Journal Article: Optical-flow based non-invasive analysis of cardiomyocyte contractility
Czirok, Andras, Isai, Dona Greta, Kosa, Edina, Rajasingh, Sheeja, Kinsey, William, Neufeld, Zoltan and Rajasingh, Johnson (2017) Optical-flow based non-invasive analysis of cardiomyocyte contractility. Scientific Reports, 7 1: . doi:10.1038/s41598-017-10094-7
Priya, Rashmi, Gomez, Guillermo A., Budnar, Srikanth, Acharya, Bipul R., Czirok, Andras, Yap, Alpha S. and Neufeld, Zoltan (2017) Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. Plos Computational Biology, 13 3: . doi:10.1371/journal.pcbi.1005411
Journal Article: Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas, Francois, Mathias and Khosrotehrani, Kiarash (2017) Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process. Circulation, 135 8: 786-805. doi:10.1161/CIRCULATIONAHA.116.024754
A mechanotransduction apparatus to coordinate epithelial collective cell migration
(2017–2020) NHMRC Project Grant
Mathematical modelling of the dynamics of multi-layered biological tissues
(2016–2019) ARC Discovery Projects
Mathematical modeling of multicellular organization of epithelial tissues
(2014–2018) ARC Future Fellowships
Simulating the collective behaviour of a mono-layer of epithelial cells using a cellular Potts model
Doctor Philosophy
TISSUE MECHANICS & MORPHOGENESIS
This project will investigate the role of mechanical interactions between cells in determining the structure, morphology of different types of biological tissues. The project will use mathematical models, based on partial differential equations and/or stochastic models of interacting particles, and computer simulations and involves collaboration with experimental biology groups.
This research project will develop a biologically realistic mathematical model and computer simulations of the growth of glioblastoma brain tumours, that then can be used for testing and optimising treatment strategies, including surgery, radio- and chemo-therapy. The project will develop and investigate partial different equation models that describe the distribution and spreading of cancer cells in the tissue. The modelling work will be supported by experiments and MRI imaging data from the Centre of Advanced Imaging at UQ.
SKIN REGENERATION AND RADIATION INDUCED CANCER
The aim of this project is to understand the hierarchy and relative contributions of different stem cell populations to epidermal homeostasis and to develop a comprehensive computational model that accurately describes the spatial/temporal organization of tissue self-renewal. The project will analyze experimental data obtained from advanced imaging and genetic technology at the UQ Clinical Research Centre. The project will also study the effects of UV radiation induced carcinogenesis on epidermal regeneration by developing a predictive model for the growth dynamics of mutant clones.
Chemical and biological processes in fluid flows: A dynamical systems approach
Neufeld, Zoltan and Hernandez-Garcia, Emilio Chemical and biological processes in fluid flows: A dynamical systems approach. London , U.K.: Imperial College Press, 2009.
Spatial patterns in chemically and biologically reacting ﬂows
Hernandez-Garcia, E., Lopez, C. and Neufeld, Z. (2003). Spatial patterns in chemically and biologically reacting ﬂows. In G. Boffetta, G. Lacorata, G. Visconti and A. Vulpiani (Ed.), Chaos in geophysical flows (pp. 35-62) Rome, Italy: OTTO Editore.
Optical-flow based non-invasive analysis of cardiomyocyte contractility
Czirok, Andras, Isai, Dona Greta, Kosa, Edina, Rajasingh, Sheeja, Kinsey, William, Neufeld, Zoltan and Rajasingh, Johnson (2017) Optical-flow based non-invasive analysis of cardiomyocyte contractility. Scientific Reports, 7 1: . doi:10.1038/s41598-017-10094-7
Priya, Rashmi, Gomez, Guillermo A., Budnar, Srikanth, Acharya, Bipul R., Czirok, Andras, Yap, Alpha S. and Neufeld, Zoltan (2017) Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. Plos Computational Biology, 13 3: . doi:10.1371/journal.pcbi.1005411
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas, Francois, Mathias and Khosrotehrani, Kiarash (2017) Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process. Circulation, 135 8: 786-805. doi:10.1161/CIRCULATIONAHA.116.024754
Roy, Edwige, Neufeld, Zoltan, Cerone, Luca, Wong, Ho Yi, Hodgson, Samantha, Livet, Jean and Khosrotehrani, Kiarash (2016) Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. EMBO Journal, 35 24: 2658-2670. doi:10.15252/embj.201693806
Coburn, Luke, Lopez, Hender, Caldwell, Benjamin J., Moussa, Elliott, Yap, Chloe, Priya, Rashmi, Noppe, Adrian, Roberts, Anthony P., Lobaskin, Vladimir, Yap, Alpha S., Neufeld, Zoltan and Gomez, Guillermo A. (2016) Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates. Molecular Biology of the Cell, 27 22: 3436-3448. doi:10.1091/mbc.E16-04-0226
Modelling wound closure in an epithelial cell sheet using the cellular Potts model
Noppe, Adrian R., Roberts, Anthony P., Yap, Alpha S., Gomez, Guillermo A. and Neufeld, Zoltan (2015) Modelling wound closure in an epithelial cell sheet using the cellular Potts model. Integrative Biology (United Kingdom), 7 10: 1253-1264. doi:10.1039/c5ib00053j
Self-organizing actomyosin patterns on the cell cortex of epithelial cell-cell junctions
Moore, Thomas, Wu, Selwin, Michael, Magdalene, Yap, Alpha S.K., Gomez, Guillermo A. and Neufeld, Zoltan (2014) Self-organizing actomyosin patterns on the cell cortex of epithelial cell-cell junctions. Biophysical Journal, 107 11: 2652-2661. doi:10.1016/j.bpj.2014.10.045
Roy, Edwige, Neufeld, Zoltan, Livet, Jean and Khosrotehrani, Kiarash (2014) Concise review: understanding clonal dynamics in homeostasis and injury through multicolor lineage tracing. Stem Cells, 32 12: 3046-3054. doi:10.1002/stem.1804
Hodgson, Samantha S., Neufeld, Zoltan, Villani, Rehan M., Roy, Edwige and Khosrotehrani, Kiarash (2014) Transgenic flash mice for in vivo quantitative monitoring of canonical wnt signaling to track hair follicle cycle dynamics. Journal of Investigative Dermatology, 134 6: 1519-1526. doi:10.1038/jid.2014.92
Wu, Selwin K., Gomez, Guillermo A., Michael, Magdalene, Verma, Suzie, Cox, Hayley L., Lefevre, James G., Parton, Robert G., Hamilton, Nicholas A., Neufeld, Zoltan and Yap, Alpha S. (2014) Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia. Nature Cell Biology, 16 2: 167-178. doi:10.1038/ncb2900
Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells
Coburn, Luke, Cerone, Luca, Torney, Colin, Couzin, Iain D. and Neufeld, Zoltan (2013) Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells. Physical Biology, 10 4: 046002.1-046002.8. doi:10.1088/1478-3975/10/4/046002
Salvucci, Manuela, Neufeld, Zoltan and Newsholme, Philip (2013) Mathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a beta-cell line. PloS One, 8 3: . doi:10.1371/journal.pone.0052611
Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe
Cerone, Luca, Novak, Bela and Neufeld, Zoltan (2012) Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe. PLoS One, 7 11: e49675.1-e49675.11. doi:10.1371/journal.pone.0049675
Stirring effects in models of oceanic plankton populations
Neufeld, Zoltan (2012) Stirring effects in models of oceanic plankton populations. Chaos, 22 3: 037102.1-037102.9. doi:10.1063/1.4751329
Differential gene expression regulated by oscillatory transcription factors
Cerone, Luca and Neufeld, Zoltán (2012) Differential gene expression regulated by oscillatory transcription factors. PLoS One, 7 1: e30283.1-e30283.11. doi:10.1371/journal.pone.0030283
Integrating multiple signals into cell decisions by a network of protein modification cycles
Cerone, Luca, Munoz-Garcia, Javier and Neufeld, Zoltan (2011) Integrating multiple signals into cell decisions by a network of protein modification cycles. Biophysical Journal, 101 7: 1590-1596. doi:10.1016/j.bpj.2011.08.04
Brunig, Ulrike, Cerone, Luca, Neufeld, Zoltan, Simpson, David A., Leonard, Martin O., Tambuwala, Murtaza M., Cummins, Eoin P. and Taylor, Cormac T. (2011) MicroRNA promotes resolution of hypoxia-inducible factor activity during prolonged hypoxia in intestinal epithelial cell. Molecular and Cellular Biology, 31 19: 4087-4096. doi:10.1128/MCB.01276-10
Resonance phenomenon in plankton patchiness induced by turbulent mixing
McKiver, William J. and Neufeld, Zoltan (2011) Resonance phenomenon in plankton patchiness induced by turbulent mixing. Physical Review E, 83 1: 016303.1-016303.9. doi:10.1103/PhysRevE.83.01630
Nutrient exposure of chemotactic organisms in small-scale turbulent flows
Munoz-Garcia, Javier, Neufeld, Zoltan and Torney, Colin (2010) Nutrient exposure of chemotactic organisms in small-scale turbulent flows. New Journal of Physics, 12 October: 1-14. doi:10.1088/1367-2630/12/10/103043
Formation of intracellular concentration landscapes by multisite protein modification
Munoz-Garcia, Javier, Kholodenko, Boris N. and Neufeld, Zoltan (2010) Formation of intracellular concentration landscapes by multisite protein modification. Biophysical Journal, 99 1: 59-66. doi:10.1016/j.bpj.2010.04.014
Aggregation of chemotactic organisms in a differential flow
Munoz-Garcia, Javier and Neufeld, Zoltan (2009) Aggregation of chemotactic organisms in a differential flow. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), 80 6: 061902.1-061902.7. doi:10.1103/PhysRevE.80.061902
Context-dependent interaction leads to emergent search behaviour in social aggregates
Torney, Colin, Neufeld, Zoltan and Couzin, Iain D. (2009) Context-dependent interaction leads to emergent search behaviour in social aggregates. Proceedings of National Academy of Sciences, USA, 106 52: 22055-22060. doi:10.1073/pnas.0907929106
Influence of turbulent advection on a phytoplankton ecosystem with nonuniform carrying capacity
McKiver, William J. and Neufeld, Zoltan (2009) Influence of turbulent advection on a phytoplankton ecosystem with nonuniform carrying capacity. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), 79 6: 061902.1-061902.8. doi:10.1103/PhysRevE.79.061902
Positional information generated by spatially distributed signaling cascades
Munoz-Garcia, Javier, Neufeld, Zoltan and Kholodenko, Boris N. (2009) Positional information generated by spatially distributed signaling cascades. PLoS Computational Biology, 5 3: e1000330.1-e1000330.11. doi:10.1371/journal.pcbi.1000330
Plankton bloom controlled by horizontal stirring
McKiver, W., Neufeld, Z. and Scheuring, I. (2009) Plankton bloom controlled by horizontal stirring. Nonlinear Processes in Geophysics, 16 5: 623-630.
Phototactic clustering of swimming microorganisms in a turbulent velocity field
Torney, Colin and Neufeld, Zoltan (2008) Phototactic clustering of swimming microorganisms in a turbulent velocity field. Physical Review Letters, 101 7: 1-4. doi:10.1103/PhysRevLett.101.078105
Transport and aggregation of self-propelled particles in fluid flows
Torney, Colin and Neufeld, Zoltan (2007) Transport and aggregation of self-propelled particles in fluid flows. Physical Review Letters, 99 7: 1-4. doi:10.1103/PhysRevLett.99.078101
Karolyi, Gyorgy, Neufeld, Zoltan and Scheuring, Istvan (2005) Rock-scissors-paper game in a chaotic flow: The effect of dispersion on the cyclic competition of microorganisms. Journal of Theoretical Biology, 236 1: 12-20. doi:10.1016/j.jtbi.2005.02.012
Multifractal spectra of chemical fields in fluid flows
Benczik, Izabella Julia, Neufeld, Zoltan and Tel, Tamas (2005) Multifractal spectra of chemical fields in fluid flows. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), 71 1: 1-6. doi:10.1103/PhysRevE.71.016208
Homogenization induced by chaotic mixing and diffusion in an oscillatory chemical reaction
Kiss, I. Z., Merkin, J. H. and Neufeld, Z. (2004) Homogenization induced by chaotic mixing and diffusion in an oscillatory chemical reaction. Physical Review E, 70 2: . doi:10.1103/PhysRevE.70.026216
Reaction front propagation in a turbulent ﬂow
Koudella, Christophe R. and Neufeld, Zoltán (2004) Reaction front propagation in a turbulent ﬂow. Physical Review E- Statistical, Nonlinear, and Soft Matter Physics, 70 2: 026307.1-026307.8. doi:10.1103/PhysRevE.70.026307
Combustion initiation and extinction in a 2D chaotic flow
Kiss, IZ, Merkin, JH and Neufeld, Z (2003) Combustion initiation and extinction in a 2D chaotic flow. Physica D-Nonlinear Phenomena, 183 3-4: 175-189. doi:10.1016/S0167-2789(03)00172-6
Synchronization and oscillator death in oscillatory media with stirring
Neufeld, Zoltan, Kiss, Istvan Z., Zhou, Changsong and Kurths, Jurgen (2003) Synchronization and oscillator death in oscillatory media with stirring. Physical Review Letters, 91 8: 084101.1-084101.4. doi:10.1103/PhysRevLett.91.084101
Filament bifurcations in a one-dimensional model of reacting excitable ﬂuid ﬂow
Hernandez-Garcia, Emilio, Lopez, Cristóbal and Neufeld, Zoltán (2003) Filament bifurcations in a one-dimensional model of reacting excitable ﬂuid ﬂow. Physica A, 327 1-2: 59-64. doi:10.1016/S0378-4371(03)00451-5
Noise-sustained coherent oscillations of excitable media in a chaotic flow
Zhou, C. S., Kurths, J., Neufeld, Z. and Kiss, I. Z. (2003) Noise-sustained coherent oscillations of excitable media in a chaotic flow. Physical Review Letters, 91 15: 150601.1-150601.4. doi:10.1103/PhysRevLett.91.150601
The structure of ﬂame ﬁlaments in chaotic ﬂows
Kiss, I. Z., Merkin, J. H., Kalliadasis, S., Scott, S. K. and Neufeld, Z. (2003) The structure of ﬂame ﬁlaments in chaotic ﬂows. Physica D, 176 1-2: 67-81. doi:10.1016/S0167-2789(02)00741-8
Chaotic mixing induced transitions in reaction-diffusion systems
Neufeld, Zoltan, Haynes, Peter H. and Tel, Tamas (2002) Chaotic mixing induced transitions in reaction-diffusion systems. Chaos, 12 2: 426-438. doi:10.1063/1.1476949
Dynamics of "leaking" Hamiltonian systems
Schneider, Judit, Neufeld, Zoltan and Tel, Tamas (2002) Dynamics of "leaking" Hamiltonian systems. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 66 6: 066218.1-066218.6. doi:10.1103/PhysRevE.66.066218
Excitable media in open and closed chaotic ﬂows
Neufeld, Z., Lopez, C., Hernandez-Garcia, E, Lopez, C. and Piro, O (2002) Excitable media in open and closed chaotic ﬂows. Physical Review E, 66 6: 066208.1-066208.12. doi:10.1103/PhysRevE.66.066208
Ocean fertilization experiments may initiate a large scale phytoplankton bloom
Neufeld, Z., Haynes, P. H., Garcon, C. V. and Sudre, J. (2002) Ocean fertilization experiments may initiate a large scale phytoplankton bloom. Geophysical Research Letters, 29 11: 1534.1-1534.4. doi:10.1029/2001GL013677
Small-scale structure of nonlinearly interacting species advected by chaotic ﬂows
Hernandez-Garcia, E, Lope, C. and Neufeld, Z. (2002) Small-scale structure of nonlinearly interacting species advected by chaotic ﬂows. Chaos, 12 2: 470-480. doi:10.1063/1.1468248
Chaotic advection of reacting substances: Plankton dynamics on a meandering jet
Lopez, C., Neufeld, Z., Hernandez-Garcia, E. and Haynes, P. H. (2001) Chaotic advection of reacting substances: Plankton dynamics on a meandering jet. Physics and Chemistry of the Earth Part B: Hydrology, Oceans and Atmosphere, 26 4: 313-317. doi:10.1016/S1464-1909(01)00012-0
Excitable media in a chaotic ﬂow
Neufeld, Zoltan (2001) Excitable media in a chaotic ﬂow. Physical Review Letters, 87 10: 108301.1-108301.4. doi:10.1103/PhysRevLett.87.108301
The latitudinal gradient of potential vorticity in the mid-latitudes of the troposphere
Satoh, Masaki and Neufeld, Zoltan (2001) The latitudinal gradient of potential vorticity in the mid-latitudes of the troposphere. Geophysical Research Letters, 28 1: 163-166. doi:10.1029/2000GL011527
The effect of forcing on the spatial structure and spectra of chaotically advected passive scalars
Neufeld, Zoltan, Haynes, Peter H. and Picard, Guillemette (2000) The effect of forcing on the spatial structure and spectra of chaotically advected passive scalars. Physics of Fluids, 12 10: 2506-2513. doi:10.1063/1.1289504
Multifractal structure of chaotically advected chemical ﬁelds
Neufeld, Z., Lopez, C., Hernandez-Garcia, E. and Tel, T. (2000) Multifractal structure of chaotically advected chemical ﬁelds. Physical Review E, 61 4: 3857-3866. doi:10.1103/PhysRevE.61.3857
Chemical dynamics versus transport dynamics in a simple model
Lustfeld, H. and Neufeld, Z. (1999) Chemical dynamics versus transport dynamics in a simple model. Journal of Physics A: Mathematical and Theoretical, 32 20: 3717-3731. doi:10.1088/0305-4470/32/20/305
Smooth-ﬁlamental transition of active tracer ﬁelds stirred by chaotic advection
Neufeld, Z., Lopez, C. and Haynes, P. H. (1999) Smooth-ﬁlamental transition of active tracer ﬁelds stirred by chaotic advection. Physical Review Letters, 82 12: 2606-2609. doi:10.1103/PhysRevLett.82.2606
Advection in chaotically time-dependent open ﬂows
Neufeld, Z. and Tel, T. (1998) Advection in chaotically time-dependent open ﬂows. Physical Review E, 57 3 Supplement A: 2832-2842. doi:10.1103/PhysRevE.57.2832
Neufeld, Z. and Tel, T. (1997) The vortex dynamics analogue of the restricted three-body problem: advection in the ﬁeld of three identical point vortices. Journal Of Physics A, 30 6: 2263-2280. doi:10.1088/0305-4470/30/6/043
Complex spatio-temporal patterns in two lattice models with instability
Neufeld, Z., Vicsek, M. and Vicsek, T. (1996) Complex spatio-temporal patterns in two lattice models with instability. Physica A, 233 3-4: 754-766. doi:10.1016/S0378-4371(96)00188-4
Spatiotemporal chaos in a coupled map lattice with unstable couplings
Neufeld, Z. and Vicsek, T. (1995) Spatiotemporal chaos in a coupled map lattice with unstable couplings. Journal Of Physics A, 28 18: 5257-5266. doi:10.1088/0305-4470/28/18/015
Hodgson, S., Neufeld, Z. and Khosrotehrani, K. (2013). A mouse model for in vivo quantitative monitoring of Wnt/B-Catenin signalling in skin reveals macroscopic hair cycle dynamics in health and disease. In: International Investigative Dermatology Meeting, Edinburgh, Scotland, (S84-S84). 8-11 May 2013. doi:10.1038/jid.2013.97
Roy, E., Neufeld, Z., Cerone, L., Wong, A., Hodgson, S., Tabansky, I., Eggan, K., Livet, J. and Khosrotehrani, K. (2013). The interfollicular epidermis is maintained by a hierarchy defined by stem cells within the non-cycling portion of hair follicles and committed progenitors. In: International Investigative Dermatology Meeting, Edinburgh, Scotland, (S244-S244). 8-11 May 2013. doi:10.1038/jid.2013.106
Roy, E., Neufeld, Z., Livet, J. and Khosrotehrani, K. (2012). A multicolour unbiased model to determine the Epidermal cell fate: localization and study of the epidermal stem cell niche. In: Abstracts of the 42nd Annual ESDR (European Society for Dermatological Research) Meeting. 42nd Annual Meeting of the European Society for Dermatological Research (ESDR), Venice Italy, (S75-S75). 07-10 September 2012. doi::10.1038/jid.2012.301
