The University of Queensland

Engineering and functional analysis of mitotic kinases through chemical genetics

Jones, Mathew J. K. and Jallepalli, Prasad V. (2016). Engineering and functional analysis of mitotic kinases through chemical genetics. The Mitotic Spindle. (pp. 349-363) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3542-0_22

Chromatin modifications involved in the DNA damage response to double strand breaks

Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death

Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316

Targeting BRF2 in cancer using repurposed drugs

Rashidieh, Behnam, Molakarimi, Maryam, Mohseni, Ammar, Tria, Simon Manuel, Truong, Hein, Srihari, Sriganesh, Adams, Rachael C., Jones, Mathew, Duijf, Pascal H. G., Kalimutho, Murugan and Khanna, Kum Kum (2021). Targeting BRF2 in cancer using repurposed drugs. Cancers, 13 (15) 3778, 1-28. doi: 10.3390/cancers13153778

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

Jones, Mathew J. K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A, Santos, Ruth E, Olsen, Jesper V, McCarroll, Steven A, Frattini, Mark G, Takahashi, Tatsuro S and Jallepalli, Prasad V (2021). Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell, 81 (3), 426-441.e8. doi: 10.1016/j.molcel.2021.01.004

Everything in moderation: lessons learned by exploiting moderate replication stress in cancer

Nazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320

SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function

Coleman, Kate E., Békés, Miklós, Chapman, Jessica R., Crist, Sarah B., Jones, Mathew J.K., Ueberheide, Beatrix M. and Huang, Tony T. (2017). SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function. eLife, 6 e24325. doi: 10.7554/eLife.24325

Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation

Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D. and Jallepalli, Prasad V. (2017). Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2), 143-156.e6. doi: 10.1016/j.devcel.2017.03.025

Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells

Rahman, Sadia, Jones, Mathew J.K. and Jallepalli, Prasad V. (2015). Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (36), 11270-11275. doi: 10.1073/pnas.1505323112

T cell help controls the speed of the cell cycle in germinal center B cells

Gitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J. K., Koren, Amnon and Nussenzweig, Michel C. (2015). T cell help controls the speed of the cell cycle in germinal center B cells. Science, 349 (6248), 643-646. doi: 10.1126/science.aac4919

ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress

Chen, Yu-Hung, Jones, Mathew J.K., Yin, Yandong, Crist, Sarah B., Colnaghi, Luca, Sims, Robert J., Rothenberg, Eli, Jallepalli, Prasad V. and Huang, Tony T. (2015). ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress. Molecular Cell, 58 (2), 323-338. doi: 10.1016/j.molcel.2015.02.031

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

Grabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew J.K., Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, HaoHsuan and Bar-Sagi, Dafna (2014). Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell, 25 (2), 243-256. doi: 10.1016/j.ccr.2014.01.005

DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells

Békés, Miklós, Okamoto, Keiji, Crist, Sarah B., Jones, Mathew J., Chapman, Jessica R., Brasher, Bradley B., Melandri, Francesco D., Ueberheide, Beatrix M., LazzeriniDenchi, Eros and Huang, Tony T. (2013). DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Reports, 5 (3), 826-838. doi: 10.1016/j.celrep.2013.10.008

The Fanconi anemia pathway in replication stress and DNA crosslink repair

Jones, Mathew J. K. and Huang, Tony T. (2012). The Fanconi anemia pathway in replication stress and DNA crosslink repair. Cellular and Molecular Life Sciences, 69 (23), 3963-3974. doi: 10.1007/s00018-012-1051-0

Chromothripsis: chromosomes in crisis

Jones, Mathew J.K. and Jallepalli, Prasad V. (2012). Chromothripsis: chromosomes in crisis. Developmental Cell, 23 (5), 908-917. doi: 10.1016/j.devcel.2012.10.010

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

Jones, Mathew J. K., Colnaghi, Luca and Huang, Tony T. (2012). Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. The EMBO Journal, 31 (4), 908-918. doi: 10.1038/emboj.2011.457

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

Cotto-Rios, Xiomaris M., Jones, Mathew J.K. and Huang, Tony T. (2011). Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle, 10 (23), 4009-4016. doi: 10.4161/cc.10.23.18501

APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele and Huang, Tony T. (2011). APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. Journal of Cell Biology, 194 (2), 177-186. doi: 10.1083/jcb.201101062

Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

Colnaghi, Luca, Jones, Mathew J. K., Cotto-Rios, Xiomaris M., Schindler, Detlev, Hanenberg, Helmut and Huang, Tony T. (2011). Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. Blood, 117 (7), 2247-2256. doi: 10.1182/blood-2010-07-295758

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200