 24 November 2006.

  • Simerska, P., Bong, Y. K., McGeary, R. P., Moyle, P. M. and Toth, I. (2006). Liposaccharide based vaccine carrier adjuvant systems. In: Drug Design Amongst the Vines, Hunter Valley, (). 3 - 7 December 2006.

  • Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2006). Liposaccharides in peptide, gene and vaccine delivery. In: Proceedings of Drug Design Amongst the Vines. Drug Design Amongst the Vines, Hunter Valley, (Abstract). 3 - 7 December, 2006.

  • Simerska, Pavla, Kuzma, Marek, Monti, Daniela, Riva, Sergio, Mackova, Martina and Kren, Vladimir (2006). Unique transglycosylation potential of extracellular α-d-galactosidase from Talaromyces flavus. In: Maurice C. R. Franssen, Proceedings of the 7th international symposium on biocatalysis and biotransformations. 7th International Symposium on Biocatalysis and Biotransformations (BIOTRANS 2005), Delft, The Netherlands, (128-134). 3–8 July 2005. doi:10.1016/j.molcatb.2006.01.006

PhD and MPhil Supervision