Professor Ian Brereton

Director, Research and Technology

Centre for Advanced Imaging
i.brereton@uq.edu.au
+61 7 336 54245

Overview

Director

Professor Ian Brereton is the Director (Research and Technology) of the Centre and is responsible for the high resolution NMR service. He has over 20 years experience in the application of NMR spectroscopy to the chemical and biomedical sciences. NMR is a key technology for determining the structures of molecules and visualising the anatomy of living tissue and microscopic structure, and has revolutionised chemistry, diagnostic medicine and structural biology. NMR is one of only two techniques available for determining the structures of proteins, providing the fundamental molecular information used in drug design programs.

Prof Brereton is the inaugural Director of the Queensland NMR Network, which received Smart State Research Facilities Funding (SSRFF) to establish a network of state-of-the-art, high field nuclear magnetic resonance (NMR) equipment, including the most powerful machine of its kind in the southern hemisphere – a 900 MHz high-resolution spectrometer. The facilities will allow researchers from universities, institutes and companies to carry out cutting-edge research in a broad range of fields, particularly focusing on biodiscovery, drug design, neuroscience and instrument development.

Research Interests

  • Queensland NMR Network
    NMR (Nuclear Magnetic Resonance) is a key technology for determining the structures of molecules and visualising the anatomy of living tissue and microscopic structure. It has revolutionised chemistry, physics, diagnostic medicine and structural biology. NMR is one of only two techniques available for determining the structures of proteins, providing the fundamental molecular information used in drug design programs. The Queensland Nuclear Magnetic Resonance Network is funded by a Smart State Research Facilities Fund (SSRFF) grant. QNN is a network of high field NMR equipment in Queensland which supports a developing biotechnology industry in this State. The facility allows researchers from universities, institutes and companies to carry out high-resolution structure determination, to support research in a broad range of fields, particularly biodiscovery, drug design, neuroscience, and instrument development. The facility attracts national and international researchers and establishes Queensland as a central hub for NMR spectroscopy research in Australia. QNN facilitates access by regional Queensland centres to world class research infrastructure.

Qualifications

  • B.Sc (Hons), S.Aust.
  • PhD, S.Aust.

Publications

View all Publications

Supervision

View all Supervision

Publications

Journal Article

Conference Publication

  • Cowin, Gary, Leong, Lilly, Mardon, Karine, Janke, Andrew, Vegh, Viktor and Brereton, Ian (2015). Simultaneous MRI-PET bladder imaging of 18F-FDG and Gd-Magnevist. In: Australian Society for Molecular Imaging, Melbourne, Australia, (). December 2015.

  • Tieng, Quang, Vegh, Viktor, Brereton, Ian M., Reutens, David and Yang, Zhengyi (2012). The use of inverse phase Fourier image to accommodate intensity inhomogeneities in medical image registration. In: Proceedings: CIMSiM 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation. 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation (CIMSiM), Kuantan, Malaysia, (276-281). 25 - 27 September 2012. doi:10.1109/CIMSim.2012.60

  • Kerbler, Georg, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2011). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 10th International Conference on Alzheimer's and Parkinson Diseases, Barcelona, Spain, (). 9-13 March 2011.

  • Georg Kerbler, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2010). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 3rd Brain Plasticity Symposium, Brisbane, Australia, (). 14-16 September 2010.

  • Keller, Marianne D., Kerbler, Georg, Hamlin, Adam S., Brereton, Ian and Coulson, Elizabeth J. (2010). Tractography in a Saporine Alzheimer's Disease mouse model. In: Proceedings of the 2010 World Molecular Imaging Congress. World Molecular Imaging Conference in Kyoto, Japan, Kyoto, Japan, (). 8-11 September 2010.

  • Tieng, Q. M., Vegh, V. and Brereton, I. M. (2008). Minimum stored energy (MSE)compact superconducting magnets. In: 2008 Nuclear Science Symposium, Medical Imaging Conference and 16th Room Temperature Semiconductor Detector Workshop, Dresden, Germany, (). 19-25 Oct 2008.

  • Vegh, V., Brereton, I. M. and Galloway, G. (2008). Novel numerical modelling of lumped circuit elements in RF coils for identifying resonant frequencies. In: ISMRM-ESMRMB Joint Annual Meeting 2007. ISMRM-ESMRMB Joint Annual Meeting 2007, Berlin, Germany, (3248-3248). 19-25 May 2007.

  • Tucker, D. J., Lamb, D. L., Powell, K. S., Blanchfield, A. L. and Brereton, I. M. (2007). Detection of Phylloxera infestation in grapevines by NMR methods. In: Kevin S. Powell and Carolyn J. Threthowan, Proceedings of the Third International Grapevine Phylloxera Symposium. III International Grapevine Phylloxera Symposium, Fremantle, Australia, (173-181). 2-7 October 2005. doi:10.17660/ActaHortic.2007.733.19

  • Vegh, Viktor, Zhao, Huawei, Galloway, Graham J. and Brereton, Ian M. (2007). Tapered Head Gradient Coil Design Using the Wave Equation Method. In: Joint Annual Meeting International Symposium on Magnetic Resonance in Medicine (ISMRM) - ESMRMB, Berlin, Germany, (1015-1015). 19-25 May 2007.

  • Vegh, Viktor, Sanchez, Hector, Brereton, Ian M. and Crozier, Stuart (2007). Toward designing asymmetric head gradient coils for high-resolution imaging. In: Concepts In Magnetic Resonance Part B-magnetic Resonance Engineering . Proceedings of: 15th Scientific Meeting ISMRM. 15th Scientific Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Berlin, Germany, (1-11). 21 - 25 May, 2007. doi:10.1002/cmr.b.20082

  • Vegh, Viktor, Zhao, Huawei, Doddrell, David M., Galloway, Graham J. and Brereton, Ian M. (2006). A Flexible flow model for gradient coil design for the purpose of clinical MRI. In: ISMRM-2006 Proceedings. ISMRM 14th Scientific Meeting (ISMRM 2006), Seattle, Washington, USA, (671-671). 6-12 May 2006.

  • Cowin, Gary J., Weerasinghe, G., South, G., Tuck, A., Galloway, Graham J. and Brereton, Ian M. (2006). Contrast enhanced microimaging at 700 MHz. In: 45th Annual Meeting of the NMR Society of Japan, Kyoto, Japan, (). 22-24 October 2006.

  • Cowin, Gary J., Weerasinghe, G., South, S,, Tuck. A., Galloway, Graham J. and Brereton, Ian M. (2006). Contrast enhanced microimaging with Gd and Mn at 190 MHz and 700 MHz. In: Proceedings of: UWS Symposium and Workshop on NMR Imaging and Diffusion. UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, NSW, Australia, (). 21-22 October 2006.

  • Tucker, D., Brereton, I., Powell, K., Blanchfield, A., Murison, R. and Lamb, D. (2006). Detection of Phylloxera Infestation in Grape Vines using NMR methods. In: ANZMAG2006, Abstracts of the 6th Conference of the Australian and New Zealand Society for Magnetic Resonance. ANZMAG2006, Murramarang, New South Wales, (77-77). Feb 2006.

  • Kurniawan, N. D., Fox , B., Rogers, F., Butler, T., Li, L., Wallace, R., Cowin, G., Rose, S., Coulson, E., Galloway, G., Bartlett, P. F. and Brereton, I. M. (2006). Magnetic resonance neuroimaging at 16.4T. In: UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, Australia, (). 21-22 October 2006.

  • Talbot, Cavin Lee, Friese, Marlies Elly Joy, Rubensztein-Dunlop, Halina, Baldwin, Katie M., Whittaker, Andrew K., Brereton, Ian, Heckenberg, Norman R., Doddrell, David M. and Wang, Deming (2006). Using Laser Frequency Narrowing to Improve Production of Hyperpolarised Xe for Imaging and Surface Analysis. In: ISMRM-2006 Proceedings. ISMRM 14th Scientific Meeting (ISMRM 2006), Seattle, Washington, USA, (269-269). 6-12 May, 2006.

  • V. Vegh, H. Zhao, D. M. Doddrell, G. J. Galloway and I. M. Brereton (2005). A Novel Porous Media Fluid Propagation Approach for Designing Gradient Coils. In: international Society for Magnetic Resonance in Medicine, Miami, USA, (). 7-13 May.

  • Qu, J., Riley, M. J., Wang, D. and Brereton, I. M. (2005). Computational and experimental study of the interactions between xenon and crown ethers by 129Xe NMR. In: Scott Kable and Simon Apte, Connect 2005 : chemical challenges for the 21st century : abstract book : the 12th Royal Australian Chemical Institute (RACI) Convention. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, (). 3-7 July 2005.

  • Tucker, D., Brereton, I., Murison, R., Powell, K., Lamb, D. and Held, A. (2004). Detection of Phylloxera Infestation in Grape Vines using NMR methods. In: ANZMAG2004, Abstracts of the 5th Conference of the Australian and New Zealand Society for Magnetic Resonance. ANZMAG2004, Tanunda, South Australia, (76-76). 15-19 Feb, 2004.

  • Talbot, C. L., Friese, M. E. J., Wang, D., Doddrell, D., Brereton, I., Heckenberg, N. R. and Rubinsztein-Dunlop, H. (2003). Improved laser source for producing hyperpolarized noble gases for MRI applications. In: IFMBE Proceedings WC2003: World Congress on Medical Physics and Biomedical Engineering. World Congress in Medical Physics and Biomedical Engineering, Sydney Australia, (x-x). 24-29 August.

  • Talbot, C. L., Friese, M. E. J., Wang, D., Brereton, I., Heckenberg, N. R. and Rubinsztein-Dunlop, H. (2003). Production of Hyperpolarised Helium by Optical Pumping Using Laser Diode Arrays. In: ACOLS, Melbourne, (). 2003.

  • Devasahayam, S., Brereton, I. M., Whittaker, A. K. and Hill, D. (2001). Radiation chemistry of Ultem by NMR. In: 24th Australiasian Polymer Symposium. 24th Australiasian Polymer Symposium, Beechworth, Victoria, (PB9-PB9). 4-8 February, 2001.

  • Graham, V., Brereton, I. M. and De Jersey, J. (2001). Reaction of acetaldehyde with cysteine and its potential significance in alcoholic liver disease. In: Combio 2001. Combio 2001, Canberra, (1-028 (Poster)). 1-4 Oct, 2001.

  • Devasahayam, S., Brereton, I. M., Whittaker, A. K. and Hill, D. (2000). Identifying the crosslink structures formed in Y-irradiated Ultem using NMR. In: Radiation 2000 Conference Handbook. Radiation 2000, AINSE, Lucas Hts, NSW, (49). 26-28 Nov, 2000.

  • Kurniawan, N. D., Brereton, I. M., Aliabadizadeh, K., Kroon, P. A. and Smith, R. W. (2000). Solution structure of the epidermal growth factor-homology modules of the human low-density lipoprotein receptor. In: ICMRBS XIX. ICMRBS XIX, Florence, Italy, ((Abstract)). 20-25 Aug, 2000.

  • Crozier, S., Doddrell, D. M., Roffmann, W. U., Brereton, I. M., Luescher, K. and Hinds, G. W. (2000). The Tilt Coil, a tool to study structural anisotropy in cartilage. In: Proceedings of ANZMAG 2000. ANZMAG 2000, Mt Buller, Vic, (23-24). 13-17 February 2000.

  • Brereton, I. M., Clayton, D., Kroon, P. A. and Smith, R. W. (2000). Three-dimensional structure of the sixth ligand-binding repeat of the human low-density lipoprotein receptor. In: 25th Lorne Protein Conference. 25th Lorne Protein Conf, Lorne, Vic, ((Abstract)). 7 Feb 2000.

  • Kurniawan, N., Atkins, A. R., Bieri, S., Brereton, I. M., Kroon, P. A. and Smith, R. W. (1999). Solution structure of the first and second ligand binding modules of the human low density lipoprotein receptor. In: 24th Annual Lorne Conference on Protein Structure and Function. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House Lorne, Vic., (B56). 6-11 February, 1999.

  • Towner, RA, Williams, JP, Endre, ZH, Kadkhodaee, M, Wilson, S, Brereton, IM, Hanson, G and Doddrell, DM (1995). MR Assessment of Oxidative Stress Processes in Rat Liver and Kidneys. In: Gorenstein, DG, Bulletin of Magnetic Resonance: Proceedings of the International Society of Magnetic Resonance Xllth Meeting. International Society of Magnetic Resonance, ISMAR 95, Sydney, Australia, (190-192). 16th - 21st July 1995.

  • Irving, MG, Brooks, WM, Galloway, GJ, Brereton, IM, Brooks, WM, Baddeley, H and Doddrell, DM (1987). Invivo Volume-Selected H-1 Magnetic-Resonance Spectroscopy of Leukemia in Humans. In: Australian and New Zealand Journal of Medicine. , , (176-176). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision