Associate Professor Antje Blumenthal

Principal Research Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine

Affiliate Senior Research Fellow

Institute for Molecular Bioscience
a.blumenthal@uq.edu.au
+61 7 344 36984

Overview

A microbiology graduate from Kiel University (Germany), Dr Antje Blumenthal pursued her PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences (Germany). After postdoctoral work at Weill Cornell Medical College, New York (USA), Dr Blumenthal now heads the Infection and Inflammation Group at The University of Queensland Diamantina Institute in Brisbane, Australia.

Dr Blumenthal’s research focuses on innate immune sensors, regulators of inflammation, and discovery of new therapeutic opportunities for challenging infectious diseases, with a specific emphasis on tuberculosis and sepsis. The Blumenthal lab employs in vivo and in vitro model systems, and fosters cross-disciplinary collaborations with immunologists, microbiologists, systems biologists, chemists, clinical research teams and industry partners.

Research Interests

  • Tuberculosis
    - immune response - pathogenesis - novel anti-TB drugs
  • Innate Immunity
    molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence
  • Macrophage biology
    infection and inflammation related macrophage functions
  • Inflammation
    molecular regulation of inflammatory responses
  • Sepsis
    immune responses and biomarker discovery

Qualifications

  • Doctor of Philosophy, University of Lübeck

Publications

View all Publications

Supervision

  • Master Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

  • Gatica-Andrades, Marcela, Vagenas, Dimitrios, Kling, Jessica, Nguyen, Tam T. K., Benham, Helen, Thomas, Ranjeny, Korner, Heinrich, Venkatesh, Bala, Cohen, Jeremy and Blumenthal, Antje (2017) WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice. Blood Advances, 1 16: 1274-1286. doi:10.1182/bloodadvances.2017006163

  • Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole L., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017) CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 3: 837-844. doi:10.1189/jlb.1AB0217-065R

  • Kling, Jessica C. and Blumenthal, Antje (2017) Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes. Journal of Leukocyte Biology, 101 4: 827-840. doi:10.1189/jlb.1MR0616-272R

  • Chen, Y. C. E., Mapp, S., Blumenthal, A., Burgess, M. L., Mazzieri, R., Mattarollo, S., Mollee, P., Gill, D. and Saunders, N. A. (2017) The duality of macrophage function in Chronic Lymphocytic Leukaemia. Biochimica et Biophysica Acta (BBA) Reviews on Cancer, 1868 1: 176-182. doi:10.1016/j.bbcan.2017.03.006

  • Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J. and Stow, Jennifer L. (2017) Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors. Journal of Biological Chemistry, 292 11: 4411-4422. doi:10.1074/jbc.M116.766337

  • Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017) Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 5: 491-495. doi:10.1038/icb.2017.5

  • Schultz, Thomas E. and Blumenthal, Antje (2017) The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications. Journal of Leukocyte Biology, 101 1: 183-192. doi:10.1189/jlb.2VMR1215-582R

  • Cohen, Jeremy, Pretorius, Carel J., Ungerer, Jacobus P. J., Cardinal, John, Blumenthal, Antje, Presneill, Jeff, Gatica-Andrades, Marcela, Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Dunlop, Rachel, Starr, Therese and Venkatesh, Bala (2016) Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity. Critical Care Medicine, 44 6: 1034-1041. doi:10.1097/CCM.0000000000001633

  • Ariffin, Juliana K., Kapetanovic, Ronan, Schaale, Kolja, Gatica-Andrades, Marcela, Blumenthal, Antje, Schroder, Kate and Sweet, Matthew J. (2016) The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology, 100 1: 155-161. doi:10.1189/jlb.2AB0815-339R

  • Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Alam, Intikhab, Albanese, Davide, Altschuler, Gabriel M., Arakawa, Takahiro, Archer, John A. C., Arner, Peter, Babina, Magda, Baker, Sarah, Balwierz, Piotr J., Beckhouse, Anthony G., Pradhan, Swati, Blake, Judith A., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Burroughs, A. Maxwell, Califano, Andrea, Cannistraci, Carlo V., Carbajo, Daniel, Chen, Yun, Chierici, Marco, Ciani, Yari, Clevers, Hans C., Dalla, Emiliano, Davis, Carrie A., Detmar, Michael, Diehl, Alexander D., Dohi, Taeko, Drablos, Finn, Edge, Albert S. B., Edinger, Matthias, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Fagiolini, Michela, Fairbairn, Lynsey, Fang, Hai, Farach-Carson, Mary C., Faulkner, Geoffrey J., Favorov, Alexander V., Fisher, Malcolm E., Frith, Martin C., Fujita, Rie, Fukuda, Shiro, Furlanello, Cesare, Furuno, Masaaki, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gibson, Andrew ., Gingeras, Thomas, Goldowitz, Daniel, Gough, Julian, Guhl, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Harbers, Matthias, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Takehiro, Herlyn, Meenhard, Hitchens, Kelly J., Ho Sui, Shannan J., Hofmann, Oliver M., Hoof, Ilka, Hori, Fumi, Huminiecki, Lukasz, Iida, Kei, Ikawa, Tomokatsu, Jankovic, Boris R., Jia, Hui, Joshi, Anagha, Jurman, Giuseppe, Kaczkowski, Bogumil, Kai, Chieko, Kaida, Kaoru, Kaiho, Ai, Kajiyama, Kazuhiro, Kanamori-Katayama, Mutsumi, Kasianov, Artem S., Kasukawa, Takeya, Katayama, Shintaro, Kato, Sachi, Kawaguchi, Shuji, Kawamoto, Hiroshi, Kawamura, Yuki I., Kawashima, Tsugumi, Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klinken, S. Peter, Knox, Alan J., Kojima, Miki, Kojima, Soichi, Kondo, Naoto, Koseki, Haruhiko, Koyasu, Shigeo, Krampitz, Sarah, Kubosaki, Atsutaka, Kwon, Andrew T., Laros, Jeroen F. J., Lee, Weonju, Lennartsson, Andreas, Li, Kang, Lilje, Berit, Lipovich, Leonard, Mackay, Alan, Manabe, Riichiroh, Mar, Jessica C., Marchand, Benoit, Mathelier, Anthony, Mejhert, Niklas, Meynert, Alison, Mizuno, Yosuke, de Lima Morais, David A., Morikawa, Hiromasa, Morimoto, Mitsuru., Moro, Kazuyo, Motakis, Efthymios, Motohashi, Hozumi, Mummery, Christine L., Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nakazato, Kenichi, van Nimwegen, Erik, Ninomiya, Noriko, Nishiyori, Hiromi, Noma, Shohei, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohmiya, Hiroko, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Pain, Arnab, Passier, Robert, Patrikakis, Margaret, Persson, Helena, Piazza, Silvano, Prendergast, James G. D., Rackham, Owen J. ., Ramilowski, Jordan A., Rashid, Mamoon, Ravasi, Timothy, Rizzu, Patrizia, Roncador, Marco, Roy, Sugata, Rye, Morten B., Saijyo, Eri, Sajantila, Antti, Saka, Akiko, Sakaguchi, Shimon, Sakai, Mizuho, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schneider, Claudio, Schultes, Erik A., Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sengstag, Thierry, Sheng, Guojun, Shimoji, Hisashi, Shimoni, Yishai, Shin, Jay W., Simon, Christophe, Sugiyama, Daisuke, Sugiyama, Takaaki, Suzuki, Masanori, Suzuki, Naoko, Swoboda, Rolf K., 't Hoen, Peter A.C., Tagami, Michihira, Takahashi, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tatum, Zuotian, Thompson, Mark, Toyoda, Hiroo, Toyoda, Tetsuro, Valen, Eivind, van de Wetering, Marc, van den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Vorontsov, Ilya E., Wasserman, Wyeth W., Watanabe, Shoko, Wells, Christine A., Winteringham, Louise N., Wolvetang, Ernst, Wood, Emily J., Yamaguchi, Yoko, Yamamoto, Masayuki, Yoneda, Misako, Yonekura, Yohei, Yoshida, Shigehiro, Zabierowski, Suzan E., Zhang, Peter G., Zhao, Xiaobei, Zucchelli, Silvia, Summers, Kim M., Suzuki, Harukazu, Daub, Carsten O., Kawai, Jun, Heutink, Peter, Hide, Winston, Freeman, Tom C., Lenhard, Boris, Bajic, Vladimir B., Taylor, Martin S., Makeev, Vsevolod J., Sandelin, Albin, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2015) The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 12: . doi:10.1371/journal.pbio.1002315

  • Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015) Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 19: . doi:10.1186/s13069-015-0036-7

  • Yu, Chien-Hsiung, Micaroni, Massimo, Puyskens, Andreas, Schultz, Thomas E., Yeo, Jeremy Changyu, Stanley, Amanda C., Lucas, Megan, Kurihara, Jade, Dobos, Karen M., Stow, Jennifer L. and Blumenthal, Antje (2015) RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection. Journal of Immunology, 195 8: 3890-3900. doi:10.4049/jimmunol.1500017

  • Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015) Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 4: 949-952. doi:10.1021/acs.jnatprod.5b00095

  • Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015) Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 4: 1065-1073. doi:10.1016/j.jaci.2015.02.032

  • Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014) Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 19: 5120-5123. doi:10.1021/ol502472c

  • Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014) IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 5: 2248-2257. doi:10.4049/jimmunol.1400216

  • Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014) LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 10 9: e1004376.1-e1004376.14. doi:10.1371/journal.ppat.1004376

  • Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014) Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 1: 23784.1-23784.14. doi:10.3402/jev.v3.23784

  • Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014) IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 10: 2562-2569. doi:10.1038/jid.2014.201

  • Trujillo, Carolina, Blumenthal, Antje, Marrero, Joeli, Rhee, Kyu Y., Schnappinger, Dirk and Ehrt, Sabine (2014) Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. mBio, 5 2: e00085-14.1-e00085-14.12. doi:10.1128/mBio.00085-14

  • Raju, Ritesh, Khalil, Zeinab G., Piggott, Andrew M., Blumenthal, Antje, Gardiner, Donald L., Skinner-Adams, Tina S. and Capon, Robert J. (2014) Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244). Organic Letters, 16 6: 1716-1719. doi:10.1021/ol5003913

  • Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab, Albanese, Davide, Altschule, Gabriel M., Arakawa, Takahiro, Archer, John A. C., Arner, Peter, Babina, Magda, Rennie, Sarah, Balwierz, Piotr J., Beckhouse, Anthony G., Pradhan-Bhatt, Swati, Blake, Judith A., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Burroughs, A. Maxwell, Califano, Andrea, Cannistraci, Carlo V., Carbajo, Daniel, Chen, Yun, Chierici, Marco, Ciani, Yari, Clevers, Hans C., Dalla, Emiliano, Davis, Carrie A., Detmar, Michael, Diehl, Alexander D., Dohi, Taeko, Drablos, Finn, Edge, Albert S. B., Edinger, Matthias, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Fagiolini, Michela, Fairbairn, Lynsey, Fang, Hai, Farach-Carson, Mary C., Faulkner, Geoffrey J., Favorov, Alexander V., Fisher, Malcolm E., Frith, Martin C., Fujita, Rie, Fukuda, Shiro, Furlanello, Cesare, Furuno, Masaaki, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gibson, Andrew P., Gingeras, Thomas, Goldowitz, Daniel, Gough, Julian, Guh, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Harbers, Matthias, Harshbarger, Jayson, Hasegawa, Akira, Hasegawa, Yuki, Hashimoto, Takehiro, Herlyn, Meenhard, Hitchens, Kelly J., Sui, Shannan J. Ho, Hofmann, Oliver M., Hoof, Ilka, Hori, Fumi, Huminiecki, Lukasz, Iida, Kei, Ikawa, Tomokatsu, Jankovic, Boris R., Jia, Hui, Joshi, Anagha, Jurman, Giuseppe, Kaczkowski, Bogumil, Kai, Chieko, Kaida, Kaoru, Kaiho, Ai, Kajiyama, Kazuhiro, Kanamori-Katayama, Mutsumi, Kasianov, Artem S., Kasukawa, Takeya, Katayama, Shintaro, Kato, Sachi, Kawaguchi, Shuji, Kawamoto, Hiroshi, Kawamura, Yuki I., Kawashima, Tsugumi, Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klinken, S. Peter, Knox, Alan J., Kojima, Miki, Kojima, Soichi, Kondo, Naoto, Koseki, Haruhiko, Koyasu, Shigeo, Krampitz, Sarah, Kubosaki, Atsutaka, Kwon, Andrew T., Laros, Jeroen F. J., Lee, Weonju, Lennartsson, Andreas, Li, Kang, Lilje, Berit, Lipovich, Leonard, Mackay-sim, Alan, Manabe, Ri-ichiroh, Mar, Jessica C., Marchand, Benoit, Mathelier, Anthony, Mejhert, Niklas, Meynert, Alison, Mizuno, Yosuke, De Lima Morais, David A., Morikawa, Hiromasa, Morimoto, Mitsuru, Moro, Kazuyo, Motakis, Efthymios, Motohashi, Hozumi, Mummer, Christine L., Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nakazato, Kenichi, Van Nimwegen, Erik, Ninomiya, Noriko, Nishiyori, Hiromi, Noma, Shohei, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohmiya, Hiroko, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Pain, Arnab, Passier, Robert, Patrikakis, Margaret, Persson, Helena, Piazza, Silvano, Prendergast, James G. D., Rackham, Owen J. L., Ramilowski, Jordan A., Rashid, Mamoon, Ravasi, Timothy, Rizzu, Patrizia, Roncador, Marco, Roy, Sugata, Rye, Morten B., Saijyo, Eri, Sajantila, Antti, Saka, Akiko, Sakaguchi, Shimon, Sakai, Mizuho, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schneider, Claudio, Schultes, Erik A., Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sengstag, Thierry, Sheng, Guojun, Shimoji, Hisashi, Shimoni, Yishai, Shin, Jay W., Simon, Christophe, Sugiyama, Daisuke, Sugiyama, Takaaki, Suzuki, Masanori, Suzuki, Naoko, Swoboda, Rolf K., 'T Hoen, Peter A. C., Tagami, Michihira, Takahash, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tatum, Zuotian, Thompson, Mark, Toyoda, Hiroo, Toyoda, Tetsuro, Valen, Eivind, Van De Wetering ,Marc, Van Den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Vorontsov, Ilya E., Wasserman, Wyeth W., Watanabe, Shoko, Wells, Christine A., Winteringham,Louise N., Wolvetang, Ernst, Wood, Emily J., Yamaguchi, Yoko, Yamamoto, Masayuki, Yoneda, Misako, Yonekura, Yohei, Yoshida, Shigehiro, Zabierowski, Susan E., Zhang, Peter G., Zhao, Xiaobei, Zucchelli, Silvia, Summers, Kim M., Suzuki, Harukazu, Daub, Carsten O., Kawai, Jun, Heutink, Peter, Hide, Winston, Freeman, Tom C., Lenhard, Boris, Bajic, Vladimir B., Taylor, Martin S., Makeev, Vsevolod J., Sandelin, Albin, Hume, David A., Carninci, Piero and Hayashizaki, Yoshihide (2014) A promoter-level mammalian expression atlas. Nature, 507 7493: 462-470. doi:10.1038/nature13182

  • Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014) Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 5: 1480-1490. doi:10.1002/eji.201343959

  • Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013) Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 12: 2686-2694. doi:10.1038/jid.2013.222

  • McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje and McMillan, Nigel A. J. (2013) Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy - Nucleic Acid, 2 1: . doi:10.1038/mtna.2013.22

  • Skalamera, Dubravka, Dahmer, Mareike, Purdon, Amy S., Wilson, Benjamin M., Ranall, Max V., Blumenthal, Antje, Gabrielli, Brian and Gonda, Thomas J. (2012) Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer. PloS One, 7 12: e51733.1-e51733.15. doi:10.1371/journal.pone.0051733

  • Blumenthal, Antje, Nagalingam, Gayathri, Huch, Jennifer H., Walker, Lara, Guillemin, Gilles J., Smythe, George A., Ehrt, Sabine, Britton, Warwick J. and Saunders, Bernadette M. (2012) M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PloS One, 7 5: e37314.1-e37314.11. doi:10.1371/journal.pone.0037314

  • Park, Sae Woong, Klotzsche, Marcus, Wilson, Daniel J., Boshoff, Helena I., Eoh, Hyungjin, Manjunatha, Ujjini, Blumenthal, Antje, Rhee, Kyu, Barry III, Clifton E., Aldrich, Courtney C., Ehrt, Sabine and Schnappinger, Dirk (2011) Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathogens, 7 9: e1002264.1-e1002264.10. doi:10.1371/journal.ppat.1002264

  • Blumenthal, Antje, Trujillo, Carolina, Ehrt, Sabine and Schnappinger, Dirk (2010) Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS One, 5 12: e15667-1-e15667-12. doi:10.1371/journal.pone.0015667

  • Seimon, Tracie A., Kim, Mi-Jeong, Blumenthal, Antje, Koo, Jovanka, Ehrt, Sabine, Wainwright, Helen, Bekker, Linda-Gail, Kaplan, Gilla, Nathan, Carl, Tabas, Ira and Russell, David G. (2010) Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One, 5 9: e12772.1-e12772.12. doi:10.1371/journal.pone.0012772

  • Blumenthal, Antje, Isovski, Flonza and Rhee, Kyu Y. (2009) Tuberculosis and host metabolism: ancient associations, fresh insights. Translational Research, 154 1: 7-14. doi:10.1016/j.trsl.2009.04.004

  • Blumenthal, A., Kobayashi, Toshihiko, Pierini, Lynda M., Banaei, Niaz, Ernst, Joel D., Miyake, Kensuke and Ehrt, Sabine (2009) RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins. Cell Host and Microbe, 5 1: 35-46. doi:10.1016/j.chom.2008.12.002

  • Blumenthal, Antje, Ehlers, Stefan, Lauber, Jörg, Buer, Jan, Lange, Christoph, Goldmann, Torsten, Heine, Holger, Brandt, Ernst and Reiling, Norbert (2006) The wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood, 108 3: 965-973. doi:10.1182/blood-2005-12-5046

  • Shi, Shuangping, Blumenthal, Antje, Hickey, Christopher M., Gandotra, Sheetal, Levy, David and Ehrt, Sabine (2005) Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alpha beta receptor and STAT1. Journal of Immunology, 175 5: 3318-3328.

  • Blumenthal, Antje, Lauber, Jorg, Hoffmann, Reinhard, Ernst, Martin, Keller, Christine, Buer, Jan, Ehlers, Stefan and Reiling, Norbert (2005) Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics. Infection and Immunity, 73 6: 3330-3341. doi:10.1128/IAI.73.6.3330-3341.2005

  • Mohamed, S. A., Wesch, D., Blumenthal, A., Bruse, P., Windler, K., Ernst, M., Kabelitz, D., Oehmichen, M. and Meissner, C. (2004) Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells. Experimental Gerontology, 39 2: 181-188. doi:10.1016/j.exger.2003.10.011

  • Keller, Christopher, Lauber, Joerg, Blumenthal, Antje, Buer, Jan and Ehlers, Stefan (2004) Resistance and susceptibility to tuberculosis analysed at the transcriptome level: Lessons from mouse macrophages. Tuberculosis, 84 3-4: 144-158. doi:10.1016/j.tube.2003.12.003

  • Gronow, Sabine, Noah, Christian, Blumenthal, Antje, Lindner, Buko and Brade, Helmut (2003) Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties. Journal of Biological Chemistry, 278 3: 1647-1655. doi:10.1074/jbc.M206942200

  • Blumenthal, Antje, Ehlers, Stefan, Ernst, Martin, Flad, Hans-Dieter and Reiling, Norbert (2002) Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways. Infection and Immunity, 70 9: 4961-4967. doi:10.1128/IAI.70.9.4961-4967.2002

  • Reiling, N., Blumenthal, A., Flad, H. D., Ernst, M. and Ehlers, S. (2001) Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. Journal of Immunology, 167 6: 3339-3345.

Conference Publication

  • Tran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. In: ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, (349-349). 21-26 August 2016. doi:10.1002/eji.201670200

  • Kling, J., Meiners, J. and Blumenthal, A. (2016). Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide. In: International Congress of Immunology (ICI), Melbourne, Australia, (759-759). Aug 21-26, 2016. doi:10.1002/eji.201670200

  • Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. In: Abstracts of Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, (7-7). 28 September - 2 October 2015. doi:10.1111/jgh.13087

  • Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, (32-32). 27 March - 1 April 2015. doi:10.1111/resp.12494_9

  • Gatica-Andrades, M. D., Nguyen, T. T. K., Schultz, T. E., Wyer, O. J. K., Melo-Bolivar, J., Walker, M. J., Frazer, I. H., Barnett, T. C. and Blumenthal, A. (2014). Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo. In: Abstracts of the British Society for Immunology Annual Congress. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, (112-112). 1-4 December 2014. doi:10.1111/imm.12406

  • Blumenthal, A., Ehlers, S., Ernst, M., Flad, H.-D. and Reiling, N. (2000). Infection of human monocyte-derived macrophages with Mycobacterium avium: MAP kinase activation is inversely correlated to bacterial survival in vitro. In: Abstracts Joint Annual Meeting 2000 of the German and Dutch Societies of Immunology. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, (314-314). 29 November - 02 December 2000.

  • Reiling, N., Blumenthal, A., Flad, H.-D., Ernst, M. and Ehlers, S. (2000). Mycobacteria-induced TNF and IL-10 formation by human macrophages: the role of MAP kinases. In: Abstracts Joint Annual Meeting 2000 of the German and Dutch Societies of Immunology. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, (123-123). 29 November - 02 December 2000.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Master Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision