OR

Browse By

Dr Alysha Elliott Aparicio

Research Fellow

Institute for Molecular Bioscience
a.elliott@imb.uq.edu.au
+61 7 334 62745

Overview

Doctor Alysha Elliott is a Research Fellow at the Centre for Superbug Solutions in the Institute for Molecular Bioscience at The University of Queensland. Alysha began her research career in 2007 and has since been dedicated to multi-disciplinary drug discovery with a specific passion for anti-infective targeted research. Alysha is highly experienced in infectious disease microbiology, structural biology of peptides, and molecular biology. Developing new antibiotics to treat drug resistant pathogens and investigating mechanisms of resistance in bacteria are Alysha’s core research activities.

Dr Elliott is the Program Coordinator for Microbiology and Screening for the Community for Open Antimicrobial Drug Discovery (CO-ADD), a global antibiotic discovery initiative that has screened >300,000 unique compounds via high throughput screening technologies for antimicrobial activity from over 270 research groups from 47 countries. Alysha’s antimicrobial drug development research has been funded by NHMRC, CARB-X (Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator), the Wellcome Trust and the Queensland Government (Advance Queensland). She has published more than sixty research articles and is active in collaborating with industry and public private partnerships for translational outcomes.

Dr Elliott’s current core research focus is on alternative therapies to treat extensively drug resistant Gram-negative bacterial infections, in particular the use of potentiators (inactive or inefficient compounds when used alone as an antimicrobial) to restore activity of traditional antibiotics that are no longer effective due to the development of antimicrobial resistance.

Research Interests

  • Bacterial pathogens
  • Antimicrobial Resistance
  • Alternative therapies to treat bacterial infections

Research Impacts

Dr Elliott's research focuses on the development of new antimicrobial therapies to combat multi-drug and extensively drug resistant bacteria. New therapies are critical to the treatment of bacterial infections as drug resistance increases at alarming rates, with an estimate of 10 million deaths per year by 2050 if nothing substantial is done, and very few candidates are left in the pharmaceutical development pipeline. Going hand in hand with development of new therapies is the investigation of resistance mechanisms in bacteria, where understanding how bacteria develop resistance to antibiotics over time provides guidance on how to better design new compounds or treatment strategies to fight drug resistant infections.

Qualifications

  • Bachelor of Applied Science (Biochemistry), Queensland University of Technology
  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Hons), The University of Queensland

Publications

View all Publications

Grants

View all Grants

Supervision

  • How does cannabidiol kill bacteria?

    Doctor Philosophy

  • Antibiotic potentiators as an alternative therapeutic option for the treatment of extensively drug-resistant Gram-negative infections.

    Doctor Philosophy

  • Investigations of the interactions between fluorescent antibiotics and bacteria

    Doctor Philosophy

View all Supervision

Publications

Featured Publications

Journal Article

  • Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines

    Boer, Gareth E., Hickey, Shane M., Elliott, Alysha G. and Pfeffer, Frederick M. (2022). Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines. European Journal of Medicinal Chemistry Reports, 6 100089, 100089. doi: 10.1016/j.ejmcr.2022.100089

  • Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First <i>In Vivo</i> Experiments

    Frei, Angelo, Elliott, Alysha G., Kan, Alex, Dinh, Hue, Bräse, Stefan, Bruce, Alice E., Bruce, Mitchell R., Chen, Feng, Humaidy, Dhirgam, Jung, Nicole, King, A. Paden, Lye, Peter G., Maliszewska, Hanna K., Mansour, Ahmed M., Matiadis, Dimitris, Muñoz, María Paz, Pai, Tsung-Yu, Pokhrel, Shyam, Sadler, Peter J., Sagnou, Marina, Taylor, Michelle, Wilson, Justin J., Woods, Dean, Zuegg, Johannes, Meyer, Wieland, Cain, Amy K., Cooper, Matthew A. and Blaskovich, Mark A. T. (2022). Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments. JACS Au, 2 (10), 2277-2294. doi: 10.1021/jacsau.2c00308

  • A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

    Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381. doi: 10.1126/scitranslmed.abj238

  • A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

    Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381, 1-16. doi: 10.1126/scitranslmed.abj2381

  • Investigations into the membrane activity of arenicin antimicrobial peptide AA139

    Edwards, Ingrid A., Henriques, Sónia T., Blaskovich, Mark A.T., Elliott, Alysha G. and Cooper, Matthew A. (2022). Investigations into the membrane activity of arenicin antimicrobial peptide AA139. Biochimica et Biophysica Acta - General Subjects, 1866 (8) 130156, 130156. doi: 10.1016/j.bbagen.2022.130156

  • Synthesis of 2-[2-(tert-butoxycarbonyl)-3-(acyl)guanidino]ethylamine salts for convergent introduction of acyl guanidines

    Boer, Gareth E., Hickey, Shane M., Elliott, Alysha G. and Pfeffer, Frederick M. (2022). Synthesis of 2-[2-(tert-butoxycarbonyl)-3-(acyl)guanidino]ethylamine salts for convergent introduction of acyl guanidines. New Journal of Chemistry, 46 (17), 8131-8137. doi: 10.1039/d2nj01510b

  • Amino alcohols as potential antibiotic and antifungal leads

    Baker, Jennifer R., Cossar, Peter J., Blaskovich, Mark A. T., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Lewis, Peter J. and McCluskey, Adam (2022). Amino alcohols as potential antibiotic and antifungal leads. Molecules, 27 (7) 2050. doi: 10.3390/molecules27072050

  • Synthesis, antibacterial and antifungal activity of new 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine quaternary salts

    Demchenko, Sergii, Lesyk, Roman, Yadlovskyi, Oleh, Zuegg, Johannes, Elliott, Alysha G., Drapak, Iryna, Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2021). Synthesis, antibacterial and antifungal activity of new 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine quaternary salts. Molecules, 26 (14) 4253, 1-13. doi: 10.3390/molecules26144253

  • Antimicrobial screening of a historical collection of over 140 000 small molecules

    Semenov, Victor V., Raihstat, Mikhail M., Konyushkin, Leonid D., Semenov, Roman V., Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G., Hansford, Karl A. and Cooper, Matthew A. (2021). Antimicrobial screening of a historical collection of over 140 000 small molecules. Mendeleev Communications, 31 (4), 484-487. doi: 10.1016/j.mencom.2021.07.015

  • Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

    Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767

  • Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus

    Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716

  • Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021)

    Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021). Chemistry – A European Journal, 27 (6), 1861-1861. doi: 10.1002/chem.202004912

  • Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity

    Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity. Chemistry – A European Journal, 27 (6), 2021-2029. doi: 10.1002/chem.202003545

  • The antimicrobial potential of cannabidiol

    Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y

  • Platinum cyclooctadiene complexes with activity against gram-positive bacteria

    Frei, Angelo, Ramu, Soumya, Lowe, Gabrielle J., Dinh, Hue, Semenec, Lucie, Elliott, Alysha G., Zuegg, Johannes, Deckers, Anke, Jung, Nicole, Bräse, Stefan, Cain, Amy K. and Blaskovich, Mark A. T. (2021). Platinum cyclooctadiene complexes with activity against gram-positive bacteria. ChemMedChem, 16 (20) cmdc.202100157, 1-8. doi: 10.1002/cmdc.202100157

  • Multi-institution research and education collaboration identifies new antimicrobial compounds

    Fuller, Amelia A., Dounay, Amy B., Schirch, Douglas, Rivera, Daniel G., Hansford, Karl A., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Blaskovich, Mark A. T., Hitchens, Jacob R., Burris-Hiday, Sarah, Tenorio, Kristiana, Mendez, Yanira, Samaritoni, J. Geno, O’Donnell, Martin J. and Scott, William L. (2020). Multi-institution research and education collaboration identifies new antimicrobial compounds. ACS Chemical Biology, 15 (12), 3187-3196. doi: 10.1021/acschembio.0c00732

  • Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis, and activity

    Peacock, Hayden, Henriques, Sónia Troeira, Benfield, Aurélie H., Elliott, Alysha G., Luo, Jinghui, Luccarelli, James, Nagano, Masanobu, Craik, David J. and Hamilton, Andrew D. (2020). Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis, and activity. ChemMedChem, 15 (20) cmdc.202000474, 1932-1939. doi: 10.1002/cmdc.202000474

  • Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides

    Demchenko, Sergii, Lesyk, Roman, Zuegg, Johannes, Elliott, Alysha G., Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2020). Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. European Journal of Medicinal Chemistry, 201 112477, 112477. doi: 10.1016/j.ejmech.2020.112477

  • Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

    Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k

  • An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

    Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x

  • How to stimulate and facilitate early stage antibiotic discovery

    Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163

  • Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020)

    Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher G., Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M., Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna K., Rutledge, Peter J., Sadler, Peter J., Todd, Matthew H., Willans, Charlotte E., Wilson, Justin J., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020). Chemical Science, 11 (17), 4531-4531. doi: 10.1039/d0sc90075c

  • Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model

    Rineh, Ardeshir, Soren, Odel, McEwan, Timothy, Ravikumar, Vikashini, Poh, Wee Han, Azamifar, Fereshteh, Naimi-Jamal, M. Reza, Cheung, Chen-Yi, Elliott, Alysha G., Zuegg, Johannes, Blaskovich, Mark A. T., Cooper, Matthew A., Dolange, Victoria, Christodoulides, Myron, Cook, Gregory M., Rice, Scott A., Faust, Saul N., Webb, Jeremy S. and Kelso, Michael J. (2020). Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model. ACS Infectious Diseases, 6 (6) acsinfecdis.0c00070, 1460-1479. doi: 10.1021/acsinfecdis.0c00070

  • Metal complexes as a promising source for new antibiotics

    Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e

  • Elucidating the effect of sequence and degree of polymerization on antimicrobial properties for block copolymers

    Barbon, Stephanie M., Truong, Nghia P., Elliott, Alysha G., Cooper, Matthew A., Davis, Thomas P., Whittaker, Michael R., Hawker, Craig J. and Anastasaki, Athina (2020). Elucidating the effect of sequence and degree of polymerization on antimicrobial properties for block copolymers. Polymer Chemistry, 11 (1), 84-90. doi: 10.1039/c9py01435g

  • Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

    Braga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c

  • An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

    Grace, James L., Amado, Maite, Reid, Janet C., Elliott, Alysha G., Landersdorfer, Cornelia B., Truong, Nghia P., Kempe, Kristian, Cooper, Matthew A., Davis, Thomas P., Montembault, Véronique, Pascual, Sagrario, Fontaine, Laurent, Velkov, Tony, Quinn, John F. and Whittaker, Michael R. (2019). An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform. Journal of Materials Chemistry B, 7 (43), 6796-6809. doi: 10.1039/c9tb01624d

  • In vitro antimicrobial activity of acne drugs against skin-associated bacteria

    Blaskovich, Mark A. T., Elliott, Alysha G., Kavanagh, Angela M., Ramu, Soumya and Cooper, Matthew A. (2019). In vitro antimicrobial activity of acne drugs against skin-associated bacteria. Scientific Reports, 9 (1) 14658, 14658. doi: 10.1038/s41598-019-50746-4

  • Antimicrobial anilinium polymers: The properties of poly(N,N‐dimethylaminophenylene methacrylamide) in solution and as coatings

    Chen, Ao, Er, Gerald, Zhang, Cheng, Tang, Joyce, Alam, Mahbub, T. Ta, Hang, Elliott, Alysha G., Cooper, Matthew A., Perera, Janesha, Swift, Simon, Blakey, Idriss, Whittaker, Andrew K. and Peng, Hui (2019). Antimicrobial anilinium polymers: The properties of poly(N,N‐dimethylaminophenylene methacrylamide) in solution and as coatings. Journal of Polymer Science Part A: Polymer Chemistry, 57 (18), 1908-1921. doi: 10.1002/pola.29314

  • The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity

    James, Amy M., Haywood, Joel, Leroux, Julie, Ignasiak, Katarzyna, Elliott, Alysha G., Schmidberger, Jason W., Fisher, Mark F., Nonis, Samuel G., Fenske, Ricarda, Bond, Charles S. and Mylne, Joshua S. (2019). The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity. Plant Journal, 98 (6) tpj.14293, 988-999. doi: 10.1111/tpj.14293

  • Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent

    Matiadis, Dimitris, Tsironis, Dimitrios, Stefanou, Valentina, Elliott, Alysha G., Kordatos, Konstantinos, Zahariou, Georgia, Ioannidis, Nikolaos, McKee, Vickie, Panagiotopoulou, Angeliki, Igglessi-Markopoulou, Olga and Markopoulos, John (2019). Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent. Journal of Inorganic Biochemistry, 194, 65-73. doi: 10.1016/j.jinorgbio.2019.02.008

  • Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs

    Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238

  • Structure-function studies of polymyxin B lipononapeptides

    Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019). Structure-function studies of polymyxin B lipononapeptides. Molecules, 24 (3) 553, 553. doi: 10.3390/molecules24030553

  • Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane

    Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A. and Pfeffer, Frederick M. (2018). Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. European Journal of Medicinal Chemistry, 160, 9-22. doi: 10.1016/j.ejmech.2018.09.072

  • Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

    Grace, James L., Schneider-Futschik, Elena K., Elliott, Alysha G., Amado, Maite, Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2018). Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers. Biomacromolecules, 19 (12) acs.biomac.8b01317, 4629-4640. doi: 10.1021/acs.biomac.8b01317

  • Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

    Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018). Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 (6), 485-499. doi: 10.1080/14787210.2018.1483240

  • Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae

    Pitt, Miranda E., Elliott, Alysha G., Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2018). Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microbial Genomics, 4 (3) 000158. doi: 10.1099/mgen.0.000158

  • Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

    Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005

  • Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

    Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w

  • Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1

    Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017). Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 (12), 917-926. doi: 10.1021/acsinfecdis.7b00123

  • Redesigned spider peptide with improved antimicrobial and anticancer properties

    Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017). Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 (9), 2324-2334. doi: 10.1021/acschembio.7b00459

  • An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics

    Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017). An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, 561-572. doi: 10.1016/j.ejmech.2017.05.039

  • From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators

    Hussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 (5), 640-650. doi: 10.1089/mdr.2016.0196

  • Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities

    Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017). Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 (29), 8495-8499. doi: 10.1002/anie.201703360

  • Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

    Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017). Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2407-2409. doi: 10.1016/j.bmcl.2017.04.027

  • Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals

    Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 (2) FSO171, FSO171. doi: 10.4155/fsoa-2016-0093

  • Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia

    Galappathie, Savithri, Edwards, David J., Elliott, Alysha G., Cooper, Matthew A., Palombo, Enzo A., Butler, Mark S. and Mahon, Peter J. (2017). Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia. Journal of Natural Products, 80 (4), 1178-1181. doi: 10.1021/acs.jnatprod.6b00888

  • Scaffolding and completing genome assemblies in real-time with nanopore sequencing

    Cao, Minh Duc, Nguyen, Son Hoang, Ganesamoorthy, Devika, Elliott, Alysha G., Cooper, Matthew A. and Coin, Lachlan J. M. (2017). Scaffolding and completing genome assemblies in real-time with nanopore sequencing. Nature Communications, 8 (1) 14515, 14515. doi: 10.1038/ncomms14515

  • Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies

    Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028

  • Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

    Grace, James L., Elliott, Alysha G., Huang, Johnny X., Schneider, Elena K., Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2016). Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency. Journal of Materials Chemistry B, 5 (3), 531-536. doi: 10.1039/C6TB02787C

  • Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines

    Yousfi, Tarek, Elliott, Alysha, Hanane, Messiad, Merdes, Rachid and Moyano, Albert (2016). Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines. Molecules, 21 (12) 21121655, 1655. doi: 10.3390/molecules21121655

  • Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives

    Kumar, Rohitesh, Lu, Yuting, Elliott, Alysha G., Kavanagh, Angela M., Cooper, Matthew A. and Davis, Rohan A. (2016). Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives. Magnetic Resonance in Chemistry, 54 (11), 880-886. doi: 10.1002/mrc.4482

  • Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing

    Cao, Minh Duc, Ganesamoorthy, Devika, Elliott, Alysha G., Zhang, Huihui, Cooper, Matthew A. and Coin, Lachlan J. M. (2016). Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing. Gigascience, 5 (1) 32, 32. doi: 10.1186/s13742-016-0137-2

  • Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603

    Elliott, Alysha G., Ganesamoorthy, Devika, Coin, Lachlan, Cooper, Matthew A. and Cao, Minh Duc (2016). Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603. Genome Announcements, 4 (3) e00438-16. doi: 10.1128/genomeA.00438-16

  • Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

    Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053

  • Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides

    Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045

  • Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F

    Beattie, Karren D., Ellwood, Nicola, Kumar, Rohitesh, Yang, Xinzhou, Healy, Peter C., Choomuenwai, Vanida, Quinn, Ronald J., Elliott, Alysha G., Huang, Johnny X., Chitty, Jessica L., Fraser, James A., Cooper, Matthew A. and Davis, Rohan A. (2016). Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry, 124, 79-85. doi: 10.1016/j.phytochem.2015.12.014

  • Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B

    Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593

  • Natural structural diversity within a conserved cyclic peptide scaffold

    Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x

  • Mucin binding reduces colistin antimicrobial activity

    Huang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015). Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 (10), 5925-5931. doi: 10.1128/AAC.00808-15

  • Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum

    Rees, Karlee A., Bermudez, Cindy, Edwards, David J., Elliott, Alysha G., Ripen, Jovita E., Seta, Cynthia, Huang, Johnny X., Cooper, Matthew A., Fraser, James A., Yeo, Tiong C. and Butler, Mark S. (2015). Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum. Journal of Natural Products, 78 (8), 2141-2144. doi: 10.1021/acs.jnatprod.5b00410

  • Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites

    Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019

  • Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

    Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015). Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 (1) 7719, 1-11. doi: 10.1038/ncomms8719

  • Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents

    Hickey, Shane M., Ashton, Trent D., Khosa, Simren K., Robson, Ryan N., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015). Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents. Organic and Biomolecular Chemistry, 13 (22), 6225-6241. doi: 10.1039/c5ob00621j

  • Helping chemists discover new antibiotics

    Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044

  • Peptide macrocyclization by a bifunctional endoprotease

    Bernath-Levin, Kalia, Nelson, Clark, Elliott, Alysha G., Jayasena, Achala S., Millar, A. Harvey, Craik, David J. and Mylne, Joshua S. (2015). Peptide macrocyclization by a bifunctional endoprotease. Chemistry and Biology, 22 (5), 571-582. doi: 10.1016/j.chembiol.2015.04.010

  • Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

    Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137

  • Synthesis of norbornane bisether antibiotics via silver-mediated alkylation

    Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015). Synthesis of norbornane bisether antibiotics via silver-mediated alkylation. Rsc Advances, 5 (36), 28582-28596. doi: 10.1039/c5ra03321g

  • Evolutionary origins of a bioactive peptide buried within preproalbumin

    Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3), 981-995. doi: 10.1105/tpc.114.123620

  • Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

    Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013). Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 (52), 21183-21188. doi: 10.1073/pnas.1311183110

  • Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

    Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011). Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5), 257-259. doi: 10.1038/nchembio.542

  • Distribution and evolution of circular miniproteins in flowering plants

    Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Note for students: Dr Alysha Elliott Aparicio is not currently available to take on new students.

Current Supervision

  • How does cannabidiol kill bacteria?

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Antibiotic potentiators as an alternative therapeutic option for the treatment of extensively drug-resistant Gram-negative infections.

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Investigations of the interactions between fluorescent antibiotics and bacteria

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Deciphering antibiotic modes of action and microbial resistance mechanisms with novel molecular probes

    Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

For Media assistance please contact The Office of Marketing and Communications, (07) 3365 1120

Links

ResearcherID: K-2733-2015

ORCID: 0000-0002-2983-0484

Scopus ID: 25925778300

Google Scholar ID: Egh7L7cAAAAJ

Personal Profile: Link

Unit Links
Other Media
Social Media

Related Resources

Similar Staff
Researchers in Associated Units
Fields of Research