The University of Queensland

Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane

Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A. and Pfeffer, Frederick M. (2018) Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane. European Journal of Medicinal Chemistry, 160 9-22. doi:10.1016/j.ejmech.2018.09.072

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018) Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 6: 485-499. doi:10.1080/14787210.2018.1483240

Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae

Pitt, Miranda E., Elliott, Alysha G., Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S., Blaskovich, Mark A. T., Cooper, Matthew A. and Coin, Lachlan J. M. (2018) Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae. Microbial Genomics, 4 3: . doi:10.1099/mgen.0.000158

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018) Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 4: 380-391.e5. doi:10.1016/j.chembiol.2018.01.005

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A, Paterson, David L. and Cooper, Matthew A. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 1: 22. doi:10.1038/s41467-017-02123-w

Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1

Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017) Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 12: 917-926. doi:10.1021/acsinfecdis.7b00123

An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics

Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136 561-572. doi:10.1016/j.ejmech.2017.05.039

Redesigned spider peptide with improved antimicrobial and anticancer properties

Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017) Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 9: 2324-2334. doi:10.1021/acschembio.7b00459

Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities

Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017) Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 129 29: 8615-8619. doi:10.1002/ange.201703360

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators

Hussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017) From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 5: 640-650. doi:10.1089/mdr.2016.0196

Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities

Dekan, Zoltan, Headey, Stephen J. , Scanlon, Martin, Baldo, Brian A. , Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R. , Vetter, Irina, Elliott, Alysha G. , Amado, Maite, Cooper, Matthew A. , Alewood, Dianne and Alewood, Paul F. (2017) Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 29: 8495-8499. doi:10.1002/anie.201703360

Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017) Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 11: 2407-2409. doi:10.1016/j.bmcl.2017.04.027

Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals

Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 2: FSO171. doi:10.4155/fsoa-2016-0093

Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia

Galappathie, Savithri, Edwards, David J., Elliott, Alysha G., Cooper, Matthew A., Palombo, Enzo A., Butler, Mark S. and Mahon, Peter J. (2017) Antibacterial nerol cinnamates from the Australian plant Eremophila longifolia. Journal of Natural Products, 80 4: 1178-1181. doi:10.1021/acs.jnatprod.6b00888

Scaffolding and completing genome assemblies in real-time with nanopore sequencing

Cao, Minh Duc, Nguyen, Son Hoang, Ganesamoorthy, Devika, Elliott, Alysha G., Cooper, Matthew A. and Coin, Lachlan J. M. (2017) Scaffolding and completing genome assemblies in real-time with nanopore sequencing. Nature Communications, 8 14515. doi:10.1038/ncomms14515

Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies

Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017) Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167 134-141. doi:10.1016/j.jinorgbio.2016.11.028

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

Grace, James L., Elliott, Alysha G., Huang, Johnny X., Schneider, Elena K., Truong, Nghia P., Cooper, Matthew A., Li, Jian, Davis, Thomas P., Quinn, John F., Velkov, Tony and Whittaker, Michael R. (2016) Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency. Journal of Materials Chemistry B, 5 3: 531-536. doi:10.1039/C6TB02787C

Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines

Yousfi, Tarek, Elliott, Alysha, Hanane, Messiad, Merdes, Rachid and Moyano, Albert (2016) Expedient organocatalytic syntheses of 4-substituted pyrazolidines and isoxazolidines. Molecules, 21 12: 1655. doi:10.3390/molecules21121655

Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives

Kumar, Rohitesh, Lu, Yuting, Elliott, Alysha G., Kavanagh, Angela M., Cooper, Matthew A. and Davis, Rohan A. (2016) Semi-synthesis and NMR spectral assignments of flavonoid and chalcone derivatives. Magnetic Resonance in Chemistry, 54 11: 880-886. doi:10.1002/mrc.4482

Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing

Cao, Minh Duc, Ganesamoorthy, Devika, Elliott, Alysha G., Zhang, Huihui, Cooper, Matthew A. and Coin, Lachlan J. M. (2016) Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION (TM) sequencing. Gigascience, 5 1: 32. doi:10.1186/s13742-016-0137-2

Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603

Elliott, Alysha G., Ganesamoorthy, Devika, Coin, Lachlan, Cooper, Matthew A. and Cao, Minh Duc (2016) Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603. Genome Announcements, 4 3: . doi:10.1128/genomeA.00438-16

Scaffolding and completing genome assemblies in real-time with nanopore sequencing

Cao, Minh Duc, Nguyen, Hoang Son, Ganesamoorthy, Devika, Elliott, Alysha, Cooper, Matthew and Coin, Lachlan J. M. (2016) Scaffolding and completing genome assemblies in real-time with nanopore sequencing. bioRxiv, . doi:10.1101/054783

Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation

Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016) Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 10: 2235-2241. doi:10.1016/j.bmc.2016.03.053

Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides

Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016) Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 6: 442-450. doi:10.1021/acsinfecdis.6b00045

Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F

Beattie, Karren D., Ellwood, Nicola, Kumar, Rohitesh, Yang, Xinzhou, Healy, Peter C., Choomuenwai, Vanida, Quinn, Ronald J., Elliott, Alysha G., Huang, Johnny X., Chitty, Jessica L., Fraser, James A., Cooper, Matthew A. and Davis, Rohan A. (2016) Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry, 124 79-85. doi:10.1016/j.phytochem.2015.12.014

Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B

Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016) Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 3: 1068-1077. doi:10.1021/acs.jmedchem.5b01593

Natural structural diversity within a conserved cyclic peptide scaffold

Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016) Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 1: 1-14. doi:10.1007/s00726-016-2333-x

Mucin binding reduces colistin antimicrobial activity

Huang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015) Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 10: 5925-5931. doi:10.1128/AAC.00808-15

Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum

Rees, Karlee A., Bermudez, Cindy, Edwards, David J., Elliott, Alysha G., Ripen, Jovita E., Seta, Cynthia, Huang, Johnny X., Cooper, Matthew A., Fraser, James A., Yeo, Tiong C. and Butler, Mark S. (2015) Flemingin-type prenylated chalcones from the sarawak rainforest plant desmodium congestum. Journal of Natural Products, 78 8: 2141-2144. doi:10.1021/acs.jnatprod.5b00410

Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites

Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015) Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 96-102. doi:10.1016/j.ejmech.2015.06.019

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 1: 1-11. doi:10.1038/ncomms8719

Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents

Hickey, Shane M., Ashton, Trent D., Khosa, Simren K., Robson, Ryan N., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015) Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents. Organic and Biomolecular Chemistry, 13 22: 6225-6241. doi:10.1039/c5ob00621j

Helping chemists discover new antibiotics

Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015) Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 7: 285-287. doi:10.1021/acsinfecdis.5b00044

Peptide macrocyclization by a bifunctional endoprotease

Bernath-Levin, Kalia, Nelson, Clark, Elliott, Alysha G., Jayasena, Achala S., Millar, A. Harvey, Craik, David J. and Mylne, Joshua S. (2015) Peptide macrocyclization by a bifunctional endoprotease. Chemistry and Biology, 22 5: 571-582. doi:10.1016/j.chembiol.2015.04.010

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015) Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 22: 3359-3371. doi:10.2217/nnm.15.137

Synthesis of norbornane bisether antibiotics via silver-mediated alkylation

Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A. and Pfeffer, Frederick M. (2015) Synthesis of norbornane bisether antibiotics via silver-mediated alkylation. Rsc Advances, 5 36: 28582-28596. doi:10.1039/c5ra03321g

Evolutionary origins of a bioactive peptide buried within preproalbumin

Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014) Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 3: 981-995. doi:10.1105/tpc.114.123620

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Craik, David J., Freissmuth, Michael and Gruber, Christian W. (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America, 110 52: 21183-21188. doi:10.1073/pnas.1311183110

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011) Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 5: 257-259. doi:10.1038/nchembio.542

Distribution and evolution of circular miniproteins in flowering plants

Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008) Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 9: 2471-2483. doi:10.1105/tpc.108.062331

Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides

Edwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. In: 34th European Peptide Symposium, Leipzig, Germany, (S122-S122). 4‐9 September 2016. doi:10.1002/psc.2950

Structural Diversity of a Novel Family of Cyclic Plant Peptides

Rosengren, K. J., Elliott, A. G., Franke, B. and Mylne, J. S. (2014). Structural Diversity of a Novel Family of Cyclic Plant Peptides. In: Journal of Peptide Science. 33rd European Peptide Symposium, Sofia Bulgaria, (S67-S67). August 31 – September 5 2014.

Sunflower trypsin inhibitor-1: chemical v. biological synthesis

Elliott, Alysha G., Craik, David J. and Mylne, Joshua S. (2011). Sunflower trypsin inhibitor-1: chemical v. biological synthesis. In: Michal Lebl, Peptides: Building Bridges: Proceedings of the Twenty-Second American Peptide Symposium. 22nd American Peptide Symposium, San Diego, United States, (86-87). 25-30 June 2011.

A new class of daisy seed peptides

Elliott, Alysha Gai (2013). A new class of daisy seed peptides PhD Thesis, The Institute for Molecular Bioscience, The University of Queensland.