Lecturer - Biostatistics
Overview
Dr. Darsy Darssan obtained three degrees in Statistics at mathematical sciences schools of three different universities. A Bachelor of Science with Honours in 2005 at University of Jaffna, a Master of Applied Science in 2008 at RMIT University and a Doctor of Philosophy in 2014 at Queensland University of Technology.
While doing his two years full time traditional face to face master degree, Darsy worked as a part time Statistician at Australian Council for Educational Research for a year.
Between the two bouts of postgraduate studies Darsy worked for two years. As a Statistician at University of New South Wales for an year and as an Associate Research Fellow in Applied Statistics at University of Wollongong.
While doing the highest degree in Statistics Darsy worked as a sessional academic, contributed to teaching introductory statistics to various cohorts of first year undergraduate students. Upon completion of the doctoral degree Darsy moved to University of Liverpool in UK to do his Postdoctoral research in Biostatistics. Darsy returned home in late 2015 and worked as a Biostatistician at The University of Queensland for three years prior taking the current position.
Teaching:
Dr. Darsy Darssan is appointed as a full time continuing teaching and research academic. Darsy is currently teaching postgraduate coursework subject, Introduction to Biostatistics (PUBH7630).
Career Statistician:
As a career statistician Darsy is interested in developing novel statistical methodologies and publishes in Statistics Journals. The following three research streams currently flow smooth: time to event outcomes and dynamic prediction, rigid strategies for pooling study results, and design methodologies for phase I/II trials.
Service Statistician:
Darsy has long experience working as a service statistician, mainly on clinical trials, designing studies, randomisation, preparation of protocols, statistical analysis plans, final statistical reports, and participating in data safety monitoring boards. Darsy is successfully provided statistical service to Biologists, Rheumatologists, Ophthalmologists, Nephrologist, Endocrinologist and Health Service Researchers. Service statistician role is currently limited to those full time academic researchers who formally recognise Darsy as an investigator in their projects at the time of preparing the research proposals.
Research Interests
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Experimetal design methodology
Statistical methods in designing clinical and lab based studies. Adaptive design methodologies in early phase clinical trial design. Continual reassessment method and its variations. -
Personalized Predictive Modeling
Dynamic prediction using statistical machine learning methods -
Bayesian modelling
Using statistical models under Bayesian paradigm
Qualifications
- Bachelor of Science, University of Jaffna
- Master of Applied Science, Royal Melbourne Institute of Technology
- Doctor of Philosophy, Queensland University of Technology
Publications
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Journal Article: Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies
Zhang, Yuhui, Darssan, Darsy, Pascoe, Elaine M., Johnson, David W., Pi, Haichen and Dong, Jie (2018) Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies. Nephrology, Dialysis, Transplantation, 33 10: 1742-1751. doi:10.1093/ndt/gfy016
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Journal Article: Carvedilol and cardiac biomarkers in dialysis patients: secondary analysis of a randomized controlled trial
Roberts, Matthew A., Darssan, Darsy, Badve, Sunil V., Carroll, Robert P., Fahim, Magid A., Haluska, Brian A., Hawley, Carmel M., Isbel, Nicole M., Marshall, Mark R., Pascoe, Elaine M., Pedagogos, Eugenie, Pilmore, Helen L., Snelling, Paul, Stanton, Tony, Tan, Ken-Soon, Tonkin, Andrew M., Vergara, Liza A. and Ierino, Francesco L. (2017) Carvedilol and cardiac biomarkers in dialysis patients: secondary analysis of a randomized controlled trial. Kidney and Blood Pressure Research, 42 6: 1033-1044. doi:10.1159/000485589
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Scarfe, Lauren, Rak-Raszewska, Aleksandra, Geraci, Stefania, Darssan, Darsy, Sharkey, Jack, Huang, Jiaguo, Burton, Neal C., Mason, David, Ranjzad, Parisa, Kenny, Simon, Gretz, Norbert, Lévy, Raphaël, Park, B. Kevin, García-Fiñana, Marta, Woolf, Adrian S., Murray, Patricia and Wilm, Bettina (2015) Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Scientific Reports, 5 . doi:10.1038/srep13601
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Journal Article: Incorporating adverse event relatedness into dose‐finding clinical trial designs
Darssan, Darsy, Thompson, Mery H. and Pettitt, Anthony N. (2014) Incorporating adverse event relatedness into dose‐finding clinical trial designs. Statistics in Medicine, 33 7: 1146. doi:10.1002/sim.6011
Supervision
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REthinking MOdel of Diabetes care using E-heaLth (REMODEL)
Doctor Philosophy
Publications
Featured Publications
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Zhang, Yuhui, Darssan, Darsy, Pascoe, Elaine M., Johnson, David W., Pi, Haichen and Dong, Jie (2018) Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies. Nephrology, Dialysis, Transplantation, 33 10: 1742-1751. doi:10.1093/ndt/gfy016
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Roberts, Matthew A., Darssan, Darsy, Badve, Sunil V., Carroll, Robert P., Fahim, Magid A., Haluska, Brian A., Hawley, Carmel M., Isbel, Nicole M., Marshall, Mark R., Pascoe, Elaine M., Pedagogos, Eugenie, Pilmore, Helen L., Snelling, Paul, Stanton, Tony, Tan, Ken-Soon, Tonkin, Andrew M., Vergara, Liza A. and Ierino, Francesco L. (2017) Carvedilol and cardiac biomarkers in dialysis patients: secondary analysis of a randomized controlled trial. Kidney and Blood Pressure Research, 42 6: 1033-1044. doi:10.1159/000485589
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Scarfe, Lauren, Rak-Raszewska, Aleksandra, Geraci, Stefania, Darssan, Darsy, Sharkey, Jack, Huang, Jiaguo, Burton, Neal C., Mason, David, Ranjzad, Parisa, Kenny, Simon, Gretz, Norbert, Lévy, Raphaël, Park, B. Kevin, García-Fiñana, Marta, Woolf, Adrian S., Murray, Patricia and Wilm, Bettina (2015) Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Scientific Reports, 5 . doi:10.1038/srep13601
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Incorporating adverse event relatedness into dose‐finding clinical trial designs
Darssan, Darsy, Thompson, Mery H. and Pettitt, Anthony N. (2014) Incorporating adverse event relatedness into dose‐finding clinical trial designs. Statistics in Medicine, 33 7: 1146. doi:10.1002/sim.6011
Journal Article
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Nataatmadja, Melissa S., Johnson, David W., Pascoe, Elaine M., Darssan, Darsy, Hawley, Carmel M., Cho, Yeoungjee and on behalf of the balANZ Trial Investigators (2018) Associations Between Peritoneal Glucose Exposure, Glucose Degradation Product Exposure, and Peritoneal Membrane Transport Characteristics in Peritoneal Dialysis Patients: Secondary Analysis of the balANZ Trial. Peritoneal Dialysis International, 38 5: 349-355. doi:10.3747/pdi.2017.00223
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The relationship between body mass index and organism-specific peritonitis
Jegatheesan, Dev, Johnson, David W., Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Htay, Htay, Hawley, Carmel, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil, McDonald, Stephen P. and Nadeau-Fredette, Annie-Claire (2018) The relationship between body mass index and organism-specific peritonitis. Peritoneal Dialysis International, 38 3: 206-214. doi:10.3747/pdi.2017.00188
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Krishnasamy, R., Hawley, C. M., Jardine, M. J., Roberts, M. A., Cho, Y. J., Wong, M. G., Heath, A., Nelson, C. L., Sen, S., Mount, P. F., Pascoe, E. M., Darssan, D., Vergara, L. A., Paul-Brent, P. A., Toussaint, N. D., Johnson, D. W. and Hutchison, C. A. (2018) Design and methods of the REMOVAL-HD study: a tRial evaluating mid cut-off value membrane clearance of albumin and light chains in HaemoDialysis patients. BMC Nephrology, 19 1: 89. doi:10.1186/s12882-018-0883-8
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Zhang, Yuhui, Darssan, Darsy, Pascoe, Elaine M., Johnson, David W., Pi, Haichen and Dong, Jie (2018) Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies. Nephrology, Dialysis, Transplantation, 33 10: 1742-1751. doi:10.1093/ndt/gfy016
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Center Effects and Peritoneal Dialysis Peritonitis Outcomes: Analysis of a National Registry
Htay, Htay, Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Nadeau-Fredette, Annie-Claire, Hawley, Carmel, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil, McDonald, Stephen P. and Johnson, David W. (2017) Center Effects and Peritoneal Dialysis Peritonitis Outcomes: Analysis of a National Registry. American Journal of Kidney Diseases, 71 6: 814-821. doi:10.1053/j.ajkd.2017.10.017
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Roberts, Matthew A., Darssan, Darsy, Badve, Sunil V., Carroll, Robert P., Fahim, Magid A., Haluska, Brian A., Hawley, Carmel M., Isbel, Nicole M., Marshall, Mark R., Pascoe, Elaine M., Pedagogos, Eugenie, Pilmore, Helen L., Snelling, Paul, Stanton, Tony, Tan, Ken-Soon, Tonkin, Andrew M., Vergara, Liza A. and Ierino, Francesco L. (2017) Carvedilol and cardiac biomarkers in dialysis patients: secondary analysis of a randomized controlled trial. Kidney and Blood Pressure Research, 42 6: 1033-1044. doi:10.1159/000485589
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Outcomes of corynebacterium peritonitis: a multicenter registry analysis
Htay, Htay, Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Hawley, Carmel, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil, McDonald, Stephen P. and Johnson, David W. (2017) Outcomes of corynebacterium peritonitis: a multicenter registry analysis. Peritoneal Dialysis International, 37 6: 619-626. doi:10.3747/pdi.2017.00028
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Nataatmadja, Melissa, Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Hawley, Carmel M. and Johnson, David W. (2017) Association between peritoneal glucose exposure and peritonitis in peritoneal dialysis patients: the balANZ trial. Peritoneal Dialysis International, 37 4: 407-413. doi:10.3747/pdi.2016.00263
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Htay, Htay, Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Nadeau-Fredette, Annie-Claire, Hawley, Carmel, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil, McDonald, Stephen P. and Johnson, David W. (2017) Multicenter registry analysis of center characteristics associated with technique failure in patients on incident peritoneal dialysis. Clinical Journal of the American Society of Nephrology, 12 7: 1090-1099. doi:10.2215/CJN.12321216
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Early peritonitis and its outcome in incident peritoneal dialysis patients
See, Emily J., Johnson, David W., Hawley, Carmel M., Pascoe, Elaine M., Darssan, Darsy, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil C. and Cho, Yeoungjee (2017) Early peritonitis and its outcome in incident peritoneal dialysis patients. Peritoneal Dialysis International, . doi:10.3747/pdi.2017.00029
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Predictors of residual renal function decline in peritoneal dialysis patients: the balANZ trial
Htay, Htay, Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Hawley, Carmel and Johnson, David W. (2017) Predictors of residual renal function decline in peritoneal dialysis patients: the balANZ trial. Peritoneal Dialysis International, 37 3: 283-289. doi:10.3747/pdi.2016.00206
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Scarfe, Lauren, Rak-Raszewska, Aleksandra, Geraci, Stefania, Darssan, Darsy, Sharkey, Jack, Huang, Jiaguo, Burton, Neal C., Mason, David, Ranjzad, Parisa, Kenny, Simon, Gretz, Norbert, Lévy, Raphaël, Park, B. Kevin, García-Fiñana, Marta, Woolf, Adrian S., Murray, Patricia and Wilm, Bettina (2015) Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Scientific Reports, 5 . doi:10.1038/srep13601
-
Incorporating adverse event relatedness into dose‐finding clinical trial designs
Darssan, Darsy, Thompson, Mery H. and Pettitt, Anthony N. (2014) Incorporating adverse event relatedness into dose‐finding clinical trial designs. Statistics in Medicine, 33 7: 1146. doi:10.1002/sim.6011
Conference Publication
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Menon, A., Darssan, D., Fatehi, F., Bird, D., Russell, A. and Gray, L. (2018). Comparison of clinical characteristics of a diabetes telehealth service with specialist face-to-face outpatients: a cross-sectional survey. In: The Official Journal of ATTD Advanced Technologies & Treatments for Diabetes Conference, Vienna, Austria, (A117-A117). 14–17 February 2018.
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Menon, Anish, Gray, Leonard C., Fatehi, Farhad, Darssan, Darsy, Bird, Dominique, Bennett, Denise and Russell, Anthony W. (2017). A comparison of characteristics of patients seen in a tertiary hospital diabetes telehealth service versus specialist face-to-face outpatients. In: 17th International Conference on Successes and Failures in Telehealth (SFT-17), Brisbane, Australia, (842-849). 30-31 October 2017. doi:10.1177/1357633X17733295
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Viecelli, A., Pascoe, E., Polkinghorne, K., Paul-Brent, P., Darssan, D., Hooi, L., Ong, L., Mori, T., Badve, S., Cass, A., Kerr, P., Voss, D., Hawley, C., Johnson, D. and Irish, A. (2016). A comparison of arteriovenous fistula failure between Malaysian and Australian and New Zealand participants enrolled in the favoured trial. In: The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, (115-116). 17–21 September 2016. doi:10.1111/nep.12887
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Roberts, M., Badve, S., Carroll, R., Darssan, D., Fahim, M., Hawley, C., Isbel, N., Marshall, M., Pascoe, E., Pedagogos, E., Pilmore, H., Snelling, P., Tan, K., Tonkin, A., Vergara, L. and Ierino, F. (2016). Cardiovascular Biomarkers, Global Left Ventricular Strain, and Tolerability of the Beta-Blocker Carvedilol in Patients Receiving Dialysis. In: The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, (95-95). 17–21 September 2016.
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Roberts, M., Badve, S., Carroll, R., Darssan, D., Fahim, M., Hawley, C., Isbel, N., Marshall, M., Pascoe, E., Pedagogos, E., Pilmore, H., Snelling, P., Tan, K., Tonkin, A., Vergara, L. and Ierino, F. (2016). Effect of the Beta-Blocker Carvedilol On Biomarkers of Cardiovascular Disease in Patients Receiving Dialysis. In: The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, (94-94). 17–21 September 2016.
PhD and MPhil Supervision
Current Supervision
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REthinking MOdel of Diabetes care using E-heaLth (REMODEL)
Doctor Philosophy — Associate Advisor
Other advisors:
