Dr Laura Garcia Carrascosa

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology

Overview

I am an enthusiastic of biology and biosensing technology, and I have always striven to combine both disciplines to deliver translational-directed technology of interest for research and medicine fields. In this quest, I use optical, electrochemical or colorimetric tools to understand how biological species interact between them and with metal surfaces enabling innovative approaches for their specific capture and for underpinning their biological roles in the onset of diseases.

RESEARCH CAREER PROFILE

I am a postdoctoral research fellow with over 6.5 years of experience. Since December 2012, I work as postdoctoral Fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN) with former Federation Fellow, Prof. Matt Trau. I currently lead a small group of researchers within Trau group to develop next generation techniques for molecular and cellular biomarker discovery, detection and translation to clinical practice. This research has a particular emphasis on epigenetics applications. Prior to joining Trau Group at AIBN, I was a postdoctoral research fellow in the Catalan Institute for Nanoscience and Nanotechnology (CIN2) in Barcelona, Spain (Advisor: Prof. L. M. Lechuga) and Member of the Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) in Spain.

RESEARCH OUTPUT

I have co-authored 40 publications including 3 book chapters, many of which appear in the high-ranking journal in the field, e.g., Analytical Chemistry, Chemical Communications, TrAC, Scientific Reports, Cell Reports, Nucleic Acids Research and Optics Express. I have maintained an average citation count for my referred publications of 22 cites/paper resulting in over 870 total citations. Further details of my research publication output can be accessed in my Google scholar profile (link on the right)

Research Impacts

I am internationally recognized for significant contributions in terms of fundamental scientific understanding and also for the innovative cross-disciplinary applications of my research. Some important developments are the first opto-nanomechanical integrated microsystem for genetic applications, several fundamental studies involving DNA assembly and hybridization on gold surfaces, and optical and electrochemical devices for detection of cancer biomarkers including, DNA mutations, DNA methylation, RNA, clinically relevant exosomes, circulating tumor cells and the discovery of a new triplex-forming non-coding RNA.

Qualifications

  • Doctor of Philosophy, Universidad Autonoma de Madrid

Publications

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Grants

View all Grants

Supervision

  • (2017) Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Every 3 minutes a woman is diagnosed with breast cancer. Despite the increasing incidence of breast cancer in the Western world, death rates have been decreasing since 1990. This is the result of treatment advances, increased awareness and early detection. It is widely accepted that early detection results in much higher survival rates, but it is proving difficult to detect the cancer in its early stages. In this project, we aim to develop a simple device for the early detection of breast cancer by monitoring changes on DNA methylation biomarkers. Detection approach is based on gold-DNA affinity interactions, which provide a new capability of detecting DNA methylation by simply monitoring the relative adsorption of DNA samples derived from breast cancer cells onto a gold substrate. Optical or electrochemical readouts will be used. For details see Anal. Chem. 2014 86, 10179-10185; Chem. Commun. 2014, 50, 13153-13156; Analyst,2014, 139, 6178-6184. This interdisciplinary project will provide an opportunity for students to acquire diverse skills in chemistry, molecular biology and bioengineering.

View all Available Projects

Publications

Book Chapter

  • Alvarez, Mar, Carrascosa, Laura G., Zinoviev, Kiril, Plaza, J.ose A. and Lechuga, Laura M. (2009). Biosensors based on cantilevers. In Rasooly, Avraham and Herold, Keith E. (Ed.), Biosensors and biodetection : methods and protocols (pp. 51-71) New York , NY, United States: Humana Press. doi:10.1007/978-1-60327-569-9_4

  • Carrascosa, L. G., Mauriz, E., Sanchez del Rio, J., Moreno, M., Zinoviev, K., Calle, A., Domínguez, C. and Lechuga, L.M. (2008). Portable nanobiosensor platforms for ultrasensitive multidetection of biological warfare agents in real time. In Laura M Lechuga, F. P. Milanovich, P. Skiadal, O. Ignatov and T. R. Austin (Ed.), Commercial and pre-commercial cell detection technologies for defence against bioterror : technology, market and society (pp. 10-20) Amsterdam. The Netherlands: IOS Press.

  • Lechuga, Laura M., Zinoviev, Kirill, Carrascosa, Laura G. and Moreno, Miguel (2007). Nanodevices for biosensing: design,fabrication and applications. In Nanotechnologies for the life sciences (pp. 317-347) Weinheim, Germany: Wiley Interscience. doi:10.1002/9783527610419.ntls0044

Journal Article

Conference Publication

  • Shiddiky, Muhammad J, Vaidyanathan, Ramanathan, Naghibosadat, Maedeh, Rauf, Sakandar, Korbie, Darren, Carrascosa, Laura G and Trau, Matt (2014). Detecting Exosomes Specifically: a Microfluidic Approach Based on Alternating Current Electrohydrodynamic Induced Nanoshearing. In: Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio, TX United States, (674-676). 26-30 October 2014.

  • Shiddiky, Muhammad J, Sina, Abu Ali Ibn, Carracosa, Laura G, Palanisamy, Ramkumar, Rauf, Sakandar and Trau, Matt (2014). Methylsorb: A Simple Method for Quantifying DNA Methylation Using DNA-gold Affinity Interactions. In: ICECE 2014, 8th International Conference on Electrical and Computer Engineering. 8th International Conference on Electrical and Computer Engineering, Dhaka, Bangladesh, (17-20). 20-22 December 2014. doi:10.1109/ICECE.2014.7027002

  • Sepulveda, B., Carrascosa, L. G., Regatos, D., Otte, M. A., Farina, D. and Lechuga, L. M. (2009). Surface plasmon resonance biosensors for highly sensitive detection in real samples. In: Manijeh Razeghi and Hooman Mohseni, Biosensing II. Conference on Biosensing II, San Diego, United States, (73970Y.1-73970Y.11). 4-6 August 2009. doi:10.1117/12.827062

  • Sanchez del Rio, J., Carrascosa, L. G., Blanco, F. J., Moreno, M., Berganzo, J., Calle, A., Dominguez, C. and Lechuga, L. M. (2007). Lab-on-a-chip platforms based on highly sensitive nanophotonic Si biosensors for single nucleotide DNA testing. In: Joel A. Kubby and Graham T. Reed, Silicon Photonics II. Conference on Silicon Photonics II, San Jose, United States, (64771B.1-64771B.9). 22-25 January 2007. doi:10.1117/12.713977

  • Alvarez, M., Carrascosa, L. G., Tamayo, J., Calle, A. and Lechuga, L. M. (2003). Nanomechanics for specific biological detection. In: Robert Vajtai, Xavier Aymerich, Laszlo B. Kish and Angel Rubio, Nanotechnology. Conference on Nanotechnology, Maspalomas, Gran Canaria, Spain, (197-206). 19-21May 2003. doi:10.1117/12.498629

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

  • (2017) Doctor Philosophy — Associate Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Every 3 minutes a woman is diagnosed with breast cancer. Despite the increasing incidence of breast cancer in the Western world, death rates have been decreasing since 1990. This is the result of treatment advances, increased awareness and early detection. It is widely accepted that early detection results in much higher survival rates, but it is proving difficult to detect the cancer in its early stages. In this project, we aim to develop a simple device for the early detection of breast cancer by monitoring changes on DNA methylation biomarkers. Detection approach is based on gold-DNA affinity interactions, which provide a new capability of detecting DNA methylation by simply monitoring the relative adsorption of DNA samples derived from breast cancer cells onto a gold substrate. Optical or electrochemical readouts will be used. For details see Anal. Chem. 2014 86, 10179-10185; Chem. Commun. 2014, 50, 13153-13156; Analyst,2014, 139, 6178-6184. This interdisciplinary project will provide an opportunity for students to acquire diverse skills in chemistry, molecular biology and bioengineering.