Dr Ligong Liu

Senior Research Officer

Institute for Molecular Bioscience
l.liu@imb.uq.edu.au
+61 7 334 62988
+61 7 334 62381

Overview

Dr Ligong Liu received BSc (organic chemistry) in 1990 from Nankai University, China, MSc (medicinal chemistry) in 1993 from Beijing Medical University (currently Peking University Health Science Center) with research thesis studying steroids, and PhD in 1997 from Central Queensland University, Australia, investigating protoberberine alkaloids - the active components in many folkloric medicines. Following postdoctoral research at Central Queensland University and the Australian National University (1997-2001), he spent seven years in Australian biotech industries (Alchemia Ltd and Progen Pharmaceuticals Ltd) specializing in carbohydrate and oligosaccharide based therapeutics. Since 2008, he has been a Senior Research Officer in Professor Fairlie’s group at the Institute for Molecular Bioscience, University of Queensland. His research interests are in chemical synthesis, medicinal chemistry, drug design and development, combinatorial chemistry, modulators of enzymes/growth factors/G protein-coupled receptors associated with inflammatory disorders and cancers, and modulators of T cell immunity

Research Impacts

Dr Liu has published over 60 peer-reviewed papers and is a co-inventor of 12 patent applications. His research generated one market drug and several drugs at various stages of clinical trials. His recent discovery of a new class of antigens, now protected by patents, has powered immunologists across the world to study a class of abundant but less known T cells called Mucosal-Associated Invariant T cells. This work led to two highly cited papers in Nature and several papers in other high impact journals since 2012 (e.g. Nature Immunology, Immunity, Journal of Experimental Medicine, Nature Communications, Journal of Immunology, Mucosal Immunity).

Qualifications

  • PhD, C.Qld.

Publications

  • Cheng, Janice, Liu, Ligong, Pellicci, Daniel, Reddiex, Scott J.J., Cotton, Rachel, Cheng, Tan-Yun, Young, David, Van Rhijn, Ildiko, Moody, Branch, Rossjohn, Jamie, Fairlie, David, Godfrey, Dale and Williams, Spencer John (2017) Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition. Chemistry - A European Journal, 23 7: 1694-1701. doi:10.1002/chem.201605287

  • Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016) PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 12: 1179-1184. doi:10.1021/acsmedchemlett.6b00306

  • Corbett, Alexandra J., Eckle, Sidonia B. G., Birkinshaw, Richard W., Liu, Ligong, Patel, Onisha, Mahony, Jennifer, Chen, Zhenjun, Reantragoon, Rangsima, Meehan, Bronwyn, Cao, Hanwei, Williamson, Nicholas A., Strugnell, Richard A., Van Sinderen, Douwe, Mak, Jeffrey Y. W., Fairlie, David P., Kjer-Nielsen, Lars, Rossjohn, Jamie and McClusky, James (2014) T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 509 7500: 361-365. doi:10.1038/nature13160

  • Yau, Mei-Kwan, Liu, L.igong and Fairlie, David P. (2013) Toward drugs for protease-activated receptor 2 (PAR2). Journal of Medicinal Chemistry, 56 19: 7477-7497. doi:10.1021/jm400638v

  • Karoli, Tomislav, Liu, Ligong, Fairweather, Jon K., Hammond, Edward, Li, Cai Ping, Cochran, Siska, Bergefall, Kicki, Trybala, Edward, Addison, Russell S. and Ferro, Vito (2005) Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88). Journal of Medicinal Chemistry, 48 26: 8229-8236. doi:10.1021/jm050618p

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Grants

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Supervision

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Publications

Featured Publications

Journal Article

Conference Publication

  • Gherardin, N. A., Keller, A. N., Woolley, R. E., Le Nours, J., Ritchie, D. S., Neeson, P. J., Birkinshaw, R. W., Eckle, S. B., Waddington, J. N., Liu, L., Fairlie, D. P., McCluskey, J., Pellicci, D. G., Uldrich, A. P., Rossjohn, J. and Godfrey, D., I (2016). A broad family of MR1-restricted T cells. In: International Congress of Immunology (ICI), Melbourne Australia, (153-154). 21-26 August 2016.

  • Keller, A. N., Eckle, S. B. G., Xu, W., Liu, L., Hughes, V. A., Mak, J., Meehan, B., Pediongco, T., Birkinshaw, R. W., Chen, Z., Wang, H., Souza, C., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., McCluskey, J. and Rossjohn, J. (2016). Common drugs modulate mucosal-associated invariant T cell function. In: International Congress of Immunology (ICI), Melbourne, VIC, Australia, (257-257). 21-26 August 2016. doi:10.1002/eji.201670200

  • Eckle, S. B. G., Keller, A. N., Xu, W., Meehan, B., Pediongco, T., Liu, L., Hughes, V. A., Mak, J. Y. W., Birkinshaw, R. W., Chen, Z., Wang, H., D'Souza, C., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., Rossjohn, J. and McCluskey, J. (2016). Drugs/drug analogues modulate MAIT cell function in an MR1-dependent manner. In: International Congress of Immunology (ICI), Melbourne, VIC, Australia, (587-587). 21-26 August 2016. doi:10.1002/eji.201670200

  • Godfrey, D., Koay, H. -F, Gherardin, N., Enders, A., Loh, L., Chen, Z., Corbett, A., Eckle, S., Meehan, B., d'Udekem, Y., Konstantinov, I, Lappas, M., Liu, L., Goodnow, C., Fairlie, D., Rossjohn, J., Kedzierska, K., Berzins, S., McCluskey, J., Uldrich, A. and Pellicci, D. (2016). Thymic precursors to the mucosal-associated invariant T cell lineage. In: International Congress of Immunology (ICI), Melbourne Australia, (256-257). 21-26 August 2016.

  • Yau, Annika M., Liu, Ligong, Reid, Robert C., Barry, Grant D., Suen, Jacky Y., Lohman, Rink-Jan, Le, Giang T., Cotterell, Adam and Fairlie, David P. (2011). Novel agonists and antagonists for protease activated receptor 2. In: Abstracts of Papers of the 242nd National Meeting of the American Chemical Society. National Meeting of the American Chemical Society (242nd, ACS, 2011), Denver, CO, U.S.A., (). 28 August-1 September 2011.

  • Fairlie, David P., Stoermer, Martin, Lucke, Andrew, Lohman, Rink-Jan, Liu, Ligong and Ruiz-Gomez, Gloria (2011). Towards orally bioavailable peptides and peptidomimetics. In: Abstracts of Papers of the American Chemical Society. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim, CA, United States, (). 27-31 March 2011.

  • Dredge, K, Davis, K, Liu, L, Johnstone, K, Handley, P, Wimmer, N, Bytheway, I, Hammond, E, Li, CP, Rowley, J, Ferro, V and Gautam, A (2007). Heparan sulfate mimetics - potent angiogenesis inhibitors for cancer therapy. In: Molecular Cancer Therapeutics. Unknown, Unknown, (3339S-3339S). Unknown.

Other Outputs

  • Ferro, V., Karoli, T., Liu, L., Handley, P.N., Johnstone, K.D., Wimmer, N. and Hammond, E.T. (2009). Novel sulfated oligosaccharide derivatives. WO/2009/049370.

  • Ferro, Vito, Fairweather, Jon, Karoli, Tomislav and Liu, Ligong (2005). Sulfated oligosaccharide derivatives. WO/2005/085264.

  • Don, Robert Hugh, Ferro, Vito, Bytheway, Ian, Cochran, Siska, Fairweather, Jon Krueger, Hammond, Edward Timothy, Karoli, Tomislav, Li, Cai Ping and Liu, Ligong (2005). Glycosaminoglycan (GAG) mimetics. WO/2005/061523.

  • West, Michael Leo, Andrews, Peter, Ramsdale, Tracie Elizabeth, Meutermans, Wim, Thanh Le, Giang, Clark, Chris, Abbenante, Giovani and Liu, Ligong (2004). Derivatives of synthesis of monosaccharides for drug discovery. WO 2004014929.

  • Banwell, Martin Gerhardt, Liu, Ligong, Parish, Christopher Richard and Freeman, Craig Geoffrey (2003). Linked cyclitols and their polysulfated derivatives. WO/2003/004454.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision