Dr Anna Henningham

UQ Fellow

Child Health Research Centre
Faculty of Medicine
a.henningham@uq.edu.au
+61 7 3069 7461

Overview

Qualifications

  • Doctor of Philosophy, University of Wollongong
  • Bachelor of Biotechnology (Honours), University of Wollongong

Publications

View all Publications

Available Projects

  • Exposure to air pollution and other environmental stressors have adverse effects on human health, including increasing susceptibility to acute respiratory illnesses (ARI) and chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease. While the epidemiological evidence is strong, the mechanism(s) underlying this phenomenon remains uncertain. Children exposed to second-hand tobacco smoke are at increased risk of ARI, including acute viral bronchiolitis, pneumonia and middle ear infections. Children exposed to household air pollution have increased rates of pneumonia and tuberculosis and exaggerated respiratory symptoms and ARI are seen in children exposed totraffic related air pollution. The respiratory epithelium in the nose and large airways represents the point of first contact of environmental stressors and infecting microorganisms, as well as the site of initial defence against such insults. The respiratory epithelium orchestrated the innate immune response to microorganisms and if this is inadequate the risk of infection increases. Thus understanding which environmental stressors compromise innate immunity and how this occurs is vital knowledge that can inform evidence-based policy decisions in air quality monitoring.

View all Available Projects

Publications

Book Chapter

Journal Article

  • McNeilly, Celia, Cosh, Samantha, Vu, Therese, Nichols, Jemma, Henningham, Anna, Hofmann, Andreas, Fane, Anne, Smeesters, Pierre R., Rush, Catherine M., Hafner, Louise M., Ketheesan, Natkuman, Sriprakash, Kadaba S. and McMillan, David J. (2016) Predicted coverage and immuno-safety of a recombinant c-repeat region based Streptococcus pyogenes vaccine candidate. Plos One, 11 6: . doi:10.1371/journal.pone.0156639

  • Barnett, Timothy C., Cole, Jason N., Rivera-Hernandez, Tania, Henningham, Anna, Paton, James C., Nizet, Victor and Walker, Mark J. (2015) Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17 12: 1721-1741. doi:10.1111/cmi.12531

  • Henningham, Anna, Döhrmann, Simon, Nizet, Victor and Cole, Jason N. (2015) Mechanisms of group A Streptococcus resistance to reactive oxygen species. FEMS Microbiology Reviews, 39 4: 488-508. doi:10.1093/femsre/fuu009

  • Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo,Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N. (2014) Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus. Journal of Biological Chemistry, 289 46: 32303-32315. doi:10.1074/jbc.M114.602847

  • Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014) A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 8: 1325-1338. doi:10.1093/infdis/jiu260

  • van Sorge, Nina M., Cole, Jason N., Kuipers, Kristen, Henningham, Anna, Aziz, Ramy K., Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien T. M., Davies, Mark R., Dougan, Gordon, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph A., Hutter, Julia, Lepenies, Bernd, Rooijakkers, Suzan H. M., Malley, Richard, Walker, Mark J., Shattil, Sanford J., Schlievert, Patrick M., Choudhury, Biswa and Nizet, Victor (2014) The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host and Microbe, 15 6: 729-740. doi:10.1016/j.chom.2014.05.009.

  • Walker, Mark J., Barnett, Timothy C., McArthur, Jason D., Cole, Jason N., Gillen, Christine M., Henningham, Anna, Sriprakash, K. S., Sanderson-Smith, Martina L. and Nizet, Victor (2014) Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clinical Microbiology Reviews, 27 2: 264-301. doi:10.1128/CMR.00101-13

  • Moyle, Peter M., Hartas, Jon, Henningham, Anna, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013) An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system. Nanomedicine: Nanotechnology, Biology and Medicine, 9 7: 935-944. doi:10.1016/j.nano.2013.01.009

  • Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013) Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 4: . doi:10.1128/mBio.00509-13

  • Maamary, Peter G., Ben Zakour, Nouri L., Cole, Jason N., Hollands, Andrew, Aziz, Ramy K., Barnett, Timothy C., Cork, Amanda J., Henningham, Anna, Sanderson-Smith, Martina, McArthur, Jason D., Venturini, Carola, Gillen, Christine M., Kirk, Joshua K., Johnson, Dwight R., Taylor, William L., Kaplan, Edward L., Kotb, Malak, Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2012) Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB Journal, 26 11: 4675-4684. doi:10.1096/fj.12-212142

  • Henningham, Anna, Barnett, Timothy C., Maamary, Peter G. and Walker, Mark J. (2012) Pathogenesis of group A streptococcal infections. Discovery Medicine, 13 72: 329-342.

  • Bauer, Michelle J., Georgousakis, Melina M., Vu, Therese, Henningham, Anna, Hofmann, Andreas, Rettel, Mandy, Hafner, Louise M., Sriprakash, Kadaba S. and McMillan, David J. (2012) Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein. Vaccine, 30 12: 2197-2205. doi:10.1016/j.vaccine.2011.12.115

  • Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012) Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 10: 1197-1207. doi:10.1007/s00109-012-0897-9

  • Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008) Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 3: 387-410. doi:10.1002/prca.200780048

  • Cole, Jason N., Aquilina, John A., Hains, Peter G., Henningham, Anna, Sriprakash, Kadaba S., Caparon, Michael G., Nizet, Victor, Kotb, Malak, Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2007) Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics, 7 24: 4488-4498. doi:10.1002/pmic.200700626

  • Walker, Mark J., Hollands, Andrew, Sanderson-Smith, Martina L., Cole, Jason N., Kirk, Joshua K., Henningham, Anna, McArthur, Jason D., Dinkla, Katrin, Aziz, Ramy K., Kansal, Rita G., Simpson, Amelia J., Buchanan, John T., Chhatwal, Gursharan S., Kotb, Malak and Nizet, Malak (2007) DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nature Medicine, 13 8: 981-985. doi:10.1038/nm1612

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Exposure to air pollution and other environmental stressors have adverse effects on human health, including increasing susceptibility to acute respiratory illnesses (ARI) and chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease. While the epidemiological evidence is strong, the mechanism(s) underlying this phenomenon remains uncertain. Children exposed to second-hand tobacco smoke are at increased risk of ARI, including acute viral bronchiolitis, pneumonia and middle ear infections. Children exposed to household air pollution have increased rates of pneumonia and tuberculosis and exaggerated respiratory symptoms and ARI are seen in children exposed totraffic related air pollution. The respiratory epithelium in the nose and large airways represents the point of first contact of environmental stressors and infecting microorganisms, as well as the site of initial defence against such insults. The respiratory epithelium orchestrated the innate immune response to microorganisms and if this is inadequate the risk of infection increases. Thus understanding which environmental stressors compromise innate immunity and how this occurs is vital knowledge that can inform evidence-based policy decisions in air quality monitoring.