Salvucci, M., Neufeld, Z. and Newsholme, P. (2011). Mathematical model of the mechanism by which alanine potentiates glucose-stimulated insulin secretion. In: Abstracts of the 47th Annual Meeting of the EASD. 47th Annual Meeting of the European Association for the Study of Diabetes (EASD), Lisbon, Portugal, (S.198-S.198). 12-16 September 2011. doi:10.1007/s00125-011-2276-4
Salvucci, M., Neufeld, Z. and Newsholme, P. (2010). Developing a mathematical model of the mechanism by which alanine enhances glucose-stimulated insulin secretion. In: Abstracts of the EASD, Stockholm 2010. 46th Annual Meeting of the European Association for the Study-of-Diabetes (EASD), Stockholm, Sweden, (S223-S224). 20-24 September 2010. doi:10.1007/s00125-010-1872-z
Noise-sustained oscillation and synchronization of excitable media with stirring
Zhou, Changsong, Kurths, Jürgen, Neufeld, Zoltan and Kiss, István Z. (2004). Noise-sustained oscillation and synchronization of excitable media with stirring. In: Noise in Complex Systems and Stochastic Dynamics II. Conference on Noise in Complex Systems and Stochastic Dynamics II, Maspalomas, Spain, (193-202). 26-28 May 2004. doi:10.1117/12.546755
Oxygen vacancy ordering and the density-of-states in YBa2Cu3O7-Y
Crisan, V., Vernes, A., Neufeld, Z., Mostis, K., Lupulescu, A. and Janosi, A. (1993). Oxygen vacancy ordering and the density-of-states in YBa2Cu3O7-Y. In: Proceedings of the International Conference on the Physics of Transition Metals ( ICPTM ). International Conference on the Physics of Transition Metals ( ICPTM ), Darmstadt, Germany, (174-177). 20-24 July 1992. doi:10.1142/S0217979293000391
A mechanotransduction apparatus to coordinate epithelial collective cell migration
(2017–2020) NHMRC Project Grant
Mathematical modelling of the dynamics of multi-layered biological tissues
(2016–2019) ARC Discovery Projects
Mathematical modeling of multicellular organization of epithelial tissues
(2014–2018) ARC Future Fellowships
(Dys)Regulating junctional tension: a novel mechanism in tumor cell biology
(2014–2016) NHMRC Project Grant
Simulating the collective behaviour of a mono-layer of epithelial cells using a cellular Potts model
Doctor Philosophy — Principal Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
TISSUE MECHANICS & MORPHOGENESIS
This project will investigate the role of mechanical interactions between cells in determining the structure, morphology of different types of biological tissues. The project will use mathematical models, based on partial differential equations and/or stochastic models of interacting particles, and computer simulations and involves collaboration with experimental biology groups.
This research project will develop a biologically realistic mathematical model and computer simulations of the growth of glioblastoma brain tumours, that then can be used for testing and optimising treatment strategies, including surgery, radio- and chemo-therapy. The project will develop and investigate partial different equation models that describe the distribution and spreading of cancer cells in the tissue. The modelling work will be supported by experiments and MRI imaging data from the Centre of Advanced Imaging at UQ.
SKIN REGENERATION AND RADIATION INDUCED CANCER
The aim of this project is to understand the hierarchy and relative contributions of different stem cell populations to epidermal homeostasis and to develop a comprehensive computational model that accurately describes the spatial/temporal organization of tissue self-renewal. The project will analyze experimental data obtained from advanced imaging and genetic technology at the UQ Clinical Research Centre. The project will also study the effects of UV radiation induced carcinogenesis on epidermal regeneration by developing a predictive model for the growth dynamics of mutant clones.