Dr Manuel Rodriguez Valle

Honorary Professor

Centre for Animal Science
Queensland Alliance for Agriculture and Food Innovation

Overview

Manuel Rodriguez Valle has a major in Biochemistry and PhD in Genetics obtained at The University of Havana. During his research fellowship in the Virology Institute at the University of Kyoto demonstrated the effect of oncogenes on the replication of human papilloma virus. In the course of his PhD thesis research, he developed a vaccine against cattle tick (Rhipicephalus microplus), and integrated methods of tick control. In parallel he was researcher at Centre for Genetic Engineering and Biotechnology, at Havana, Cuba focusing in the expression of recombinant proteins for human and animal treatment such as interferon, human Tissue plasminogen Activator (TPA) and vaccinal antigens. In 2007, as Postdoctoral Fellow in Molecular Parasitology at the Department of Primary Industries and Fisheries in Queensland, Australia, he worked in reverse vaccinology, genomic and immunology applied to the study of the tick - host interaction in order to develop new generation of tick vaccine.

From 2012, Rodriguez- Valle is senior Research fellow at The University of Queensland/ QAAFI focused on the application of Biotechnology and Genomic to study the host – pathogen interaction to develop vaccines for the control of vector and pathogens that affect human, domestic and wild animals. In 2013 obtained an Organisation for Economic Co-operation and Development (OECD) fellowship to work at USDA-ARS Knipling-Bushland, US Livestock Insects Res. Lab. on DNA vaccine using multi-epitope genes to protect cattle against ectoparasite. His current research includes application of genomic and immunology to study Ixodes holocyclus (Australian Paralysis tick) to develop a new control method and paralysis treatment.

Rodriguez-Valle is member of Australian Society of Parasitology and International Society for Pest Information (ISPI). At national and international levels, he has served as member of Australia Research grant review panels and on the editorial advisory boards of multiple journals.

Research Interests

  • Novel pharmaceuticals and vaccines for veterinary medicine.
    Research interests include the application of Genomic, Functional Genomic and Biotechnology to animal vaccine development, and to study the function of pathogenic genes in their interaction with the host, such as gene virulence or host pathogenicity in relation with host immune response. Currently, my studies are focused in the study of endo / ectoparasites and their interactions with the host. Other areas of my research interest are immunology and biomaterial science applied to animal biotechnology in order to develop novel pharmaceuticals and vaccines for veterinary medicine.

Research Impacts

My research interests are associated with the application of Biotechnology, Genomic and Proteomics to study the host – pathogen interaction in order to develop vaccines for the control of vector and pathogens that affect human, domestic and wild animals. Other areas of research interest are the characterization of the immune response against vectors and infectious agents and development of biotechnological process for the production of recombinant proteins. The application of these studies resulted in the developed of a recombinant vaccine against the tick cattle tick (Rhipicephalus microplus), expression of human Tissue plasminogen Activator (TPA), Bovine Interferon omega, Bm86, protease Inhibitors (serpins) and VP60 (rabbit haemorrhagic viral protein).

All my projects, along with my experiences in Biochemistry and Immunology have focused my research into the area of animal vaccine. I am very interesting to explore collaborations with other scientists in this field in order to development new vaccine delivery platforms.

My research has a strong interest to work with post-graduate students and has supervised students in Australia and overseas. Currently I supervises or co-supervises National and International PhD, Master and Honours students.

Qualifications

  • Doctor of Philosophy, University of Havana
  • Bachelor of Biochemistry, University of Havana

Publications

  • Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016) Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 . doi:10.1038/srep29446

  • Ong, C. T., Rodriguez-Valle, M., Moolhuijzen, P. M., Barrero, R. A., Hunter, A., Szabo, T., Bellgard, M. I. and Lew-Tabor, A. E. (2016) Exploring the transcriptomic data of the Australian paralysis tick, Ixodes holocyclus. GSTF Journal of Veterinary Science (JVet), 3 1: . doi:10.7603/s40871-016-0001-y

  • Schetters, Theo, Bishop, Richard, Crampton, Michael, Kopacek, Petr, Lew-Tabor, Alicja, Maritz-Olivier, Christine, Miller, Robert, Mosqueda, Juan, Patarroyo, Joaquin, Rodriguez-Valle, Manuel, Scoles, Glen A. and de la Fuente, Jose (2016) Cattle tick vaccine researchers join forces in CATVAC. Parasites and Vectors, 9 1: . doi:10.1186/s13071-016-1386-8

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Grants

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Supervision

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Publications

Book Chapter

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision