Dr Fernanda Caldas Cardoso

Research Fellow

Institute for Molecular Bioscience

Overview

Dr Fernanda Cardoso completed her MSc in Molecular Pharmacology (2002) and PhD in Immunology (2008) at the Federal University of Minas Gerais, Brazil. In 2008 Dr Cardoso joined the Queensland Institute for Medical Research in Brisbane holding a prestigious CAPES Postdoctoral Fellowship. During this period, she developed unique HTS platforms to identify key membrane surface proteins and peptides to develop novel therapies to combat infectious diseases. In 2011, Dr Cardoso joined the Institute for Molecular Bioscience at UQ to develop therapies to treat complex neurological diseases. Her background in drug discovery, design and development, and her interdisciplinary training in the fields of pharmacology, immunology, and neuroscience provide her with the skills needed to identify and characterise highly potent bioactive molecules and to study their effects in human physiology with applications in neurologic disorders such as chronic pain, IBS and neurodegenerative diseases. Dr Cardoso is currently part of the Centre for Pain Research and Prof Richard Lewis’ group. She manages a number of industry and academia projects studying ion channels modulators derived from bioactive natural molecules and the development of novel effective drugs.

Research Interests

  • Motor Neuron Disease - Therapeutics development
  • Irritable Bowel Syndrome - Therapeutics development
  • Natural Peptides Chemistry and Biology
  • Chronic and neuropathic pain - Mechanisms of pain and Therapeutics development
  • Spiders, Cone snails and Snake venoms
  • Development of high throughput screen platforms for drug discovery
  • Sodium channels (Nav)
  • Calcium channels (Cav)

Research Impacts

Dr Fernanda Cardoso's research has provided remarkable insights in the discovery biology of vaccines against tropical diseases, as well as in the identification of new agents for therapeutical use in complex disorders such as chronic pain and irritable bowel syndrome. Her discovery in vaccine research has the potential to improve the lifes of milllions of people in Africa, Asia and South America through a vaccine against schistosomiasis., and her research in ion channels modulators has provided unique leads for treating neuropthic pain disorders which could improve the lifes of at least 10% of the world population.

Qualifications

  • Doctor of Philosophy, Universidade Federal de Minas Gerais
  • Masters of Biological Sciences, Universidade Federal de Minas Gerais
  • Bachelor of Biological Sciences, Universidade Federal de Minas Gerais

Publications

  • Slagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018) Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148 213-222. doi:10.1016/j.toxicon.2018.04.022

  • Sairaman, Anjali, Cardoso, Fernanda Caldas, Bispat, Anjie, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2018) Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic and Medicinal Chemistry, 26 11: 3046-3059. doi:10.1016/j.bmc.2018.03.031

  • Stefanucci, Azzurra, Novelino, Ettore, Macedonio, Giorgia, Dimmito, Marilia Pia, Mirzaie, Sako, Cardoso, Fernanda Caldas , Lewis, Richard, Zador, Ferenc, Erdei, Anna I., Dvoracsko, Szabolcs, Tomboly, Csaba, Benych, Sandor, Pieretti, Stefano, Minosi, Paola and Mollica, Adriano (2018) Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42 8: 5656-5659. doi:10.1039/c7nj04969b

View all Publications

Supervision

View all Supervision

Available Projects

View all Available Projects

Publications

Book Chapter

  • Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. In Brian Cox and Martin Gosling (Ed.), Ion channel drug discovery (pp. 297-313) Cambridge, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849735087-00297

Journal Article

Conference Publication

Other Outputs

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Focus in spider, snakes and cone snails venoms.