Professor Christel Middeldorp

Professor Child & Youth Psychiatry

Child Health Research Centre
Faculty of Medicine
c.middeldorp@uq.edu.au
+61 7 3069 7595

Overview

Prof Christel Middeldorp has a conjoint appointment with the Child Health Research Centre (CHRC), UQ, and Child and Youth Mental Health Service (CYMHS), Children’s Health Queensland Hospital and Health Service (CHQ HHS). She is also affiliated to the department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands.

Her research interests involve the role of genetic and other familial influences on the development and persistence of psychopathology across the lifespan. She is the PI of CAPICE: Childhood and Adolescence Psychopathology: unravelling the complex etiologyby a large Interdisciplinary Collaboration in Europe. This is an international training network funded by an EU Marie Curie grant, coordinated by the Vrije Universiteit Amsterdam. This projects aims to identify genetic variants underlying the development and persistence of common childhood psychopathology by using data from population based longitudinal child and adolescent cohorts from over the world. Many of these cohorts participate in the EArly Genetics and Lifecourse Epidemology (EAGLE) consortium (http://www.wikigenes.org/e/art/e/348.html). She further investigates associations between parental and offspring psychopathology and the development of these associations over time in a clinical cohort consisting of families with children treated at outpatient psychiatric services, who are followed longitudinally.

Qualifications

  • Child and Adolescent Psychiatry, Netherlands
  • Arts, Netherlands
  • Propaedutic, Netherlands
  • Doctor, Vrije Universiteit

Publications

  • Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M., Blackwood, D. H. R., Boks, M. P., Boomsma, D. I., Børglum, A. D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H. N., Byrne, E. M., Cervantes, P., Clarke, T. -K., Craddock, N., Cruceanu, C., Curtis, D., Czerski, P. M., Dannlowski, U., Davis, T., de Geus, E. J. C., Di Florio, A., Djurovic, S., Domenici, E., Edenberg, H. J., Etain, B., Fischer, S. B., Forty, L., Fraser, C., Frye, M. A., Fullerton, J. M., Gade, K., Gershon, E. S., Giegling, I., Gordon, S. D., Gordon-Smith, K., Grabe, H. J., Green, E. K., Greenwood, T. A., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hall, L. S., Hamshere, M., Hauser, J., Hautzinger, M., Heilbronner, U., Herms, S., Hitturlingappa, S., Hoffmann, P., Holmans, P., Hottenga, J. -J., Jamain, S., Jones, I., Jones, L. A., Juréus, A., Kahn, R. S., Kammerer-Ciernioch, J., Kirov, G., Kittel-Schneider, S., Kloiber, S., Knott, S. V., Kogevinas, M., Landén, M., Leber, M., Leboyer, M., Li, Q. S., Lissowska, J., Lucae, S., Martin, N. G., Mayoral-Cleries, F., McElroy, S. L., McIntosh, A. M., McKay, J. D., McQuillin, A., Medland, S. E., Middeldorp, C. M., Milaneschi, Y., Mitchell, P. B., Montgomery, G. W., Morken, G., Mors, O., Mühleisen, T. W., Müller-Myhsok, B., Myers, R. M., Nievergelt, C. M., Nurnberger, J. I., O'Donovan, M. C., Loohuis, L. M. O., Ophoff, R., Oruc, L., Owen, M. J., Paciga, S. A., Penninx, B. W. J. H., Perry, A., Pfennig, A., Potash, J. B., Preisig, M., Reif, A., Rivas, F., Rouleau, G. A., Schofield, P. R., Schulze, T. G., Schwarz, M., Scott, L., Sinnamon, G. C. B., Stahl, E. A., Strauss, J., Turecki, G., Van der Auwera, S., Vedder, H., Vincent, J. B., Willemsen, G., Witt, C. C., Wray, N. R., Xi, H. S., Bipolar Disorders Working Group, Major Depressive Disorder Working Group, Schizophrenia Working Group, Tadic, A., Dahmen, N., Schott, B. H., Cichon, S., Nöthen, M. M., Ripke, S., Mobascher, A., Rujescu, D., Lieb, K., Roepke, S., Schmahl, C., Bohus, M. and Rietschel, M. (2017) Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 6: . doi:10.1038/tp.2017.115

  • Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olie, E., Villafuerte, S., Air, T. M., Araya, R., Bowes, L., Burns, R., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A., Hottenga, J. -J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J. R., Lajnef, M., Little, K., zu Schwabedissen, H. M., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W. J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., van der Auwera, S., Wainwright, N., Wang, J. -C., Willemsen, G., Anderson, I. M., Arolt, V., Aslund, C., Bagdy, G., Baune, B. T., Bellivier, F., Boomsma, D. I., Courtet, P., Dannlowski, U., de Geus, E. J. C., Deakin, J. F. W., Easteal, S., Eley, T., Fergusson, D. M., Goate, A. M., Gonda, X., Grabe, H. J., Holzman, C., Johnson, E. O., Kennedy, M., Laucht, M., Martin, N. G., Munafo, M. R., Nilsson, K. W., Oldehinkel, A. J., Olsson, C. A., Ormel, J., Otte, C., Patton, G. C., Penninx, B. W. J. H., Ritchie, K., Sarchiapone, M., Scheid, J. M., Serretti, A., Smit, J. H., Stefanis, N. C., Surtees, P. G., Volzke, H., Weinstein, M., Whooley, M., Nurnberger Jr, J. I., Breslau, N. and Bierut, L. J. (2017) Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, . doi:10.1038/mp.2017.44

  • Wesseldijk, Laura W., Fedko, Iryna O., Bartels, Meike, Nivard, Michel G., van Beijsterveldt, Catharina E. M., Boomsma, Dorret I. and Middeldorp, Christel M. (2017) Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 174 3: 251-260. doi:10.1002/ajmg.b.32500

View all Publications

Publications

Journal Article

  • Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M., Blackwood, D. H. R., Boks, M. P., Boomsma, D. I., Børglum, A. D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H. N., Byrne, E. M., Cervantes, P., Clarke, T. -K., Craddock, N., Cruceanu, C., Curtis, D., Czerski, P. M., Dannlowski, U., Davis, T., de Geus, E. J. C., Di Florio, A., Djurovic, S., Domenici, E., Edenberg, H. J., Etain, B., Fischer, S. B., Forty, L., Fraser, C., Frye, M. A., Fullerton, J. M., Gade, K., Gershon, E. S., Giegling, I., Gordon, S. D., Gordon-Smith, K., Grabe, H. J., Green, E. K., Greenwood, T. A., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hall, L. S., Hamshere, M., Hauser, J., Hautzinger, M., Heilbronner, U., Herms, S., Hitturlingappa, S., Hoffmann, P., Holmans, P., Hottenga, J. -J., Jamain, S., Jones, I., Jones, L. A., Juréus, A., Kahn, R. S., Kammerer-Ciernioch, J., Kirov, G., Kittel-Schneider, S., Kloiber, S., Knott, S. V., Kogevinas, M., Landén, M., Leber, M., Leboyer, M., Li, Q. S., Lissowska, J., Lucae, S., Martin, N. G., Mayoral-Cleries, F., McElroy, S. L., McIntosh, A. M., McKay, J. D., McQuillin, A., Medland, S. E., Middeldorp, C. M., Milaneschi, Y., Mitchell, P. B., Montgomery, G. W., Morken, G., Mors, O., Mühleisen, T. W., Müller-Myhsok, B., Myers, R. M., Nievergelt, C. M., Nurnberger, J. I., O'Donovan, M. C., Loohuis, L. M. O., Ophoff, R., Oruc, L., Owen, M. J., Paciga, S. A., Penninx, B. W. J. H., Perry, A., Pfennig, A., Potash, J. B., Preisig, M., Reif, A., Rivas, F., Rouleau, G. A., Schofield, P. R., Schulze, T. G., Schwarz, M., Scott, L., Sinnamon, G. C. B., Stahl, E. A., Strauss, J., Turecki, G., Van der Auwera, S., Vedder, H., Vincent, J. B., Willemsen, G., Witt, C. C., Wray, N. R., Xi, H. S., Bipolar Disorders Working Group, Major Depressive Disorder Working Group, Schizophrenia Working Group, Tadic, A., Dahmen, N., Schott, B. H., Cichon, S., Nöthen, M. M., Ripke, S., Mobascher, A., Rujescu, D., Lieb, K., Roepke, S., Schmahl, C., Bohus, M. and Rietschel, M. (2017) Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 6: . doi:10.1038/tp.2017.115

  • Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olie, E., Villafuerte, S., Air, T. M., Araya, R., Bowes, L., Burns, R., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A., Hottenga, J. -J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J. R., Lajnef, M., Little, K., zu Schwabedissen, H. M., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W. J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., van der Auwera, S., Wainwright, N., Wang, J. -C., Willemsen, G., Anderson, I. M., Arolt, V., Aslund, C., Bagdy, G., Baune, B. T., Bellivier, F., Boomsma, D. I., Courtet, P., Dannlowski, U., de Geus, E. J. C., Deakin, J. F. W., Easteal, S., Eley, T., Fergusson, D. M., Goate, A. M., Gonda, X., Grabe, H. J., Holzman, C., Johnson, E. O., Kennedy, M., Laucht, M., Martin, N. G., Munafo, M. R., Nilsson, K. W., Oldehinkel, A. J., Olsson, C. A., Ormel, J., Otte, C., Patton, G. C., Penninx, B. W. J. H., Ritchie, K., Sarchiapone, M., Scheid, J. M., Serretti, A., Smit, J. H., Stefanis, N. C., Surtees, P. G., Volzke, H., Weinstein, M., Whooley, M., Nurnberger Jr, J. I., Breslau, N. and Bierut, L. J. (2017) Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, . doi:10.1038/mp.2017.44

  • Wesseldijk, Laura W., Fedko, Iryna O., Bartels, Meike, Nivard, Michel G., van Beijsterveldt, Catharina E. M., Boomsma, Dorret I. and Middeldorp, Christel M. (2017) Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 174 3: 251-260. doi:10.1002/ajmg.b.32500

  • Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A, Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschon, H. N., Byrne, E. M., Cichon, S., Clarke, T-K, Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., Dunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P., Hardiman, O., Hayward, C., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Hottenga, J-J, Ising, M., Jansen, R., Kloiber, S., Knowles, J. A., Lang, M., Li, Q. S., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Martin, N. G., McGrath, P. J., McGuffin, P., McIntosh, A. M., Medland, S. E., Mehta, D., Middeldorp, C. M., Milaneschi, Y., Montgomery, G. W., Mors, O., Mueller-Myhsok, B., Nauck, M., Nyholt, D. R., Noethen, M. M., Owen, M. J., Penninx, B. W. J. H., Pergadia, M. L., Perlis, R. H., Peyrot, W. J., Porteous, D. J., Potash, J. B., Rice, J. P., Rietschel, M., Riley, B. P., Rivera, M., Schoevers, R., Schulze, T. G., Shi, J., Shyn, S. I., Smit, J. H., Smoller, J. W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., Van der Auwera, S., van Grootheest, G., van Hemert, A. M., Voelzke, H., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Witt, S. H., Levinson, D. F., Lewis, C. M., Wray, N. R., Flint, J., Sullivan, P. F. and Kendler, K. S. (2017) Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7 . doi:10.1038/tp.2016.292

  • Fedko, Iryna O., Wesseldijk, Laura W., Nivard, Michel G., Hottenga, Jouke-Jan, van Beijsterveldt, Catharina E. M., Middeldorp, Christel M., Bartels, Meike and Boomsma, Dorret I. (2017) Heritability of behavioral problems in 7-year olds based on shared and unique aspects of parental views. Behavior Genetics, 47 2: 152-163. doi:10.1007/s10519-016-9823-1

  • Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L, Foecker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M., Adan, R., Brandys, M., van Elburg, A., Perica, V. Boraska, Franklin, C. S., Tschoep, M. H., Zeggini, E., Bulik, C. M., Collier, D., Scherag, A., Mueller, T. D., Hebebrand, J., EARLY GROWTH GENETICS CONSORTIUM (EGG) and Middeldorp, Christel (2017) Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 2: 192-201. doi:10.1038/mp.2016.71

  • Bot, M., Middeldorp, C. M., de Geus, E. J. C., Lau, H. M., Sinke, M., van Nieuwenhuizen, B., Smit, J. H., Boomsma, D. I. and Penninx, B. W. J. H. (2017) Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder. Psychological Medicine, 47 2: 279-289. doi:10.1017/S0033291716002312

  • Lee, Minyoung, Aggen, Steven H., Otowa, Takeshi, Castelao, Enrique, Preisig, Martin, Grabe, Hans J., Hartman, Catharina A., Oldehinkel, Albertine J., Middeldorp, Christel M., Tiemeier, Henning and Hettema, John M. (2016) Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. International Journal of Methods in Psychiatric Research, 25 4: 255-266. doi:10.1002/mpr.1519

  • Nivard, Michel G., Middeldorp, Christel M., Lubke, Gitta, Hottenga, Jouke-Jan, Abdellaoui, Abdel, Boomsma, Dorret I. and Dolan, Conor V. (2016) Detection of gene-environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics, 24 12: 1803-1809. doi:10.1038/ejhg.2016.88

  • Middeldorp, Christel M., Hammerschlag, Anke R., Ouwens, Klaasjan G., Groen-Blokhuis, Maria M., St Pourcain, Beate, Greven, Corina U., Pappa, Irene, Tiesler, Carla M. T., Ang, Wei, Nolte, Ilja M., Vilor-Tejedor, Natalia, Bacelis, Jonas, Ebejer, Jane L., Zhao, Huiying, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Guxens, Monica, Hottenga, Jouke-Jan, Hudziak, James J., Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Martin, Nicholas G., Murcia, Mario, Myhre, Ronny, Ormel, Johan, Ring, Susan M., Standl, Marie, Stergiakouli, Evie, Stoltenberg, Camilla, Thiering, Elisabeth, Timpson, Nicholas J., Trzaskowski, Maciej, van der Most, Peter J., Wang, Carol, Nyholt, Dale R., Medland, Sarah E., Neale, Benjamin, Jacobsson, Bo, Sunyer, Jordi, Hartman, Catharina A., Whitehouse, Andrew J. O., Pennell, Craig E., Heinrich, Joachim, Plomin, Robert, Smith, George Davey, Tiemeier, Henning, Posthuma, Danielle and Boomsma, Dorret I. (2016) A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry, 55 10: 896-905.e6. doi:10.1016/j.jaac.2016.05.025

  • Lubke, Gitta H., Miller, Patrick J., Verhulst, Brad, Bartels, Meike, van Beijsterveldt, Toos, Willemsen, Gonneke, Boomsma, Dorret I. and Middeldorp, Christel M. (2016) A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 7: 948-957. doi:10.1002/ajmg.b.32375

  • Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. -J., Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Van Der Most, P. J., Nolte, I. M., Van Oort, F. V. A., Hartman, C. A., Oldehinkel, A. J., Preisig, M., Grabe, H. J., Middeldorp, C. M., Penninx, B. W. J. H., Boomsma, D., Martin, N. G., Montgomery, G., Maher, B. S., Van Den Oord, E. J., Wray, N. R., Tiemeier, H. and Hettema, J. M. (2016) Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry, 21 10: 1391-1399. doi:10.1038/mp.2015.197

  • Middeldorp, Christel M., Wesseldijk, Laura W., Hudziak, James J., Verhulst, Frank C., Lindauer, Ramon J. L. and Dieleman, Gwen C. (2016) Parents of children with psychopathology: psychiatric problems and the association with their child’s problems. European Child and Adolescent Psychiatry, 25 8: 919-927. doi:10.1007/s00787-015-0813-2

  • Hagenbeek, Fiona A., Kluft, Cornelis, Hankemeier, Thomas, Bartels, Meike, Draisma, Harmen H. M., Middeldorp, Christel M., Berger, Ruud, Noto, Antonio, Lussu, Milena, Pool, Rene, Fanos, Vassilios and Boomsma, Dorret I. (2016) Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 5: 719-732. doi:10.1002/ajmg.b.32435

  • Porsch, Robert M., Middeldorp, Christel M., Cherny, Stacey S., Krapohl, Eva, van Beijsterveldt, Catharina E. M., Loukola, Anu, Korhonen, Tellervo, Pulkkinen, Lea, Corley, Robin, Rhee, Soo, Kaprio, Jaakko, Rose, Richard R., Hewitt, John. K., Sham, Pak, Plomin, Robert, Boomsma, Dorret I. and Bartels, Meike (2016) Longitudinal heritability of childhood aggression. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 5: 697-707. doi:10.1002/ajmg.b.32420

  • Power, Robert A., Tansey, Katherine E., Buttenschøn, Henriette Nørmølle, Cohen-Woods, Sarah, Bigdeli, Tim, Hall, Lynsey S., Kutalik, Zoltán, Lee, S. Hong, Ripke, Stephan, Steinberg, Stacy, Teumer, Alexander, Viktorin, Alexander, Wray, Naomi R., Arolt, Volker, Baune, Bernard T., Boomsma, Dorret I., Børglum, Anders D., Byrne, Enda M., Castelao, Enrique, Craddock, Nick, Craig, Ian, Dannlowski, Udo, Deary, Ian J., Degenhardt, Franziska, Forstner, Andreas J., Gordon, Scott D., Grabe, Hans J., Grove, Jakob, Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Hocking, Lynne J., Homuth, Georg, Hottenga, Jouke J., Kloiber, Stefan, Krogh, Jesper, Landén, Mikael, Lang, Maren, Levinson, Douglas F., Lichtenstein, Paul, Lucae, Susanne, MacIntyre, Donald J., Madden, Pamela, Magnusson, Patrik K. E., Martin, Nicholas G., McIntosh, Andrew M., Middeldorp, Christel M., Milaneschi, Yuri, Montgomery, Grant W., Mors, Ole, Müller-Myhsok, Bertram, Nyholt, Dale R., Oskarsson, Hogni, Owen, Michael J., Padmanabhan, Sandosh, Penninx, Brenda W. J. H., Pergadia, Michele L., Porteous, David J., Potash, James B., Preisig, Martin, Rivera, Margarita, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Smit, Johannes H., Smith, Blair H., Stefansson, Hreinn, Stefansson, Kari, Strohmaier, Jana, Sullivan, Patrick F., Thomson, Pippa, Thorgeirsson, Thorgeir E., Van der Auwera, Sandra, Weissman, Myrna M., CONVERGE consortium, CARDIoGRAM Consortium, GERAD1 Consortium, Breen, Gerome and Lewis, Cathryn M. (2016) Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81 4: 325-335. doi:10.1016/j.biopsych.2016.05.010

  • Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. and Middeldorp, C. M. (2016) Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology. European Psychiatry, 34 49-55. doi:10.1016/j.eurpsy.2016.01.2423

  • Molenaar, Dylan, Middeldorp, Christel M., Willemsen, Gonneke, Ligthart, Lannie, Nivard, Michel G. and Boomsma, Dorret I. (2016) Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression. Behavior Genetics, 46 1: 59-71. doi:10.1007/s10519-015-9752-4

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  • Brandys, Marek K., Kas, Martien J. H., van Elburg, Annemarie A., Ophoff, Roel, Slof-Op't Landt, Margarita C. T., Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, P. Eline and Adan, Roger A. H. (2013) The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis. World Journal of Biological Psychiatry, 14 6: 441-451. doi:10.3109/15622975.2011.605470

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  • Cousminer D.L., Berry D.J., Timpson N.J., Ang W., Thiering E., Byrne E.M., Rob Taal H., Huikari V., Bradfield J.P., Kerkhof M., Groen-Blokhuis M.M., Kreiner-Moller E., Marinelli M., Holst C., Leinonen J.T., Perry J.R.B., Surakka I., Pietilainen O., Kettunen J., Anttila V., Kaakinen M., Sovio U., Pouta A., Das S., Lagou V., Power C., Prokopenko I., Evans D.M., Kemp J.P., St Pourcain B., Ring S., Palotie A., Kajantie E., Osmond C., Lehtimaki T., Viikari J.S., Kahonen M., Warrington N.M., Lye S.J., Palmer L.J., Tiesler C.M.T., Flexeder C., Montgomery G.W., Medland S.E., Hofman A., Hakonarson H., Guxens M., Bartels M., Salomaa V., Murabito J.M., Kaprio J., Sorensen T.I.A., Ballester F., Bisgaard H., Boomsma D.I., Koppelman G.H., Grant S.F.A., Jaddoe V.W.V., Martin N.G., Heinrich J., Pennell C.E., Raitakari O.T., Eriksson J.G., Smith G.D., Hypponen E., Jarvelin M.-R., McCarthy M.I., Ripatti S., Widen E., Early Growth Genetics (EGG) Consortium and Middeldorp, Christel (2013) Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22 13: 2735-2747. doi:10.1093/hmg/ddt104

  • de Geus, Eco J. C. and Middeldorp, Christel M. (2013) Serotonin transporter gene: will epigenetics prove less depressing than genetics?. Psychosomatic Medicine, 75 6: 520-522. doi:10.1097/PSY.0b013e318298708f

  • Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Wray, Naomi, Byrne, Enda M., Martin, Nicholas G., Gordon, Scott D., Henders, Anjali K., Montgomery, Grant M., Nyholt, Dale R. and Middeldorp, Christel M. (2013) A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18 4: 497-511. doi:10.1038/mp.2012.21

  • Smoller, Jordan W., Craddock, Nicholas, Kendler, Kenneth, Lee, Phil Hyoun, Neale, Benjamin M., Nurnberger, John I., Ripke, Stephan, Santangelo, Susan, Sullivan, Patrick F., Cross-Disorder Group of the Psychiatric Genomics Consortium and Middeldorp, Christel (2013) Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet, 381 9875: 1371-1379. doi:10.1016/S0140-6736(12)62129-1

  • Peyrot, Wouter J., Middeldorp, Christel M., Jansen, Rick, Smit, Johannes H., de Geus, Eco J. C., Hottenga, Jouke-Jan, Willemsen, Gonneke, Vink, Jacqueline M., Virding, Susanne, Barragan, Isabel, Ingelman-Sundberg, Magnus, Sim, Sarah C., Boomsma, Dorret I. and Penninx, Brenda W. J. H. (2013) Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. Journal of Affective Disorders, 146 1: 91-99. doi:10.1016/j.jad.2012.08.044

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  • Kan, Kees-Jan, Dolan, Conor V., Nivard, Michel G., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Willemsen, Gonneke and Boomsma, Dorret I. (2013) Genetic and environmental stability in attention problems across the lifespan: evidence from The Netherlands twin register. Journal of the American Academy of Child and Adolescent Psychiatry, 52 1: 12-25. doi:10.1016/j.jaac.2012.10.009

  • Slof-Op't Landt, Margarita C. T., Bartels, Meike, Middeldorp, Christel M., van Beijsterveldt, Catherina E. M., Slagboom, P. Eline, Boomsma, Dorret I., van Furth, Eric F. and Meulenbelt, Ingrid (2013) Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders. Behavior Genetics, 43 1: 24-33. doi:10.1007/s10519-012-9569-3

  • Geels, Lot M., Groen-Blokhuis, Maria M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Middeldorp, Christel M., Bartels, Meike, Nelson, Kelly A., Huizenga, Patricia E., Davies, Gareth E. and Boomsma, Dorret I. (2012) Maternal Prenatal Smoking and Offspring Emotional Problems: No Moderating Effect of Maternal or Child 5-HTTLPR Genotype. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 159B 8: 1009-1012. doi:10.1002/ajmg.b.32110

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  • Lubke, Gitta H., Hottenga, Jouke Jan, Walters, Raymond, Laurin, Charles, de Geus, Eco J. C., Willemsen, Gonneke, Smit, Jan H., Middeldorp, Christel M., Penninx, Brenda W. J. H., Vink, Jacqueline M. and Boomsma, Dorret I. (2012) Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biological Psychiatry, 72 8: 707-709. doi:10.1016/j.biopsych.2012.03.011

  • Luciano, Michelle, Huffman, Jennifer E., Arias-Vasquez, Alejandro, Vinkhuyzen, Anna A. E., Middeldorp, Christel M., Giegling, Ina, Payton, Antony, Davies, Gail, Zgaga, Lina, Janzing, Joost, Ke, Xiayi, Galesloot, Tessel, Hartmann, Annette M., Ollier, William, Tenesa, Albert, Hayward, Caroline, Verhagen, Maaike, Montgomery, Grant W., Hottenga, Jouke-Jan, Konte, Bettina, Starr, John M., Vitart, Veronique, Vos, Pieter E., Madden, Pamela A. F., Willemsen, Gonneke, Konnerth, Heike, Horan, Michael A., Porteous, David J., Campbell, Harry, Vermeulen, Sita H., Heath, Andrew C., Wright, Alan, Polasek, Ozren, Kovacevic, Sanja B., Hastie, Nicholas D., Franke, Barbara, Boomsma, Dorret I., Martin, Nicholas G., Rujescu, Dan, Wilson, James F., Buitelaar, Jan, Pendleton, Neil, Rudan, Igor and Deary, Ian J. (2012) Genome-wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B 6: 684-695. doi:10.1002/ajmg.b.32072

  • Lamb, Diane J., Middeldorp, Christel M., Van Beijsterveldt, Catarina E. M. and Boomsma, Dorret I. (2012) Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins. Journal of Child Psychology and Psychiatry, 53 8: 818-825. doi:10.1111/j.1469-7610.2011.02497.x

  • Brandys, Marek K., Landt, Margarita C. T. Slof-Op't, van Elburg, Annemarie A., Ophoff, Roel, Verduijn, Willem, Meulenbelt, Ingrid, Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, Eline, Kas, Martien J. H. and Adan, Roger A. H. (2012) Anorexia nervosa and the Val158Met polymorphism of the COMT gene: Meta-analysis and new data. Psychiatric Genetics, 22 3: 130-136. doi:10.1097/YPG.0b013e328351859e

  • Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J., McMahon, George, Mentch, Frank D., Müller-Nurasyid, Martina, O'Reilly, Paul F., Prokopenko, Inga, Rivadeneira, Fernando, Steegers, Eric A. P., Sunyer, Jordi, Tiesler, Carla, Yaghootkar, Hanieh, Breteler, Monique M. B., Debette, Stéphanie, Fornage, Myriam, Gudnason, Vilmundur, Launer, Lenore J., van der Lugt, Aad, Mosley Jr., Thomas H., Seshadri, Sudha, Smith, Albert V., Vernooij, Meike W., Blakemore, Alexandra I. F., Chiavacci, Rosetta M., Feenstra, Bjarke, Fernandez-Banet, Julio, Grant, Struan F. A., Hartikainen, Anna-Liisa, van der Heijden, Albert J., Iñiguez, Carmen, Lathrop, Mark, McArdle, Wendy L., Mølgaard, Anne, Newnham, John P., Palmer, Lyle J., Palotie, Aarno, Pouta, Annneli, Ring, Susan M., Sovio, Ulla, Standl, Marie, Uitterlinden, Andre G., Wichmann, H.-Erich, Vissing, Nadja Hawwa, DeCarli, Charles, van Duijn, Cornelia M., McCarthy, Mark I., Koppelman, Gerard H., Estivill, Xavier, Hattersley, Andrew T., Melbye, Mads, Bisgaard, Hans, Pennell, Craig E., Widen, Elisabeth, Hakonarson, Hakon, Smith, George Davey, Heinrich, Joachim, Jarvelin, Marjo-Riitta, Jaddoe, Vincent W. V., The Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE ) Consortium, The Early Genetics & Lifecourse Epidemiology (EAGLE ) Consortium, Coin, Lachlan and Middeldorp, Christel (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 5: 532-538. doi:10.1038/ng.2238

  • Webb, Bradley T., Guo, An-Yuan, Maher, Brion S., Zhao, Zhongming, van den Oord, Edwin J., Kendler, Kenneth S., Riley, Brien P., Gillespie, Nathan A., Prescott, Carol A., Middeldorp, Christel M., Willemsen, Gonneke, de Geus, Eco J. C., Hottenga, Jouke-Jan, Boomsma, Dorret I., Slagboom, Eline P., Wray, Naomi R., Montgomery, Grant W., Martin, Nicholas G., Wright, Margie J., Heath, Andrew C., Madden, Pamela A., Gelernter, Joel, Knowles, James A., Hamilton, Steven P., Weissman, Myrna M., Fyer, Abby J., Huezo-Diaz, Patricia, McGuffin, Peter, Farmer, Anne, Craig, Ian W., Lewis, Cathryn, Sham, Pak, Crowe, Raymond. R., Flint, Jonathan and Hettema, John M. (2012) Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics, 20 10: 1078-1084. doi:10.1038/ejhg.2012.47

  • Lamb, Diane J., Vink, Jacqueline M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Haak, Monique C., Overbeek, Lucy I. H. and Boomsma, Dorret I. (2012) Effects of chorionicity and zygosity on triplet birth weight. Twin Research and Human Genetics, 15 2: 149-157. doi:10.1375/twin.15.2.149

  • Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stephanie, Vrooman, Henri A., Sigurdsson, S., Ropele, Sigurdur, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., Destefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack,Clifford R., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J., Jarvelin, Marjo-Riitta, Mccarthy, Mark I., Grant, Struan F. A., St Pourcain, Beate, Timpson, Nicholas J., Smith, George D., Sovio, Ulla, Nalls, Mike A., Au, Rhoda, Hofman, Albert, Gudnason, Haukur, Van Der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., Van Buchem, Mark A., Catellier, Diane, Jaddoe, Vincent W. V., Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., Van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., Decarli, Charles, Early Growth Genetics (EGG) Consortium, Coin, Lachlan, Middeldorp, Christel and . (2012) Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 5: 539-544. doi:10.1038/ng.2245

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2012) Crying Without a Cause and Being Easily Upset in Two-Year-Olds: Heritability and Predictive Power of Behavioral Problems-Corrigendum. Twin Research and Human Genetics, 16 2: 650-650.

  • Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., MacLean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., De Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., Van Den Oord, E. J. C. G., Liu, J. Z., MacGregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Madden, P. A. F. and Sullivan, P. F. (2012) Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular Psychiatry, 17 1: 36-48. doi:10.1038/mp.2010.109

  • Distel, Marijn A., Carlier, Angela, Middeldorp, Christel M., Derom, Catherine A., Lubke, Gitta H. and Boomsma, Dorret I. (2011) Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity. American Journal of Medical Genetics Part B - Neuropsychiatric Genetics, 156 7: 817-825. doi:10.1002/ajmg.b.31226

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011) Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child and Adolescent Psychiatry, 50 12: 1247-1254. doi:10.1016/j.jaac.2011.09.007

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011) Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems. Twin Research and Human Genetics, 14 5: 393-400. doi:10.1375/twin.14.5.393

  • Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Haak, Monique C. and Boomsma, Dorret I. (2011) Birth weight in a large series of triplets. BMC Pediatrics, 11 24.1-24.11. doi:10.1186/1471-2431-11-24

  • Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G. and Boomsma, D. I. (2011) Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation. Psychological Medicine, 41 4: 849-860. doi:10.1017/S0033291710001297

  • Slof-Op't Landt, M. C. T. , Meulenbelt, I., Bartels, M., Suchiman, E., Middeldorp, C. M., Houwing-Duistermaat, J. J., van Trier, J., Onkenhout, E. J., Vink, J. M., van Beijsterveldt, C. E. M., Brandys, M. K., Sanders, N., Zipfel, S., Herzog, W., Herpertz-Dahlmann, B., Klampfl, K., Fleischhaker, C., Zeeck, A., de Zwaan, M., Herpertz, S., Ehrlich, S., van Elburg, A. A., Adan, R. A. H., Scherag, S., Hinney, A., Hebebrand, J., Boomsma, D. I., van Furth, E. F. and Slagboom, P. E. (2011) Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes, Brain and Behavior, 10 2: 236-243. doi:10.1111/j.1601-183X.2010.00660.x

  • Bartels, Meike, van de Aa, Niels, van Beijsterveldt, Catherina E. M., Middeldorp, Christel M. and Boomsma, Dorret I. (2011) Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age. Canadian Academy of Child and Adolescent Psychiatry, 20 1: 35-52.

  • Demirkan, A., Phenninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlanden, A. G., Hottenga, J.-J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. and Middeldorp, C. M. (2011) Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16 7: 773-783. doi:10.1038/mp.2010.65

  • van Beijsterveldt, Catherina E. M., Middeldorp, Christel M., Landt, Margarita C. T. Slof-Op't, Bartels, Meike, Hottenga, Jouke-Jan, Suchiman, H. Eka D., Slagboom, P. Eline and Boomsma, Dorret I. (2011) Influence of candidate genes on attention problems in children: a longitudinal study. Behavior Genetics, 41 1: 155-164. doi:10.1007/s10519-010-9406-5

  • Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, D. R., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J-J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A, Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davis, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, Grant G., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Raikkonen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. and Boomsma, D. I. (2011) The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1 e50.1-e50.8. doi:10.1038/tp.2011.45

  • Kendler, Kenneth S., Eaves, Lindon J., Loken, Erik K., Pedersen, Nancy L., Middeldorp, Christel M., Reynolds, Chandra, Boomsma, Dorret, Lichtenstein, Paul, Silberg, Judy and Gardner, Charles O. (2011) The impact of environmental experiences on symptoms of anxiety and depression across the life span. Psychological Science, 22 10: 1343-1352. doi:10.1177/0956797611417255

  • Perlis, Roy H., Huang, Jie, Purcell, Shaun, Fava, Maurizio, Rush, A. John, Sullivan, Patrick F., Hamilton, Steven P., McMahon, Francis J., Schulze, Thomas, Potash, James B., Zandi, Peter P., Willour, Virginia L., Penninx, Brenda W., Boomsma, Dorret I., Vogelzangs, Nicole, Middeldorp, Christel M., Rietschel, Marcella, Noethen, Markus, Cichon, Sven, Gurling, Hugh, Bass, Nick, McQuillin, Andrew, Hamshere, Marian, Craddock, Nick, Sklar, Pamela and Smoller, Jordan W. (2010) Genome-wide association study of suicide attempts in mood disorder patients. American Journal of Psychiatry, 167 12: 1499-1507. doi:10.1176/appi.ajp.2010.10040541

  • Middeldorp, Christel M., de Geus, Eco J. C., Willemsen, Gonneke, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2010) The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Research and Human Genetics, 13 6: 544-549. doi:10.1375/twin.13.6.544

  • Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., Hottenga, J. -J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., Neale, M. C., Slagboom, P. E. and Boomsma, D. I. (2010) Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?. Genes, Brain and Behavior, 9 7: 808-816. doi:10.1111/j.1601-183X.2010.00619.x

  • Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catarina E. M., Bartels, Meike, van der Aa, Niels, Polderman, Tinca J. C. and Boomsma, Dorret I. (2010) Heritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 49 3: 248-255. doi:10.1016/j.jaac.2009.11.014

  • Middeldorp, Christel M., Vink, Jacqueline M., Hettema, John M., de Geus, Eco J. C., Kendler, Kenneth S., Willemsen, Gonneke, Neale, Michael C., Boomsma, Dorret I. and Chen, Xiangning (2010) An association between Epac-1 gene variants and anxiety and depression in two independent samples. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 153 1: 214-219. doi:10.1002/ajmg.b.30976

  • Franic, Sanja, Middeldorp, Christel M., Dolan, Conor V., Ligthart, Lannie and Boomsma, Dorret I. (2010) Childhood and adolescent anxiety and depression: Beyond heritability. Journal of the American Academy of Child and Adolescent Psychiatry, 49 8: 820-829. doi:10.1016/j.jaac.2010.05.013

  • Middeldorp, C. M., Cath, D. C., Beem, A. L., Willemsen, G. and Boomsma, D. I. (2008) Life events, anxious depression and personality: A prospective and genetic study. Psychological Medicine, 38 11: 1557-1565. doi:10.1017/S0033291708002985

  • Middeldorp, CM, Sullivan, PF, Wray, NR, Hottenga, JJ, de Geus, EJC, van den Berg, M, Montgomery, GW, Coventry, WL, Statham, DJ, Andrews, G, Slagboom, PE, Boomsma, DI and Martin, NG (2008) Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B 3: 352-358. doi:10.1002/ajmg.b.30817

  • Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., Hettema, J. M., An, S. S., Neale, M. C., van den Oord, E. J., Kendler, K. S., Chen, X., Boomsma, D. I., Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E. and Flint, J. (2008) A whole genome association study of neuroticism using DNA pooling. Molecular Psychiatry, 13 3: 302-312. doi:10.1038/sj.mp.4002048

  • Wray, Naomi R., Middeldorp, Christel M., Birley, Andrew J., Gordon, Scott D., Sullivan, Patrick F., Visscher, Peter M., Nyholt, Dale R, Willemsen, Gonneke, de Geus, Eco J.C., Slagboom, P. Eline, Montgomery, Grant W., Martin, Nicholas G. and Boomsma, Dorret I. (2008) Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Archives of General Psychiatry, 65 6: 649-658. doi:10.1001/archpsyc.65.6.649

  • Distel, Marijn A., Vink, Jacqueline M., Willemsen, Gonneke, Middeldorp, Christel M., Merckelbach, Harald L. G. J. and Boomsma, Dorret I. (2008) Heritability of self-reported phobic fear. Behavior Genetics, 38 1: 24-33. doi:10.1007/s10519-007-9182-z

  • Middeldorp, C. M., Hottenga, J-J, Slagboom, P. E., Sullivan, P. F., de Geus, E. J. C., Posthuma, D., Willemsen, G. and Boomsma, D. I. (2008) Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Molecular Psychiatry, 13 1: 84-89. doi:10.1038/sj.mp.4002061

  • Middeldorp, Christel M., de Geus, Eco J. C., Beem, A. Leo, Lakenberg, Nico, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2007) Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behavior Genetics, 37 2: 294-301. doi:10.1007/s10519-006-9139-7

  • Middeldorp, CM, Cath, DC and Boomsma, DI (2006) A twin-family study of the association between employment, burnout and anxious depression. Journal of Affective Disorders, 90 2-3: 163-169. doi:10.1016/j.jad.2005.11.004

  • Middledorp, Christel M., Birley, Andrew J., Cath, Danielle C., Gillespie, Nathan A., Willemsen, Gonneke, Statham, Dixie J., de Geus, Eco J. C., Andrews, J. Gavin, van Dyck, Richard, Beem, A. Leo, Sullivan, Patrick F., Martin, Nicholas G. and Boomsma, Dorret I. (2005) Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. Twin Research and Human Genetics, 8 6: 609-615. doi:10.1375/183242705774860123

  • Middeldorp, CM, Cath, DC, Vink, JM and Boomsma, DI (2005) Twin and genetic effects on life events. Twin Research and Human Genetics, 8 3: 224-231. doi:10.1375/1832427054253130

  • Middeldorp, CM, Cath, DC, Van Dyck, R and Boomsma, DI (2005) The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychological Medicine, 35 5: 611-624. doi:10.1017/S003329170400412X

  • Middeldorp, CM, Stubbe, JH, Cath, DC and Boomsma, DI (2005) Familial clustering in burnout: A twin-family study. Psychological Medicine, 35 1: 113-120. doi:10.1017/S0033291704002983

  • Vink, JM, Willemsen, G, Stubbe, JH, Middeldorp, CM, Ligthart, RSL, Baas, KD, Dirkzwager, HJC, de Geus, EJC and Boomsma, DI (2004) Estimating non-response bias in family studies: Application to mental health and lifestyle. European Journal of Epidemiology, 19 7: 623-630.

  • Middeldorp, CM, Geerts, AT, Brouwer, TF, Peters, ACB, Stroink, H, van Donselaar, CA and Arts, WFM (2002) Nonsymptomatic generalized epilepsy in children younger than six years: Excellent prognosis, but classification should be reconsidered after follow-up: The Dutch Study of Epilepsy in Childhood. Epilepsia, 43 7: 734-739. doi:10.1046/j.1528-1157.2002.72601.x

Conference Publication

  • Porsch, Robert, Middeldorp, Christel, Cherny, Stacey, Krapohl, Eva, van Beijsterveldt, Catherina, Loukola, Anu, Korhonen, Tellervo, Pulkkinen, Lea, Corley, Robin, Rhee, Soo, Kaprio, Jaakko, Rose, Richard, Hewitt, John, Sham, Pak, Plomin, Robert, Boomsma, Dorret and Bartels, Meike (2016). A cross-cultural comparison of the longitudinal heritability of childhood aggression. In: 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, (802-802). Jun 20-23, 2016.

  • Wesseldijk, Laura, Fedko, Iryna, Bartels, Meike, Nivard, Michel, Hottenga, Jouke-Jan, van Beijsterveldt, Catherina, Boomsma, Dorret and Middeldorp, Christel (2016). Differences in maternal and paternal ratings of psychopathology and the genetic epidemiology in 12,000 7-year old twin pairs. In: 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, (813-814). Jun 20-23, 2016.

  • Conde, Lucia Colodro, Martin, Nicholas, Hatemi, Peter, Boomsma, Dorret, Middeldorp, Christel, van Beijsterveldt, Toos, Bartels, Meike and Medland, Sarah (2016). Heritability of different aggression phenotypes in an Australian and a Dutch cohort. In: 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, (776-777). Jun 20-23, 2016.

  • Walters, Raymond, Mattheisen, Manuel, Demontis, Ditte, Daly, Mark, Borglum, Anders, Faraone, Stephen, Middeldorp, Christel, Boomsma, Dorret and Neale, Benjamin (2016). Integrating GWAS of ADHD and continuous ADHD-related traits. In: 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, (812-813). Jun 20-23, 2016.

  • Nivard, Michel, Middeldorp, Christel, Hottenga, Jouke-Jan, Fedko, Iryna, Ehli, Erik, Davies, Gareth, van Beijsterveldt, Catherina, Bartels, Meike and Boomsma, Dorret (2016). Multivariate and repeated measure GWAS of aggression phenotypes. In: 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, (798-799). Jun 20-23, 2016.

  • Bot, M., Middeldorp, C., de Geus, E., Lau, H. M., Sinke, M., van Nieuwenhuizen, B., Smit, J., Boomsma, D. and Penninx, B. (2016). Self-reported online assessment of lifetime major depressive disorder: a validation study. In: 18th Annual Conference of the International-Society-for-Bipolar-Disorders / 8th Biennial Conference of the International-Society-for-Affective-Disorders, Amsterdam, Netherlands, (128-128). Jul 13-16, 2016.

  • Miller, Patrick, Verhulst, Brad, Bartels, Meike, van Beijsterveldt, Toos, Willemsen, Gonneke, Boomsma, Dorret, Middeldorp, Christel and Lubke, Gitta (2015). Choosing a powerful depression phenotype: trajectories of anxiety and depression between age 7 and age 18 and the influence of genetic factors in Dutch twins. In: Behavior Genetics. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, (674-674). Jun 20, 2015.

  • Boomsma, Dorret, van den Berg, Stephanie, Abdellaoui, Abdel, de Geus, Eco, Willemsen, Gonneke, Hottenga, Jouke-Jan, Middeldorp, Christel, Milaneschi, Yuri, Nivard, Michel, Vink, Jacqueline, Bartels, Meike, Van Grootheest, Gerard, Penninx, Brenda and de Moor, Marleen (2015). Prediction from polygenic scores based on GWA of Neuroticism to psychiatric and lifestyle traits. In: Behavior Genetics. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, (644-644). Jun 20, 2015.

  • Nivard, Michel, Dolan, Conor, Peyrot, Wouter, Abdellaoui, Abdel, Hottenga, Jouke-Jan, Middeldorp, Christel and Boomsma, Dorret (2015). Rapid genetic (co) variance estimation based on measured SNPs applied to item level data. In: Behavior Genetics. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, (676-676). Jun 20, 2015.

  • Lindauer, R., Brilleslijper-kater, S., Diehle, J., Verlinden, E., Teeuw, A., Middeldorp, C., Tuinebreijer, W., Bosschaart, T., Van Duin, E. and Verhoeff, A. (2015). The Amsterdam sexual abuse case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet. In: European Child & Adolescent Psychiatry. , , (S274-S275). .

  • Middeldorp, Christel, Wesseldijk, Laura, Lindauer, Ramon, Batelaan, Neeltje, Verhulst, Frank, Boomsma, Dorret and Dieleman, Gwen (2014). Spouse and parent-offspring correlations for psychiatric symptoms in a clinical sample. In: Behavior Genetics. 44th Annual Meeting of the Behavior-Genetics-Association, Charlottesville Va, (672-673). Jun 18-21, 2014.

  • Groen-Blokhuis, Maria, Whitehouse, Andrew, Tiemeier, Henning, Pappa, Irene, Jugessur, Astanand, McGue, Matthew, Hinney, Anke, St Pourcain, Beate, Tiesler, Carla, Trzaskowski, Maciej, Bustamante, Mariona, Middeldorp, Christel and Boomsma, Dorret (2013). Meta-analysis of genome-wide association studies on ADHD: A dimensional approach. In: Behavior Genetics. 43rd Annual Meeting of the Behavior-Genetics-Association, Marseille France, (520-521). Jun 28-Jul 02, 2013.

  • Middeldorp, Christel, Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Scheet, Paul, Nivard, Michel, van Beijsterveldt, Toos, Bartels, Meike, Vink, Jacqueline, de Geus, Eco, Willemsen, Gonneke, Hudziak, Jim and Boomsma, Dorret (2012). Are symptoms of anxiety and depression during childhood and adolescence influenced by similar genetic factors as major depression in adulthood?. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (954-954). Jun 22-25, 2012.

  • Nivard, Michel, van der Sluis, Sophie, Franic, Sanja, Cramer, Angelique, Visser, Ingmar, Middeldorp, Christel, Lubke, Gitta, Boomsma, Dorret and Borsboom, Denny (2012). Phenotypic complexity as genetic dark matter: A network explanation of missing heritability. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (958-958). Jun 22-25, 2012.

  • Lamb, Diane, Middeldorp, Christel, Vink, Jacqueline, van Beijsterveldt, Toos, Lindauer, Ramon and Boomsma, Dorret (2012). Short and long-term effects of nonparental child care on internalizing and externalizing problems: A behavior genetic study in Dutch twins. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (946-946). Jun 22-25, 2012.

  • Abdellaoui, Abdel, Bartels, Meike, Boomsma, Dorret, Davies, Gareth, Dolan, Conor, Geels, Lot, Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Kendler, Kenneth, Middeldorp, Christel, Nivard, Michel, Scheet, Paul, Sullivan, Patrick, van Beek, Jenny, van Beijsterveldt, Toos and Willemsen, Gonneke (2012). Stability and change in anxious depression as a function of genes and environment. A longitudinal twin and GWA study from age 3 to 65 years. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (915-915). Jun 22-25, 2012.

  • Groen-Blokhuis, Maria, de Graaff, Jurgen, Bartels, Meike, Duran, Maryse, van Beijsterveldt, Toos, Kalkman, Cor, Middeldorp, Christel and Boomsma, Dorret (2012). The influence of early anesthesia exposure on ADHD. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (936-936). Jun 22-25, 2012.

  • Breen, Gerome, Alsabban, Shaza, Nivard, Michel and Middeldorp, Christel (2012). What have modern genetic studies told us about depression?. In: Behavior Genetics. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, (921-921). Jun 22-25, 2012.

  • Distel, Marijn A., Middeldorp, Christel M., Willemsen, Gonneke, Trull, Timothy J., Derom, Catherine A. and Boomsma, Dorret I. (2009). Life events and borderline personality disorder. In: Behavior Genetics. 39th Annual Meeting of the Behavior-Genetics-Association, Mineapolis Mn, (646-646). Jun 17-20, 2009.

  • Middeldorp, Christel, Hottenga, Jouke Jan, Slagboom, P. Eline, Sullivan, Patrick F., Beem, A. Leo, Willemsen, Gonneke and Boomsma, Dorret I. (2006). Significant linkage on chromosome 14 for anxiety. In: American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 14th World Congress on Psychiatric Genetics, Cagliari Italy, (725-726). Oct 28-Nov 01, 2006.

  • Middeldorp, CM, Cath, DC, Beem, AL and Boomsma, DI (2004). Genetic epidemiology of depression in a selected population of Dutch twins and their siblings. In: Behavior Genetics. 34th Annual Meeting of the Behavior-Genetics-Association, Aix en Provence France, (652-653). Jun 27-30, 2004.

  • Middeldorp, CM, Ruigrok, P, Cath, DC, Van Dyck, R and Boomsma, DI (2002). Candidate genes for mood disorders in humans. A literature review. In: American Journal of Medical Genetics. 10th World Congress of Psychiatric Genetics, Brussels Belgium, (768-768). Oct 09-13, 2002.