Journal Article: Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase
Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619
Journal Article: Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD
Boittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158
Journal Article: Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate
Chhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453
Synthesis of novel inhibitors of heparan sulfate-binding proteins
(2021) Doctor Philosophy
Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert, Bernhardt, Paul V., Ashmus, Roger A., Vocadlo, David J., Armstrong, Zach W. B., Davies, Gideon J., Maccarana, Marco, Li, Jin-ping, Kayal, Yasmin and Ferro, Vito (2023). Synthesis of uronic acid 1‐Azasugars as putative inhibitors of α‐Iduronidase, β‐glucuronidase and heparanase. ChemBioChem, 24 (4) e202200619, 1-7. doi: 10.1002/cbic.202200619
Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD
Boittier, Eric D., Wimmer, Norbert, Harris, Alexandria K., Schembri, Mark A. and Ferro, Vito (2022). Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD. Australian Journal of Chemistry, 76 (1), 30-36. doi: 10.1071/ch22158
Chhabra, Mohit, Wimmer, Norbert, He, Qi Qi and Ferro, Vito (2021). Development of improved synthetic routes to pixatimod (PG545), a sulfated oligosaccharide-steroid conjugate. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00453, 2420-2431. doi: 10.1021/acs.bioconjchem.1c00453
See, Nicholas W., Wimmer, Norbert, Krenske, Elizabeth H. and Ferro, Vito (2021). A substituent‐directed strategy for the selective synthesis of L‐hexoses: an expeditious route to L‐idose. European Journal of Organic Chemistry, 2021 (10), 1575-1584. doi: 10.1002/ejoc.202100042
Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide
Wu, Liang, Wimmer, Norbert, Davies, Gideon J. and Ferro, Vito (2020). Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide. Chemical Communications, 56 (89), 13780-13783. doi: 10.1039/d0cc05932c
Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545
Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004
He, Q. Q., Wimmer, N., Verquin, G., Meutermans, W. and Ferro, V. (2015). Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library. Organic and Biomolecular Chemistry, 13 (13), 4070-4079. doi: 10.1039/C5OB00122F
Ferro, Vito, Liu, Ligong, Johnstone, Ken D., Wimmer, Norbert, Karoli, Tomislav, Handley, Paul, Rowley, Jessica, Dredge, Keith, Li, Cai Ping, Hammond, Edward, Davis, Kat, Sarimaa, Laura, Harenberg, Job and Bytheway, Ian (2012). Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. Journal of Medicinal Chemistry, 55 (8), 3804-3813. doi: 10.1021/jm201708h
Lipopeptides for the fragment-based pharmaceutics design
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2012). Lipopeptides for the fragment-based pharmaceutics design. International Journal of Organic Chemistry, 2 (01), 75-81. doi: 10.4236/ijoc.2012.21013
Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011). Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 (12), 1439-1444. doi: 10.1016/j.carres.2011.03.019
Abbenante, Giovanni, Becker, Bernd, Blanc, Sebastien, Clark, Chris, Condie, Glenn, Fraser, Graeme, Grathwohl, Matthias, Halliday, Judy, Henderson, Senka, Lam, Ann, Liu, Ligong, Mann, Maretta, Muldoon, Craig, Pearson, Andrew, Premraj, Rajaratnam, Ramsdale, Tracie, Rossetti, Tony, Schafer, Karl, Le Thanh, Giang, Tometzki, Gerald, Vari, Frank, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010). Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold. Journal of Medicinal Chemistry, 53 (15), 5576-5586. doi: 10.1021/jm1002777
Sekljic, H. , Wimmer, N., Hofinger, A., Brade, H. and Kosma, P. (2010). ChemInform Abstract: Synthesis of Neoglycoproteins Containing L-glycero-α-D-manno- Heptopyranosyl-(1→4)- and -(1→5)-linked 3-Deoxy-α- D-manno-oct-2-ulopyranosylonic Acid (Kdo) Phosphate Determinants. ChemInform, 28 (45), no-no. doi: 10.1002/chin.199745240
Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1
Said, J, Trybala, E, Andersson, E, Johnstone, K, Liu, LG, Wimmer, N, Ferro, V and Bergstrom, T (2010). Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. Antiviral Research, 86 (3), 286-295. doi: 10.1016/j.antiviral.2010.03.011
Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V. and Bytheway, I. (2010). The PG500 series: Novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy. Investigational New Drugs, 28 (3), 276-283. doi: 10.1007/s10637-009-9245-5
A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds
Thanh, Giang Le, Abbenante, Giovanni, Adamson, George, Becker, Bernd, Clark, Chris, Condie, Glenn, Falzun, Tania, Grathwohl, Matthias, Gupta, Praveer, Hanson, Michael, Huynh, Ngoc, Katavic, Peter, Kuipers, Krystle, Lam, Ann, Liu, Ligong, Mann, Maretta, Mason, Jeff, McKeveney, Declan, Muldoon, Craig, Pearson, Andrew, Rajaratnam, Premraj, Ryan, Sarah, Tometzki, Gerry, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wilcox, Neil, Wimmer, Norbert, Yau, Annika ... Meutermans, Wim (2010). A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds. Journal of Organic Chemistry, 75 (1), 197-203. doi: 10.1021/jo9021919
Rajaratnam, Premraj, Gupta, Praveer, Katavic, Peter, Kuipers, Krystle, Huyh, Ngoc, Ryan, Sarah, Falzun, Tania, Tometzki, Gerrald B., Bornaghi, Laurent, Le Thanh, Giang, Abbenante, Giovanni, Liu, Ligong, Meutermans, Wim, Wimmer, Norbert and West, Michael L. (2010). Orthogonally Protected Monosaccharide Building Blocks for Solid Phase Production of Diversity Oriented Libraries. Australian Journal of Chemistry, 63 (4), 693-699. doi: 10.1071/CH09480
Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
Fujita, Yoshio, Abdel-Aal, Abu-Baker M., Wimmer, Norbert, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2008). Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates. Bioorganic & Medicinal Chemistry, 16 (19), 8907-8913. doi: 10.1016/j.bmc.2008.08.064
Novel cationic lipophilic peptides for oligodeoxynucleotide delivery
Chan, E, Amon, M, Marano, R. J., Wimmer, N, Kearns, P. S., Manolios, N, Rakoczy, P. E. and Toth, I (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic & Medicinal Chemistry, 15 (12), 4091-4097. doi: 10.1016/j.bmc.2007.03.078
Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells
Wimmer, N., Robinson, J. A., Gopisetty Venkata, N., Roberts-Thomson, S. J., Monteith, G. R. and Toth, I. (2006). Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells. Medicinal Chemistry, 2 (1), 79-87. doi: 10.2174/157340606775197714
Marano, R. J., Toth, I., Wimmer, N., Brankov, M. and Rakoczy, E. P. (2005). Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Therapy, 12 (21), 1544-1550. doi: 10.1038/sj.gt.3302579
Functional implications of modifying RyR‐activating peptides for membrane permeability
Dulhunty, Angela F., Cengia, Louise, Young, Jacqui, Pace, Suzy M., Harvey, Peta J., Lamb, Graham D., Chan, Yiu-Ngok, Wimmer, Norbert, Toth, Istvan and Casarotto, Marco G. (2005). Functional implications of modifying RyR‐activating peptides for membrane permeability. British Journal of Pharmacology, 144 (6), 743-754. doi: 10.1038/sj.bjp.0705981
Marano, Robert J., Wimmer, Norbert, Kearns, Philip S., Thomas, Bradley G., Toth, Istvan, Brankov, Meliha and Rakoczy, P. Elizabeth (2004). Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Experimental Eye Research, 79 (4), 525-535. doi: 10.1016/j.exer.2004.06.023
Wimmer, Norbert, Marano, Robert J., Kearns, Phillip S., Rakoczy, Elizabeth P. and Toth, Istvan (2002). Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorganic and Medicinal Chemistry Letters, 12 (18), 2635-2637. doi: 10.1016/S0960-894X(02)00511-5
Brade, Lore, Gronow, Sabine, Wimmer, Norbert, Kosma, Paul and Brade, Helmut (2002). Monoclonal antibodies against 3-deoxy-a-D-manno-oct-2-ulosonic acid (Kdo) and D-glycero-a-D-talo-oct-2-ulosonic acid (Ko). Journal of Endotoxin Research, 8 (5), 357-364. doi: 10.1179/096805102125000687
Wimmer, Norbert, Brade, Helmut and Kosma, Paul (2000). Synthesis of neoglycoproteins containing D-glycero-D-talo-oct-2-ulopyranosylonic acid (Ko) ligands corresponding to core units from Burkholderia and Acinetobacter lipopolysaccharide. Carbohydrate Research, 329 (3), 549-560. doi: 10.1016/s0008-6215(00)00213-5
Synthesis of inner core antigens related to Chlamydia, Pseudomonas and Acinetobacter LPS
Kosma, Paul, Reiter, Andreas, Zamyatina, Alla, Wimmer, Norbert, Glück, Alexander and Brade, Helmut (1999). Synthesis of inner core antigens related to Chlamydia, Pseudomonas and Acinetobacter LPS. Journal of Endotoxin Research, 5 (3), 157-163. doi: 10.1179/096805199101531679
Sekljic, Harald, Wimmer, Norbert, Hofinger, Andreas, Brade, Helmut and Kosma, Paul (1997). Synthesis of neoglycoproteins containing L-glycero-alpha-D-manno-heptopyranosyl-(1->4)- and -(1->5)-linked 3-deoxy-alpha-D-manno-oct-2-ulopyranosylonic acid (Kdo) phosphate determinants. Journal of the Chemical Society-Perkin Transactions 1 (13), 1973-1982. doi: 10.1039/a700497d
Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy
Dredge, K, Davis, K, Liu, L, Johnstone, K, Handley, P, Wimmer, N, Bytheway, I, Hammond, E, Li, CP, Rowley, J, Ferro, V and Gautam, A (2007). Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, San Francisco, CA, United States, 22-26 October 2007. Philadelphia, PA, United States: American Association for Cancer Research.
Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci
Moyle, Peter M., Horvath, Aniko, Karpati, Levente, Olive, Colleen, Barozzi, Nadia, Wimmer, Norbert, Good, Michael and Toth, Istvan (2006). Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci. 19th American Peptide Symposium, San Diego, United States, 18-23 June 2005. New York, United States: Springer. doi: 10.1007/978-0-387-26575-9_169
Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells
Wimmer, N, Robinson, JA, Gopisetty-Venkatta, N, Roberts-Thomson, SJ, Monteith, GR and Toth, I (2006). Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells. 19th American Peptide Symposium, San Diego, CA, United States, June 18-23 2005. New York, N.Y., United States: Springer. doi: 10.1007/978-0-387-26575-9_148
Wimmer, N., Robinson, J. A., Thomson, S. J., Monteith, G. R. and Toth, I. (2005). Anti-proliferative effects of novel glyco-lipoaminoacid-modified arsenicals (III) on MCF-7 human breast cancer cells. 19th American Peptide Symposium, San Diego, U.S., 18-23 June, 2005. Hoboken, U.S.: Wiley Interscience.
Lipid and carbohydrate based macromolecules in drug and vaccine delivery
Toth, I., Horvath, A., Blanchfield, J. T., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E.P. (2004). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. 18th American Peptide Symposium, Boston, 19-23 July, 2004.
Lipid and carbohydrate based macromolecules in drug and vaccine delivery
Toth, I., Horvath, A., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E. P. (2003). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. 26th Australian Polymer Symposium, Noosa, Queensland, 13-17 July 2003. Australia: Royal Australian Chemical Institute.
Lipid and carbohydrate based macromolecules in drug and vaccine delivery
Toth, I., Horvath, A., Blanchfield, J. T., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E. P. (2003). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. Brisbane Biological and Organic Chemistry Symposium, Gold Coast, 28 November, 2003.
Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Toth, I., Wilson, A. S., Brankov, M. and Rakoczy, P. E. (2003). Oligonucleotide gene therapy for choroidal neovascularisation enhanced by dendrimer mediated delivery. 3rd Meeting of the Australasian-Gene-Therapy-Society, Brisbane Australia, Apr 30-May 02, 2003. CHICHESTER: Wiley.
Use of synthetic dendrimer peptide's to mediate the delivery of a sense oligonucleotide
Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Toth, I., Wilson, A. S., Brankov, M. and Rakoczy, P. E. (2003). Use of synthetic dendrimer peptide's to mediate the delivery of a sense oligonucleotide. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale Florida, May, 2003. Rockville, MD United States: Association for Research in Vision and Ophthalmology.
Use of brucine to crystallise a disaccharide from a bacterial source
Gould, R. O., Walkinshaw, M. D., Wimmer, N. and Kosma, P. (2002). Use of brucine to crystallise a disaccharide from a bacterial source. XIX IUCr Congress, Geneva, Switzerland, August 2002. International Union of Crystallography (IUCr). doi: 10.1107/s0108767302090050
Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.
Kearns, P. S., Wimmer, N., Rakoczy, P. E. and Toth, I. (2001). Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.
Novel sulfated oligosaccharide derivatives
Ferro, V., Karoli, T., Liu, L., Handley, P.N., Johnstone, K.D., Wimmer, N. and Hammond, E.T. (2009). Novel sulfated oligosaccharide derivatives. WO/2009/049370.
Synthesis of novel inhibitors of heparan sulfate-binding proteins
(2021) Doctor Philosophy — Associate Advisor
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