Professor Chen Chen

Dir, Internat/Prof Endocrinology

School of Biomedical Sciences
Faculty of Medicine
chen.chen@uq.edu.au
+61 7 336 53856

Overview

Prevention and treatment of diabetes, obesity, heart diseases and cancers.

MBBS from Shanghai Fudan University Medical School, Master of Science from Peking Union Medical College, China and PhD from the University of Bordeaux, France. Postdoctoral training was received at Glaxo Inc., USA and then many years of research leader at Prince Henry's Institute of Medical Research in Melbourne. Current position was taken since 2008.

Research Interests

  • Endocrine Cell Biology
    The Endocrinology laboratory focuses on the link of cell biological properties and functions. Functions of cells may be the secretion of hormones in endocrine cells, contraction and dilation of cardiomyocytes, or proliferation and apoptosis of cancer cells. We concentrate on hormones, which are important in controlling growth, development, metabolic balance, body mass composition, ageing process, and the plasma glucose levels, such as growth hormone, leptin, orexin, insulin, glucagon, and adipocyte-derived hormones and factors. Several endogenous and synthetic regulatory peptides have been tested for their regulatory roles in pituitary and pancreatic islet endocrine cells on the membrane ion channel kinetics, exocytosis / endocytosis, key molecule expression and synthesis, and receptor expression. The long-term goal of these researches is to find effective way to therapeutically correct growth hormone and insulin deficiency in treating obesity and diabetes. In addition, possible paracrine or autocrine effect of a newly discovered hormone, Ghrelin, in the regulation of uterine endometrial cancer development, is under the investigation in this laboratory. We also investigate the function of cardiomyocytes in chronic heart failure, atrial fibrillation, ischemic cardiomyopathy and diabetic cardiomyopathy. The laboratory is using cutting edge techniques in single cell research, including patch clamping, single cell exocytosis measurement, cell image analysis, single cell shortening (contraction), and super-sensitive hormone assay methods. Modern molecular biology techniques are also employed in the laboratory for different projects, including GFP-transgenic mouse, shRNA-gene knock down using virus transfection, and real-time PCR.

Research Impacts

Over 150 peer-reviewed publications in International Scientific journals.

Qualifications

  • Bachelor in Medicine and Surgery, Fudan University
  • Doctor in NeuroSciences and Pharmacology, University of Bordeaux II

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Steyn, Frederik J. and Chen, Chen (2013). Adiponectin. In Abba J. Kastin (Ed.), Handbook of biologically active peptides 2nd ed. (pp. 983-989) Amsterdam, Netherlands: Academic Press/Elsevier. doi:10.1016/B978-0-12-385095-9.00130-5

  • Fung, Jenny N.T. and Chen, Chen (2012). Endometrial cancer: diagnosis, treatment and prevention. In Hiroto S. Watanabe (Ed.), Horizons in cancer research. Volume 49 (pp. 1-32) Hauppauge, NY, USA: Nova Publishers.

  • Zhao, Yufeng and Chen, Chen (2011). Adipsin as an adipokine. In Victor R. Preedy and Ross J. Hunter (Ed.), Adipokines (pp. 20-28) Enfield, NH, United States: Science Publishers.

  • Chen, Chen (2002). Cell biology and membrane function. In Textbook of Medical Physiology (pp. 7-26) China: People's Health Press.

  • Chen, Chen and Clarke, Iain J. (1999). Intracellular GHRP signalling. In E. Ghigo, M. Boghen, F. F. Casanueva and C. Dieguez (Ed.), Growth hormone secretagogues: basic findings and clinical implications (pp. 53-63) Amsterdam, The Netherlands: Elsevier.

  • Chen, Chen (1998). Introduction of a new laboratory technique to investigate roles of intracellular signal pathways in the regulation of cell membrane ion channels. In Proceedings of Chinese Academy of Medical Sciences (pp. 1-26) Beijing, China: Peking Union Medical College and Chinese Academy of Medical Sciences.

  • Lledo, Pierre-Marie, Kukstas, Lucy A., Chen, Chen, Vincent, Jean-Didier and Israel, Jean-Marc (1990). Ionic currents in the regulation of stimulus-secretion coupling in normal and tumoral adenohypophyseal cells. In F. F. Casanueva and C. Dieguez (Ed.), Recent advances in basic and clinical neuroendocrinology (pp. 65-74) Amsterdam, The Netherlands: Elsevier Science Publishers.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision