The University of Queensland

Synthesis and evaluation of novel purple acid phosphatase inhibitors

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019) Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 1: 61-71. doi:10.1039/c8md00491a

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

Khongkow, Mattaka, Liu, Tzu-yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018) Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 3: 183-193. doi:10.33218/prnano1(3).181003.1

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

Khongkow, Mattaka, Liu, Tzu-Yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018) Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 3: 186-196. doi:10.29016/181025.1

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018) Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157 462-479. doi:10.1016/j.ejmech.2018.08.004

Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2

Hussein, Waleed M., Choi, Phil M., Zhang, Cheng, Sierecki, Emma, Johnston, Wayne, Jia, Zhongfan, Monteiro, Michael J., Skwarczynski, Mariusz, Gambin, Yann and Toth, Istvan (2018) Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2. AIMS Allergy and Immunology, 2 3: 141-147. doi:10.3934/allergy.2018.3.141

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

Nevagi, Reshma J., Khalil, Zeinab G., Hussein, Waleed M., Powell, Jessica, Batzloff, Michael R., Capon, Robert J., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2018) Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomaterialia, 80 278-287. doi:10.1016/j.actbio.2018.09.037

Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer

Hussein, Waleed M., Mukaida, Saori, Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2017) Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer. Vaccination Research Open Journal, 1 1: 39-44. doi:10.17140/VROJ-1-107

Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties

Fagan, Vincent, Hussein, Waleed M., Su, Mei, Gidda, Ashwini K., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Simerska, Pavla (2017) Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties. ChemBioChem, 18 6: 545-553. doi:10.1002/cbic.201600639

Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines

Hussein, Waleed M., Mukaida, Saori, Azmi, Fazren, Bartlett, Stacey, Olivier, Celine, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017) Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines. ACS Medicinal Chemistry Letters, 8 2: 227-232. doi:10.1021/acsmedchemlett.6b00453

Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus

Hussein, Waleed M., Xu, Jiaxin, Simerska, Pavla and Toth, Istvan (2017) Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus. Australian Journal of Chemistry, 70 2: 184-190. doi:10.1071/CH16501

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery

Marasini, Nirmal, Giddam, Ashwini K., Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Skwarczynski, Mariusz (2016) Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery. Nanomedicine, 11 24: 3223-3235. doi:10.2217/nnm-2016-0291

Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus

Marasini, Nirmal, Khalil, Zeinab G., Giddam, Ashwini K., Abdul Ghaffar, Khairunnisa, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016) Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. International Journal of Pharmaceutics, 513 1-2: 410-420. doi:10.1016/j.ijpharm.2016.09.057

Linear and branched polyacrylates as a delivery platform for peptide-based vaccines

Chandrudu, Saranya, Bartlett, Stacey, Khalil, Zeinab G., Jia, Zhongfan, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2016) Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery, 7 9: 601-609. doi:10.4155/tde-2016-0037

Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer

Hussein, Waleed M., Liu, Tzu-Yu, Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2016) Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer. Bioorganic & Medicinal Chemistry, 24 18: 4372-4380. doi:10.1016/j.bmc.2016.07.036

Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1

Arjomandi, Omid Khalili, Hussein, Waleed M., Vella, Peter, Yusof, Yusralina, Sidjabat, Hanna E., Schenk, Gerhard and McGeary, Ross P. (2016) Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1. European Journal of Medicinal Chemistry, 114 318-327. doi:10.1016/j.ejmech.2016.03.017

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2016) Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chemical Science, 7 4: 2492-2500. doi:10.1039/C5SC04392A

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2016) Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines. Chemical Science, 7 3: 2308-2321. doi:10.1039/C5SC03859F

Evaluation of lipopeptides as toll-like receptor 2 ligands

Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan and Simerska, P. (2016) Evaluation of lipopeptides as toll-like receptor 2 ligands. Current Drug Delivery, 14 7: 935-943. doi:10.2174/1567201813666160804114107

Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates

Chan, Amy, Hussein, Waleed M., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Mostafa, Ahmed, Eskandari, Sharareh, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016) Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorganic and Medicinal Chemistry, 24 14: 3095-3101. doi:10.1016/j.bmc.2016.03.063

Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors

Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015) Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 23: 5570-5575. doi:10.1016/j.bmcl.2015.10.049

Levofloxacin and indolicidin for combination antimicrobial therapy

Ghaffar, Khairunnisa Abdul, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2015) Levofloxacin and indolicidin for combination antimicrobial therapy. Current Drug Delivery, 12 1: 108-114. doi:10.2174/1567201811666140910094050

Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine

Liu, Tzu-Yu, Hussein, Waleed M., Giddam, Ashwini Kumar, Jia, Zhongfan, Reiman, Jennifer M., Zaman, Mehfuz, McMillan, Nigel A. J., Good, Michael F., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015) Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine. Journal of Medicinal Chemistry, 58 2: 888-896. doi:10.1021/jm501514h

Self-Adjuvanting Therapeutic Peptide-Based Vaccine Induce CD8+ Cytotoxic T Lymphocyte Responses in a Murine Human Papillomavirus Tumor Model

Liu, Tzu-Yu, Giddam, Ashwini Kumar, Hussein, Waleed M., Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015) Self-Adjuvanting Therapeutic Peptide-Based Vaccine Induce CD8+ Cytotoxic T Lymphocyte Responses in a Murine Human Papillomavirus Tumor Model. Current Drug Delivery, 12 1: 3-8. doi:10.2174/1567201811666141001155729

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015) Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 22: 3359-3371. doi:10.2217/nnm.15.137

Use of ethyl (benzothiazol-2-ylsulfonyl)acetate for malonic ester-type syntheses of carboxylic acids and esters

Hussein, Waleed M. and McGeary, Ross P. (2014) Use of ethyl (benzothiazol-2-ylsulfonyl)acetate for malonic ester-type syntheses of carboxylic acids and esters. Australian Journal of Chemistry, 67 8-9: 1222-1227. doi:10.1071/CH14085

A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation

Christie, Michelle P., Simerská, Pavla, Jen, Freda E.-C., Hussein, Waleed M., Rawi, Mohamad F. M., Hartley-Tassell, Lauren E., Day, Christopher J., Jennings, Michael P. and Toth, Istvan (2014) A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. PLoS One, 9 4: e95024.1-e95024.10. doi:10.1371/journal.pone.0095024

Toll-like receptor agonists: a patent review (2011 - 2013)

Hussein, Waleed M., Liu, Tzu-Yu, Skwarczynski, Mariusz and Toth, Istvan (2014) Toll-like receptor agonists: a patent review (2011 - 2013). Expert Opinion on Therapeutic Patents, 24 4: 453-470. doi:10.1517/13543776.2014.880691

Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer

Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013) Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 8: 2798-2806. doi:10.1021/bm400626w

Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method

Hussein, Waleed M., Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2013) Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Organic and Biomolecular Chemistry, 11 14: 2370-2376. doi:10.1039/c3ob00030c

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012) Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 5: 665-674. doi:10.1111/j.1747-0285.2012.12001.x

Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives

Varamini, Pegah, Hussein, Waleed M., Mansfeld, Friederike M. and Toth, Istvan (2012) Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives. Bioorganic & Medicinal Chemistry, 20 21: 6335-6343. doi:10.1016/j.bmc.2012.09.003

Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Hussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012) Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 4: 500-515. doi:10.1111/j.1747-0285.2012.01440.x

Advances in peptide-based Human papillomavirus therapeutic vaccines

Liu, Tzu-Yu, Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2012) Advances in peptide-based Human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry, 12 14: 1581-1592. doi:10.2174/156802612802652402

2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications

Wu, Feng-Ling, Hussein, Waleed M., Ross, Benjamin P. and McGeary, Ross P. (2012) 2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications. Current Organic Chemistry, 16 13: 1555-1580. doi:10.2174/138527212800840964

Penicillin inhibitors of purple acid phosphatase

Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012) Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 7: 2555-2559. doi:10.1016/j.bmcl.2012.01.123

3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors

Faridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012) 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 1: 380-386. doi:10.1016/j.bmcl.2011.10.116

Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Mohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011) Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 12: 6075-6082. doi:10.1016/j.ejmech.2011.10.030

The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening

Vella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011) The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 11: 3282-3285. doi:10.1016/j.bmcl.2011.04.027

Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase

Mohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011) Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 10: 3092-3094. doi:10.1016/j.bmcl.2011.03.024

Molecular packing of functionalized fluorinated lipids in langmuir mono layers

Landsberg, MJ, Ruggles, JL, Hussein, WM, McGeary, RP, Gentle, IR and Hankamer, B (2010) Molecular packing of functionalized fluorinated lipids in langmuir mono layers. Langmuir, 26 24: 18868-18873. doi:10.1021/la103743e

Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations

Hussein, Waleed M., Ross, Benjamin P., Landsberg, Michael J., Levy, Daniel, Hankamer, Ben and McGeary, Ross P. (2009) Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations. Journal of Organic Chemistry, 74 4: 1473-1479. doi:10.1021/jo802651p

Synthetic approaches to functionalized lipids for protein monolayer crystallizations

Hussein. Waleed M., Ross, Benjamin P., Landsberg, M. J., Hankamer, B and McGeary, Ross P. (2009) Synthetic approaches to functionalized lipids for protein monolayer crystallizations. Current Organic Chemistry, 13 14: 1378-1405. doi:10.2174/138527209789055081

Synthesis of therapeutic vaccine against cervical cancer

Skwarczynski, Mariusz, Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J. and Toth, Istvan (2014). Synthesis of therapeutic vaccine against cervical cancer. In: Yuji Nishiuchi and Tadashi Teshima, Peptide Science 2013: Proceedings of the 4th Asia-Pacific International Peptide Symposium held in conjunction with the 50th Japanese Peptide Symposium. 4th Asia-Pacific International Peptide Symposium in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan, (65-68). 6-8 November 2013.

Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations

Waleed Hussein (2009). Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations PhD Thesis, School of Chemistry and Molecular Bioscience, The University of Queensland.