The University of Queensland

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2

Shaffer, Karl J., Smith, Raymond A. A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F. R., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2024). Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2. Carbohydrate Polymers, 333 121979, 121979. doi: 10.1016/j.carbpol.2024.121979

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

Smith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671

Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting

Tan Kwan Zen, Nicholas, Zeming, Kerwin Kwek, Teo, Kim Leng, Loberas, Mavis, Lee, Jialing, Goh, Chin Ren, Yang, Da Hou, Oh, Steve, Hui Hoi Po, James, Cool, Simon M., Hou, Han Wei and Han, Jongyoon (2023). Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting. Lab on a Chip, 23 (19), 4313-4323. doi: 10.1039/d3lc00379e

Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis

Luo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na and Cool, Simon M. (2023). Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports, 13 (1) 11774, 1-15. doi: 10.1038/s41598-023-38818-y

Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications

Guo, Jiayi, Park, Eun Ju, Teo, Yew Chin, Abbas, Asyraf, Goh, Denise, Smith, Raymond Alexander Alfred, Nie, Yuntong, Nguyen, Hang T. L., Yeong, Joe Poh Sheng, Cool, Simon, Haruyuki, Makio and Teo, Peili (2023). Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications. Polymer Chemistry, 14 (15), 1743-1751. doi: 10.1039/d2py01545e

Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering

Teo, Yew Chin, Park, Eun Ju, Guo, Jiayi, Abbas, Asyraf, Smith, Raymond Alexander Alfred, Goh, Denise, Yeong, Joe Poh Sheng, Cool, Simon and Teo, Peili (2022). Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering. ACS Applied Bio Materials, 5 (10), 4770-4778. doi: 10.1021/acsabm.2c00455

Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion

Srinivasan, Akshaya, Sathiyanathan, Padmapriya, Yin, Lu, Liu, Tong Ming, Lam, Alan, Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Loh, Han Ping, Zhang, Ying, Ling, Ling, Ng, Say Kong, Yang, Yuan Sheng, Lezhava, Alexander, Hui, James, Oh, Steve and Cool, Simon M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24 (5), 456-472. doi: 10.1016/j.jcyt.2021.11.009

FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells

Zhang, Ying, Ling, Ling, Ajayakumar, Arya Ajay D. O., Eio, Yating Michelle, van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2022). FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells. Gene, 818 146199, 146199. doi: 10.1016/j.gene.2022.146199

Variability in the composition of porcine mucosal heparan sulfates

Sargison, Liam, Smith, Raymond A A, Carnachan, Susan M, Daines, Alison M, Brackovic, Amira, Kidgell, Joel T, Nurcombe, Victor, Cool, Simon M, Sims, Ian M and Hinkley, Simon F R (2022). Variability in the composition of porcine mucosal heparan sulfates. Carbohydrate Polymers, 282 119081, 119081. doi: 10.1016/j.carbpol.2021.119081

A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants

Cohen, Talia, Kossover, Olga, Peled, Eli, Bick, Tova, Hasanov, Lena, Chun, Tan Tuan, Cool, Simon, Lewinson, Dina and Seliktar, Dror (2022). A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants. Journal of Tissue Engineering and Regenerative Medicine, 16 (4), 380-395. doi: 10.1002/term.3285

Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model

Hu, Tao, Liu, Ling, Lam, Raymond Wing Moon, Toh, Soo Yein, Abbah, Sunny Akogwu, Wang, Ming, Ramruttun, Amit Kumarsing, Bhakoo, Kishore, Cool, Simon, Li, Jun, Cho-Hong Goh, James and Wong, Hee-Kit (2021). Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. Journal of Tissue Engineering and Regenerative Medicine, 16 (1), 63-75. doi: 10.1002/term.3260

Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary study

Hey, Hwee Weng Dennis, Lam, Wing Moon Raymond, Chan, Chloe Xiaoyun, Zhuo, Wen-Hai, Crombie, Elisa Marie, Tan, Tuan Chun, Chen, Way Cherng, Cool, Simon and Tsai, Shih Yin (2021). Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary study. The Spine Journal, 22 (3), 483-494. doi: 10.1016/j.spinee.2021.09.003

Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction model

Lui, Hayman, Samsonraj, Rebekah M., Vaquette, Cedryck, Denbeigh, Janet, Kakar, Sanjeev, Cool, Simon M., Dudakovic, Amel and Van Wijnen, Andre J. (2021). Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction model. Tissue Engineering - Part A, 27 (15-16), 1084-1098. doi: 10.1089/ten.tea.2020.0218

Application of a BMP2-binding heparan sulphate to promote periodontal regeneration

Le, B. Q., Too, J. H., Tan, T. C., Smith, R. A. A., Nurcombe, , Cool, S. M. and Yu, N. (2021). Application of a BMP2-binding heparan sulphate to promote periodontal regeneration. European Cells and Materials, 42, 139-153. doi: 10.22203/eCM.v042a10

Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5)

Lui, Hayman, Denbeigh, Janet, Vaquette, Cedryck, Tran, Hoai My, Dietz, Allan B., Cool, Simon M., Dudakovic, Amel, Kakar, Sanjeev and van Wijnen, Andre J. (2021). Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5). Gene, 788 145662, 1-11. doi: 10.1016/j.gene.2021.145662

Age-related changes in the inflammatory status of human mesenchymal stem cells: Implications for cell therapy

Zhang, Ying, Ravikumar, Maanasa, Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2021). Age-related changes in the inflammatory status of human mesenchymal stem cells: Implications for cell therapy. Stem Cell Reports, 16 (4), 694-707. doi: 10.1016/j.stemcr.2021.01.021

A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery

Le, Bach Quang, Tan, Tuan Chun, Lee, Seong-Baek, Jang, Ju Woong, Kim, Young Sik, Lee, Jung Soo, Choi, Jae Won, Sathiyanathan, Padmapriya, Nurcombe, Victor and Cool, Simon M. (2021). A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery. Gene, 769 145217, 145217. doi: 10.1016/j.gene.2020.145217

Heparan sulfate proteoglycans: key mediators of stem cell function

Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor and Cool, Simon M. (2020). Heparan sulfate proteoglycans: key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8 581213, 581213. doi: 10.3389/fcell.2020.581213

A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability

Sathiyanathan, Padmapriya, Samsonraj, Rebekah M., Tan, Clarissa L. L., Ling, Ling, Lezhava, Alexander, Nurconnbe, Victor, Stanton, Lawrence W. and Cool, Simon M. (2020). A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability. Stem Cells, 38 (9), 1124-1136. doi: 10.1002/stem.3203

Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia

Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A. A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H. and Nurcombe, Victor (2020). Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia. Stroke, 51 (9), 2844-2853. doi: 10.1161/STROKEAHA.119.025304

In reply

Cool, Simon M., Sathiyanathan, Padmapriya, Samsonraj, Rebekah M., Tan, Clarissa L. L., Ling, Ling, Lezhava, Alexander, Nurcombe, Victor and Stanton, Lawrence W. (2020). In reply. Stem Cells, 38 (11), E7-E8. doi: 10.1002/stem.3264

Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

Dudakovic, Amel, Samsonraj, Rebekah M., Paradise, Christopher R., Galeano-Garces, Catalina, Mol, Merel O., Galeano-Garces, Daniela, Zan, Pengfei, Galvan, M Lizeth, Hevesi, Mario, Pichurin, Oksana, Thaler, Roman, Begun, Dana L., Kloen, Peter, Karperien, Marcel, Larson, A. Noelle, Westendorf, Jennifer J., Cool, Simon M. and van Wijnen, Andre J. (2020). Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. The Journal of Biological Chemistry, 295 (23), 7877-7893. doi: 10.1074/jbc.RA119.011685

Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells

Liu, Tong Ming, Yildirim, Ege Deniz, Li, Pin, Fang, Hai Tong, Denslin, Vinitha, Kumar, Vibhor, Loh, Yuin Han, Lee, Eng Hin, Cool, Simon M., Teh, Bin Tean, Hui, James H., Lim, Bing and Shyh-Chang, Ng (2020). Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, 14 (2), 210-225. doi: 10.1016/j.stemcr.2020.01.002

Enhancing the efficacy of stem cell therapy with glycosaminoglycans

Ling, Ling, Ren, Xiafei, Cao, Xue, Hassan, Afizah Binte Mohd, Mah, Sophia, Sathiyanathan, Padmapriya, Smith, Raymond A. A., Tan, Clarissa L. L., Eio, Michelle, Samsonraj, Rebekah M., Van Wijnen, Andre J., Raghunath, Michael, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2020). Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports, 14 (1), 105-121. doi: 10.1016/j.stemcr.2019.12.003

Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective

Nurcombe, Victor, Ling, Ling, Hondermarck, Hubert, Cool, Simon M. and Smith, Raymond A. A. (2019). Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective. Proteomics, 19 (21-22) 1800466, 1800466. doi: 10.1002/pmic.201800466

Vascular cells and tissue constructs derived from human pluripotent stem cells for toxicological screening

Titmarsh, Drew M., Nurcombe, Victor, Cheung, Christine and Cool, Simon M. (2019). Vascular cells and tissue constructs derived from human pluripotent stem cells for toxicological screening. Stem Cells and Development, 28 (20), 1347-1364. doi: 10.1089/scd.2018.0246

A heparan sulfate device for the regeneration of osteochondral defects

Lee, Jonathan H., Luo, Xiaoman, Ren, Xiafei, Tan, Tuan Chun, Smith, Raymond A.A., Swaminathan, Kunchithapadam, Sekar, Sakthivel, Bhakoo, Kishore, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2019). A heparan sulfate device for the regeneration of osteochondral defects. Tissue Engineering - Part A, 25 (5-6), 352-363. doi: 10.1089/ten.tea.2018.0171

Autologous bone marrow clot as an alternative to autograft for bone defect healing

Lim, Z. X.H., Rai, B., Tan, T. C., Ramruttun, A. K., Hui, J. H., Nurcombe, V., Teoh, S. H. and Cool, S. M. (2019). Autologous bone marrow clot as an alternative to autograft for bone defect healing. Bone and Joint Research, 8 (3), 107-117. doi: 10.1302/2046-3758.83.BJR-2018-0096.R1

A polycaprolactone-beta-tricalcium phosphateeheparan sulphate device for cranioplasty

Le, Bach Quang, Rai, Bina, Lim, Zophia Xue Hui, Tan, Tuan Chun, Lin, Tingxuan, Lee, Jaslyn Jie Lin, Murali, Sadasivam, Teoh, Swee Hin, Nurcombe, Victor and Cool, Simon McKenzie (2019). A polycaprolactone-beta-tricalcium phosphateeheparan sulphate device for cranioplasty. Journal of Cranio-Maxillofacial Surgery, 47 (2), 341-348. doi: 10.1016/j.jcms.2018.11.013

Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate

Poon, Selina, Lu, Xiaohua, Smith, Raymond A. A., Ho, Pei, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2018). Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate. Angiogenesis, 21 (4), 777-791. doi: 10.1007/s10456-018-9622-9

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056

Validation of osteogenic properties of cytochalasin D by high-resolution RNA-sequencing in mesenchymal stem cells derived from bone marrow and adipose tissues

Samsonraj, Rebekah M., Paradise, Christopher R., Dudakovic, Amel, Sen, Buer, Nair, Asha A., Dietz, Allan B., Deyle, David R., Cool, Simon M., Rubin, Janet and Van Wijnen, Andre J. (2018). Validation of osteogenic properties of cytochalasin D by high-resolution RNA-sequencing in mesenchymal stem cells derived from bone marrow and adipose tissues. Stem Cells and Development, 27 (16), 1136-1145. doi: 10.1089/scd.2018.0037

Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone

Soreide, Endre, Denbeigh, Janet M., Lewallen, Eric A., Samsonraj, Rebekah M., Berglund, Lawrence J., Dudakovic, Amel, Cool, Simon M., Nordsletten, Lars, Kakar, Sanjeev and van Wijnen, Andre J. (2018). Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone. Journal of Cellular Biochemistry, 119 (7), 5715-5724. doi: 10.1002/jcb.26755

Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells

Yap, Lynn, Murali, Sadasivam, Bhakta, Gajadhar, Titmarsh, Drew M., Chen, Allen Kuan-Liang, Chiin Sim, Lyn, Bardor, Muriel, Lim, Yu Ming, Goh, James C.H., Oh, Steve K.W., Choo, Andre B.H., van Wijnen, Andre J., Robinson, David E., Whittle, Jason D., Birch, William R., Short, Robert D., Nurcombe, Victor and Cool, Simon M. (2018). Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 106 (5), 1887-1896. doi: 10.1002/jbm.b.33999

Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation

Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor and Cool, Simon M. (2018). Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation. Tissue Engineering - Part A, 24 (9-10), 729-739. doi: 10.1089/ten.tea.2017.0263

Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2

Su, Yan, Denbeigh, Janet M., Camilleri, Emily T., Riester, Scott M., Parry, Joshua A., Wagner, Eric R., Yaszemski, Michael J., Dietz, Allan B., Cool, Simon M., van Wijnen, Andre J. and Kakar, Sanjeev (2018). Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2. Gene Reports, 10, 149-156. doi: 10.1016/j.genrep.2017.12.004

Osteogenic stimulation of human adipose-derived mesenchymal stem cells using a fungal metabolite that suppresses the polycomb group protein EZH2

Samsonraj, Rebekah M., Dudakovic, Amel, Manzar, Bushra, Sen, Buer, Dietz, Allan B., Cool, Simon M., Rubin, Janet and van Wijnen, Andre J. (2018). Osteogenic stimulation of human adipose-derived mesenchymal stem cells using a fungal metabolite that suppresses the polycomb group protein EZH2. Stem Cells Translational Medicine, 7 (2), 197-209. doi: 10.1002/sctm.17-0086

The components of bone and what they can teach us about regeneration

Le, Bach Quang, Nurcombe, Victor, Cool, Simon McKenzie, van Blitterswijk, Clemens A., de Boer, Jan and LaPointe, Vanessa Lydia Simone (2017). The components of bone and what they can teach us about regeneration. Materials, 11 (1) 14, 14. doi: 10.3390/ma11010014

Fabrication of polycaprolactone-silanated β-tricalcium phosphate-heparan sulfate scaffolds for spinal fusion applications

Bhakta, Gajadhar, Ekaputra, Andrew K., Rai, Bina, Abbah, Sunny A., Tan, Tuan Chun, Le, Bach Quang, Chatterjea, Anindita, Hu, Tao, Lin, Tingxuan, Arafat, M. Tarik, van Wijnen, Andre J., Goh, James, Nurcombe, Victor, Bhakoo, Kishore, Birch, William, Xu, Li, Gibson, Ian, Wong, Hee-Kit and Cool, Simon M. (2017). Fabrication of polycaprolactone-silanated β-tricalcium phosphate-heparan sulfate scaffolds for spinal fusion applications. Spine Journal, 18 (5), 818-830. doi: 10.1016/j.spinee.2017.12.002

Concise review: Multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine

Samsonraj, Rebekah M., Raghunath, Michael, Nurcombe, Victor, Hui, James H., van Wijnen, Andre J. and Cool, Simon M. (2017). Concise review: Multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine. Stem Cells Translational Medicine, 6 (12), 2173-2185. doi: 10.1002/sctm.17-0129

A versatile protocol for studying calvarial bone defect healing in a mouse model

Samsonraj, Rebekah M., Dudakovic, Amel, Zan, Pengfei, Pichurin, Oksana, Cool, Simon M. and Van Wijnen, Andre J. (2017). A versatile protocol for studying calvarial bone defect healing in a mouse model. Tissue Engineering - Part C: Methods, 23 (11), 686-693. doi: 10.1089/ten.tec.2017.0205

Endogenous regeneration: Engineering growth factors for stroke

Chan, Su Jing, Love, Christopher, Spector, Myron, Cool, Simon M., Nurcombe, Victor and Lo, Eng H. (2017). Endogenous regeneration: Engineering growth factors for stroke. Neurochemistry International, 107, 57-65. doi: 10.1016/j.neuint.2017.03.024

Long-term culture of self-renewing pancreatic progenitors derived from human pluripotent stem cells

Trott, Jamie, Tan, Ee Kim, Ong, Sheena, Titmarsh, Drew M., Denil, Simon L. I. J., Giam, Maybelline, Wong, Cheng Kit, Wang, Jiaxu, Shboul, Mohammad, Eio, Michelle, Cooper-White, Justin, Cool, Simon M., Rancati, Giulia, Stanton, Lawrence W., Reversade, Bruno and Dunn, N. Ray (2017). Long-term culture of self-renewing pancreatic progenitors derived from human pluripotent stem cells. Stem Cell Reports, 8 (6), 1675-1688. doi: 10.1016/j.stemcr.2017.05.019

Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications

Ayerst, Bethanie I., Smith, Raymond A.A., Nurcombe, Victor, Day, Anthony J., Merry, Catherine L.R. and Cool, Simon M. (2017). Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications. Tissue Engineering - Part A, 23 (7-8), 275-292. doi: 10.1089/ten.tea.2016.0364

Microfluidic screening reveals heparan sulfate enhances human mesenchymal stem cell growth by modulating fibroblast growth factor-2 transport

Titmarsh, Drew M., Tan, Clarissa L. L., Glass, Nick R., Nurcombe, Victor, Cooper-White, Justin J. and Cool, Simon M. (2017). Microfluidic screening reveals heparan sulfate enhances human mesenchymal stem cell growth by modulating fibroblast growth factor-2 transport. Stem Cells Translational Medicine, 6 (4), 1178-1190. doi: 10.1002/sctm.16-0343

Affinity selection of FGF2-binding heparan sulfates for ex vivo expansion of human mesenchymal stem cells

Wijesinghe, Sampath Jeewantha, Ling, Ling, Murali, Sadasivam, Qing, Yeong Hui, Hinkley, Simon F.R., Carnachan, Susan M., Bell, Tracey J., Swaminathan, Kunchithapadam, Hui, James H., van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2017). Affinity selection of FGF2-binding heparan sulfates for ex vivo expansion of human mesenchymal stem cells. Journal of Cellular Physiology, 232 (3), 566-575. doi: 10.1002/jcp.25454

Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment

Carnachan, Susan M., Bell, Tracey J., Sims, Ian M., Smith, Raymond A.A., Nurcombe, Victor, Cool, Simon M. and Hinkley, Simon F.R. (2016). Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment. Carbohydrate Polymers, 152, 592-597. doi: 10.1016/j.carbpol.2016.07.024

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes

Lewallen, Eric A., Bonin, Carolina A., Li, Xin, Smith, Jay, Karperien, Marcel, Larson, A. Noelle, Lewallen, David G., Cool, Simon M., Westendorf, Jennifer J., Krych, Aaron J., Leontovich, Alexey A., Im, Hee-Jeong and van Wijnen, Andre J. (2016). The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes. Gene, 591 (2), 456-464. doi: 10.1016/j.gene.2016.06.063

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production

Camilleri, Emily T., Gustafson, Michael P., Dudakovic, Amel, Riester, Scott M., Garces, Catalina Galeano, Paradise, Christopher R., Takai, Hideki, Karperien, Marcel, Cool, Simon, Sampen, Hee-Jeong Im, Larson, A. Noelle, Qu, Wenchun, Smith, Jay, Dietz, Allan B. and Van Wijnen, Andre J. (2016). Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Research and Therapy, 7 (1) 107, 1-16. doi: 10.1186/s13287-016-0370-8

Heparin-based polyelectrolyte complex enhances the therapeutic efficacy of bone morphogenetic protein-2 for posterolateral fusion in a large animal model

Wang, Ming, Lam, Raymond W.M., Abbah, Sunny A., Hu, Tao, Toh, Soo Y., Cool, Simon, Bhakoo, Kishore, Li, Jun, Goh, James C.H. and Wong, Hee-Kit (2016). Heparin-based polyelectrolyte complex enhances the therapeutic efficacy of bone morphogenetic protein-2 for posterolateral fusion in a large animal model. Spine, 41 (15), 1199-1207. doi: 10.1097/BRS.0000000000001543

Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells

Ling, Ling, Camilleri, Emily T., Helledie, Torben, Samsonraj, Rebekah M., Titmarsh, Drew M., Chua, Ren Jie, Dreesen, Oliver, Dombrowski, Christian, Rider, David A., Galindo, Mario, Lee, Ian, Hong, Wanjin, Hui, James H., Nurcombe, Victor, van Wijnen, Andre J. and Cool, Simon M. (2016). Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Gene, 576 (1), 292-303. doi: 10.1016/j.gene.2015.10.039

Mode of heparin attachment to nanocrystalline hydroxyapatite affects its interaction with bone morphogenetic protein-2

Goonasekera, Chandhi S., Jack, Kevin S., Bhakta, Gajadhar, Rai, Bina, Luong-Van, Emma, Nurcombe, Victor, Cool, Simon M., Cooper-White, Justin J. and Grondahl, Lisbeth (2015). Mode of heparin attachment to nanocrystalline hydroxyapatite affects its interaction with bone morphogenetic protein-2. Biointerphases, 10 (4) 04A308, 1-12. doi: 10.1116/1.4933109

Repair of segmental ulna defects using a β-TCP implant in combination with a heparan sulfate glycosaminoglycan variant

Rai, B., Chatterjea, A., Lim, Z. X.H., Tan, T. C., Sawyer, A. A., Hosaka, Y. Z., Murali, S., Lee, J. J.L., Fenwick, S. A., Hui, J. H., Nurcombe, V. and Cool, S. M. (2015). Repair of segmental ulna defects using a β-TCP implant in combination with a heparan sulfate glycosaminoglycan variant. Acta Biomaterialia, 28, 193-204. doi: 10.1016/j.actbio.2015.09.008

Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling

Lee, Jonathan, Wee, Sheena, Gunaratne, Jayantha, Chua, R. J. E., Smith, Raymond A. A., Ling, Ling, Fernig, David G., Swaminathan, Kunchithapadam, Nurcombe, Victor and Cool, Simon M. (2015). Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling. Glycobiology, 25 (12), 1491-1504. doi: 10.1093/glycob/cwv064

Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity

Okolicsanyi, Rachel K., Van Wijnen, Andre J., Cool, Simon M., Stein, Gary S., Griffiths, Lyn R. and Haupt, Larisa M. (2014). Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. Journal of Cellular Biochemistry, 115 (5), 967-976. doi: 10.1002/jcb.24746

Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2014). Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy. Biomaterials, 35 (25), 6776-6786. doi: 10.1016/j.biomaterials.2014.04.084

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Van Der Deen, Margaretha, Taipaleenmäki, Hanna, Zhang, Ying, Teplyuk, Nadiya M., Gupta, Anurag, Cinghu, Senthilkumar, Shogren, Kristen, Maran, Avudaiappan, Yaszemski, Michael J., Ling, Ling, Cool, Simon M., Leong, David T., Dierkes, Christian, Zustin, Jozef, Salto-Tellez, Manuel, Ito, Yoshiaki, Bae, Suk-Chul, Zielenska, Maria, Squire, Jeremy A., Lian, Jane B., Stein, Janet L., Zambetti, Gerard P., Jones, Stephen N., Galindo, Mario, Hesse, Eric, Stein, Gary S. and Van Wijnen, Andre J. (2013). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry, 288 (29), 21307-21319. doi: 10.1074/jbc.M112.445890

Multifunctional silica nanoparticles with potentials of imaging and gene delivery

Bhakta, Gajadhar, Sharma, Rakesh Kumar, Gupta, Nikesh, Cool, Simon, Nurcombe, Victor and Maitra, Amarnath (2011). Multifunctional silica nanoparticles with potentials of imaging and gene delivery. Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (4), 472-479. doi: 10.1016/j.nano.2010.12.008

Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling

Tian, Jing, Ling, Ling, Shboul, Mohammad, Lee, Hane, O'Connor, Brian, Merriman, Barry, Nelson, Stanley F., Cool, Simon, Ababneh, Osama H., Al-Hadidy, Azmy, Masri, Amira, Hamamy, Hanan and Reversade, Bruno (2010). Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. American Journal of Human Genetics, 87 (6), 768-778. doi: 10.1016/j.ajhg.2010.11.005

Functional coupling between the extracellular matrix and nuclear lamina by wnt signaling in progeria

Hernandez, Lidia, Roux, Kyle J., Wong, Esther Sook Miin, Mounkes, Leslie C., Mutalif, Rafidah, Navasankari, Raju, Rai, Bina, Cool, Simon, Jeong, Jae-Wook, Wang, Honghe, Lee, Hyun-Shik, Kozlov, Serguei, Grunert, Martin, Keeble, Thomas, Jones, C. Michael, Meta, Margarita D., Young, Stephen G., Daar, Ira O., Burke, Brian, Perantoni, Alan O. and Stewart, Colin L. (2010). Functional coupling between the extracellular matrix and nuclear lamina by wnt signaling in progeria. Developmental Cell, 19 (3), 413-425. doi: 10.1016/j.devcel.2010.08.013

Composite electrospun scaffolds for engineering tubular bone grafts

Ekaputra, Andrew Krishna, Zhou, Yefang, Cool, Simon McKenzie and Hutmacher, Dietmar Werner (2009). Composite electrospun scaffolds for engineering tubular bone grafts. Tissue Engineering - Part A, 15 (12), 3779-3788. doi: 10.1089/ten.tea.2009.0186

De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton

Kumarasuriyar, A., Lee, I., Nurcombe, V. and Cool, S. M. (2009). De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. Journal of Cellular Physiology, 219 (3), 572-583. doi: 10.1002/jcp.21700

Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo

Tonks, Ian D., Mould, Arne, Nurcombe, Victor, Cool, Simon M., Walker, Graeme J., Hacker, Elke, Keith, Patricia, Schroder, Wayne A., Cotterill, Andrew, Hayward, Nicholas K. and Kay, Graham F. (2009). Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo. Pigment Cell and Melanoma Research, 22 (3), 328-330. doi: 10.1111/j.1755-148X.2009.00560.x

Wnt signaling controls the fate of mesenchymal stem cells

Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2009). Wnt signaling controls the fate of mesenchymal stem cells. Gene, 433 (1-2), 1-7. doi: 10.1016/j.gene.2008.12.008

Glycosaminoglycan composition changes with MG-63 osteosarcoma osteogenesis in vitro and induces human mesenchymal stem cell aggregation

Kumarasuriyar, A., Murali, S., Nurcombe, V. and Cool, S. M. (2009). Glycosaminoglycan composition changes with MG-63 osteosarcoma osteogenesis in vitro and induces human mesenchymal stem cell aggregation. Journal of Cellular Physiology, 218 (3), 501-511. doi: 10.1002/jcp.21620

Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(β-hydroxybutyrate-co-β-hydroxyvalerate)

Kumarasuriyar, Arjuna, Grondahl, Lisbeth, Nurcombe, Victor and Cool, Simon M. (2009). Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(β-hydroxybutyrate-co-β-hydroxyvalerate). Gene, 428 (1-2), 53-58. doi: 10.1016/j.gene.2008.09.020

Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells

Dombrowski, Christian, Song, Shu Jun, Chuan, Peiying, Lim, Xinhong, Susanto, Evelyn, Sawyer, Amber A., Woodruff, Maria A., Hutmacher, Dietmar W., Nurcombe, Victor and Cool, Simon M. (2008). Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells. Stem Cells and Development, 18 (4), 661-670. doi: 10.1089/scd.2008.0157

A simple and reliable electroporation method for human bone marrow mesenchymal stem cells

Helledie, T., Nurcombe, V. and Cool, S. M. (2008). A simple and reliable electroporation method for human bone marrow mesenchymal stem cells. Stem Cells Dev, 17 (4), 837-848. doi: 10.1089/scd.2007.0209

Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells

Rider, D. A., Dombrowski, C., Sawyer, A. A., Ng, G. H., Leong, D., Hutmacher, D. W., Nurcombe, V. and Cool, S. M. (2008). Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells, 26 (6), 1598-1608. doi: 10.1634/stemcells.2007-0480

Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs

Ekaputra, A. K., Prestwich, G. D., Cool, S. M. and Hutmacher, D. W. (2008). Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. Biomacromolecules, 9 (8), 2097-2103. doi: 10.1021/bm800565u

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma

Nathan, S. S., Pereira, B. P., Zhou, Y. F., Gupta, A., Dombrowski, C., Soong, R., Pho, R. W., Stein, G. S., Salto-Tellez, M., Cool, S. M. and van Wijnen, A. J. (2008). Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. Mol Biol Rep, 36 (1), 153-158. doi: 10.1007/s11033-008-9378-1

Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals

Grunert, M., Nurcombe, V. and Cool, S. M. (2008). Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals. Current Stem Cell Research and Therapy, 3 (1), 1-8. doi: 10.2174/157488808783489417

Sustained release and osteogenic potential of heparan sulfate-doped fibrin glue scaffolds within a rat cranial model

Woodruff, Maria Ann, Rath, Subha Narayan, Susanto, Evelyn, Haupt, Larisa M., Hutmacher, Dietmar W., Nurcombe, Victor and Cool, Simon M. (2007). Sustained release and osteogenic potential of heparan sulfate-doped fibrin glue scaffolds within a rat cranial model. Journal of Molecular Histology, 38 (5), 425-433. doi: 10.1007/s10735-007-9137-y

The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells

Luong-Van, E, Grondahl, L, Song, SJ, Nurcombe, V and Cool, S (2007). The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells. Journal of Molecular Histology, 38 (5), 459-468. doi: 10.1007/s10735-007-9129-y

Concepts of scaffold-based tissue engineering - The rationale to use solid free-form fabrication techniques

Hutmacher, D. W. and Cool, S. (2007). Concepts of scaffold-based tissue engineering - The rationale to use solid free-form fabrication techniques. Journal of Cellular and Molecular Medicine, 11 (4), 654-669. doi: 10.1111/j.1582-4934.2007.00078.x

Investigations into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface properties causing delayed osteoblast growth

Keen, I., Raggatt, L.J., Cool, S.M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2007). Investigations into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface properties causing delayed osteoblast growth. Journal of Biomaterials Science-polymer Edition, 18 (9), 1101-1123. doi: 10.1163/156856207781554046

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite biomaterials for bone tissue regeneration: In vitro performance assessed by osteoblast proliferation, osteoclast adhesion and resorption, and macrophage proinflammatory response

Cool, SM, Kenny, B, Wu, A, Nurcombe, V, Trau, M, Cassady, AI and Grondahl, L (2007). Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite biomaterials for bone tissue regeneration: In vitro performance assessed by osteoblast proliferation, osteoclast adhesion and resorption, and macrophage proinflammatory response. Journal of Biomedical Materials Research Part A, 82A (3), 599-610. doi: 10.1002/jbm.a.31174

In vitro biocompatibility and bioactivity of microencapsulated heparan sulfate

Luong-Van, E, Grondahl, L, Nurcombe, V and Cool, S (2007). In vitro biocompatibility and bioactivity of microencapsulated heparan sulfate. Biomaterials, 28 (12), 2127-2136. doi: 10.1016/j.biomaterials.2007.01.002

A novel use of TAT-EGFP to validate techniques to alter osteosarcoma cell surface glycosaminoglycan expression

Kumarasuriyar, A, Dombrowski, C, Rider, DA, Nurcombe, V and Cool, SM (2007). A novel use of TAT-EGFP to validate techniques to alter osteosarcoma cell surface glycosaminoglycan expression. Journal of Molecular Histology, 38 (5), 435-447. doi: 10.1007/s10735-007-9136-z

Control of cell fate decisions.

Cool SM (2007). Control of cell fate decisions.. Journal of Molecular Histology, 38 (5), 377-379. doi: 10.1007/s10735-007-9146-x

Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways.

Manton, KJ, Leong, DF, Cool, SM and Nurcombe, V (2007). Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways.. Stem Cells: the international journal of cell differentiation and proliferation, 25 (11), 2845-2854. doi: 10.1634/stemcells.2007-0065

Glycosaminoglycan and growth factor mediated murine calvarial cell proliferation

Manton, KJ, Haupt, LM, Vengadasalam K, Nurcombe V and Cool SM (2007). Glycosaminoglycan and growth factor mediated murine calvarial cell proliferation. Journal of Molecular Histology, 38 (5), 415-424. doi: 10.1007/s10735-007-9121-6

Heparan sulfate control of proliferation and differentiation in the stem cell niche.

Nurcombe, V and Cool, SM (2007). Heparan sulfate control of proliferation and differentiation in the stem cell niche.. Critical Reviews in Eukaryotic Gene Expression, 17 (2), 159-171.

Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2

Jackson, RA, Murali, S, Van Wijnen, AJ, Stein, GS, Nurcombe, V and Cool, SM (2007). Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2. Journal of Cellular Physiology, 210 (1), 38-50. doi: 10.1002/jcp.20813

Isolation of a native osteoblast matrix with a specific affinity for BMP2

Grunert, M, Dombrowski, C, Sadasivam, M, Manton, K, Cool, SM and Nurcombe, V (2007). Isolation of a native osteoblast matrix with a specific affinity for BMP2. Journal of Molecular Histology, 38 (5), 393-404. doi: 10.1007/s10735-007-9119-0

Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors.

Woei Ng, K, Speicher, T, Dombrowski, C, Helledie, T, Haupt, LM, Nurcombe, V and Cool, SM (2007). Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors.. Stem Cells and Development, 16 (2), 305-318. doi: 10.1089/scd.2006.0044

Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2

Song, SJ, Cool, SM and Nurcombe, V (2007). Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2. Journal of Cellular Biochemistry, 100 (2), 402-411. doi: 10.1002/jcb.21068

Selection using the alpha-1 integrin (CD49a) enhances the multipotentiality of the mesenchymal stem cell population from heterogeneous bone marrow stromal cells

Rider, DA, Nalathamby, T, Nurcombe, V and Cool, SM (2007). Selection using the alpha-1 integrin (CD49a) enhances the multipotentiality of the mesenchymal stem cell population from heterogeneous bone marrow stromal cells. Journal of Molecular Histology, 38 (5), 449-458. doi: 10.1007/s10735-007-9128-z

Temporal and functional changes in glycosaminoglycan expression during osteogenesis.

Nurcombe, V, Goh, FJ, Haupt, LM, Murali, S and Cool, SM (2007). Temporal and functional changes in glycosaminoglycan expression during osteogenesis.. Journal of Molecular Histology, 38 (5), 469-481. doi: 10.1007/s10735-007-9123-4

Characterisation and differentiation of porcine bone marrow mesenchymal stem cells in 2D and 3D mPCL-TCP-collagen scaffolds

Zhen, Chum Zhi, Woodruff, M. A., Sugunan, Suman Lal Chirammal, Cool, S. M., Nurcombe, V. and Hutmacher, D. W. (2006). Characterisation and differentiation of porcine bone marrow mesenchymal stem cells in 2D and 3D mPCL-TCP-collagen scaffolds. European Cells and Materials, 11 (S2), 82-82.

Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers

Luong-Van, Emma, Grondahl, Lisbeth, Chua, Kian Ngiap, Leong, Kam W., Nurcombe, Victor and Cool, Simon M. (2006). Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. Biomaterials, 27 (9), 2042-2050. doi: 10.1016/j.biomaterials.2005.10.028

Bone-Specific Heparan Sulfates Induce Osteoblast Growth Arrest and Downregulation of Retinoblastoma Protein

Manton, J., Sadasivam,, Cool, S M and Nurcombe, V (2006). Bone-Specific Heparan Sulfates Induce Osteoblast Growth Arrest and Downregulation of Retinoblastoma Protein. Journal Of Cellular Physiology, 209 (1), 219-229. doi: 10.1002/jcp.20727

Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis

Jackson, A, Nurcombe, V and Cool, S M (2006). Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene, 379, 79-91. doi: 10.1016/j.gene.2006.04.028

Heparan Sulfate Regulation of Progenitor Cell Fate

Cool, S M and Nurcombe, V (2006). Heparan Sulfate Regulation of Progenitor Cell Fate. Journal of Cellular Biochemistry, 99 (4), 1040-1051. doi: 10.1002/jcb.20936

Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells

Jackson, RA, Kumarasuriyar, A, Nurcombe, V and Cool, SM (2006). Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells. Journal of Cellular Physiology, 209 (3), 894-904. doi: 10.1002/jcp.20779

Sulfated Glycosaminoglycans Mediate the Effects of FGF2 on the Osteogenic Potential of Rat Calvarial Osteoprogenitor Cells

Ling,, Sadasivam,, Dombrowski,, Haupt, L. M., Stein,, Van Wijnen,, Nurcombe, V and Cool, S M (2006). Sulfated Glycosaminoglycans Mediate the Effects of FGF2 on the Osteogenic Potential of Rat Calvarial Osteoprogenitor Cells. Journal Of Cellular Physiology, 209 (3), 811-825. doi: 10.1002/jcp.20760

Temporal expression of proteoglycans in the rat limb during bone healing

Song, J., Hutmacher, D., Nurcombe, V. and Cool, S. M. (2006). Temporal expression of proteoglycans in the rat limb during bone healing. Gene, 379, 92-100. doi: 10.1016/j.gene.2006.04.029

Adult CNS explants as a source of neural progenitors

Chipperfield, H, Cool, SM, Bedi, K and Nurcombe, V (2005). Adult CNS explants as a source of neural progenitors. Brain Research Protocols, 14 (3), 146-153. doi: 10.1016/j.brainresport.2004.12.003

Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells

Cool, S. M., Grunert, M., Jackson, R., Li, H., Nurcombe, V. and Waters, M. J. (2005). Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells. Biochemical And Biophysical Research Communications, 338 (2), 1048-1058. doi: 10.1016/j.bbrc.2005.10.035

Temporal expression of fibroblast growth factor receptors during primary ligament repair

Cool, Simon M., Synman, Charles P., Nurcombe, Victor and Forwood, Mark (2004). Temporal expression of fibroblast growth factor receptors during primary ligament repair. Knee Surgery Sports Traumatology Arthroscopy, 12 (5), 490-496. doi: 10.1007/s00167-003-0444-x

Functional maturation of isolated neural progenitor cells from the adult rat hippocampus

Hogg, R. C., Chipperfield, H., Whyte, K. A., Stafford, M. R., Hansen, M. A., Cool, S. M., Nurcombe, V. and Adams, D. J. (2004). Functional maturation of isolated neural progenitor cells from the adult rat hippocampus. European Journal of Neuroscience, 19 (9), 2410-2420. doi: 10.1111/j.0953-816X.2004.03346.x

Comparisons between bone and cementum compositions and the possible basis for their layered appearances

Cool, S. M., Forwood, M. R., Campbell, P. and Bennett, M. B. (2002). Comparisons between bone and cementum compositions and the possible basis for their layered appearances. Bone, 30 (2), 386-392. doi: 10.1016/S8756-3282(01)00686-X

Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures

Cool, S, Jackson, R, Pincus, P, Dickinson, I and Nurcombe, V (2002). Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures. International Journal of Developmental Biology, 46 (4), 519-523.

Heparan sulfates isolated from adult neural progenitor cells can direct phenotypic maturation

Chipperfield, H., Bedi, K. S., Cool, S. M. and Nurcombe, V. (2002). Heparan sulfates isolated from adult neural progenitor cells can direct phenotypic maturation. International Journal of Developmental Biology, 46 (4), 1-6.

Temporal and spatial expression of fibroblast growth factor receptor 4 isoforms in murine tissues

Cool, S. M., Sayer, R. E., van Heumen, W. R., Pickles, J. O. and Nurcombe, V. (2002). Temporal and spatial expression of fibroblast growth factor receptor 4 isoforms in murine tissues. Histochemical Journal, 34 (6-7), 291-297. doi: 10.1023/A:1023326524562

Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways

Descamps, S, Toillon, RA, Adriaenssens, E, Pawlowski, V, Cool, SM, Nurcombe, V, Le Bourhis, XF, Boilly, B, Peyrat, JP and Hondermarck, H (2001). Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. Journal of Biological Chemistry, 276 (21), 17864-17870. doi: 10.1074/jbc.M010499200

The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates

Nurcombe, Victor, Smart, Chanel E., Chipperfield, Hiram, Cool, Simon M., Boilly, Benoni and Hondermarck, Hubert (2000). The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. Journal of Biological Chemistry, 275 (39), 30009-30018. doi: 10.1074/jbc.M003038200

High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates

Titmarsh, D., Glass, N., Nurcombe, V., Cooper-White, J. and Cool, S. (2015). High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates. 4th TERMIS World Congress, Boston, MA USA, 8-11 September 2015. New Rochelle, NY USA: Mary Ann Liebert.

Raman mapping glucose metabolism during adipogenesis from human mesenchymal stem cells

Gomathy, S. S., Stylianou, C., Phang, I. Y., Cool, S., Nurcombe, V., Ample, F., Lear, M. J., Gorelik, S. and Hobley, J. (2010). Raman mapping glucose metabolism during adipogenesis from human mesenchymal stem cells. Photonics Global Conference, Orchard, Singapore, 14-16 December 2010. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/PGC.2010.5705978

Heparan sulfate promotes human mesenchymal stem cell growth and viability in vitro and stimulates bone repair in vivo

Sawyer, Amber A., Lim, Xinhong, Hosaka, Yoshi, Rider, David A., Poh, Wei Theng, Hui, James, Doshi, Hitendra, Nurcombe, Vic and Cool, Simon (2008). Heparan sulfate promotes human mesenchymal stem cell growth and viability in vitro and stimulates bone repair in vivo. World Biomaterials Congress, _, _.

Tailoring poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for bone tissue engineering

Grondahl, L, Keen, I, Raggatt, L, Chandler-Temple, A. F., Cool, S M and Trau, M (2006). Tailoring poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for bone tissue engineering. 28th Australasian Polymer Symposium & Aust Society for Biomat, Rotorua, 5-9 Feb, 2006.

Parathyroid hormone stimulation of syndecan-4 in osteoblastic cells.

Raggatt, L. J., Qin, L., Cool, S., Nurcombe, V. and Partridge, N. (2005). Parathyroid hormone stimulation of syndecan-4 in osteoblastic cells.. 27th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Nashville, TN USA, 23-27 September 2005. Hoboken, NJ USA: Wiley-Blackwell Publishing.

Characterisation of alginate and hydroxyapatite/alginate drug delivery systems

Grondahl, L., Lawrie, G. A. and Cool, S. M. (2005). Characterisation of alginate and hydroxyapatite/alginate drug delivery systems. Aust Society for Biomaterials 14th Annual Conference, Victor Harbor, Mar, 2005.

Electrospun polycaprolactone fiber membranes for the sustained delivery of heparin

Luong-Van, E. K., Grondahl, L., Chua, K.B., Leong, K.C., Nurcombe, V. and Cool, S. M. (2005). Electrospun polycaprolactone fiber membranes for the sustained delivery of heparin. Indo-Australian Conference on Biomaterials, Implantable Devicg, India, Jan, 2005.

Parathyroid hormone regulation of syndecan-4 in osteoblast cells

Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge, N. C. (2005). Parathyroid hormone regulation of syndecan-4 in osteoblast cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 23-27 September 2005. Washington, DC USA: Wiley-Blackwell.

Parathyroid hormone stimulation of Syndecan-4 in osteoblastic cells

Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge N. C. (2005). Parathyroid hormone stimulation of Syndecan-4 in osteoblastic cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 24-26 September, 2005. Malden, MA USA: American Society for Bone and Mineral Research.

Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) supports in vitro osteogenesis

Kumarasuriyar, A., Jackson, R. A., Grondahl, L., Trau, M., Nurcombe, V. and Cool, S. M. (2005). Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) supports in vitro osteogenesis. New Rochelle: Mary Ann Liebert Inc. doi: 10.1089/ten.2005.11.1281

Response of osteoblast cells to the surface properties of Poly(3-hydroxybutyrate-co-hydroxyvalerate) PHBV

Keen, I., Raggatt, L., Cool, S. M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2005). Response of osteoblast cells to the surface properties of Poly(3-hydroxybutyrate-co-hydroxyvalerate) PHBV. 2nd ARC Centre For Functional Nanomaterials Annual Conference, Maroochydore, Nov, 2005.

Development and in vitro testing of a biodegradable bone scaffold

Grondahl, L., Lutton, C. J., Kenny, B., Cool, S. M., Cassady, A.I. and Trau, M. (2004). Development and in vitro testing of a biodegradable bone scaffold. 7th World Biomaterials Congress, Sydney, May, 2004.

Heparan sulfate loaded Poly( -caprolactone) microparticles for bone repair

Luong-Van, E. K., Grondahl, L., Nurcombe, V. and Cool, S. M. (2004). Heparan sulfate loaded Poly( -caprolactone) microparticles for bone repair. 7th World Biomaterials Congress, Sydney, May, 2004.

In vitro analysis of a bioactive, biodegradable material for bone repair

Kumarasuriyar, A., Jackson, R., Grondahl, L., Trau, M., Nurcombe, V. and Cool, S. M. (2004). In vitro analysis of a bioactive, biodegradable material for bone repair. 7th World Biomaterials Congress, Sydney, May, 2004.

Influence of solvent on the surface properties of PHBV solvent cast films

Keen, I., Grondahl, L., Raggatt, L., Fredericks, P.M., Nurcombe, V., Trau, M. and Cool, S. M. (2004). Influence of solvent on the surface properties of PHBV solvent cast films. 27th Australasian Polymer Symposium, Adelaide, Nov, 2004.

Surface modification of PHBV for bone tissue engineering

Keen, I., Grondahl, L., Cool, S. M., Nurcombe, V. and Trau, M. (2004). Surface modification of PHBV for bone tissue engineering. 7th World Biomaterials Congress, Sydney, May, 2004.

Teaching gross anatomy in a PBL-based medical curriculum

Kippers, V., Cool, S. and Aland, R. C. (2004). Teaching gross anatomy in a PBL-based medical curriculum. 16th International Congress of the International Federation of Associations of Anatomists (IFAA 2004): Morphological Sciences as the Basis of New Life Science in the 21st Century, Kyoto International Conference Hall, Kyoto, Japan, 22-27 August 2004. Victoria: Blackwell Publishing Asia.

Biodegradable polyester materials: Uses in bone regeneration

Grondahl, L., Chandler-Temple, A. F., Luong-Van, E. K., Riding, A. S., Kumarasuriyar, A., Kenny, B., Cool, S. M., Nurcombe, V., Whittaker, A. K., Cassady, I.A. and Trau, M. (2003). Biodegradable polyester materials: Uses in bone regeneration. 26th Australian Polymer Conference, Noosa, July, 2003.

Surface modification for PHBV for enhanced biocompatibility

Chandler-Temple, A. F., Grondahl, L., Trau, M., Cool, S. M. and Nurcombe, V. (2003). Surface modification for PHBV for enhanced biocompatibility. 13th Annual Conference of Australian Society for Biomaterials, Brisbane, March, 2003.

Fluid shear stress as a mediator of fibroblast growth factor receptor (FGFR) expression and osteoblast phenotype

Jackson, R., Nurcombe, V. and Cool, S. M. (2001). Fluid shear stress as a mediator of fibroblast growth factor receptor (FGFR) expression and osteoblast phenotype. Australia and New Zealand Bone and Mineral Society 11th Annual Scientific Meeting, Auckland, NZ, October 2001.

Peritoneal fluid: a potential source of stem cells with osteogenic potential?

Cool, S. M., Jackson, R., Campbell, J. H. and Nurcombe, V. (2001). Peritoneal fluid: a potential source of stem cells with osteogenic potential?. Australia and New Zealand Bone and Mineral Society 11th Annual Scientific Meeting, Auckland, NZ, October 2001.