The University of Queensland

Ryanodine receptor activity and store‐operated Ca ²⁺ entry: critical regulators of Ca ²⁺ content and function in skeletal muscle

Pearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca 2+ entry: critical regulators of Ca 2+ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

Singh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120

Tiny changes in cytoplasmic [Ca²⁺] cause large changes in mitochondrial Ca²⁺: what are the triggers and functional implications?

Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca2+] cause large changes in mitochondrial Ca2+: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412

Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166

Comparative label-free mass spectrometric analysis of temporal changes in the skeletal muscle proteome after impact trauma in rats

Liu, Lian, Broszczak, Daniel A., Broadbent, James A., Singh, Daniel P., Steck, Roland, Parker, Tony J. and Peake, Jonathan M. (2020). Comparative label-free mass spectrometric analysis of temporal changes in the skeletal muscle proteome after impact trauma in rats. AJP: Endocrinology and Metabolism, 318 (6), E1022-E1037. doi: 10.1152/ajpendo.00433.2019

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1

Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle

Koenig, Xaver, Choi, Rocky H., Schicker, Klaus, Singh, Daniel P., Hilber, Karlheinz and Launikonis, Bradley S. (2019). Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle. Biochimica et Biophysica Acta, 1866 (7), 1239-1248. doi: 10.1016/j.bbamcr.2019.02.014

Effects of topical icing on inflammation, angiogenesis, revascularization, and myofiber regeneration in skeletal muscle following contusion injury

Singh, Daniel P., Lonbani, Zohreh Barani, Woodruff, Maria A., Parker, Tony J., Steck, Roland and Peake, Jonathan M. (2017). Effects of topical icing on inflammation, angiogenesis, revascularization, and myofiber regeneration in skeletal muscle following contusion injury. Frontiers in Physiology, 8, 93. doi: 10.3389/fphys.2017.00093

High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development

Rebbeck, Robyn T., Singh, Daniel P., Ginsburg, Kenneth S., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Launikonis, Bradley S. and Cornea, Razvan L. (2019). High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March, 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2062

High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications

Rebbeck, Robyn T., Dong, Xiaoqiong, Ginsburg, Kenneth S., Singh, Daniel P., Gillispie, Gregory D., Thomas, David D., Launikonis, Bradley S., Bers, Donald M. and Cornea, Razvan L. (2018). High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications. 62nd Annual Meeting of the Biophysical Society, San Francisco, California, 17-21 February 2018. St. Louis, MO, United States: Cell Press.

Ryanodine receptor calcium regulation in healthy and compromised skeletal muscle

Singh, Daniel (2021). Ryanodine receptor calcium regulation in healthy and compromised skeletal muscle. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/ba6ef1f