Postdoctoral Research Fellow
Overview
I am currently looking for PhD students! If you're a curious engineer, and interested in any of the following
- Ventricular assist devices
- Designing medical devices for mechanical circulatory support
- Computational fluid dynamics
- In vitro evaluation of medical device prototypes
- ...and more
Then please contact me!
Qualifications
- PhD- Doctor of Philosophy, Griffith University
Publications
-
Journal Article: Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure
Boone, Alice C., Gregory, Shaun D., Wu, Eric L., Stephens, Andrew, Liao, Sam, Pauls, Jo P., Salamonsen, Robert, Fraser, John and Tansley, Geoff D. (2019) Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure. Artificial Organs, . doi:10.1111/aor.13454
-
Other Outputs: Patient-specific right heart models
Garrick, Kristy M and Pauls, Jo P (2019): Patient-specific right heart models. The University of Queensland. Dataset. doi:10.14264/uql.2019.35
-
Journal Article: OpenHeart Project—An open-source research community in the field of mechanical circulatory support
Pauls, Jo P., Miotto, Amanda, Stephens, Andrew, Gregory, Shaun D. and Tansley, Geoff (2018) OpenHeart Project—An open-source research community in the field of mechanical circulatory support. Artificial Organs, 42 10: 939-942. doi:10.1111/aor.13361
Available Projects
-
Development of a Hydraulic System for a Novel Axial Flow Blood Pump for Right Ventricular Support
Background: Right heart failure is a common post-operative complication following left ventricular assist device (LVAD) implantation. At present, there is no clinically-approved right ventricular assist device (RVAD) for long-term use, thus a second rotary LVAD may be used to support the failing right ventricle. Since LVADs are designed to support the systemic circulation where the pressure is notably greater than in the pulmonary circulation, LVADs are adapted for RVAD support. However, these adaptations come with inherent complications resulting in an increased risk of blood damage.
Aim: The aim of the present project is to design and evaluate a hydraulic system (i.e. housing / impeller) of a novel axial flow blood pump for right ventricular support.
Task: Specific tasks include:
- Define End-User requirements for a novel RVAD.
- 3D design of pump housing and impeller.
- Prototype manufacturing and in vitro bench testing including pump performance curves (i.e. pump efficiency, H-Q curves).
- Development of a Computational Fluid Design (CFD) model and validation against in vitro data.
- Design improvement within CFD including haemocompatiblity evaluation.
- Haemocompatibility testing of improved design in blood circulation loops.
Significance: The present project will result in a hydraulic system for a novel RVAD which will be essential towards the development of a RVAD system.
Skills needed: Knowledge in 3D design (Solidworks), Computational Fluid Design (Ansys, Fluent)
Publications
Book Chapter
-
First-generation ventricular assist devices
Wu, Eric L., Stevens, Michael C., Pauls, Jo P. and Steinseifer, Ulrich (2018). First-generation ventricular assist devices. In Shaun D. Gregory, Michael C. Stevens and John F. Fraser (Ed.), Mechanical circulatory and respiratory support (pp. 93-115) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810491-0.00003-5
-
Pauls, Jo P., Bartnikowski, Nicole, Jansen, So-Hyun, Lim, Einly and Dasse, Kurt (2018). Preclinical evaluation. In Shaun D. Gregory, Michael C. Stevens and John F. Fraser (Ed.), Mechanical circulatory and respiratory support (pp. 407-438) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810491-0.00013-8
Journal Article
-
Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure
Boone, Alice C., Gregory, Shaun D., Wu, Eric L., Stephens, Andrew, Liao, Sam, Pauls, Jo P., Salamonsen, Robert, Fraser, John and Tansley, Geoff D. (2019) Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure. Artificial Organs, . doi:10.1111/aor.13454
-
OpenHeart Project—An open-source research community in the field of mechanical circulatory support
Pauls, Jo P., Miotto, Amanda, Stephens, Andrew, Gregory, Shaun D. and Tansley, Geoff (2018) OpenHeart Project—An open-source research community in the field of mechanical circulatory support. Artificial Organs, 42 10: 939-942. doi:10.1111/aor.13361
-
Horobin, Jarod T., Simmonds, Michael J., Nandakumar, Deepika, Gregory, Shaun D., Tansley, Geoff, Pauls, Jo P., Girnghuber, Angela, Balletti, Nicoletta and Fraser, John F. (2018) Speed modulation of the heartWare HVAD to assess in vitro hemocompatibility of pulsatile and continuous flow regimes in a rotary blood pump. Artificial Organs, 42 9: 879-890. doi:10.1111/aor.13142
-
Time Course Response of the Heart and Circulatory System to Active Postural Changes
Pauls, Jo P., Roberts, Llion, Burgess, Tom, Fraser, John F., Gregory, Shaun D. and Tansley, Geoff (2018) Time Course Response of the Heart and Circulatory System to Active Postural Changes. Journal of Biomechanical Engineering, 140 3: 1-4. doi:10.1115/1.4038429
-
Pauls, Jo P., Nandakumar, Deepika, Horobin, Jarod, Prendeville, Justin D., Simmonds, Michael J., Fraser, John F., Tansley, Geoff and Gregory, Shaun D. (2017) The effect of compliant inflow cannulae on the hemocompatibility of rotary blood pump circuits in an in vitro model. Artificial Organs, 41 10: E118-E128. doi:10.1111/aor.12919
-
Pulmonary valve opening with two rotary left ventricular assist devices for biventricular support
Wu, Eric L., Nestler, Frank, Kleinheyer, Matthias, Stevens, Michael C., Pauls, Jo P., Fraser, John F. and Gregory, Shaun D. (2017) Pulmonary valve opening with two rotary left ventricular assist devices for biventricular support. Artificial Organs, 42 1: 31-40. doi:10.1111/aor.12967
-
Preload-based Starling-like control of rotary blood pumps: an in-vitro evaluation
Mansouri, Mahdi, Gregory, Shaun D., Salamonsen, Robert F., Lovell, Nigel H., Stevens, Michael C., Pauls, Jo P., Akmeliawati, Rini and Lim, Einly (2017) Preload-based Starling-like control of rotary blood pumps: an in-vitro evaluation. PLoS One, 12 2: e0172393. doi:10.1371/journal.pone.0172393
-
Pauls, Jo P., Stevens, Michael C., Bartnikowski, Nicole, Fraser, John F., Gregory, Shaun D. and Tansley, Geoff (2016) Evaluation of physiological control systems for rotary left ventricular assist devices: an in-vitro study. Annals of Biomedical Engineering, 44 8: 2377-2387. doi:10.1007/s10439-016-1552-3
-
Gregory, Shaun D., Stevens, Michael C., Wu, Eric L., Pauls, Jo P., Kleinheyer, Matthias and Fraser, John F. (2016) Mitral valve regurgitation with a rotary left ventricular assist device: the haemodynamic effect of inlet cannulation site and speed modulation. Annals of Biomedical Engineering, 44 9: 2674-2682. doi:10.1007/s10439-016-1579-5
-
Gregory, Shaun D., Stevens, Michael C., Pauls, Jo P., Schummy, Emma, Diab, Sara, Thomson, Bruce, Anderson, Ben, Tansley, Geoff, Salamonsen, Robert, Fraser, John F. and Timms, Daniel (2016) In vivo evaluation of active and passive physiological control systems for rotary left and right ventricular assist devices. Artificial Organs, 40 9: 894-903. doi:10.1111/aor.12654
-
Pauls, Jo P., Stevens, Michael C., Schummy, Emma, Tansley, Geoff, Fraser, John F., Timms, Daniel and Gregory, Shaun D. (2015) In vitro comparison of active and passive physiological control systems for biventricular assist devices. Annals of Biomedical Engineering, 44 5: 1-11. doi:10.1007/s10439-015-1425-1
-
Gregory, Shaun D., Schummy, Emma, Pearcy, Mark, Pauls, Jo P., Tansley, Geoff, Fraser, John F. and Timms, Daniel (2014) A compliant, banded outflow cannula for decreased afterload sensitivity of rotary right ventricular assist devices. Artificial Organs, 39 2: 102-109. doi:10.1111/aor.12338
-
Stevens, Michael C., Gregory, Shaun D., Nestler, Frank, Thomson, Bruce, Choudhary, Jivesh, Garlick, Bruce, Pauls, Jo P., Fraser, John F. and Timms, Daniel (2014) In vitro and in vivo characterization of three different modes of pump operation when using a left ventricular assist device as a right ventricular assist device. Artificial Organs, 38 11: 931-939. doi:10.1111/aor.12289
Conference Publication
-
Pauls, Jo P., Gregory, Shaun D., Stevens, Michael and Tansley, Geoff (2014). In-vitro Evaluation of Physiological Controller Response of Rotary Blood Pumps to Changes in Patient State. In: 2014 36Th Annual International Conference of the Ieee Engineering in Medicine and Biology Society (Embc). 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Chicago Il, (294-297). Aug 26-30, 2014. doi:10.1109/EMBC.2014.6943587
Other Outputs
-
Patient-specific right heart models
Garrick, Kristy M and Pauls, Jo P (2019): Patient-specific right heart models. The University of Queensland. Dataset. doi:10.14264/uql.2019.35
-
Severely dilated patient-specific left ventricle
Liao, Sam and Pauls, Jo P. (2018): Severely dilated patient-specific left ventricle. The University of Queensland. Dataset. doi:10.14264/uql.2018.542
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
-
Development of a Hydraulic System for a Novel Axial Flow Blood Pump for Right Ventricular Support
Background: Right heart failure is a common post-operative complication following left ventricular assist device (LVAD) implantation. At present, there is no clinically-approved right ventricular assist device (RVAD) for long-term use, thus a second rotary LVAD may be used to support the failing right ventricle. Since LVADs are designed to support the systemic circulation where the pressure is notably greater than in the pulmonary circulation, LVADs are adapted for RVAD support. However, these adaptations come with inherent complications resulting in an increased risk of blood damage.
Aim: The aim of the present project is to design and evaluate a hydraulic system (i.e. housing / impeller) of a novel axial flow blood pump for right ventricular support.
Task: Specific tasks include:
- Define End-User requirements for a novel RVAD.
- 3D design of pump housing and impeller.
- Prototype manufacturing and in vitro bench testing including pump performance curves (i.e. pump efficiency, H-Q curves).
- Development of a Computational Fluid Design (CFD) model and validation against in vitro data.
- Design improvement within CFD including haemocompatiblity evaluation.
- Haemocompatibility testing of improved design in blood circulation loops.
Significance: The present project will result in a hydraulic system for a novel RVAD which will be essential towards the development of a RVAD system.
Skills needed: Knowledge in 3D design (Solidworks), Computational Fluid Design (Ansys, Fluent)
