Dr Stefanie Hennig

Lecturer

School of Pharmacy
Faculty of Health and Behavioural Sciences
s.hennig@uq.edu.au
+61 7 334 61970

Overview

My research focuses on the application of pharmacometric methods. Pharmacometrics is the quantitative description of the behaviour of drugs in the body and their effect size using mathematical models to be able to improve personalised dosing strategies and consequently improving therapy outcomes.

Most of my research involves the analysis of big data, pooled data and longitudinal data overarching several therapeutic areas, including cystic fibrosis, tuberculosis, infectious disease and oncology.

I graduated as a Pharmacist with a Masters of Science degree at the Ernst-Moritz-Arndt-University in Greifswald, Germany in 2001. After working in pharmacies throughout Germany, I started working at the Royal Children's Hospital ( now Lady Cilento Children's Hopsital) in Brisbane while graduating with a PhD at the University of Queensland in 2006. I established more appropriate dosing schedules of antimicrobial drugs in cystic fibrosis patients, particularly in children, using a population modelling approach. Afterwards, I was a postdoctoral fellow at UQ and at the Uppsala University in Sweden, where I worked, learned and taught with Prof. Mats Karlsson and his group, who leads arguably one of the largest and most renowned groups world wide in the pharmacokinetic and pharmacodynamic (PKPD) modeling and simulation area. This has given me an excellent background and specific technical knowledge in pharmacometric PKPD modeling and simulation and optimal design.

Stefanie joined the School of Pharmacy in 2011 as a Lecturer, after returning from Sweden and has since then worked in areas of optimal design, pharmacokinetic projects on several antimircrobial agents, TB and HIV drugs as well as anticancer agents.

Research interests for future RhD students:

My research area is Pharmacometrics and applicable to any therapeutic area, in particular:

  • Concepts, methodology and application of population pharmacokinetic and pharmacodynamic modelling and simulation approach (Pharmacometrics)
  • Application of optimal experimental design theory to improve clinical trial design.

RHD students will be trained in:

  • the area of pharmacokinetic and pharmacodynamic modelling and simulation and optimal experimental design reaching from clinical questions to drug discovery
  • Programs that are used by students in my group include (but are not limited to): NONMEM, PsN , WFN, Xpose, R, Pirana, Berkley Madonna, PopED, WinPOPT, Monolix
  • Students in this group have been attending a variety of conferences including: PAGE, PAGANZ, ASCEPT, WCOP
  • Researchers trained in the pharmacometric area are highly sought after in academia and even more so in the pharmaceutical industry and will have the unique opportunity to change patients care in a clinical setting with their gained knowledge.
  • I encourage honours, postgraduate students and post-doctoral researchers from a diverse array of backgrounds including Pharmacy, Science, Engineering, Pharmacology, Biotechnology and Health Science to contact her via email or phone to discuss research opportunities.

Current Team Members

  • Carolina Consuelo Llanos Paez (PhD student, BECAS-Chile (CONYCYT) Scholarship)
  • Rachael Lawson ( PhD student)
  • Yanhua Gao (BPharm student (Major Clin Ther))
  • Alzana Kumar (BPharm student (Major Clin Ther))

Previous Team Members/ Completed Students

  • Rani George (PhD student, Griffith University collaboration)
  • Sabariah Noor Harun (PhD student, Malaysian government scholarship)
  • Samantha Nelis (PhD student)
  • Sudeep Bista (PhD student, Griffith University collaboration)
  • Christina Chau (MClinPharm student)
  • Sophie Paviour (BPharm (Postgrad Hon))
  • Yuan Tshao Beverly Teo (BPharm (1st Class Hon))
  • Marianne Fenton (Research officer)
  • Elisabet Størset (UQ Summer Research Student - Norway)
  • Franziska Stiller, Hana Starobova, Alexander Mueller (International Intern Students - Germany)
  • Celeste Bloomfield (BPharm (1st Class Hon))
  • Daniel Natanek (BPharm (1st Class Hon))
  • Violet Zhu (BPharm (Major Clin Ther, 1st class Hon))
  • Michael van Esdonk (International intern student, Masters in Bio-Pharmaceutical Sciences, from Leiden University, The Netherlands)
  • Lachlan Paterson (BPharm (Major Clin Ther, 1st class Hon))
  • Marc Burgard (International Intern Student - Germany, summa cum laude Diplomarbeit)

Research Interests

  • Pharmacometrics
    Quantitative data analysis describing the relationship between drug treatment, drug exposure and outcomes.
  • Pharmacokinetics
  • Pharmacodynamics
  • Optimal design of experimental and clinical studies

Research Impacts

My group's research has led to PKPD models that are now utilised in model-based therapeutic drug monitoring software for personalised dosing of drugs.

These results are in implemented in tools such as the open-source online software (TDMx), and several commercial software.

Here you can find our model on gentamicin PK in children with cancer available for personlised dosing and our model to optimise tobramycin dosing in patients with cystic fibrosis.

Qualifications

  • PhD, The University of Queensland
  • MSc, University of Greifswald
  • BPharm, University of Greifswald

Publications

View all Publications

Supervision

View all Supervision

Available Projects

View all Available Projects

Publications

Journal Article

Conference Publication

Other Outputs

  • Hennig, Stefanie (2006). Population pharmacokinetics of itraconazole PhD Thesis, School of Pharmacy, The University of Queensland.

  • Hennig, Stefanie and Klein, Kerenaftali : Balanced prior data. The University of Queensland. Dataset. doi:10.14264/uql.2016.141

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.