Associate Professor Marie-Odile Parat

Associate Professor

School of Pharmacy
Faculty of Health and Behavioural Sciences

Affiliate Associate Professor

Mater Research Institute-UQ
Faculty of Medicine
m.parat@pharmacy.uq.edu.au
+61 7 334 61851

Overview

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Research Interests

  • Morphine and metastasis
  • Caveola-forming proteins and cancer
  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis
  • Caveolae and cellular entry of drug delivery systems
  • Plant bioactive discovery

Research Impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Qualifications

  • Doctor of Pharmacy, University of Grenoble
  • Doctor of Biology, University Joseph Fourier

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • (2018) Doctor Philosophy

View all Supervision

Publications

Book

  • Morphine and metastasis. Edited by Marie-Odile Parat Dordrecht, Netherlands: Springer, 2013. doi:10.1007/978-94-007-5678-6

Book Chapter

  • Nassar, Zeyad D. and Parat, Marie-Odile (2015). Cavin family: new players in the biology of caveolae. In Kwang W. Jeon (Ed.), International review of cell and molecular biology (pp. 235-306) Maryland Heights, MO, United States: Academic Press. doi:10.1016/bs.ircmb.2015.07.009

  • Buggy, Donal, Shannon, Hilary and Parat, Marie-Odile (2013). Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence. In Marie-Odile Parat (Ed.), Morphine and metastasis (pp. 79-94) Dordrecht , Netherlands: Springer. doi:10.1007/978-94-007-5678-6_6

  • Parat, Marie-Odile (2013). Morphine and metastasis: from bench to bedside. In Marie-Odile Para (Ed.), Morphine and metastasis (pp. 1-13) Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-5678-6_1

  • Parat, Marie-Odile (2009). The biology of caveolae: Achievements and perspectives. In Kwang W. Jeon (Ed.), International review of cell and molecular biology (pp. 117-162) Maryland Heights, MO, United States: Academic Press. doi:10.1016/S1937-6448(08)01804-2

  • Parat, Marie-Odile and Fox, Paul L. (2004). Oxidative Stress, Caveolae and Caveolin-1. In Peter. J. Quinn (Ed.), Membrane dynamics and domains (pp. 425-441) New York: Springer.

  • Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. In Quinn, Peter J. (Ed.), Membrane Dynamics and Domains (pp. 425-441) Boston. MA, United States: Springer. doi:10.1007/978-1-4757-5806-1_13

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision