The University of Queensland

Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity

Stocker, William A., Howard, James A., Maskey, Shreya, Luan, Haitong, Harrison, Sophie G., Hart, Kaitlin N., Hok, Lucija, Thompson, Thomas B., Walton, Kelly L. and Harrison, Craig A. (2023). Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity. The FASEB Journal, 38 (1) e23377, e23377. doi: 10.1096/fj.202301335rr

Activin A level is associated with physical function in critically ill patients

Wang, Yi Tian, Harrison, Craig A., Skinner, Elizabeth H., Haines, Kimberley J., Holdsworth, Clare, Lang, Jenna K., Hibbert, Elizabeth, Scott, David, Eynon, Nir, Tiruvoipati, Ravindranath, French, Craig J., Stepto, Nigel K., Bates, Samantha, Walton, Kelly L., Crozier, Tim M. and Haines, Terry P. (2023). Activin A level is associated with physical function in critically ill patients. Australian Critical Care, 36 (5), 702-707. doi: 10.1016/j.aucc.2022.10.019

Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Hagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1), 1-15. doi: 10.1530/joe-22-0290

Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonism

Kappes, Emily C, Kattamuri, Chandramohan, Czepnik, Magdalena, Yarawsky, Alexander E, Brûlé, Emilie, Wang, Ying, Ongaro, Luisina, Herr, Andrew B, Walton, Kelly L, Bernard, Daniel J and Thompson, Thomas B (2023). Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonism. Endocrinology, 164 (3) bqad017. doi: 10.1210/endocr/bqad017

Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss

Walton, Kelly L., Goney, Monica P., Peppas, Zoe, Stringer, Jessica M., Winship, Amy, Hutt, Karla, Goodchild, Georgia, Maskey, Shreya, Chan, Karen L., Brûlé, Emilie, Bernard, Daniel J., Stocker, William A. and Harrison, Craig A. (2022). Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss. Endocrinology, 163 (4) bqac025. doi: 10.1210/endocr/bqac025

Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice

Houston, Brendan J, O’Connor, Anne E, Wang, Degang, Goodchild, Georgia, Merriner, D Jo, Luan, Haitong, Conrad, Don F, Nagirnaja, Liina, Aston, Kenneth I, Kliesch, Sabine, Wyrwoll, Margot J, Friedrich, Corinna, Tüttelmann, Frank, Harrison, Craig, O’Bryan, Moira K and Walton, Kelly (2022). Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice. Endocrinology, 163 (3) bqab269. doi: 10.1210/endocr/bqab269

TGFBR3L is an inhibin B co-receptor that regulates female fertility

Brûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P. and Bernard, Daniel J. (2021). TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances, 7 (51) eabl4391, eabl4391. doi: 10.1126/sciadv.abl4391

Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family

Hart, Kaitlin N., Stocker, William A., Nagykery, Nicholas G., Walton, Kelly L., Harrison, Craig A., Donahoe, Patricia K., Pépin, David and Thompson, Thomas B. (2021). Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. Proceedings of the National Academy of Sciences of the United States of America, 118 (26) e2104809118. doi: 10.1073/pnas.2104809118

TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass

Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225

New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing

Jaillard, Sylvie, Bell, Katrina, Akloul, Linda, Walton, Kelly, McElreavy, Kenneth, Stocker, William A., Beaumont, Marion, Harrisson, Craig, Jääskeläinen, Tiina, Palvimo, Jorma J., Robevska, Gorjana, Launay, Erika, Satié, Anne-Pascale, Listyasari, Nurin, Bendavid, Claude, Sreenivasan, Rajini, Duros, Solène, van den Bergen, Jocelyn, Henry, Catherine, Domin-Bernhard, Mathilde, Cornevin, Laurence, Dejucq-Rainsford, Nathalie, Belaud-Rotureau, Marc-Antoine, Odent, Sylvie, Ayers, Katie L., Ravel, Célia, Tucker, Elena J. and Sinclair, Andrew H. (2020). New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing. Maturitas, 141, 9-19. doi: 10.1016/j.maturitas.2020.06.004

Engineering the ovarian hormones inhibin A and inhibin B to enhance synthesis and activity

Goney, Monica P., Wilce, Matthew C. J., Wilce, Jacqueline A., Stocker, William A., Goodchild, Georgia M., Chan, Karen L., Harrison, Craig A. and Walton, Kelly L. (2020). Engineering the ovarian hormones inhibin A and inhibin B to enhance synthesis and activity. Endocrinology, 161 (8), 1-12. doi: 10.1210/endocr/bqaa099

A variant of human growth differentiation factor-9 that improves oocyte developmental competence

Stocker, William A., Walton, Kelly L., Richani, Dulama, Chan, Karen L., Beilby, Kiri H., Finger, Bethany J., Green, Mark P., Gilchrist, Robert B. and Harrison, Craig A. (2020). A variant of human growth differentiation factor-9 that improves oocyte developmental competence. Journal of Biological Chemistry, 295 (23), 7981-7991. doi: 10.1074/jbc.ra120.013050

Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice

Walton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257

Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies

Riepsamen, Angelique H., Chan, Karen, Lien, Shelly, Sweeten, Prudence, Donoghoe, Mark W., Walker, Glenda, Fraison, Eloïse H. J., Stocker, William A., Walton, Kelly L., Harrison, Craig A., Ledger, William L., Robertson, David M. and Gilchrist, Robert B. (2019). Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies. Endocrinology, 160 (10), 2298-2313. doi: 10.1210/en.2019-00264

Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadias

Bouty, Aurore, Walton, Kelly, Listyasari, Nurin Aisyiyah, Robevska, Gorjana, Van den Bergen, Jocelyn, Santosa, Ardy, Faradz, Sultana M H, Harrison, Craig, Ayers, Katie L and Sinclair, Andrew H (2019). Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadias. Journal of the Endocrine Society, 3 (4), 814-824. doi: 10.1210/js.2018-00333

Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro

Richani, Dulama, Constance, Katherine, Lien, Shelly, Agapiou, David, Stocker, William A., Hedger, Mark P., Ledger, William L., Thompson, Jeremy G., Robertson, David M., Mottershead, David G., Walton, Kelly L., Harrison, Craig A. and Gilchrist, Robert B. (2019). Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro. Endocrinology, 160 (4), 853-862. doi: 10.1210/en.2018-01026

Inhibin: To Betaglycan, or Not to Betaglycan

Walton, Kelly L. and Harrison, Craig A. (2018). Inhibin: To Betaglycan, or Not to Betaglycan. Endocrinology, 160 (2), 341-342. doi: 10.1210/en.2018-01049

Molecular characterization of latent GDF8 reveals mechanisms of activation

Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115

Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis

Walton, Kelly L., Johnson, Katharine E. and Harrison, Craig A. (2017). Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis. Frontiers in Pharmacology, 8 (JUL) 461. doi: 10.3389/fphar.2017.00461

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114

Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling

Wang, Yao, Chen, Qi, Zhao, Min, Walton, Kelly, Harrison, Craig and Nie, Guiying (2017). Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling. The Journal of Clinical Endocrinology & Metabolism, 102 (8), 3065-3074. doi: 10.1210/jc.2017-01150

Structural basis for potency differences between GDF8 and GDF11

Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T. and Thompson, Thomas B. (2017). Structural basis for potency differences between GDF8 and GDF11. BMC Biology, 15 (1) 19. doi: 10.1186/s12915-017-0350-1

BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9

Patino, Liliana C., Walton, Kelly L., Mueller, Thomas D., Johnson, Katharine E., Stocker, William, Richani, Dulama, Agapiou, David, Gilchrist, Robert B., Laissue, Paul and Harrison, Craig A. (2017). BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9. Journal of Clinical Endocrinology and Metabolism, 102 (3), 1009-1019. doi: 10.1210/jc.2016-3503

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

Coulson, Rhiannon, Liew, Seng H., Connelly, Angela A., Yee, Nicholas S., Deb, Siddhartha, Kumar, Beena, Vargas, Ana C., O'Toole, Sandra A., Parslow, Adam C., Poh, Ashleigh, Putoczki, Tracy, Morrow, Riley J., Alorro, Mariah, Lazarus, Kyren A., Yeap, Evie F.W., Walton, Kelly L., Harrison, Craig A., Hannan, Natalie J., George, Amee J., Clyne, Colin D., Ernst, Matthias, Allen, Andrew M. and Chand, Ashwini L. (2017). The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget, 8 (12), 18640-18656. doi: 10.18632/oncotarget.15553

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348). doi: 10.1126/scitranslmed.aac4976

A novel, more efficient approach to generate bioactive inhibins

Walton, Kelly L., Kelly, Emily K., Johnson, Katharine E., Robertson, David M., Stanton, Peter G. and Harrison, Craig A. (2016). A novel, more efficient approach to generate bioactive inhibins. Endocrinology, 157 (7), 2799-2809. doi: 10.1210/en.2015-1963

Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity

Heng, Sophea, Dynon, Kemperly, Li, Ying, Edgell, Tracey, Walton, Kelly, Rombauts, Luk J., Vollenhoven, Beverley and Nie, Guiying (2015). Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. Analytical Biochemistry, 475, 14-21. doi: 10.1016/j.ab.2014.12.012

Development of novel activin-targeted therapeutics

Chen, Justin L., Walton, Kelly L., Al-Musawi, Sara L., Kelly, Emily K., Qian, Hongwei, La, Mylinh, Lu, Louis, Lovrecz, George, Ziemann, Mark, Lazarus, Ross, El-Osta, Assam, Gregorevic, Paul and Harrison, Craig A. (2015). Development of novel activin-targeted therapeutics. Molecular Therapy, 23 (3), 434-444. doi: 10.1038/mt.2014.221

Elevated expression of activins promotes muscle wasting and cachexia

Chen, Justin L., Walton, Kelly L., Winbanks, Catherine E., Murphy, Kate T., Thomson, Rachel E., Makanji, Yogeshwar, Qian, Hongwei, Lynch, Gordon S., Harrison, Craig A. and Gregorevic, Paul (2014). Elevated expression of activins promotes muscle wasting and cachexia. Faseb Journal, 28 (4), 1711-1723. doi: 10.1096/fj.13-245894

Germline mutations of inhibins in early-onset ovarian epithelial tumors

Tournier, Isabelle, Marlin, Régine, Walton, Kelly, Charbonnier, Françoise, Coutant, Sophie, Théry, Jean-Christophe, Charbonnier, Camille, Spurrell, Cailyn, Vezain, Myriam, Ippolito, Lorena, Bougeard, Gaëlle, Roman, Horace, Tinat, Julie, Sabourin, Jean-Christophe, Stoppa-Lyonnet, Dominique, Caron, Olivier, Bressac-de Paillerets, Brigitte, Vaur, Dominique, King, Mary-Claire, Harrison, Craig and Frebourg, Thierry (2014). Germline mutations of inhibins in early-onset ovarian epithelial tumors. Human Mutation, 35 (3), 294-297. doi: 10.1002/humu.22489

Activin signaling regulates sertoli cell differentiation and function

Nicholls, Peter K., Stanton, Peter G., Chen, Justin L., Olcorn, Justine S., Haverfield, Jenna T., Qian, Hongwei, Walton, Kelly L., Gregorevic, Paul and Harrison, Craig A. (2012). Activin signaling regulates sertoli cell differentiation and function. Endocrinology, 153 (12), 6065-6077. doi: 10.1210/en.2012-1821

HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum Screening

Dynon, Kemperly, Heng, Sophea, Puryer, Michelle, Li, Ying, Walton, Kelly, Endo, Yaeta and Nie, Guiying (2012). HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum Screening. Plos One, 7 (9) ARTN e45956. doi: 10.1371/journal.pone.0045956

Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domain

Simpson, Courtney M., Stanton, Peter G., Walton, Kelly L., Chan, Karen L., Ritter, Lesley J., Gilchrist, Robert B. and Harrison, Craig A. (2012). Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domain. Endocrinology, 153 (3), 1301-1310. doi: 10.1210/en.2011-1632

Generation of a specific activin antagonist by modification of the activin A propeptide

Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M. and Harrison, Craig A. (2011). Generation of a specific activin antagonist by modification of the activin A propeptide. Endocrinology, 152 (10), 3758-3768. doi: 10.1210/en.2011-1052

Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation

Nicholls, Peter K., Harrison, Craig A., Walton, Kelly L., McLachlan, Robert I., O'Donnell, Liza and Stanton, Peter G. (2011). Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation. Endocrinology, 152 (4), 1670-1683. doi: 10.1210/en.2010-1341

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex

Walton, Kelly L., Makanji, Yogeshwar, Chen, Justin, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2010). Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex. Journal of Biological Chemistry, 285 (22), 17029-17037. doi: 10.1074/jbc.M110.110288

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β(TGFβ) ligands

Walton, Kelly L., Makanji, Yogeshwar, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2009). A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β(TGFβ) ligands. Journal of Biological Chemistry, 284 (14), 9311-9320. doi: 10.1074/jbc.M808763200

Suppression of inhibin A biological activity by alterations in the binding site for betaglycan

Makanji, Yogeshwar, Walton, Kelly L., Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2008). Suppression of inhibin A biological activity by alterations in the binding site for betaglycan. Journal of Biological Chemistry, 283 (24), 16743-16751. doi: 10.1074/jbc.M801045200