The University of Queensland

Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2023). Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery. Expert Opinion on Drug Discovery, 18 (8), 893-901. doi: 10.1080/17460441.2023.2224554

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

Bignon, Yohan, Wigger, Leonore, Ansermet, Camille, Weger, Benjamin D., Lagarrigue, Sylviane, Centeno, Gabriel, Durussel, Fanny, Götz, Lou, Ibberson, Mark, Pradervand, Sylvain, Quadroni, Manfredo, Weger, Meltem, Amati, Francesca, Gachon, Frédéric and Firsov, Dmitri (2023). Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. Journal of Clinical Investigation, 133 (8) e167133, 1-17. doi: 10.1172/JCI167133

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119

The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2022). The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review. Cellular Physiology and Biochemistry, 56 (S2), 1-11. doi: 10.33594/000000489

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Weger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Weger, Meltem, Alpern, Daniel, Cherix, Antoine, Ghosal, Sriparna, Grosse, Jocelyn, Russeil, Julie, Gruetter, Rolf, de Kloet, E Ronald, Deplancke, Bart and Sandi, Carmen (2020). Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Scientific Reports, 10 (1) 18308, 1-15. doi: 10.1038/s41598-020-75326-9

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Weger, Meltem, Weger, Benjamin D, Schink, Andrea, Takamiya, Masanari, Stegmaier, Johannes, Gobet, Cédric, Parisi, Alice, Kobitski, Andrei Yu, Mertes, Jonas, Krone, Nils, Strähle, Uwe, Nienhaus, Gerd Ulrich, Mikut, Ralf, Gachon, Frédéric, Gut, Philipp and Dickmeis, Thomas (2020). MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife, 9 e57068, 1-35. doi: 10.7554/elife.57068

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Papilloud, Aurélie, Weger, Meltem, Bacq, Alexandre, Zalachoras, Ioannis, Hollis, Fiona, Larrieu, Thomas, Battivelli, Dorian, Grosse, Jocelyn, Zanoletti, Olivia, Parnaudeau, Sébastien, Tronche, François and Sandi, Carmen (2020). The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents. Psychoneuroendocrinology, 112 104538, 104538. doi: 10.1016/j.psyneuen.2019.104538

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Weger, Meltem, Weger, Benjamin D., Goerling, Benjamin, Poschet, Gernot, Yildiz, Melek, Hell, Ruediger, Luy, Burkhard, Akcay, Teoman, Guran, Tulay, Dickmeis, Thomas, Mueller, Ferenc and Krone, Nils (2018). Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine, 36, 376-389. doi: 10.1016/j.ebiom.2018.09.024

Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish

Weger, M., Diotel, N., Weger, B. D., Beil, T., Zaucker, A., Eachus, H. L., Oakes, J. A., do Rego, J. L., Storbeck, K. -H., Gut, P., Straehle, U., Rastegar, S., Mueller, F. and Krone, N. (2018). Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of Neuroendocrinology, 30 (4) e12586, e12586. doi: 10.1111/jne.12586

High anxiety trait: a vulnerable phenotype for stress-induced depression

Weger, Meltem and Sandi, Carmen (2018). High anxiety trait: a vulnerable phenotype for stress-induced depression. Neuroscience and Biobehavioral Reviews, 87, 27-37. doi: 10.1016/j.neubiorev.2018.01.012

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Weger, Meltem, Sevelinges, Yannick, Grosse, Jocelyn, de Suduiraut, Isabelle Guillot, Zanoletti, Olivia and Sandi, Carmen (2018). Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination. Physiology and Behavior, 186, 31-36. doi: 10.1016/j.physbeh.2018.01.008

Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia

Eachus, Helen, Zaucker, Andreas, Oakes, James A., Griffin, Aliesha, Weger, Meltem, Guran, Tulay, Taylor, Angela, Harris, Abigail, Greenfield, Andy, Quanson, Jonathan L., Storbeck, Karl-Heinz, Cunliffe, Vincent T., Muller, Ferenc and Krone, Nils (2017). Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158 (12), 4165-4173. doi: 10.1210/en.2017-00549

Stem cells and the circadian clock

Weger, Meltem, Diotel, Nicolas, Dorsemans, Anne-Claire, Dickmeis, Thomas and Weger, Benjamin D. (2017). Stem cells and the circadian clock. Developmental Biology, 431 (2), 111-123. doi: 10.1016/j.ydbio.2017.09.012

Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish

Dorsemans, Anne-Claire, Soule, Stephanie, Weger, Meltem, Bourdon, Emmanuel, d'Hellencourt, Christian Lefebvre, Meilhac, Olivier and Diotel, Nicolas (2017). Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish. Journal of Comparative Neurology, 525 (3), 442-458. doi: 10.1002/cne.24065

Extensive regulation of diurnal transcription and metabolism by glucocorticoids

Weger, Benjamin D., Weger, Meltem, Goerling, Benjamin, Schink, Andrea, Gobet, Cedric, Keime, Celine, Poschet, Gernot, Jost, Bernard, Krone, Nils, Hell, Ruediger, Gachon, Frederic, Luy, Burkhard and Dickmeis, Thomas (2016). Extensive regulation of diurnal transcription and metabolism by glucocorticoids. PLoS Genetics, 12 (12) e1006512, e1006512. doi: 10.1371/journal.pgen.1006512

Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish

Griffin, Aliesha, Parajes, Silvia, Weger, Meltem, Zaucker, Andreas, Taylor, Angela E., O'Neil, Donna M., Mueller, Ferenc and Krone, Nils (2016). Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish. Endocrinology, 157 (3), 1122-1134. doi: 10.1210/en.2015-1480

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

Tixier, Vanessa, Bataille, Laetitia, Etard, Christelle, Jagla, Teresa, Weger, Meltem, DaPonte, Jean Philippe, Straehle, Uwe, Dickmeis, Thomas and Jagla, Krzysztof (2013). Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 18982-18987. doi: 10.1073/pnas.1301262110

The circadian clock and glucocorticoids - Interactions across many time scales

Dickmeis, Thomas, Weger, Benjamin D. and Weger, Meltem (2013). The circadian clock and glucocorticoids - Interactions across many time scales. Molecular and Cellular Endocrinology, 380 (1-2), 2-15. doi: 10.1016/j.mce.2013.05.012

A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system

Weger, Benjamin D., Weger, Meltem, Jung, Nicole, Lederer, Christin, Braese, Stefan and Dickmeis, Thomas (2013). A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. Journal of Visualized Experiments (79) e50439. doi: 10.3791/50439

Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock

Weger, Meltem, Weger, Benjamin D., Diotel, Nicolas, Rastegar, Sepand, Hirota, Tsuyoshi, Kay, Steve A., Straehle, Uwe and Dickmeis, Thomas (2013). Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology, 380 (2), 259-273. doi: 10.1016/j.ydbio.2013.04.035

A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate

Weger, Benjamin D., Weger, Meltem, Nusser, Michael, Brenner-Weiss, Gerald and Dickmeis, Thomas (2012). A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate. ACS Chemical Biology, 7 (7), 1178-1183. doi: 10.1021/cb3000474

The light responsive transcriptome of the zebrafish: function and regulation

Weger, Benjamin D., Sahinbas, Meltem, Otto, Georg W., Mracek, Philipp, Armant, Olivier, Dolle, Dirk, Lahiri, Kajori, Vallone, Daniela, Ettwiller, Laurence, Geisler, Robert, Foulkes, Nicholas S. and Dickmeis, Thomas (2011). The light responsive transcriptome of the zebrafish: function and regulation. PloS One, 6 (2) e17080, e17080. doi: 10.1371/journal.pone.0017080

A role for caveolar proteins in regulation of the circadian clock

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.