Associate Professor Chunxia Zhao

UQ Amplify Fellow & Group Leader

Australian Institute for Bioengineering and Nanotechnology

z.chunxia@uq.edu.au
+61 7 334 64263

Overview

Associate Professor Chun-Xia Zhao is a Group leader and an Australian Research Council (ARC) Future Fellow and at AIBN. She joined Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ) in early 2008 as a Postdoctoral Fellow in Prof. Anton Middelberg's group, after obtained her PhD degree in Zhejiang University.

In 2011, A/Prof. Zhao was awarded an ARC Discovery project along with the Australian Postdoctoral Fellow as the sole investigator. In 2014, she was awarded the prestigious Australian Research Council Future Fellow. Her research in bio-inspired nanotechnology and microfluidics has attracted more than $3.5 M research funding since 2011, including three Australian Research Council projects (two ARC discovery projects and one ARC Linkage project) as the lead investigator, two national prestigious fellowship (Australian Postdoctoral Fellowship and Australian Research Council Future Fellowship), UQ Early Career Award and UQ New Staff Start-Up grant. She visited Harvard University as Fellow of the School of Engineering and Applied Science (Oct - Dec, 2014). In 2016, her research excellence was recognised by the UQ Foundation Research Excellence Award. She has been appointed as member of the 2019 ARC College of Experts (2019-2021).

A/Prof. Zhao has contributed substantial high quality scientific papers in international top refereed journals such as Angewandte Chemie International Edition, Chemical Communications, Journal of Materials Chemistry, AIChE Journal, Biotechnology and Bioengineering, Vaccine, and so on. She has been focusing on innovative research, and has been active in patent application to transfer her research into practical applications, as evidenced by her five patents. One of her patents was licensed to an international company. She has built extensive collaborations with scientists at top universities such as Harvard University, Brown University, etc. She serves as the Editor-in-Chief, Editorial Board member for several journals.

Research Interests

Multifunctional nanomaterials for drug delivery, vaccine delivery and controlled release
Dr Zhao's research expertise is nanomaterials for drug delivery and controlled release, microfluidics for making sophisticated materials and screening drug delivery systems, and biomolecular engineering for sustainable materials, including a number of directions: (1) Emulsion and biomimetic dual-templating technology for making silica capsules for controlled and sustained release; (2) Stimuli-responsive soft materials based on biomolecules manufactured from renewable resources. (3) Simple and low-cost platform technology for producing bioproducts, including peptide or protein biosurfactants, peptide antibiotics. (4) Microfluidic synthesis of hierarchical materials for applications in sustained and controlled drug release. (5) Microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties. (6) In vivo-mimicking Tissue Chips for screening and evaluating nanocarriers.

Research Impacts

A/Prof. Zhao has established a recognised international presence in the fields of nanomaterials, microfluidics and drug delivery. She has been invited to submit book chapters, reviews and research papers in leading journal, such as Advanced Drug Delivery Reviews (2013 Impact Factor 12.7), Chemical Engineering Science Special Issue on Microfluidic Engineering, Industrial Engineering & Chemical Research, Vaccines. She has also been invited to present her work at international conferences (World Congress of Chemical Engineering, Annual World Congress of Advanced Materials, Annual World Congress of NanoMedicine, Bionano Innovation Conference, etc). A/Prof. Zhao is also an invited reviewer for more than 20 journals, including Advanced Materials, Chemical Communication, Lab on a Chip, Chemical Engineering Science, AIChE Journal, Langmuir, Journal of Chromatography A, Inorganic Chemistry, Journal of Chemical & Engineering Data, etc.

Qualifications

Doctor of Philosophy, Zhejiang University

Publications

Journal Article: Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release

Yu, Lei, Sun, Qi, Hui, Yue, Seth, Arjun, Petrovsky, Nikolai and Zhao, Chun-Xia (2019) Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. Journal of Colloid and Interface Science, 539 497-503. doi:10.1016/j.jcis.2018.12.075
Journal Article: A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy

Ran, Rui, Wang, Hao-Fei, Hou, Fei, Liu, Yun, Hui, Yue, Petrovsky, Nikolai, Zhang, Fan and Zhao, Chun-Xia (2019) A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy. Advanced Healthcare Materials, 1900015. doi:10.1002/adhm.201900015
Journal Article: Recent achievements and perspectives for large-scale recombinant production of antimicrobial peptides

Wibowo, David and Zhao, Chun-Xia (2019) Recent achievements and perspectives for large-scale recombinant production of antimicrobial peptides. Applied Microbiology and Biotechnology, 103 2: 659-671. doi:10.1007/s00253-018-9524-1

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Grants

A new physical strategy for therapeutic delivery

(2019–2021) UQ Development Fellowships
Imaging in the nano-scale age: terahertz and millimetre wave microanalysis

(2018) UQ Major Equipment and Infrastructure
Platform technologies for next generation single dose vaccine delivery

(2016–2017) UQ Collaboration and Industry Engagement Fund - FirstLink

View all Grants

Supervision

Bio-inspired silica nanocapsules for understanding in vitro and in vivo nano-bio interactions

(2019) Doctor Philosophy
Microfluidic Platform for Multifunctional Liposome Preparation and Evaluation

(2019) Doctor Philosophy
Microfluidic synthesis of biodegradable polymeric nanoparticles for drug delivery

(2018) Doctor Philosophy

View all Supervision

Publications

Book Chapter

Synthesis and characterization of nanomaterials using microfluidic technology

Zhao, Chun-Xia and Middelberg, Anton P. J. (2016). Synthesis and characterization of nanomaterials using microfluidic technology. In Mahmood Aliofkhazraei (Ed.), Handbook of nanoparticles (pp. 455-473) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-15338-4_23
Stimuli-responsive peptide nanostructures at the fluid-fluid interface

Zhao, Chun-Xia and Middelberg, Anton P.J. (2013). Stimuli-responsive peptide nanostructures at the fluid-fluid interface. In Juliet A. Gerrard (Ed.), Protein nanotechnology: protocols, instrumentation, and applications 2nd ed. (pp. 179-194) New York, NY United States: Humana Press. doi:10.1007/978-1-62703-354-1_10

Journal Article

Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release

Yu, Lei, Sun, Qi, Hui, Yue, Seth, Arjun, Petrovsky, Nikolai and Zhao, Chun-Xia (2019) Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. Journal of Colloid and Interface Science, 539 497-503. doi:10.1016/j.jcis.2018.12.075
A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy

Ran, Rui, Wang, Hao-Fei, Hou, Fei, Liu, Yun, Hui, Yue, Petrovsky, Nikolai, Zhang, Fan and Zhao, Chun-Xia (2019) A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy. Advanced Healthcare Materials, 1900015. doi:10.1002/adhm.201900015
Recent achievements and perspectives for large-scale recombinant production of antimicrobial peptides

Wibowo, David and Zhao, Chun-Xia (2019) Recent achievements and perspectives for large-scale recombinant production of antimicrobial peptides. Applied Microbiology and Biotechnology, 103 2: 659-671. doi:10.1007/s00253-018-9524-1
A numerical investigation of drug extravasation using a tumour-vasculature microfluidic device

Li, Wei, Wang, Hao-Fei, Kuruneru, Sahan T. W., Wang, Tong, Sauret, Emilie, Li, Zhi-Yong, Zhao, Chun-Xia and Gu, Yuan-Tong (2018) A numerical investigation of drug extravasation using a tumour-vasculature microfluidic device. Microfluidics and Nanofluidics, 22 12: . doi:10.1007/s10404-018-2165-y
Tumor-vasculature-on-a-chip for investigating nanoparticle extravasation and tumor accumulation

Wang, Hao-Fei, Ran, Rui, Liu, Yun, Hui, Yue, Zeng, Bijun, Chen, Dong, Weitz, David A. and Zhao, Chun-Xia (2018) Tumor-vasculature-on-a-chip for investigating nanoparticle extravasation and tumor accumulation. ACS Nano, 12 11: 11600-11609. doi:10.1021/acsnano.8b06846
Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing

Sun, Qi, Tan, Say Hwa, Chen, Qiushui, Ran, Rui, Hui, Yue, Chen, Dong and Zhao, Chun-Xia (2018) Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing. ACS Biomaterials Science & Engineering, 4 12: 4425-4433. doi:10.1021/acsbiomaterials.8b00904
Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting

Ran, Rui, Wang, Haofei, Liu, Yun, Hui, Yue, Sun, Qi, Seth, Arjun, Wibowo, David, Chen, Dong and Zhao, Chun-Xia (2018) Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting. European Journal of Pharmaceutics and Biopharmaceutics, 130 1-10. doi:10.1016/j.ejpb.2018.06.017
Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting

Liu, Yun, Hui, Yue, Ran, Rui, Yang, Guang-Ze, Wibowo, David, Wang, Hao-Fei, Middelberg, Anton P. J. and Zhao, Chun-Xia (2018) Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7 15: 1800106. doi:10.1002/adhm.201800106
Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting

Hui, Yue, Wibowo, David, Liu, Yun, Ran, Rui, Wang, Hao-Fei, Seth, Arjun, Middelberg, Anton P J and Zhao, Chun-Xia (2018) Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting. ACS Nano, 12 3: 2846-2857. doi:10.1021/acsnano.8b00242
Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity

Sun, Baode, Wibowo, David, Middelberg, Anton P. J. and Zhao, Chun-Xia (2018) Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity. AMB Express, 8 1: 6. doi:10.1186/s13568-018-0541-3
Design and production of a novel antimicrobial fusion protein in Escherichia coli

Sun, Baode, Wibowo, David, Sainsbury, Frank and Zhao, Chun-Xia (2018) Design and production of a novel antimicrobial fusion protein in Escherichia coli. Applied Microbiology and Biotechnology, 102 20: 8763-8772. doi:10.1007/s00253-018-9319-4
Biocompatible amphiphilic hydrogel-solid dimer particles as colloidal surfactants

Chen, Dong, Amstad, Esther, Zhao, Chun-Xia, Cai, Liheng, Fan, Jing, Chen, Qiushui, Hai, Mingtan, Koehler, Stephan, Zhang, Huidan, Liang, Fuxin, Yang, Zhenzhong and Weitz, David A (2017) Biocompatible amphiphilic hydrogel-solid dimer particles as colloidal surfactants. ACS Nano, 11 12: 11978-11985. doi:10.1021/acsnano.7b03110
Dispersing hydrophobic natural colourant β-carotene in shellac particles for enhanced stability and tunable colour

Chen, Dong, Zhao, Chun-Xia, Lagoin, Camille, Hai, Mingtan, Arriaga, Laura R., Koehler, Stephan, Abbaspourrad, Alireza and Weitz, David A. (2017) Dispersing hydrophobic natural colourant β-carotene in shellac particles for enhanced stability and tunable colour. Royal Society Open Science, 4 12: 170919. doi:10.1098/rsos.170919
Multiphase microfluidic synthesis of micro- and nanostructures for pharmaceutical applications

Ran, Rui, Sun, Qi, Baby, Thejus, Wibowo, David, Middelberg, Anton P. J. and Zhao, Chun-Xia (2017) Multiphase microfluidic synthesis of micro- and nanostructures for pharmaceutical applications. Chemical Engineering Science, 169 78-96. doi:10.1016/j.ces.2017.01.008
Fundamental studies on throughput capacities of hydrodynamic flow-focusing microfluidics for producing monodisperse polymer nanoparticles

Baby, Thejus, Liu, Yun, Middelberg, Anton P. J. and Zhao, Chun-Xia (2017) Fundamental studies on throughput capacities of hydrodynamic flow-focusing microfluidics for producing monodisperse polymer nanoparticles. Chemical Engineering Science, 169 128-139. doi:10.1016/j.ces.2017.04.046
Design of modular peptide surfactants and their surface activity

Wang, Hao-Fei, Wibowo, David, Shao, Zhengzhong, Middelberg, Anton P. J. and Chun-Xia Zhao (2017) Design of modular peptide surfactants and their surface activity. Langmuir, 33 32: 7957-7967. doi:10.1021/acs.langmuir.7b01382
Biocompatible microcapsules with a water core templated from single emulsions

Kong, Linlin, Amstad, Esther, Hai, Mingtan, Ke, Xinyou, Chen, Dong, Zhao, Chun-Xia and Weitz, David A. (2017) Biocompatible microcapsules with a water core templated from single emulsions. Chinese Chemical Letters, 28 9: 1897-1900. doi:10.1016/j.cclet.2017.07.017
Conformation and self-assembly changes of isomeric peptide amphiphiles influenced by switching tyrosine in the sequences

Zhao, Fangyi, Guo, Hui, Zhang, Zhidong, Ye, John, Liu, Longlong, Zhao, Chun-Xia and Shao, Zhengzhong (2017) Conformation and self-assembly changes of isomeric peptide amphiphiles influenced by switching tyrosine in the sequences. Journal of Materials Chemistry B, 5 26: 5189-5195. doi:10.1039/c7tb00736a
Interfacial films formed by a biosurfactant modularized with a silken tail

Wibowo, David, Wang, Hao-Fei, Shao, Zhengzhong, Middelberg, Anton P. J. and Zhao, Chun-Xia (2017) Interfacial films formed by a biosurfactant modularized with a silken tail. The Journal of Physical Chemistry C, 121 27: 14658-14667. doi:10.1021/acs.jpcc.7b03807
Biomimetic silica nanocapsules for tunable sustained release and cargo protection

Yang, Guang-Ze, Wibowo, David, Yun, Jung-Ho, Wang, Lianzhou, Middelberg, Anton P. J. and Zhao, Chun-Xia (2017) Biomimetic silica nanocapsules for tunable sustained release and cargo protection. Langmuir, 33 23: 5777-5785. doi:10.1021/acs.langmuir.7b00590
Controlled generation of ultrathin-shell double emulsions and studies on their stability

Zhao, Chun-Xia, Chen, Dong, Hui, Yue, Weitz, David A. and Middelberg, Anton P. J. (2017) Controlled generation of ultrathin-shell double emulsions and studies on their stability. ChemPhysChem, 18 10: 1393-1399. doi:10.1002/cphc.201601334
Collective generation of milliemulsions by step-emulsification

Huang, Xing, Eggersdorfer, Max, Wu, Jinrong, Zhao, Chun-Xia, Xu, Zhongbin, Chen, Dong and Weitz, David A. (2017) Collective generation of milliemulsions by step-emulsification. RSC Advances, 7 24: 14932-14938. doi:10.1039/c7ra00935f
Non-chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules

Wibowo, David, Yang, Guang-Ze, Middelberg, Anton P.J. and Zhao, Chun-Xia (2017) Non-chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules. Biotechnology and Bioengineering, 114 2: 335-343. doi:10.1002/bit.26079
From folding to function: design of a new switchable biosurfactant protein

Zhao, Chun-Xia, Dwyer, Mirjana, Yu, Lei and Middelberg, Anton P. J. (2017) From folding to function: design of a new switchable biosurfactant protein. ChemPhysChem, 18 5: 488-492. doi:10.1002/cphc.201601277
A partially purified outer membrane protein VirB9-1 for low-cost nanovaccines against Anaplasma marginale

Zhao, Liang, Cavallaro, Antonino S., Wibowo, David, Zhang, Bing, Zhang, Jun, Mitter, Neena, Yu, Chengzhong, Zhao, Chun-Xia and Middelberg, Anton P. J. (2017) A partially purified outer membrane protein VirB9-1 for low-cost nanovaccines against Anaplasma marginale. Vaccine, 35 1: 77-83. doi:10.1016/j.vaccine.2016.11.037
Microfluidic synthesis of multifunctional liposomes for tumour targeting

Ran, Rui, Middelberg, Anton P. J. and Zhao, Chun-Xia (2016) Microfluidic synthesis of multifunctional liposomes for tumour targeting. Colloids and Surfaces B: Biointerfaces, 148 402-410. doi:10.1016/j.colsurfb.2016.09.016
Interfacial engineering for silica nanocapsules

Wibowo, David, Hui, Yue, Middelberg, Anton P. J. and Zhao, Chun-Xia (2016) Interfacial engineering for silica nanocapsules. Advances in Colloid and Interface Science, 236 83-100. doi:10.1016/j.cis.2016.08.001
Stable ultrathin-shell double emulsions for controlled release

Zhao, Chun-Xia, Chen, Dong, Hui, Yue, Weitz, David A. and Middelberg, Anton P. J. (2016) Stable ultrathin-shell double emulsions for controlled release. ChemPhysChem, 17 11: 1553-1556. doi:10.1002/cphc.201600142
Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale

Zhao, Liang, Mahony, Donna, Cavallaro, Antonino S., Zhang, Bing, Zhang, Jun, Deringer, James R., Brown, Wendy C., Zhao, Chun-Xia, Yu, Chengzhong, Mitter, Neena and Middelberg, Anton P. J. (2016) Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale. PLoS One, 11 4: e0154295. doi:10.1371/journal.pone.0154295
Insights into the role of biomineralizing peptide surfactants on making nanoemulsion-templated silica nanocapsules

Hui, Yue, Wibowo, David and Zhao, Chun-Xia (2016) Insights into the role of biomineralizing peptide surfactants on making nanoemulsion-templated silica nanocapsules. Langmuir, 32 3: 822-830. doi:10.1021/acs.langmuir.5b03811
Interfacial biomimetic synthesis of silica nanocapsules using a recombinant catalytic modular protein

Wibowo, David, Zhao, Chun-Xia and Middelberg, Anton P. J. (2015) Interfacial biomimetic synthesis of silica nanocapsules using a recombinant catalytic modular protein. Langmuir, 31 6: 1999-2007. doi:10.1021/la504684g
A simple and low-cost platform technology for producing pexiganan antimicrobial peptide in E. coli

Zhao, Chun-Xia, Dimitrijev Dwyer, Mirjana, Yu, Alice Lei, Wu, Yang, Fang, Sheng and Middelberg, Anton P. J. (2015) A simple and low-cost platform technology for producing pexiganan antimicrobial peptide in E. coli. Biotechnology and Bioengineering, 112 5: 957-964. doi:10.1002/bit.25505
Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules

Wibowo, David, Zhao, Chun-Xia, Peters, Brenton C. and Middelberg, Anton P. J. (2014) Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules. Journal of Agricultural and Food Chemistry, 62 52: 12504-12511. doi:10.1021/jf504455x
Titania microparticles using a facile microfluidic mass-transfer control method

Zhao, Chun-Xia and Middelberg, Anton P. J. (2014) Titania microparticles using a facile microfluidic mass-transfer control method. Chemical Engineering Science, 112 10-14. doi:10.1016/j.ces.2014.03.009
Nanoparticle vaccines

Zhao, Liang, Seth, Arjun, Wibowo, Nani, Zhao, Chun-Xia, Mitter, Neena, Yu, Chengzhong and Middelberg, Anton P. J. (2014) Nanoparticle vaccines. Vaccine, 32 3: 327-337. doi:10.1016/j.vaccine.2013.11.069
Emulsion-templated silica nanocapsules formed using bio-inspired silicification

Wibowo, David, Zhao, Chun-Xia and Middelberg, Anton P. J. (2014) Emulsion-templated silica nanocapsules formed using bio-inspired silicification. Chemical Communications, 50 77: 11325-11328. doi:10.1039/c4cc04904g
Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery

Zhao, Chun-Xia (2013) Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. Advanced Drug Delivery Reviews, 65 11-12: 1420-1446. doi:10.1016/j.addr.2013.05.009
One-step fabrication of titania hollow spheres by controlled interfacial reaction in a droplet-based microfluidic system

Zhao, Chun-Xia and Middelberg, Anton P. J. (2013) One-step fabrication of titania hollow spheres by controlled interfacial reaction in a droplet-based microfluidic system. Microfluidics and Nanofluidics, 14 3-4: 703-709. doi:10.1007/s10404-012-1088-2
Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release

Zhao, Chun-Xia, Yu, Lei and Middelberg, Anton P. J. (2013) Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release. Journal of Materials Chemistry B, 1 37: 4828-4833. doi:10.1039/c3tb20641f
Microfluidic synthesis of monodisperse hierarchical silica particles with raspberry-like morphology

Zhao, Chun-Xia and Middelberg, Anton P. J. (2013) Microfluidic synthesis of monodisperse hierarchical silica particles with raspberry-like morphology. RSC Advances, 3 44: 21227-21230. doi:10.1039/c3ra42362j
Development of a group contribution method for determination of thermal conductivity of ionic liquids

We, Ke-Jun, Zhao, Chun-Xia and He, Chao-Hong (2012) Development of a group contribution method for determination of thermal conductivity of ionic liquids. Fluid Phase Equilibria, 339 10-14. doi:10.1016/j.fluid.2012.11.024
Investigation of convective heat transfer with liquids in microtubes

Wu, Ke-Jun, Zhao, Chun-Xia and He, Chao-Hong (2012) Investigation of convective heat transfer with liquids in microtubes. Industrial & Engineering Chemistry Research, 51 27: 9386-9395. doi:10.1021/ie301174j
A simple corresponding-states group contribution method for estimating surface tension of ionic liquids

We, Ke-Jun, Zhao, Chun-Xia and Chao-Hong He (2012) A simple corresponding-states group contribution method for estimating surface tension of ionic liquids. Fluid Phase Equilibria, 328 42-48. doi:10.1016/j.fluid.2012.05.021
Microfluidic elucidation of the effects of interfacial rheology on droplet deformation

Zhao, Chun-Xia, Rondeau, Elisabeth, Cooper-White, Justin J. and Middelberg, Anton P. J. (2012) Microfluidic elucidation of the effects of interfacial rheology on droplet deformation. Industrial and Engineering Chemistry Research, 51 4: 2021-2029. doi:10.1021/ie200631m
Design of low-charge peptide sequences for high-yield formation of titania nanoparticles

Zhao, Chun-Xia, Yu, Lei and Middelberg, Anton P. J. (2012) Design of low-charge peptide sequences for high-yield formation of titania nanoparticles. RSC Advances, 2 4: 1292-1295. doi:10.1039/c2ra00726f
Effects of fluid-fluid interfacial elasticity on droplet formation in microfluidic devices

Zhao, Chun-Xia, Miller, Erik, Cooper-White, Justin J. and Middelberg, Anton P.J. (2011) Effects of fluid-fluid interfacial elasticity on droplet formation in microfluidic devices. AIChE Journal, 57 7: 1669-1677. doi:10.1002/aic.12382
Nanoparticle synthesis in microreactors

Zhao, Chun-Xia, He, Lizhong, Qiao, Shizhang and Middelberg, Anton P.J. (2011) Nanoparticle synthesis in microreactors. Chemical Engineering Science, 66 7: 1463-1479. doi:10.1016/j.ces.2010.08.039
Two-phase microfluidic flows

Zhao, Chun-Xia and Middelberg, Anton P. J. (2011) Two-phase microfluidic flows. Chemical Engineering Science, 66 7: 1394-1411. doi:10.1016/j.ces.2010.08.038
Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette shear cell

Fridjonsson, Einar O., Chandrasekera, Thusara C., Sederman, Andrew J., Johns, Michael L., Zhao, Chun-Xia and Middelberg, Anton P. J. (2011) Imaging the effects of peptide bio-surfactants on droplet deformation in a Taylor-Couette shear cell. Soft Matter, 7 6: 2961-2967. doi:10.1039/c0sm00951b
Mass transfer and separation criteria for high-speed countercurrent chromatography

Zhao, Chun-Xia and He, Chao-Hong (2011) Mass transfer and separation criteria for high-speed countercurrent chromatography. AIChE Journal, 57 2: 359-372. doi:10.1002/aic.12282
A nonlinear active learning based on AUC optimization and its application to obstacle detection

Han, Guang, Zhao, Chunxia and Hu, Xuelei (2010) A nonlinear active learning based on AUC optimization and its application to obstacle detection. Jiqiren, 32 3: 344-351. doi:10.3724/SP.J.1218.2010.00344
Microfluidic mass-transfer control for the simple formation of complex multiple emulsions

Zhao, Chun-Xia and Middelberg, Anton P. J. (2009) Microfluidic mass-transfer control for the simple formation of complex multiple emulsions. Angewandte Chemie-International Edition, 48 39: 7208-7211. doi:10.1002/anie.200902485
Axial dispersion coefficient in high-speed counter-current chromatography

Zhao, Chun-Xia, Xua, Ya-Lan and He, Chao-Hong (2009) Axial dispersion coefficient in high-speed counter-current chromatography. Journal of Chromatography A, 1216 24: 4841-4846. doi:10.1016/j.chroma.2009.04.020
Densities and viscosities of binary mixtures of tri-n-butyl phosphate + cyclohexane, + n-heptane at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K

Fang, Sheng, Zhao, Chun-Xia and He, Chao-Hong (2008) Densities and viscosities of binary mixtures of tri-n-butyl phosphate + cyclohexane, + n-heptane at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K. Journal of Chemical and Engineering Data, 53 9: 2244-2246. doi:10.1021/je8003707
Densities and viscosities of binary mixtures of tris(2-ethylhexyl) phosphate + cyclohexane or n-hexane at T = (293.15, 298.15, and 303.15) K and p = 0.1 MPa

Fang, Sheng, Zhao, Chun-Xia, He, Chao-Hong, Liu, Jian-Qing and Sun, Jiang-Hao (2008) Densities and viscosities of binary mixtures of tris(2-ethylhexyl) phosphate + cyclohexane or n-hexane at T = (293.15, 298.15, and 303.15) K and p = 0.1 MPa. Journal of Chemical and Engineering Data, 53 11: 2718-2720. doi:10.1021/je8006138
Retention of the stationary phase for high-speed countercurrent chromatography

He, Chao-Hong and Zhao, Chun-Xia (2007) Retention of the stationary phase for high-speed countercurrent chromatography. AIChE Journal, 53 6: 1460-1471. doi:10.1002/aic.11185
Sample capacity in preparative high-speed counter-current chromatography

Zhao, Chun-Xia and He, Chao-Hong (2007) Sample capacity in preparative high-speed counter-current chromatography. Journal of chromatography. A, 1146 2: 186-192. doi:10.1016/j.chroma.2007.01.105
Solubility of Atractylenolide III in Hexane, Ethyl Acetate, Diethyl Ether, and Ethanol from (283.2 to 323.2) K

Zhao, Chun-Xia and He, Chao-Hong (2007) Solubility of Atractylenolide III in Hexane, Ethyl Acetate, Diethyl Ether, and Ethanol from (283.2 to 323.2) K. Journal of Chemical and Engineering Data, 52 4: 1223-1225. doi:10.1021/je6005482
Preparative isolation and purification of atractylon and atractylenolide III from the Chinese medicinal plant Atractylodes macrocephala by high-speed counter-current chromatography

Zhao, Chunxia and He, Chaohong (2006) Preparative isolation and purification of atractylon and atractylenolide III from the Chinese medicinal plant Atractylodes macrocephala by high-speed counter-current chromatography. Journal of Separation Science, 29 11: 1630-1636. doi:10.1002/jssc.200500464

Conference Publication

Bio-inspired nanomaterials for controlled release

Zhao, Chun-Xia, Wibowo, David and Middelberg, Anton P. J. (2015). Bio-inspired nanomaterials for controlled release. In: 2015 AIChE Annual Meeting, Salt Lake City, UT, United States, (). 8-13 November 2015.
Double emulsions by a one-step solvent shift method

Zhao, Chun-Xia and Middelberg, Anton P. J. (2010). Double emulsions by a one-step solvent shift method. In: Chemeca2010. 40th Annual Australasian Chemical and Process Engineering Conference, Adelaide, SA, Australia, (432-440). 26-29 September 2010.
Interfacial elasticity affects droplet formation in microfluidic channels

Zhao, Chun-Xia, Miller, Erik, Cooper-White, Justin J., Dexter, Annette F. and Middelberg, Anton P. J. (2009). Interfacial elasticity affects droplet formation in microfluidic channels. In: 8th World Congress of Chemical Engineering, Montreal, Canada, (). 23 - 27 August, 2009.
The influence of interfacial viscoelasticity on droplet deformation in microchannels

Zhao, Chun-Xia, Rondeau, Elisabeth, Miller, Erik, Cooper-White, Justin J., Dexter, Annette F. and Middelberg, Anton P.J. (2009). The influence of interfacial viscoelasticity on droplet deformation in microchannels. In: WCCE8: 8th World Congress of Chemical Engineering, Montréal, QC, Canada, (1-2). 23-27 August 2009.
Separation for the mixture of petroleum ether (60-90?) and ethyl acetate

Luo, D. Z., Zhao, C. X. and He, C. H. (2005). Separation for the mixture of petroleum ether (60-90?) and ethyl acetate. In: China/USA/Japan Joint Chemical Engineering Conference, Beijing, (). Oct 11-13, 2005.

Grants (Administered at UQ)

A new physical strategy for therapeutic delivery

(2019–2021) UQ Development Fellowships
Imaging in the nano-scale age: terahertz and millimetre wave microanalysis

(2018) UQ Major Equipment and Infrastructure
Platform technologies for next generation single dose vaccine delivery

(2016–2017) UQ Collaboration and Industry Engagement Fund - FirstLink
Exosome and Bio/Nanoparticle Characterisation Facility

(2016) UQ Major Equipment and Infrastructure
Engineering improved technology for nanoparticle-based adjuvant manufacture

(2015–2018) ARC Linkage Projects
Next generation core-shell materials based on biomolecular dual-templating

(2015–2018) ARC Discovery Projects
Platform technologies for multifunctional nanocarrier systems

(2015–2018) ARC Future Fellowships
UQ Advancing Women Researchers Grant 2015 Round 1 - Dr Chunxia Zhao

(2015–2016) UQ Advancing Women Researchers Grants
pH-responsive core-shell mesoporous silica nanocomposites for bioimaging and targeted drug delivery

(2012) UQ Early Career Researcher
Engineered nanoporous materials and composites having hierarchical structures by emulsion templating

(2011–2014) ARC Discovery Projects

PhD and MPhil Supervision

Current Supervision

Development of Multifunctional Nanoparticles for Cancer Combination Therapy

Doctor Philosophy — Principal Advisor
Other advisors:
- Dr Bijun Zeng
Microchip-based human cancer models for chemoimmunotherapy

Doctor Philosophy — Principal Advisor
Other advisors:
- Dr Bijun Zeng
Biomimetic chip platforms for studying drug delivery systems

Doctor Philosophy — Principal Advisor
Other advisors:
- Dr Bijun Zeng
Bioinspired nanomaterials for drug delivery

Doctor Philosophy — Principal Advisor
Other advisors:
- Professor Andrew Whittaker
Sustainable Core-Shell Nanomaterials for Controlled Release

Doctor Philosophy — Principal Advisor
Synthetic biologic engineering of diagnostic nanosystems

Doctor Philosophy — Principal Advisor
Development of Sustained-Release Subunit Nanovaccines Against Anaplasma marginale

Doctor Philosophy — Associate Advisor
Other advisors:
- Professor Neena Mitter
- Professor Michael Yu
Optimisation of peptide-stabilised emulsion engineering using microfluidics

Doctor Philosophy — Associate Advisor
Other advisors:
- Dr Frank Sainsbury

Completed Supervision

Bio-inspired silica nanocapsules for understanding in vitro and in vivo nano-bio interactions

(2019) Doctor Philosophy — Principal Advisor
Microfluidic Platform for Multifunctional Liposome Preparation and Evaluation

(2019) Doctor Philosophy — Principal Advisor
Microfluidic synthesis of biodegradable polymeric nanoparticles for drug delivery

(2018) Doctor Philosophy — Principal Advisor
Simple Methods for Producing Valuable Antimicrobial Peptides and Proteins Products Using E. coli Systems

(2018) Master Philosophy — Principal Advisor
Development of three-dimensional microfluidic models for therapeutic testing

(2017) Master Philosophy — Principal Advisor
Bio-inspired oil-core silica-shell nanocapsules for controlled-release applications

(2015) Doctor Philosophy — Principal Advisor

This staff member is a UQ Expert for media in the following fields:

Nanotechnology, Microfluidics, Vaccines, Drug delivery, Nanomaterials, Peptides, Antibiotics, Nanoparticles, Sustainable materials, Tissue Chips, Controlled release, Emulsions

They are happy to lend their expertise to your articles or broadcasts and share their research discoveries and insights with the community via media channels.

For additional assistance with story ideas, general advice and information or help with seeking further experts, please email the UQ Media Team or telephone (07) 3365 1120.

The University of Queensland

UQ Researchers