Dr Pavla Simerska has experience in the field of vaccine and drug design, development and delivery, peptide and carbohydrate chemistry and enzymatic glycosylation. She received her Master degree in Biochemistry and Biomedicine from the Institute of Chemical Technology in Prague, Czech Republic in 2002. She was awarded 3 Votoček Fellowships while working on enzymatic glycosylations at the Czech Academy of Science. Pavla defended her PhD in 2006 and since then, she has been working as a Postdoctoral Research Fellow with Prof Istvan Toth at the School of Chemistry and Microbial Biosciences, the University of Queensland. Pavla has been teaching the Medicinal Chemistry course CHEM3008 since 2008 and coordinating it since 2011 when she received the Research & Teaching Award. She has been successful in receiving funding from UQ, Australian Research Council, National Health and Medical Research Council and she was awarded the ARC Australian Postdoctoral Fellowship in 2010 and Deputy Vice Chancellor Fellowship in 2013. Dr Simerska was elected to be a Vice-President of the Australian Chapter of the Controlled Release Society and serves on the Early Career Researcher subcommittee, SCMB, UQ. Pavla has published over 40 peer-reviewed publications/proceedings.
Fagan, Vincent, Hussein, Waleed M., Su, Mei, Gidda, Ashwini K., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Simerska, Pavla (2017) Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties. ChemBioChem, 18 6: 545-553. doi:10.1002/cbic.201600639
Journal Article: Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus
Hussein, Waleed M., Xu, Jiaxin, Simerska, Pavla and Toth, Istvan (2017) Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus. Australian Journal of Chemistry, 70 2: 184-190. doi:10.1071/CH16501
Journal Article: Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides
Pignatello, Rosario, Simerska, Pavla, Leonardi, Antonio, Abdelrahim, Adel S., Petronio, Giulio Petronio, Fuochi, Virginia, Furneri, Pio Maria, Ruozi, Barbara and Toth, Istvan (2016) Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides. European Journal of Medicinal Chemistry, 120 329-337. doi:10.1016/j.ejmech.2016.04.074
Development of Carbohydrate Based Self-adjuvanting Vaccine Delivery System
(2012–2015) NHMRC Project Grant
Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
(2010–2013) ARC Discovery Projects
Synthesis of glycolipid-associated drugs for oral delivery
(2009) UQ Early Career Researcher
(2014) Doctor Philosophy
Synthesis and Pharmacological Characterization of Endomorphin-1 Analogues
(2012) Doctor Philosophy
Charged liposaccharide based drug delivery systems
(2010) Doctor Philosophy
Strategies in oral immunization
Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. In Bernkop-Schnurch, Andreas (Ed.), Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends 1st ed. (pp. 195-222) New York, United States: Springer. doi:10.1007/978-1-4419-0200-9_11
Fagan, Vincent, Hussein, Waleed M., Su, Mei, Gidda, Ashwini K., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Simerska, Pavla (2017) Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties. ChemBioChem, 18 6: 545-553. doi:10.1002/cbic.201600639
Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus
Hussein, Waleed M., Xu, Jiaxin, Simerska, Pavla and Toth, Istvan (2017) Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus. Australian Journal of Chemistry, 70 2: 184-190. doi:10.1071/CH16501
Pignatello, Rosario, Simerska, Pavla, Leonardi, Antonio, Abdelrahim, Adel S., Petronio, Giulio Petronio, Fuochi, Virginia, Furneri, Pio Maria, Ruozi, Barbara and Toth, Istvan (2016) Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides. European Journal of Medicinal Chemistry, 120 329-337. doi:10.1016/j.ejmech.2016.04.074
Synthesis of glycolipid-based drug delivery systems for oral administration
Lee, Wan Ling, Toth, Istvan and Simerska, Pavla (2016) Synthesis of glycolipid-based drug delivery systems for oral administration. Drug Delivery Letters, 6 1: 38-45. doi:10.2174/2210303106666160506155139
Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2016) Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chemical Science, 7 4: 2492-2500. doi:10.1039/C5SC04392A
Evaluation of lipopeptides as toll-like receptor 2 ligands
Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan and Simerska, P. (2016) Evaluation of lipopeptides as toll-like receptor 2 ligands. Current Drug Delivery, 14 7: 935-943. doi:10.2174/1567201813666160804114107
Apte, Simon H., Stephenson, Rachel J., Simerska, Pavla, Groves, Penny L., Aljohani, Salwa, Eskandari, Sharareh, Toth, Istvan and Doolan, Denise L. (2016) Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses. Nanomedicine, 11 2: 137-152. doi:10.2217/nnm.15.184
Luteinizing hormone releasing hormone/galactose core/lipopeptide
Simerska, Pavla, Lai, Hoi Ling and Toth, Istvan (2015) Luteinizing hormone releasing hormone/galactose core/lipopeptide. MolBank, 2015 4: M881. doi:10.3390/M881
Goodwin, Daryn, Varamini, Pegah, Simerska, Pavla, D'Occhio, Michael J. and Toth, Istvan (2015) Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries). Vaccine, 33 12: 1453-1458. doi:10.1016/j.vaccine.2015.01.076
Christie, Michelle P., Toth, Istvan and Simerska, Pavla (2014) Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery.. Future Medicinal Chemistry, 6 18: 2113-2129. doi:10.4155/fmc.14.130
Goodwin, Daryn, Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2014) Stability, Permeability and Growth-Inhibitory Properties of Gonadotropin-Releasing Hormone Liposaccharides. Pharmaceutical Research, 32 5: 1570-1584. doi:10.1007/s11095-014-1558-1
Goodwin, Daryn, Simerska, Pavla, Chang, Cheng-Hung, Mansfeld, Friederike M., Varamini, Pegah, D'Occhio, Michael J. and Toth, Istvan (2014) Active immunisation of mice with GnRH lipopeptide vaccine candidates: importance of T helper or multi-dimer GnRH epitope. Bioorganic and Medicinal Chemistry, 22 17: 4848-4854. doi:10.1016/j.bmc.2014.06.052
Fagan, Vincent, Toth, Istvan and Simerska, Pavla (2014) Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold. Beilstein Journal of Organic Chemistry, 10 1741-1748. doi:10.3762/bjoc.10.181
Christie, Michelle P., Simerská, Pavla, Jen, Freda E.-C., Hussein, Waleed M., Rawi, Mohamad F. M., Hartley-Tassell, Lauren E., Day, Christopher J., Jennings, Michael P. and Toth, Istvan (2014) A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. PLoS One, 9 4: e95024.1-e95024.10. doi:10.1371/journal.pone.0095024
Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses
Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014) Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 37: 4743-4750. doi:10.1016/j.vaccine.2014.06.049
Simerska, Pavla, Ziora, Zyta Maria, Fagan, Vincent, Goodwin, Daryn, Edrous, Farrah and Toth, Istvan (2013) Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system. Drug Delivery and Translational Research, Online First 3: 1-10. doi:10.1007/s13346-013-0173-8
alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins
Simerska, Pavla, Christie, Michelle P., Goodwin, Daryn, Jen, Freda E.-C., Jennings, Michael P. and Toth, Istvan (2013) alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins. Journal of Molecular Catalysis B: Enzymatic, In Press, Accepted Manuscript 1-28. doi:10.1016/j.molcatb.2013.08.018
Liposomes for improved enzymatic glycosylation of lipid-modified lactose enkephalin
Christie, Michelle P., Simerska, Pavla, Jen, Freda E.-C., Jennings, Michael P. and Toth, Istvan (2013) Liposomes for improved enzymatic glycosylation of lipid-modified lactose enkephalin. ChemPlusChem, 78 8: 793-796. doi:10.1002/cplu.201300115
Chemical methods for peptide and protein production
Chandrudu, Saranya, Simerska, Pavla and Toth, Istvan (2013) Chemical methods for peptide and protein production. Molecules, 18 4: 4373-4388. doi:10.3390/molecules18044373
Peptides as therapeutics with enhanced bioactivity
Goodwin, D., Simerska, P. and Toth, I. (2012) Peptides as therapeutics with enhanced bioactivity. Current Medicinal Chemistry, 19 26: 4451-4461. doi:10.2174/092986712803251548
Development and characterization of anionic liposaccharides for enhanced oral drug delivery
Abdelrahim, Adel S., Simerska, Pavla and Toth, Istvan (2012) Development and characterization of anionic liposaccharides for enhanced oral drug delivery. International Journal of Pharmaceutics, 430 1-2: 120-128. doi:10.1016/j.ijpharm.2012.04.018
Liposaccharide-based nanoparticulate drug delivery system
Abdelrahim, Adel S., Simerska, Pavla and Toth, Istvan (2012) Liposaccharide-based nanoparticulate drug delivery system. Tetrahedron, 68 25: 4967-4975. doi:10.1016/j.tet.2012.04.064
Liposaccharides for improved oral delivery of tobramycin
Abdelrahim, Adel S., Simerska, Pavla and Toth, Istvan (2012) Liposaccharides for improved oral delivery of tobramycin. Drug Delivery Letters, 2 2: 92-97. doi:10.2174/2210304x11202020092
King, Nathan P, Sakinc, Turkan, Ben Zakour, Nouri L, Totsika, Makrina, Heras, Begona, Simerska, Pavla, Shepherd, Mark, Gatermann, Soren G, Beatson, Scott A and Schembri, Mark A (2012) Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance. BMC Microbiology, 12 1: 8.1-8.25. doi:10.1186/1471-2180-12-8
Simerska, Pavla, Moyle, Peter M. and Toth, Istvan (2011) Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products. Medicinal Research Reviews, 31 4: 520-547. doi:10.1002/med.20191
Wilke, DV, Jimenez, PC, Araujo, RM, da Silva, WMB, Pessoa, ODL, Silveira, ER, Pessoa, C, de Moraes, MO, Skwarczynski, M, Simerska, P, Toth, I and Costa-Lotufo, LV (2011) Pro-apoptotic activity of lipidic alpha-amino acids isolated from Protopalythoa variabilis (vol 18, pg 7997, 2010). Bioorganic and Medicinal Chemistry, 19 3: 1366-1366. doi:10.1016/j.bmc.2010.12.041
Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis
Wilke, Diego Veras, Jimenez, Paula Christine, Araújo, Renata Mendonça, da Silva, Wildson Max Barbosa, Pessoa, Otília Deusdênia Loiola, Silveira, Edilberto Roch, Pessoa, Claudia, de Moraes, Manoel Odorico, Skwarczynski, Mariusz, Simerska, Paul, Toth, Istvan and Costa-Lotufo, Letícia Veras (2010) Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis. Bioorganic and Medicinal Chemistry, 18 22: 7997-8004. doi:10.1016/j.bmc.2010.09.027
Zaman, Mehfuz, Simerska, Pavla and Toth, Istvan (2010) Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response. Current Drug Delivery, 7 2: 118-124. doi:10.2174/156720110791011846
Beckham, Simone A., Boyd, Sarah E., Reynolds, Simone, Willis, Charlene, Johnstone, Masego, Mika, Angela, Simerska, Pavla, Wijeyewickrema, Lakshmi C., Smith, A. Ian, Kemp, David J., Pike, Robert N. and Fischer, Katja (2009) Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei. Journal of Biological Chemistry, 284 49: 34413-34422. doi:10.1074/jbc.M109.061911
Oral vaccine delivery - New strategies and technologies
Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009) Oral vaccine delivery - New strategies and technologies. Current Drug Delivery, 6 4: 347-358. doi:10.2174/156720109789000537
Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines
Zhong, Wei, Skwarczynski, Mariusz, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009) Development of highly pure alpha-helical lipoglycopeptides as self-adjuvanting vaccines. Tetrahedron, 65 17: 3459-3464. doi:10.1016/j.tet.2009.02.060
α-Galactosidases and their applications in biotransformations
Weignerova, Lenka, Simerska, Pavla and Kren, Vladimir (2009) α-Galactosidases and their applications in biotransformations. Biocatalysis and Biotransformation, 27 2: 79-89. doi:10.1080/10242420802583416
Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope
Simerska, Pavla, Lu, Hao and Toth, Istvan (2009) Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope. Bioorganic & Medicinal Chemistry Letters, 19 3: 821-824. doi:10.1016/j.bmcl.2008.12.013
Zhong, Wei, Skwarczynski, Mariusz, Fujita, Yoshio, Simerska, Pavla, Good, Michael F. and Toth, Istvan (2009) Design and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligation. Australian Journal of Chemistry, 62 9: 993-999. doi:10.1071/CH09065
Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines
Toth, I., Simerska, P. and Fujita, Y. (2008) Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines. International Journal of Peptide Research and Therapeutics, 14 4: 333-340. doi:10.1007/s10989-008-9147-y
Simerska, Pavla, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Moyle, Peter M., McGeary, Ross P., Batzloff, Michael R., Olive, Colleen, Good, Michael F. and Toth, Istvan (2008) Development of a liposaccharide-based delivery system and its application to the design of Group A streptococcal vaccines. Journal of Medicinal Chemistry, 51 5: 1447-1452. doi:10.1021/jm701410p
Abdel-Aal, Abu-Baker M., Batzloff, Michael R., Fujita, Yoshio, Barozzi, Nadia, Faria, Andres, Simerska, Pavla, Moyle, Peter M., Good, Michael F. and Toth, Istvan (2008) Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates. Journal of Medicinal Chemistry, 51 1: 167-172. doi:10.1021/jm701091d
Induction and characterization of an unusual α-d-galactosidase from Talaromyces flavus
Simerska, Pavla, Monti, Daniela, Cechova, Ivana, Pelantova, Helena, Mackova, Martina, Bezouska, Karel, Riva, Sergio and Kren, Vladimir (2007) Induction and characterization of an unusual α-d-galactosidase from Talaromyces flavus. Journal of Biotechnology, 128 1: 61-71. doi:10.1016/j.jbiotec.2006.09.006
Glycosyl Azides – An Alternative Way to disaccharides
Bojarová, Pavla, Petrásková, Lucie, Ferrandi, Erica Elisa, Monti, Daniela, Pelantova, Helena, Kuzma, Mareka, Simerská, Pavla and Křen, Vladimir (2007) Glycosyl Azides – An Alternative Way to disaccharides. Advanced Synthesis & Catalysis, 349 8+9: 1514-1520. doi:10.1002/adsc.200700028
Regioselective enzymatic acylation of N-acetylhexosamines
Simerská, Pavla, Pišvejcová, Andrea, Kuzma, Marek, Sedmera, Petr, Křen, Vladimır, Nicotra, Silvia and Riva, Sergio (2004) Regioselective enzymatic acylation of N-acetylhexosamines. Journal of Molecular Catalysis B: Enzymatic, 29 1-6: 219-225. doi:10.1016/j.molcatb.2003.10.018
Simerská, P., Kuzma, M., Pišvejcová, A., Weignerová, L., Macková, M., Riva, S. and Křen, V. (2003) Application of selectively acylated glycosides for the alpha-galactosidase-catalyzed synthesis of disaccharides. Folia Microbiologica, 48 3: 329-338. doi:10.1007/BF02931362
Krist, P., Kuzma, M., Pelyvás, I. F., Simerská, P. and Křen, V. (2003) Synthesis of 4-Nitrophenyl 2-Acetamido-2-deoxy-b-D-mannopyranoside and 4-Nitrophenyl 2-Acetamido-2-deoxy-a-D-mannopyranoside. Collection of Czechoslovak Chemical Communications, 68 4: 801-811. doi:10.1135/cccc20030801
Krist, Pavel, Kuzma, Marek, Pelyvás, István F., Simerská, Pavla and Křen, Vladimír (2003) Synthesis of 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-mannopyranoside and 4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-mannopyranoside. Collection of Czechoslovak Chemical Communications, 68 4: 801-811. doi:10.1135/cccc20030801
Dendritic delivery systems for peptide vaccines
Toth, Istvan, Simerska, Pavla and Skwarczynsky, Mariusz (2011). Dendritic delivery systems for peptide vaccines. In: 1st European Conference of Microbiology and Immunology - Abstracts of oral presentations and posters. 1st European Conference of Microbiology and Immunology, Budapest, Hungary, (117-118). 12-14 May 2011. doi:10.1556/EuJMI.1.2011.2.1
Coles, Daniel J., Simerska, Pavla, Fujita, Yoshio and Toth, Istvan (2011). The influence of incorporating lipids or liposaccharides on the particle size of peptide therapeutics. In: Heather Benson and Istvan Toth, The Eighth Australian Peptide Conference. Peptides: Tools, Targets and Therapeutics. 8th Australian Peptide Conference. Peptides: Tools, Targets and Therapeutics, Coran Cove, South Stradbroke Island, QLD, Australia, (172-176). 11-16 October 2009. doi:10.1002/bip.21459
Vaccine delivery utilizing liposaccharides
Simerska, Pavla, McGeary, Ross P., Abdel-Aal, Abu-Baker M., Moyle, Peter M., Olive, Colleen, Good, Michael F. and Toth, Istvan (2009). Vaccine delivery utilizing liposaccharides. In: DelValle, S, Escher, E and Lubell, WD, Advances in Experimental Medicine and Biology - Peptides for Youth. The Proceedings of the 20th American Peptide Symposium. The 20th American Peptide Symposium, Montreal, Canada, (345-346). 26-30 June, 2007. doi:10.1007/978-0-387-73657-0_153
Toth, Istvan, Moyle, Peter M., Simerska, Pavla, Fujita, Yoshio, Olive, Colleen and Good, Michael F. (2009). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. In: Susan Del Valle, Emanuel Escher and William D. Lubell, Peptides for youth: The proceedings of the 20th American Peptide Symposium. 20th American Peptide Symposium, Montréal, Quebec, Canada, (347-349). 26-30 June 2007. doi:10.1007/978-0-387-73657-0_154
Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines
Toth, Istvan, Simerska, Pavla and Fujita, Yoshio (2008). Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines. In: , , (333-340). . doi:10.1007/s10989-008-9147-y
Investigation toward multi-epitope vaccine candidates using native chemical ligation
Fujita, Yoshio, Moyle, Peter M., Hieu, Suzanne, Simerska, Pavla and Toth, Istvan (2008) Investigation toward multi-epitope vaccine candidates using native chemical ligation. Biopolymers: Peptide Science, 90 5: 624-632. doi:10.1002/bip.21002
Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus
Simerska, Pavla, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2008) Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus. Biopolymers - Peptide Science, 90 5: 611-616. doi:10.1002/bip.20992
Liposaccharides in Peptide Vaccine Delivery
Simerska, P., Moyle, P. M., Abdel-Aal, A. M., Fujita, Y., Olive, C., Batzloff, M. R., Good, M. F. and Toth, I. (2007). Liposaccharides in Peptide Vaccine Delivery. In: Jackie Wilce, Proceedings of the 4th International Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th International Peptide Symposium, Cairns, (). 21-25 October 2007.
Novel lipoamino acid based vaccine adjuvant carrier system
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Novel lipoamino acid based vaccine adjuvant carrier system. In: International Proceedings of the 13th International Congress of Immunology. International Congress of Immunology, Rio de Janeiro, Brazil, (). 21-25 August 2007.
Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.
Simerska, P., Abdel-Aal, A. B., McGeary, R., Moyle, P.M., Fujita, Y., Good, M.F. and Toth, I. (2007). Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.. In: International Proceedings of the 13th International Congress of Immunology. 13th International Congress of Immunology, Rio de Janeiro, Brazil, (). August 21-25.
Abdel-Aal, A. M., Batzloff, M. R., Faria, A., Fujita, Y., Good, M. F., Phillipps, K. S. M., Simerska, P., Toth, I. and Zaman, M. (2007). The importance of epitope and lipid orientation in the design of synthetic self-adjuvanting group A streptococcal (GAS) vaccine. In: Proceedings of the 4th international Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th international Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007, Cairns, Queensland, Australia, (). 21 - 25 October 2007.
Vaccine Delivery Utilizing Liposaccharides
Simerska, P., Moyle, P. M., Zhong, W., McGeary, R., Abdel-Aal, A. B., Good, M. F. and Toth, I. (2007). Vaccine Delivery Utilizing Liposaccharides. In: Biopolymers: 20th American Peptide Symposium. 20th American Peptide Symposium, Montréal, Quebec, Canada, (534-534). 26-30 June 2007. doi:10.1002/bip.20783
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. In: 20th American Peptide Symposium, Montréal, Quebec, Canada, (535-535). 26-30 June 2007. doi:10.1002/bip.20783
Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus
Abdel-Aal, A. M., Fujita, Y., Faria, A., Simerska, P., Batzloff, M. R., Good, M. F. and Toth, I. (2006). Development of totally synthetic self-adjuvanting vaccines against Group A streptococcus. In: Andrew Davey, Annual Conference of the Australasian Pharmaceutical Science Assn. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, Australia, (). 3-5 December 2006.
Simerska, P., Moyle, P. M., Olive, C., Sun, H. K., Ho, M. F., Pandy, M. G., Dyer, J. R., Burgess, M. L. and Toth, I. (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. In: Proceedings of GPEN 2006. GPEN 2006, Lawrence, USA, (Abstract). 25-27 October, 2006.
Simerska, P, Moyle, P. M., Olive, C., Sun, H., Ho, M.-F., Pandy, M.G., Dyer, J. R., Burgess, M L and Toth, I (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. In: Abstracts of the Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 24 November 2006.
Liposaccharide based vaccine carrier adjuvant systems
Simerska, P., Bong, Y. K., McGeary, R. P., Moyle, P. M. and Toth, I. (2006). Liposaccharide based vaccine carrier adjuvant systems. In: Drug Design Amongst the Vines, Hunter Valley, (). 3 - 7 December 2006.
Liposaccharides in peptide, gene and vaccine delivery
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2006). Liposaccharides in peptide, gene and vaccine delivery. In: Proceedings of Drug Design Amongst the Vines. Drug Design Amongst the Vines, Hunter Valley, (Abstract). 3 - 7 December, 2006.
Unique transglycosylation potential of extracellular α-d-galactosidase from Talaromyces flavus
Simerska, Pavla, Kuzma, Marek, Monti, Daniela, Riva, Sergio, Mackova, Martina and Kren, Vladimir (2006). Unique transglycosylation potential of extracellular α-d-galactosidase from Talaromyces flavus. In: Maurice C. R. Franssen, Proceedings of the 7th international symposium on biocatalysis and biotransformations. 7th International Symposium on Biocatalysis and Biotransformations (BIOTRANS 2005), Delft, The Netherlands, (128-134). 3–8 July 2005. doi:10.1016/j.molcatb.2006.01.006
Development of Carbohydrate Based Self-adjuvanting Vaccine Delivery System
(2012–2015) NHMRC Project Grant
Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
(2010–2013) ARC Discovery Projects
Synthesis of glycolipid-associated drugs for oral delivery
(2009) UQ Early Career Researcher
(2009) National Heart Foundation of Australia
(2014) Doctor Philosophy — Associate Advisor
Other advisors:
Synthesis and Pharmacological Characterization of Endomorphin-1 Analogues
(2012) Doctor Philosophy — Associate Advisor
Other advisors:
Charged liposaccharide based drug delivery systems
(2010) Doctor Philosophy — Associate Advisor
Other advisors: