I have a chemical engineer degree from the Ecole Nationale Superieure de Chimie de Montpellier, France, from which I graduated in 2001. During my engineering degree, in 2000, I visited the laboratory of Tom Blundell located in Cambridge UK where I discovered the fascinating area of structural bioinformatics. I further developed my taste for the molecular modelling of biological complexes during my PhD by studying receptor-antigen complexes, including antibody-antigen binary complexes and T cell receptor-MHC-peptide ternary complexes at the ImMunoGeneTics information system® (IMGT) in Montpellier, France. My PhD research resulted in the development of databases and algorithms, including IMGT/3Dstructure-DB, which is specialised in the analysis of NMR and crystallographic structures of antigen receptors. Since its creation in 1989 by Professor Marie-Paule Lefranc, IMGT is actively developed resource in immunology and has high popularity among immunologists and clinicians. In 2007, I was awarded a prestigious Australian Reasearch Council Postdoctoral fellowship to undertake research in the laboratory of Professor David Craik at the Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. My research since then focus on the study of the interaction of active peptides with various receptors, including the neural nicotinic acetylcholine receptors and serine proteases. I am particularly interested in characterising the energetics involved in molecular interactions, which is fundamental to optimise active peptide drug leads. Professor Craik is a world leader in the study of a large family of plant cyclic proteins, the cyclotides, which have an unparalleled stability that we try to arness to create new drugs. My favorite topic is the study of toxins produced by the carnivorous marine cone snails. Cone snails produce one of the most potent, neuro active venom known to man, and attracting considerable interests for the development of drugs, one of them being already used in the clinic for the treatment of intractable pain. My main contributions in this research area included a popular database called ConoServer (http://www.conoserver.org) and several theroretical studies of the specificity of cone snail toxins for neuronal nicotinic acetylcholine receptor subtypes, which are involved in different aspects of cognition and memory. The scope of my research is mainly in theoretical computational studies and touch a wide range of subjects, from biophysics of molecular interactions to sequence analysis, databases, transcriptomics and proteomics. I also recently had significant contribution to UQ's teaching in Advanced Bioinformatics lectures, by undertaking ~50% of the lectures of this course.
Through my databases, I contribute in disseminating knowledge to the broader publich as well as in exchanging information between researchers located in different countries. The impact of databases reach far beyond the simple collection of data, as the creation and management of databases require the classification, comparison and analyses of the elements it aim to describe, allowing the creation of new discoveries. I have made major contributions to three databases:
IMG/3Dstructure-DB, which provides important information on the structure of receptors from human and other vertebrate immune system;
CyBase, which catalogues sequence and structure on families of backbone cyclic proteins with potential drug design applications; and
ConoServer, specialising on toxins produced by carnivorous marine cone snails and have important pharmaceutical applications.
Journal Article: Determination of the alpha-conotoxin Vc1.1 binding site on the alpha 9 alpha 10 nicotinic acetylcholine receptor
Yu, Rilei, Kompella, Shiva N., Adams, David J., Craik, David J. and Kaas, Quentin (2013) Determination of the alpha-conotoxin Vc1.1 binding site on the alpha 9 alpha 10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry, 56 9: 3557-3567. doi:10.1021/jm400041h
Journal Article: Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor
Yu, Rilei, Kaas, Quentin and Craik, David J. (2012) Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry B, 116 21: 6097-6105. doi:10.1021/jp301352d
Journal Article: ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012) ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 D1: D325-D330. doi:10.1093/nar/gkr886
Journal Article: Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations
Yu, Rilei, Craik, David J. and Kaas, Quentin (2011) Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Computational Biology, 7 3: e1002011-1-e1002011-16. doi:10.1371/journal.pcbi.1002011
Journal Article: Conopeptide characterization and classifications: An analysis using ConoServer
Kaas, Quentin, Westermann, Jan-Christoph and Craik, David J. (2010) Conopeptide characterization and classifications: An analysis using ConoServer. Toxicon, 55 8: 1491-1509. doi:10.1016/j.toxicon.2010.03.002
Journal Article: ConoServer, a database for conopeptide sequences and structures
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008) ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 3: 445-446. doi:10.1093/bioinformatics/btm596
(2015–2019) University of Wollongong
Development of selective melanocortin receptor agonists and antagonists
(2015–2017) NHMRC Project Grant
Development of next generation drugs for chronic myeloid leukaemia
(2014–2016) NHMRC Project Grant
Characterizing therapy induced adaptive phenotypic plasticity leading to acquired drug resistance in cancer
(2019) Doctor Philosophy
Engineering the ribbon isomer of alpha-conotoxins in the drug design application
(2019) Doctor Philosophy
Expanding the Structural Atlas of Peptide Toxins
(2019) Doctor Philosophy
Yu, Rilei, Kompella, Shiva N., Adams, David J., Craik, David J. and Kaas, Quentin (2013) Determination of the alpha-conotoxin Vc1.1 binding site on the alpha 9 alpha 10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry, 56 9: 3557-3567. doi:10.1021/jm400041h
Yu, Rilei, Kaas, Quentin and Craik, David J. (2012) Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry B, 116 21: 6097-6105. doi:10.1021/jp301352d
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012) ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 D1: D325-D330. doi:10.1093/nar/gkr886
Yu, Rilei, Craik, David J. and Kaas, Quentin (2011) Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Computational Biology, 7 3: e1002011-1-e1002011-16. doi:10.1371/journal.pcbi.1002011
Conopeptide characterization and classifications: An analysis using ConoServer
Kaas, Quentin, Westermann, Jan-Christoph and Craik, David J. (2010) Conopeptide characterization and classifications: An analysis using ConoServer. Toxicon, 55 8: 1491-1509. doi:10.1016/j.toxicon.2010.03.002
ConoServer, a database for conopeptide sequences and structures
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008) ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 3: 445-446. doi:10.1093/bioinformatics/btm596
A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)
Craik, David J., Kaas, Quentin and Wang, Conan K. (2017). A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). In Eric Marsault and Mark L Peterson (Ed.), Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies (pp. 25-57) Hoboken, New Jersey, United States: John Wiley & Sons. doi:10.1002/9781119092599.ch2
Conotoxins and other conopeptides
Kaas, Quentin and Craik, David J. (2014). Conotoxins and other conopeptides. In Stéphane La Barre and Jean-Michel Kornprobst (Ed.), Outstanding Marine Molecules: Chemistry, Biology, Analysis (pp. 319-332) Weinheim, Germany: Wiley-VCH Verlag. doi:10.1002/9783527681501.ch14
Antimicrobial Peptides in Plants
Kaas, Quentin, Westermann, Jan-Christoph, Troeira Henriques, Sonia and Craik, David J. (2010). Antimicrobial Peptides in Plants. In Guangshun Wang (Ed.), Antimicrobial Peptides: Discovery, Design, and Novel Therapeutic Strategies (pp. 40-71) Wallingford, Oxfordshire, UK: CAB International. doi:10.1079/9781845936570.0040
IMGT standardization for molecular characterization of the T-cell receptor/peptide/MHC complexes
Kaas, Quentin, Duprat, Elodie, Tourneur, Guillaume and Lefranc, Marie-Paule (2008). IMGT standardization for molecular characterization of the T-cell receptor/peptide/MHC complexes. In Immunoinformatics (pp. 19-49) : Springer New York. doi:10.1007/978-0-387-72968-8_2
Conotoxins: chemistry and biology
Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019) Conotoxins: chemistry and biology. Chemical Reviews, . doi:10.1021/acs.chemrev.9b00207
In Silico design of MDM2-targeting peptides from a naturally occurring constrained peptide
Ma, He, Qiu, Peiju, Harvey, Peta J., Li, Xiao, Zhang, Zheyu, Xu, Qingliang, Liang, Jiazhen, Kaas, Quentin, Craik, David J., Yang, Jinbo, Jiang, Tao, Bi, Xiaolin and Yu, Rilei (2019) In Silico design of MDM2-targeting peptides from a naturally occurring constrained peptide. Chemmedchem, . doi:10.1002/cmdc.201900366
A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F. and Anderson, Marilyn A. (2019) A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports, 9 1: . doi:10.1038/s41598-019-47273-7
A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F. and Anderson, Marilyn A. (2019) A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports, 9 10820. doi:10.1038/s41598-019-47273-7
Chambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019) Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 12: 1336-1350. doi:10.1002/1873-3468.13435
El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019) Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 . doi:10.3389/fphar.2019.00577
Yu, Rilei, Tae, Han‐Shen, Xu, Qingliang, Craik, David J., Adams, David J., Jiang, Tao and Kaas, Quentin (2019) Molecular dynamics simulations of dihydro‐β‐erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology, . doi:10.1111/bph.14698
Yu, Jinpeng, Zhu, Xiaopeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2018) Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist. Journal of Medicinal Chemistry, 61 20: 9256-9265. doi:10.1021/acs.jmedchem.8b00967
Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018) Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155 288-297. doi:10.1016/j.bcp.2018.07.007
Wong, Lilian L. L., Scott, Daniel James, Hossain, Mohammed Akhter, Kaas, Quentin, Rosengren, K. Johan and Bathgate, Ross A. D. (2018) Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor. Journal of Biological Chemistry, 293 41: 15777-15789. doi:10.1074/jbc.ra118.002645
Prediction of disulfide dihedral angles using chemical shifts
Armstrong, David A., Kaas, Quentin and Rosengren, K. Johan (2018) Prediction of disulfide dihedral angles using chemical shifts. Chemical Science, 9 31: 6548-6556. doi:10.1039/c8sc01423j
Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases
Jackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018) Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 1: 2411. doi:10.1038/s41467-018-04669-9
Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018) Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 8: 3674-3684. doi:10.1021/acs.jmedchem.8b00170
Bioactive compounds isolated from neglected predatory marine gastropods
Turner, Ashlin H., Craik, David J., Kaas, Quentin and Schroeder, Christina I. (2018) Bioactive compounds isolated from neglected predatory marine gastropods. Marine Drugs, 16 4: 118. doi:10.3390/md16040118
Castro, Joel, Grundy, Luke, Deiteren, Annemie, Harrington, Andrea M., O'Donnell, Tracey, Maddern, Jessica, Moore, Jessi, Garcia-Caraballo, Sonia, Rychkov, Grigori Y., Yu, Rilei, Kaas, Quentin, Craik, David J., Adams, David J. and Brierley, Stuart M. (2018) Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175 12: 2384-2398. doi:10.1111/bph.14115
Conformational Flexibility Is a Determinant of Permeability for Cyclosporin
Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018) Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 8: 2261-2276. doi:10.1021/acs.jpcb.7b12419
Computational Studies of Snake Venom Toxins
Ojeda, Paola G., Ramírez, David, Alzate-Morales, Jans, Caballero, Julio, Kaas, Quentin and González, Wendy (2017) Computational Studies of Snake Venom Toxins. Toxins, 10 1: 1-24. doi:10.3390/toxins10010008
Pineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017) ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 6: 1074-1076. doi:10.1093/bioinformatics/btx661
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 41: 17101-17112. doi:10.1074/jbc.M117.808386
Modelling the interactions between animal venom peptides and membrane proteins
Hung, Andrew, Kuyucak, Serdar, Schroeder, Christina I. and Kaas, Quentin (2017) Modelling the interactions between animal venom peptides and membrane proteins. Neuropharmacology, 127 20-31. doi:10.1016/j.neuropharm.2017.07.036
Li, Ming-Jing, Wu, Guan-Zhao, Kaas, Quentin, Jiang, Tao and Yu, Ri-Lei (2017) Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors. Journal of Molecular Graphics and Modelling, 75 241-249. doi:10.1016/j.jmgm.2017.04.004
Tabassum, Nargis, Tae, Han-Shen, Jia, Xinying, Kaas, Quentin, Jiang, Tao, Adams, David J. and Yu, Rilei (2017) Role of CysI–CysIII disulfide bond on the structure and activity of α-conotoxins at human neuronal nicotinic acetylcholine receptors. ACS Omega, 2 8: 4621-4631. doi:10.1021/acsomega.7b00639
Wu, Yong, Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Zhangsun, Manqi, Harvey, Peta J., Craik, David J., McIntosh, J. Michael and Luo, Sulan (2017) α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry, 60 13: 5826-5833. doi:10.1021/acs.jmedchem.7b00546
Zhangsun, Dongting, Zhu, Xiaopeng, Kaas, Quentin, Wu, Yong, Craik, David J. , McIntosh, J. Michael and Luo, Sulan (2017) αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. Neuropharmacology, 127 243-252. doi:10.1016/j.neuropharm.2017.04.015
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016) Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 10: 2202-2212. doi:10.1002/bit.25993
Accurate de novo design of hyperstable constrained peptides
Bhardwaj, Gaurav, Mulligan, Vikram Khipple, Bahl, Christopher D., Gilmore, Jason M., Harvey, Peta J., Cheneval, Olivier, Buchko, Garry W., Pulavarti, Surya V. S. R. K., Kaas, Quentin, Eletsky, Alexander, Huang, Po-Ssu, Johnsen, William A., Greisen, Per Jr, Rocklin, Gabriel J., Song, Yifan, Linsky, Thomas W., Watkins, Andrew, Rettie, Stephen A., Xu, Xianzhong, Carter, Lauren P., Bonneau, Richard, Olson, James M., Coutsias, Evangelos, Correnti, Colin E., Szyperski, Thomas, Craik, David J. and Baker, David (2016) Accurate de novo design of hyperstable constrained peptides. Nature, 538 7625: 329-335. doi:10.1038/nature19791
Cyclisation of disulfide-rich conotoxins in drug design applications
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016) Cyclisation of disulfide-rich conotoxins in drug design applications. European Journal of Organic Chemistry, 2016 21: 3462-3472. doi:10.1002/ejoc.201600402
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016) Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016). European Journal of Organic Chemistry, 2016 21: 3457-3457. doi:10.1002/ejoc.201670211
Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., Van Der Weerden, Nicole L., Craik, David J. and Anderson, Marilyn A. (2015) Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications, 6 10199: . doi:10.1038/ncomms10199
Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae
Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015) Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 11: 2491-2500. doi:10.1021/acschembio.5b00454
Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015) Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 Art No.: 13264: . doi:10.1038/srep13264
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015) Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 1-15. doi:10.1038/srep12974
Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor. I., Christensen, Sean, Romero, Haylie K., McIntrye, Melissa, Dowell, Cheryl, Baxter, James, C., Elmslie, Keith S., Craik, David J. and McIntosh, Michael (2015) Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 30: e4026-e4035. doi:10.1073/pnas.1503617112
Kaas, Quentin and Craik, David J. (2015) Bioinformatics-aided venomics. Toxins, 7 6: 2159-2187. doi:10.3390/toxins7062159
Zhangsun, Dongting, Zhu, Xiaopeng, Wu, Yong, Hu, Yuanyan, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Luo, Sulan (2015) Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding. The Journal of Biological Chemistry, 290 15: 9855-9862. doi:10.1074/jbc.M114.632646
Babbitt, Patricia C, Bagos, Pantelis G, Bairoch, Amos, Bateman, Alex, Chatonnet, Arnaud, Chen, Mark Jinan, Craik, David J, Finn, Robert D, Gloriam, David, Haft, Daniel H, Henrissat, Bernard, Holliday, Gemma L, Isberg, Vignir, Kaas, Quentin, Landsman, David, Lenfant, Nicolas, Manning, Gerard, Nagano, Nozomi, Srinivasan, Narayanaswamy, O'Donovan, Claire, Pruitt, Kim D, Sowdhamini, Ramanathan, Rawlings, Neil D, Saier Jr., Milton H, Sharman, Joanna L, Spedding, Michael, Tsirigos, Konstantinos D, Vastermark, Ake and Vriend, Gerrit (2015) Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database The Journal of Biological Databases and Curation, 2015 bav063: . doi:10.1093/database/bav063
The evolution of Momordica cyclic peptides
Mahatmanto, Tunjung, Mylne, Joshua S., Poth, Aaron G., Swedberg, Joakim E., Kaas, Quentin, Schaefer, Hanno and Craik, David J. (2014) The evolution of Momordica cyclic peptides. Molecular Biology and Evolution, 32 2: 392-405. doi:10.1093/molbev/msu307
Qin, Qiaoping, Kaas, Quentin, Wu, Wenming, Lin, Feifan, Lai, Qixian and Zhu, Zhujun (2014) Characterisation of the subunit genes of pyrophosphate-dependent phosphofructokinase from loquat (Eriobotrya japonica Lindl.). Tree Genetics & Genomes, 10 5: 1465-1476. doi:10.1007/s11295-014-0774-5
Discovery, synthesis, and structure: activity relationships of conotoxins
Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014) Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP 11: 1-33. doi:10.1021/cr400401e
Luo, Sulan, Zhangsun, Dongting, Schroeder, Christina I., Zhu, Xiaopeng, Hu, Yuanyan, Wu, Yong, Weltzin, Maegan M., Eberhard, Spencer, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Whiteaker, Paul (2014) A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3 beta2 vs. alpha6/alpha3 beta2 beta3 nicotinic acetylcholine receptors. FASEB Journal, Early Edition 4: 1-12. doi:10.1096/fj.13-244103
Prediction and characterization of cyclic proteins from sequences in three domains of life
Kedarisetti, Pradyumna, Mizianty, Marcin J., Kaas, Quentin, Craik, David J. and Kurgan, Lukasz (2014) Prediction and characterization of cyclic proteins from sequences in three domains of life. Biochimica et Biophysica Acta: Proteins and Proteomics, 1844 1: 181-190. doi:10.1016/j.bbapap.2013.05.002
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity
Jin, Ai-Hua, Dutertre, Sébastien, Kaas, Quentin, Lavergne, Vincent, Kubala, Petra, Lewis, Richard J. and Alewood, Paul F. (2013) Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular and Cellular Proteomics, 12 12: 3824-3833. doi:10.1074/mcp.M113.030353
Gerlach, Samantha L., Göransson, Ulf, Kaas, Quentin, Craik, David J. and Gruber, Christian W. (2013) A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic and peptidomic analysis. Biopolymers: Peptide Science, 100 5: 433-437. doi:10.1002/bip.22258
Yu, Rilei, Kompella, Shiva N., Adams, David J., Craik, David J. and Kaas, Quentin (2013) Determination of the alpha-conotoxin Vc1.1 binding site on the alpha 9 alpha 10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry, 56 9: 3557-3567. doi:10.1021/jm400041h
High-affinity cyclic peptide matriptase inhibitors
Quimbar, Pedro, Malik, Uru, Sommerhoff, Christian P., Kaas, Quentin, Chan, Lai Y., Huang, Yen-Hua, Grundhuber, Maresa, Dunse, Kerry, Craik, David J., Anderson, Marilyn A. and Daly, Norelle L. (2013) High-affinity cyclic peptide matriptase inhibitors. Journal of Biological Chemistry, 288 19: 13885-13896. doi:10.1074/jbc.M113.460030
Kaas, Quentin and Craik, David J. (2013) NMR of plant proteins. Progress in Nuclear Magnetic Resonance Spectroscopy, 71 1-34. doi:10.1016/j.pnmrs.2013.01.003
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily
Aguilar, Manuel B., Ortiz, Ernesto, Kaas, Quentin, Lopez-Vera, Estuardo, Becerril, Baltazar, Possani, Lourival D. and Heimer de la Cotera, Edgar P. (2013) Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides, 41 17-20. doi:10.1016/j.peptides.2013.01.009
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom
Dutertre, Sebastien, Jin, Ai-Hua (Jean), Kaas, Quentin, Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular and Cellular Proteomics, 12 2: 312-329. doi:10.1074/mcp.M112.021469
Qin, Qiaoping, Kaas, Quentin, Zhang, Lanlan, Xu, Kai, Li, Nanyi, Zheng, Weiwei and Lai, Qixian (2013) Isolation and characterization of a cytosolic pyruvate kinase cDNA from loquat (Eriobotrya japonica Lindl.). Plant Molecular Biology Reporter, 31 1: 109-119. doi:10.1007/s11105-012-0479-6
Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
Bathgate, Ross A. D., Oh, Maria H. Y., Ling, W. J. Jason, Kaas, Quentin, Hossain, M. Akhter, Gooley, Paul R. and Rosengren, K. Johan (2013) Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3. Frontiers in Endocrinology, 4 FEB: . doi:10.3389/fendo.2013.00013
Qin, Qiaoping, Kaas, Quentin, Zhang, Chi, Zhou, Luping, Luo, Xiaoyan, Zhou, Mingbing, Sun, Xiaoming, Zhang, Lanlan, Paek, Kee-Yoeup and Cui, Yongyi (2012) The Cold Awakening of Doritaenopsis 'Tinny Tender' Orchid Flowers: The Role of Leaves in Cold-induced Bud Dormancy Release. Journal of Plant Growth Regulation, 31 2: 139-155. doi:10.1007/s00344-011-9226-8
Yu, Rilei, Kaas, Quentin and Craik, David J. (2012) Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry B, 116 21: 6097-6105. doi:10.1021/jp301352d
Cyclization of conotoxins to improve their biopharmaceutical properties
Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012) Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 4: 446-455. doi:10.1016/j.toxicon.2010.12.003
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2012) Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38). Current Pharmaceutical Design, 18 8: . doi:10.2174/138161212799315858
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012) ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 D1: D325-D330. doi:10.1093/nar/gkr886
Engineering of conotoxins for the treatment of pain
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2011) Engineering of conotoxins for the treatment of pain. Current Pharmaceutical Design, 17 38: 4242-4253.
Yu, Rilei, Craik, David J. and Kaas, Quentin (2011) Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Computational Biology, 7 3: e1002011-1-e1002011-16. doi:10.1371/journal.pcbi.1002011
ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures
Volker, Herzig, Wood, David, Newell, Felicity, Chaumeil, Pierre-Alain, Kaas, Quentin, Binford, Greta J., Nicholson, Graham M., Gorse, Dominique and King, Glenn F. (2011) ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures. Nucleic Acids Research, 39 Supp. 1: D653-D657. doi:10.1093/nar/gkq1058
Dunse, K. M., Kaas, Q., Guarino, R. F., Barton, P. A., Craik, D. J. and Anderson, M. A. (2010) Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America., 107 34: 15016-15021. doi:10.1073/pnas.1009327107
Conopeptide characterization and classifications: An analysis using ConoServer
Kaas, Quentin, Westermann, Jan-Christoph and Craik, David J. (2010) Conopeptide characterization and classifications: An analysis using ConoServer. Toxicon, 55 8: 1491-1509. doi:10.1016/j.toxicon.2010.03.002
Qin, Qiaoping, McCallum, Emily J., Kaas, Quentin, Suda, Jan, Saska, Ivana, Craik, David J. and Mylne, Joshua S. (2010) Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics, 11 111: 1-11. doi:10.1186/1471-2164-11-111
Analysis and classification of circular proteins in CyBase
Kaas, Quentin and Craik, David J (2010) Analysis and classification of circular proteins in CyBase. Biopolymers, 94 5: 584-591. doi:10.1002/bip.21424
Ehrenmann, F., Kaas, Q. and Lefranc, M.-P. (2009) IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T-cell receptors, MHC, IgSF and MhcSF. Nucleic Acids Research, 33 Supp. 1: D301-D307. doi:10.1093/nar/gkp946
Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes
Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009) Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 5: 1471-1481. doi:10.1016/j.bpj.2009.06.032
ArachnoServer: a database of protein toxins from spiders
Wood, D. L. A., Miljenovic, T, Cai, S, Raven, R. J., Kaas, Q, Escoubas, P, Herzig, V, Wilson, D and King, G (2009) ArachnoServer: a database of protein toxins from spiders. BMC Genomics, 10 Article #375: 1-8. doi:10.1186/1471-2164-10-375
Wang, C. K., Kaas, Q., Chiche, L. and Craik, D. J. (2008) CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering. Nucleic Acids Research, 36 SUPPL. 1: D206-D210. doi:10.1093/nar/gkm953
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
Duroux, Patrice, Kaas, Quentin, Brochet, Xavier, Lane, Jérôme, Ginestoux, Chantal, Lefranc, Marie-Paule and Giudicelli, Véronique (2008) IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm. Biochimie, 90 4: 570-583. doi:10.1016/j.biochi.2007.09.003
ConoServer, a database for conopeptide sequences and structures
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008) ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 3: 445-446. doi:10.1093/bioinformatics/btm596
KNOTTIN: The knottin or inhibitor cystine knot scaffold in 2007
Gracy, Jérôme, Le Nguyen, Dung, Gelly, Jean Christophe, Kaas, Quentin, Heitz, Annie and Chiche, Laurent (2008) KNOTTIN: The knottin or inhibitor cystine knot scaffold in 2007. Nucleic Acids Research, 36 SUPPL. 1: D314-D319. doi:10.1093/nar/gkm939
IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
Kaas, Quentin, Ehrenmann, Francois and Lefranc, Marie-Paule (2007) IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?. Briefings in Functional Genomics and Proteomics, 6 4: 253-264. doi:10.1093/bfgp/elm032
Magdelaine-Beuzelin, Charlotte, Kaas, Quentin, Wehbi, Vanessa, Ohresser, Marc, Jefferis, Roy, Lefranc, Marie-Paule and Watier. Hervé (2007) Structure–function relationships of the variable domains of monoclonal antibodies approved for cancer treatment. Critical reviews in Oncology/Hematology, 64 3: 210-225. doi:10.1016/j.critrevonc.2007.04.011
Kaas, Quentin and Leffranc, Marie-Paule (2007) IMGT colliers de perles: Standardized sequence-structure representations of the IgSF and MhcSF superfamily domains. Current Bioinformatics, 2 1: 21-30. doi:10.2174/157489307779314302
Kaas, Quentin and Lefranc , Marie-Paule (2005) T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB. In Silico Biology, 5 5-6: 505-528.
IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN
Lefranc, Marie-Paule, Duprat, Elodie, Kaas, Quentin, Tranne, Madeleine, Thiriot , Aude and Lefranc, Gérard (2005) IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN. Developmental and comparative immunology, 29 11: 917-938. doi:10.1016/j.dci.2005.03.003
Lefranc, Marie-Paule, Pommié, Christelle, Kaas, Quentin, Duprat, Elodie, Bosc, Nathalie, Guiraudou, Delphine, Jean, Christelle, Ruiz, Manuel, Da Piédade, Isabelle, Rouard, Mathieu, Foulquier, Elodie, Thouvenin, Valerie and Lefranc, Gerard (2005) IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains. Developmental and Comparative Immunology, 29 3: 185-203. doi:10.1016/j.dci.2004.07.003
IMGT, the international ImMunoGeneTics information system
Lefranc, Marie-Paule, Giudicelli, Veronique, Kaas, Quentin, Clément, Oliver, Duprat, Elodie, Jabado-Michaloud, Joumana, Scaviner, Dominqiue, Ginestoux, Chantal, Chaume, Denys and Lefranc, Gerard (2005) IMGT, the international ImMunoGeneTics information system. Nucleic Acids Research, 33 Database Issue Supplement 1: D593-D597. doi:10.1093/nar/gki065
IMGT-choreography for immunogenetics and immunoinformatics
Lefranc, Marie-Paule, Clement, Oliver, Kaas, Quentin, Duprat, Elodie, Chastellan, Patrick, Coelho, Isabelle, Combres, Kora, Ginestoux, Chantal, Giudicelli, Veronique, Chaume, Denys and Lefranc, Gerard (2005) IMGT-choreography for immunogenetics and immunoinformatics. In Silico Biology, 5 1: 45-60.
Hoh, Francois, Cerdan, Rachel, Kaas, Quentin, Nishi, Yoshinri, Chiche, Laurent, Kubo, Shigeru, Chino, Naoyoshi and Kobayashi, Yjui (2004) High-Resolution X-ray Structure of the Unexpectedly Stable Dimer of the [Lys(-2)-Arg(-1)-des(17−21)]Endothelin-1 Peptide. Biochemistry, 43 48: 15154-15168. doi:10.1021/bi049098a
IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Monod, Mehdi Yousfi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys and Lefranc, Gérard (2004) IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics. In Silico Biology, 4 1: 17-29.
Kaas, Q., Ruiz, M. and LeFranc, M-P (2004) IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data. Nucleic Acids Research, 32 Database Issue: D208-D210. doi:10.1093/nar/gkh042
The KNOTTIN website and database: a new information system dedicated to the knottin scaffold
Gelly, Jean-Christophe, Gracy, Jérôme, Kaas, Quentin, Le-Nguyen, Dung, Heitz, Annie and Chiche, Laurent (2004) The KNOTTIN website and database: a new information system dedicated to the knottin scaffold. Nucleic acids research, 32(Database edition) D156-D159. doi:10.1093/nar/gkh015
Kaas, Quentin, Aumelas, André, Kubo, Shigeru, Chino, Naoyoshi, Kobayashi, Yuji and Chiche, Laurent (2002) The [Lys-2-Arg-1-des(17−21)]-Endothelin-1 Peptide Retains the Specific Arg-1−Asp8 Salt Bridge but Reveals Discrepancies between NMR Data and Molecular Dynamics Simulations. Biochemistry, 47 37: 11099-11198. doi:10.1021/bi025744z
SCORE: Predicting the core of protein models
Deane, Charlotte M., Kaas, Quentin and Blundell, Tom L. (2001) SCORE: Predicting the core of protein models. Bioinformatics, 17 6: 541-550. doi:10.1093/bioinformatics/17.6.541
SCORE: predicting the core of protein models
Deane, C M, Kaas, Q and Blundell, T L (2001) SCORE: predicting the core of protein models. Bioinformatics (Oxford, England), 17 6: 541-50.
Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins
Kaas, Quentin, Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J. and Craik, David (2018). Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S62-S62). 26-31 August 2018.
Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons
Huang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S160-S160). 26-31 August 2018.
Huang, Y. -H., Henriques, S. Troeira, Lawrence, N., Kaas, Q. and Craik, D. J. (2016). Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562. In: 34th European Peptide Symposium, Leipzig, Germany, (S174-S174). 4‐9 September 2016. doi:10.1002/psc.2950
Towards An Understanding of A- Conotoxin Receptor Specificity
Kaas, Q. and Craik, D. J. (2016). Towards An Understanding of A- Conotoxin Receptor Specificity. In: , , (S128-S128). .
Jin, Ai-hua, Dutertre, Sébastien, Kaas, Quentin, Lewis, Richard J. and Alewood, Paul F. (2012). Transcriptomic and peptidomic characterisation of the Conus marmoreus venom: Insights on conopeptide diversity and venomic processing. In: 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, 17th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, (144-145). 8-13 July 2012. doi:10.1016/j.toxicon.2012.04.099
A new "Era" for cyclotide sequencing
Colgrave, Michelle L., Poth, Aaron G., Kaas, Quentin and Craik, David J. (2010). A new "Era" for cyclotide sequencing. In: 1st International Conference on Circular Proteins. Procceedings.. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (592-601). 18-21 October 2009. doi:10.1002/bip.21400
Advances in MS/MS Sequencing of Cyclic Peptides: What's around the Bend?
Colgrave, L., Poth, A., Kaas, Q. and Craik, D. (2010). Advances in MS/MS Sequencing of Cyclic Peptides: What's around the Bend?. In: Journal of Peptide Science. x, x, (113-113). x. doi:10.1002/psc.1303
Analysis and classification of circular proteins in CyBase
Kaas, Quentin and Craik, David J. (2010). Analysis and classification of circular proteins in CyBase. In: International Conference on Circular Proteins. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (584-591). 18-21 October, 2009. doi:10.1002/bip.21424
Yu, Rilei and Kaas, Quentin (2019): Molecular model of the nicotinic acetylcholine receptor a4b2 bound to nicotine and embedded in a lipid bilayer. The University of Queensland. Dataset. doi:10.14264/uql.2019.696
(2015–2019) University of Wollongong
Development of selective melanocortin receptor agonists and antagonists
(2015–2017) NHMRC Project Grant
Development of next generation drugs for chronic myeloid leukaemia
(2014–2016) NHMRC Project Grant
Exploring the specificity of a family of peptide drug leads targeting the nervous system
(2014) UQ Early Career Researcher
Exploring the genetic origin of a protein hijack event in daisies with next-generation sequencing
(2012) UWA-UQ Bilateral Research Collaboration Award
Discovery, isolation, characterisation and application of bioactive peptides from tritons
Doctor Philosophy — Associate Advisor
Other advisors:
Discovery and applications of cyclic peptides in plants
Doctor Philosophy — Associate Advisor
Other advisors:
Design and structure-activity studies of novel conotoxins
Doctor Philosophy — Associate Advisor
Other advisors:
Animal venom drug discovery
Doctor Philosophy — Associate Advisor
Other advisors:
Characterizing therapy induced adaptive phenotypic plasticity leading to acquired drug resistance in cancer
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Engineering the ribbon isomer of alpha-conotoxins in the drug design application
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Expanding the Structural Atlas of Peptide Toxins
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Molecular Modeling and Drug Design of Alpha-conotoxins with Therapeutic Applications
(2013) Doctor Philosophy — Associate Advisor
Other advisors: