The University of Queensland

Macrocyclic bifunctional chelators and conjugation strategies for copper-64 radiopharmaceuticals

Paterson, Brett M. and Donnelly, Paul S. (2016). Macrocyclic bifunctional chelators and conjugation strategies for copper-64 radiopharmaceuticals. Insights from Imaging in Bioinorganic Chemistry. (pp. 223-251) edited by Rudi van Eldik and Colin D. Hubbard. San Diego, CA United States: Academic Press. doi: 10.1016/bs.adioch.2015.09.005

Technetium Nitrido Complexes of Tetradentate Thiosemicarbazones: Kit-Based Radiolabeling, Characterization, and <i>In Vivo</i> Evaluation

Kelderman, Cormac A. A., Maclean, Rachel C., Hungnes, Ingebjørg N., Davey, Patrick R. W. J., Salimova, Ekaterina, de Veer, Michael, Patel, Natasha, Ma, Michelle T. and Paterson, Brett M. (2023). Technetium Nitrido Complexes of Tetradentate Thiosemicarbazones: Kit-Based Radiolabeling, Characterization, and In Vivo Evaluation. Inorganic Chemistry, 62 (50), 20791-20805. doi: 10.1021/acs.inorgchem.3c02650

A biodistribution study of the radiolabeled Kv1.3-blocking peptide DOTA-HsTX1[R14A] demonstrates brain uptake in a mouse model of neuroinflammation

Reddiar, Sanjeevini Babu, de Veer, Michael, Paterson, Brett M., Sepehrizadeh, Tara, Wai, Dorothy C. C., Csoti, Agota, Panyi, Gyorgy, Nicolazzo, Joseph A. and Norton, Raymond S. (2023). A biodistribution study of the radiolabeled Kv1.3-blocking peptide DOTA-HsTX1[R14A] demonstrates brain uptake in a mouse model of neuroinflammation. Molecular Pharmaceutics, 20 (1), 255-266. doi: 10.1021/acs.molpharmaceut.2c00614

Modern developments in bifunctional chelator design for gallium radiopharmaceuticals

Davey, Patrick R. W. J. and Paterson, Brett M. (2023). Modern developments in bifunctional chelator design for gallium radiopharmaceuticals. Molecules, 28 (1) 203, 1-36. doi: 10.3390/molecules28010203

Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease

Morgan, Katherine A., de Veer, Michael, Miles, Luke A., Kelderman, Cormac A. A., McLean, Catriona A., Masters, Colin L., Barnham, Kevin J., White, Jonathan M., Paterson, Brett M. and Donnelly, Paul S. (2023). Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease. Chemical Communications, 59 (16), 2243-2246. doi: 10.1039/d2cc06850h

A silver(I) coordination polymer with bridging bis(thiosemicarbazone) ligands and unsupported argentophilic interactions

Crouch, Sophie A., Davey, Patrick R. W. J., Forsyth, Craig M., Batten, Stuart R. and Paterson, Brett M. (2022). A silver(I) coordination polymer with bridging bis(thiosemicarbazone) ligands and unsupported argentophilic interactions. Journal of Coordination Chemistry, 75 (11-14), 1691-1701. doi: 10.1080/00958972.2022.2092845

An icosanuclear silver(I) cluster supported by bis(thiosemicarbazonato) ligands

Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2022). An icosanuclear silver(I) cluster supported by bis(thiosemicarbazonato) ligands. Australian Journal of Chemistry, 75 (9), 631-635. doi: 10.1071/CH21335

A general design strategy enabling the synthesis of hydrolysis‐resistant, water‐stable titanium(IV) complexes

Koller, Angus J., Saini, Shefali, Chaple, Ivis F., Joaqui‐Joaqui, M. Andrey, Paterson, Brett M., Ma, Michelle T., Blower, Philip J., Pierre, Valérie C., Robinson, Jerome R., Lapi, Suzanne E. and Boros, Eszter (2022). A general design strategy enabling the synthesis of hydrolysis‐resistant, water‐stable titanium(IV) complexes. Angewandte Chemie, 134 (22). doi: 10.1002/ange.202201211

Crystallographic and computational characterisation of the potential PET tracer 1,4,7-triazacyclononane-1,4,7-tri(methylenephosphonato)gallium(III)

Davey, Patrick R. W. J., Forsyth, Craig M. and Paterson, Brett M. (2022). Crystallographic and computational characterisation of the potential PET tracer 1,4,7-triazacyclononane-1,4,7-tri(methylenephosphonato)gallium(III). ChemistrySelect, 7 (5) e202103698. doi: 10.1002/slct.202103698

The evolving coordination chemistry of radiometals for targeted alpha therapy

Grieve, Melyssa L. and Paterson, Brett M. (2022). The evolving coordination chemistry of radiometals for targeted alpha therapy. Australian Journal of Chemistry, 75 (2), 65-88. doi: 10.1071/CH21184

Hexadentate technetium-99m bis(thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution

Kelderman, Cormac A. A., Davey, Patrick R. W. J., Ma, Michelle T., de Veer, Michael, Salimova, Ekaterina, Donnelly, Paul S. and Paterson, Brett M. (2022). Hexadentate technetium-99m bis(thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution. Dalton Transactions, 51 (37), 14064-14078. doi: 10.1039/d2dt01264b

The synthesis of a bis(Thiosemicarbazone) macrocyclic ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) complexes

Grieve, Melyssa L., Davey, Patrick R. W. J., Forsyth, Craig M. and Paterson, Brett M. (2021). The synthesis of a bis(Thiosemicarbazone) macrocyclic ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) complexes. Molecules, 26 (12) 3646. doi: 10.3390/molecules26123646

An octadentate bis(semicarbazone) macrocycle: a potential chelator for lead and bismuth radiopharmaceuticals

Lange, Jaclyn L., Davey, Patrick R. W. J., Ma, Michelle T., White, Jonathan M., Morgenstern, Alfred, Bruchertseifer, Frank, Blower, Philip J. and Paterson, Brett M. (2020). An octadentate bis(semicarbazone) macrocycle: a potential chelator for lead and bismuth radiopharmaceuticals. Dalton Transactions, 49 (42), 14962-14974. doi: 10.1039/d0dt02673e

Modification of biodistribution and brain uptake of copper bis(thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups

Paterson, Brett M., Cullinane, Carleen, Crouch, Peter J., White, Anthony R., Barnham, Kevin J., Roselt, Peter D., Noonan, Wayne, Binns, David, Hicks, Rodney J. and Donnelly, Paul S. (2019). Modification of biodistribution and brain uptake of copper bis(thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups. Inorganic Chemistry, 58 (7), 4540-4552. doi: 10.1021/acs.inorgchem.9b00117

Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies

Cui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019). Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies. Advanced Healthcare Materials, 8 (9) 1801607, e1801607. doi: 10.1002/adhm.201801607

Tuning the properties of tris(hydroxypyridinone) ligands: efficient 68 Ga chelators for PET imaging

Imberti, Cinzia, Chen, Yu-Lin, Foley, Calum A., Ma, Michelle T., Paterson, Brett M., Wang, Yifu, Young, Jennifer D., Hider, Robert C. and Blower, Philip J. (2019). Tuning the properties of tris(hydroxypyridinone) ligands: efficient 68 Ga chelators for PET imaging. Dalton Transactions, 48 (13), 4299-4313. doi: 10.1039/c8dt04454f

64Cu-SARTATE PET imaging of patients with neuroendocrine tumors demonstrates high tumor uptake and retention, potentially allowing prospective dosimetry for peptide receptor radionuclide therapy

Hicks, Rodney J., Jackson, Price, Kong, Grace, Ware, Robert E., Hofman, Michael S., Pattison, David A., Akhurst, Timothy A., Drummond, Elizabeth, Roselt, Peter, Callahan, Jason, Price, Roger, Jeffery, Charmaine M., Hong, Emily, Noonan, Wayne, Herschtal, Alan, Hicks, Lauren J., Hedt, Amos, Harris, Matthew, Paterson, Brett M. and Donnelly, Paul S. (2018). 64Cu-SARTATE PET imaging of patients with neuroendocrine tumors demonstrates high tumor uptake and retention, potentially allowing prospective dosimetry for peptide receptor radionuclide therapy. Journal of Nuclear Medicine, 60 (6), 777-785. doi: 10.2967/jnumed.118.217745

Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

Tsionou, Maria Iris, Knapp, Caroline E., Foley, Calum A., Munteanu, Catherine R., Cakebread, Andrew, Imberti, Cinzia, Eykyn, Thomas R., Young, Jennifer D., Paterson, Brett M., Blower, Philip J. and Ma, Michelle T. (2017). Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling. RSC Advances, 7 (78), 49586-49599. doi: 10.1039/c7ra09076e

Frontispiece: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes

Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Frontispiece: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie International Edition, 56 (29). doi: 10.1002/anie.201782961

Frontispiz: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes

Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Frontispiz: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie, 129 (29). doi: 10.1002/ange.201782961

Guest-induced assembly of bis(thiosemicarbazonato) zinc(II) coordination nanotubes

Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest-induced assembly of bis(thiosemicarbazonato) zinc(II) coordination nanotubes. Angewandte Chemie - International Edition, 56 (29), 8370-8374. doi: 10.1002/anie.201701596

Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes

Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie, 129 (29), 8490-8494. doi: 10.1002/ange.201701596

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler, Melanie, Alt, Karen, Paterson, Brett M., Kanellakis, Peter, Bobik, Alex, Donnelly, Paul S., Hagemeyer, Christoph E. and Peter, Karlheinz (2016). Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets. Scientific Reports, 6 (1) 38161. doi: 10.1038/srep38161

Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer

Gourni, Eleni, Del Pozzo, Luigi, Kheirallah, Emilie, Smerling, Christiane, Waser, Beatrice, Reubi, Jean-Claude, Paterson, Brett M., Donnelly, Paul S., Meyer, Philipp T. and Maecke, Helmut R. (2015). Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer. Molecular Pharmaceutics, 12 (8), 2781-2790. doi: 10.1021/mp500671j

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

Alt, Karen, Paterson, Brett M., Westein, Erik, Rudd, Stacey E., Poniger, Stan S., Jagdale, Shweta, Ardipradja, Katie, Connell, Timothy U., Krippner, Guy Y., Nair, Ashish K. N., Wang, Xiaowei, Tochon-Danguy, Henri J., Donnelly, Paul S., Peter, Karlheinz and Hagemeyer, Christoph E. (2015). A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry. Angewandte Chemie - International Edition, 54 (26), 7515-7519. doi: 10.1002/anie.201411507

The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution

Dearling, Jason L. J., Paterson, Brett M., Akurathi, Vamsidhar, Betanzos-Lara, Soledad, Treves, S. Ted, Voss, Stephan D., White, Jonathan M., Huston, James S., Smith, Suzanne V., Donnelly, Paul S. and Packard, Alan B. (2015). The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjugate Chemistry, 26 (4), 707-717. doi: 10.1021/acs.bioconjchem.5b00049

Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: Comparison with desferrioxamine-B

Ma, Michelle T., Meszaros, Levente K., Paterson, Brett M., Berry, David J., Cooper, Maggie S., Ma, Yongmin, Hider, Robert C. and Blower, Philip J. (2015). Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: Comparison with desferrioxamine-B. Dalton Transactions, 44 (11), 4884-4900. doi: 10.1039/c4dt02978j

Engineering poly(ethylene glycol) particles for improved biodistribution

Cui, Jiwei, De Rose, Robert, Alt, Karen, Alcantara, Sheilajen, Paterson, Brett M., Liang, Kang, Hu, Ming, Richardson, Joseph J., Yan, Yan, Jeffery, Charmaine M., Price, Roger I., Peter, Karlheinz, Hagemeyer, Christoph E., Donnelly, Paul S., Kent, Stephen J. and Caruso, Frank (2015). Engineering poly(ethylene glycol) particles for improved biodistribution. ACS Nano, 9 (2), 1571-1580. doi: 10.1021/nn5061578

Bifunctional 64Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography

Paterson, Brett M., Buncic, Gojko, McInnes, Lachlan E., Roselt, Peter, Cullinane, Carleen, Binns, David S., Jeffery, Charmaine M., Price, Roger I., Hicks, Rodney J. and Donnelly, Paul S. (2015). Bifunctional 64Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography. Dalton Transactions, 44 (11), 4901-4909. doi: 10.1039/c4dt02983f

+ complexes of exo-functionalized tridentate "click" macrocycles: Synthesis, stability, photophysical properties, bioconjugation, and antibacterial activity

Noor, Asif, Huff, Gregory S., Kumar, Sreedhar V., Lewis, James E. M., Paterson, Brett M., Schieber, Christine, Donnelly, Paul S., Brooks, Heather J. L., Gordon, Keith C., Moratti, Stephen C. and Crowley, James D. (2014). + complexes of exo-functionalized tridentate "click" macrocycles: Synthesis, stability, photophysical properties, bioconjugation, and antibacterial activity. Organometallics, 33 (24), 7031-7043. doi: 10.1021/om500664v

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

Alt, Karen, Paterson, Brett M., Ardipradja, Katie, Schieber, Christine, Buncic, Gojko, Lim, Bock, Poniger, Stan S., Jakoby, Bjoern, Wang, Xiaowei, Okeefe, Graeme J., Tochon-Danguy, Henri J., Scott, Andrew M., Ackermann, Uwe, Peter, Karlheinz, Donnelly, Paul S. and Hagemeyer, Christoph E. (2014). Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets. Molecular Pharmaceutics, 11 (8), 2855-2863. doi: 10.1021/mp500209a

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody

Paterson, Brett M., Alt, Karen, Jeffery, Charmaine M., Price, Roger I., Jagdale, Shweta, Rigby, Sheena, Williams, Charlotte C., Peter, Karlheinz, Hagemeyer, Christoph E. and Donnelly, Paul S. (2014). Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody. Angewandte Chemie - International Edition, 53 (24), 6115-6119. doi: 10.1002/anie.201402613

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation

Bica, Laura, Liddell, Jeffrey R., Donnelly, Paul S., Duncan, Clare, Caragounis, Aphrodite, Volitakis, Irene, Paterson, Brett M., Cappai, Roberto, Grubman, Alexandra, Camakaris, James, Crouch, Peter J. and White, Anthony R. (2014). Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. PLoS ONE, 9 (2) e90070. doi: 10.1371/journal.pone.0090070

PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

Paterson, Brett M., Roselt, Peter, Denoyer, Delphine, Cullinane, Carleen, Binns, David, Noonan, Wayne, Jeffery, Charmaine M., Price, Roger I., White, Jonathan M., Hicks, Rodney J. and Donnelly, Paul S. (2014). PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate. Dalton Transactions, 43 (3), 1386-1396. doi: 10.1039/c3dt52647j

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action

Djoko, Karrera Y., Paterson, Brett M., Donnelly, Paul S. and McEwan, Alastair G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, Advance Article (4), 1-10. doi: 10.1039/C3MT00348E

Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2014). Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 34 (23), 8021-8031. doi: 10.1523/JNEUROSCI.4196-13.2014

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

McAllum, Erin J., Lim, Nastasia K.-H., Hickey, James L., Paterson, Brett M., Donnelly, Paul S., Li, Qiao-Xin, Liddell, Jeffrey R., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2013). Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14 (7-8), 586-590. doi: 10.3109/21678421.2013.824000

Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques

Hickey, James L., Lim, Sinchun, Hayne, David J., Paterson, Brett M., White, Jonathan M., Villemagne, Victor L., Roselt, Peter, Binns, David, Cullinane, Carleen, Jeffery, Charmaine M., Price, Roger I., Barnham, Kevin J. and Donnelly, Paul S. (2013). Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques. Journal of the American Chemical Society, 135 (43), 16120-16132. doi: 10.1021/ja4057807

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

Cater, Michael A., Pearson, Helen B., Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal (2013). Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology, 8 (7), 1621-1631. doi: 10.1021/cb400198p

Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Duncan, Clare, Bica, Laura, Crouch, Peter J., Caragounis, Aphrodite, Lidgerwood, Grace E., Parker, Sarah J., Meyerowitz, Jodi, Volitakis, Irene, Liddell, Jeffrey R., Raghupathi, Ravinarayan, Paterson, Brett M., Duffield, Michael D., Cappai, Roberto, Donnelly, Paul S., Grubman, Alexandra, Camakaris, James, Keating, Damien J. and White, Anthony R. (2013). Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics, 5 (6), 700-714. doi: 10.1039/c3mt20231c

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Kanninen, Katja M., Grubman, Alexandra, Meyerowitz, Jodi, Duncan, Clare, Tan, Jiang-Li, Parker, Sarah J., Crouch, Peter J., Paterson, Brett M., Hickey, James L., Donnelly, Paul S., Volitakis, Irene, Tammen, Imke, Palmer, David N. and White, Anthony R. (2013). Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis. PLoS ONE, 8 (3) e58644. doi: 10.1371/journal.pone.0058644

Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes

Parker, Sarah J., Meyerowitz, Jodi, James, Janine L., Liddell, Jeffrey R., Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Lim, SinChun, Paterson, Brett M., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2012). Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes. PLoS ONE, 7 (8) e42277. doi: 10.1371/journal.pone.0042277

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II

Donnelly, Paul S., Liddell, Jeffrey R., Lim, SinChun, Paterson, Brett M., Cater, Michael A., Savva, Maria S., Mot, Alexandra I., James, Janine L., Trounce, Ian A., White, Anthony R. and Crouch, Peter J. (2012). An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II . Proceedings of the National Academy of Sciences of the United States of America, 109 (1), 47-52. doi: 10.1073/pnas.1116227108

Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm)

Price, Katherine Ann, Crouch, Peter J., Lim, Sinchun, Paterson, Brett M., Liddell, Jeffrey R., Donnelly, Paul S. and White, Anthony R. (2011). Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm). Metallomics, 3 (12), 1280-1290. doi: 10.1039/c1mt00092f

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes

Price, Katherine Ann, Crouch, Peter J., Volitakis, Irene, Paterson, Brett M., Lim, Sinchun, Donnelly, Paul S. and White, Anthony R. (2011). Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes. Inorganic Chemistry, 50 (19), 9594-9605. doi: 10.1021/ic201334q

Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

Paterson, Brett M. and Donnelly, Paul S. (2011). Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals. Chemical Society Reviews, 40 (5), 3005-3018. doi: 10.1039/c0cs00215a

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

Bica, Laura, Meyerowitz, Jodi, Parker, Sarah J., Caragounis, Aphrodite, Du, Tai, Paterson, Brett M., Barnham, Kevin J., Crouch, Peter J., White, Anthony R. and Donnelly, Paul S. (2011). Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex. BioMetals, 24 (1), 117-133. doi: 10.1007/s10534-010-9380-7

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

Lim, Sinchun, Paterson, Brett M., Fodero-Tavoletti, Michelle T., O'Keefe, Graeme J., Cappai, Roberto, Barnham, Kevin J., Villemagne, Victor L. and Donnelly, Paul S. (2010). A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques. Chemical Communications, 46 (30), 5437-5439. doi: 10.1039/c0cc01175d

A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

Buncic, Gojko, Donnelly, Paul S., Paterson, Brett M., White, Jonathan M., Zimmermann, Matthias, Xiao, Zhiguang and Wedd, Anthony G. (2010). A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc. Inorganic Chemistry, 49 (7), 3071-3073. doi: 10.1021/ic902370a

A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes

Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2010). A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes. Dalton Transactions, 39 (11), 2831-2837. doi: 10.1039/b922127a

Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling

Brett M. Paterson, M. Paterson, John A. Karas, A. Karas, Denis B. Scanlon, B. Scanlon, Jonathan M. White, M. White and Donnelly, Paul S. (2010). Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling. Inorganic Chemistry, 49 (4), 1884-1893. doi: 10.1021/ic902204e

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: Synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

Lim, Sinchun, Price, Katherine A., Chong, Siow-Feng, Paterson, Brett M., Caragounis, Aphrodite, Barnham, Kevin J., Crouch, Peter J., Peach, Josephine M., Dilworth, Jonathan R., White, Anthony R. and Donnelly, Paul S. (2010). Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: Synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies. Journal of Biological Inorganic Chemistry, 15 (2), 225-235. doi: 10.1007/s00775-009-0587-4

Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Fodero-Tavoletti, Michelle T., Villemagne, Victor L., Paterson, Brett M., White, Anthony R., Li, Qiao-Xin, Camakaris, James, O'keefe, Graeme, Cappai, Roberto, Barnham, Kevin J. and Donnelly, Paul S. (2010). Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. Journal of Alzheimer's Disease, 20 (1), 49-55. doi: 10.3233/JAD-2010-1359

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity

Price, Katherine Ann, Caragounis, Aphrodite, Paterson, Brett M., Filiz, Gulay, Volitakis, Irene, Masters, Colin L., Barnham, Kevin J., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2009). Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity. Journal of Medicinal Chemistry, 52 (21), 6606-6620. doi: 10.1021/jm9007938

New bimetallic compounds based on the bis(thiosemicarbazonato) motif

Christlieb, Martin, Cowley, Andrew R., Dilworth, Jonathan R., Donnelly, Paul S., Paterson, Brett M., Struthers, Harriet S. R. and White, Jonathan M. (2007). New bimetallic compounds based on the bis(thiosemicarbazonato) motif. Dalton Transactions (3), 327-331. doi: 10.1039/b612907b

Targeting the aryl hydrocarbon receptor to monitor the kynurenine pathway in glioblastoma multiforme using fluorine-18 PET radiotracers

Lim, Ting Xiang, Migotto, Mary-Anne, Mardon, Karine, Paterson, Brett and Reutens, David (2023). Targeting the aryl hydrocarbon receptor to monitor the kynurenine pathway in glioblastoma multiforme using fluorine-18 PET radiotracers. International Symposium on Radiopharmaceutical Sciences iSRS 2023, Honolulu, HI, United States, 22-26 May 2023. Philadelphia, PA, United States: Elsevier.